Major interaction on record — check this product against your medications before combining. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Maximum Strength Cosamin ASU Ingredients & Drug Interactions

by Nutramax Laboratories Consumer Care

Maximum Strength Cosamin ASU label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Maximum Strength Cosamin ASU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Maximum Strength Cosamin ASU is a dietary supplement by Nutramax Laboratories Consumer Care with 6 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 1,236 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are AKBA Complex, Sodium, Glucosamine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care

Ask about any prescription or over-the-counter medication and we check it for interactions with Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 8 active ingredients.
  • “Avocado/Soybean Unsaponifiables (ASU) powder” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “AKBA Complex” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Proprietary Chondroitin Sulfate, ASU Powder, and AKBA Complex” is a proprietary blend — the label gives one combined amount (750 mg) without saying how much of each component you get.

Maximum Strength Cosamin ASU contains 8 active ingredients. Sodium provides an electrolyte mineral that's essential in small amounts but problematic in excess.

Mixed tocopherols (vitamin E) is an antioxidant that protects cells. Glucosamine HCl is an amino sugar that supports joint cartilage.

Avocado and soy unsaponifiables (ASU powder, the AKBA Complex, and soy unsaponifiables) are plant-derived compounds believed to support joint health. Sodium chondroitin sulfate is a carbohydrate polymer found naturally in cartilage.

Boswellia serrata extracts contain compounds traditionally used to support inflammation and joint function. Soy protein isolate adds plant protein.

The capsule also contains inactive ingredients including gelatin as a capsule material.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Joint comfort and cartilage support.
  • We looked for evidence on: Knee osteoarthritis, Hip osteoarthritis.
  • The strongest evidence on file: Glucosamine is rated "Likely Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Boswellia Serrata is rated "Possibly Effective" for Osteoarthritis.
  • Also on file: Chondroitin Sulfate is rated "Possibly Effective" for Osteoarthritis.

Glucosamine is likely effective for osteoarthritis—the main reason people take this product. Vitamin E is effective for vitamin E deficiency and possibly effective for Alzheimer's disease and several other conditions, though the doses needed may vary.

Boswellia serrata extracts are possibly effective for osteoarthritis. Chondroitin sulfate is possibly effective for osteoarthritis and cataracts.

Avocado unsaponifiables are possibly effective for high cholesterol. Glycine shows possibly effective evidence for schizophrenia at higher doses, though this product is not positioned as a schizophrenia treatment.

The evidence for many other claimed uses—such as aging skin, back pain, or metabolic health—is insufficient to establish effectiveness in the data we hold.

The evidence, ingredient by ingredient Sodium Glucosamine Chondroitin Sulfate Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is generally well tolerated at normal dietary levels but can worsen high blood pressure and strain the heart at high intakes. Vitamin E from food and standard supplements is safe, though long-term high-dose supplements may rarely increase the risk of bleeding and hemorrhagic stroke, particularly in smokers.

Glucosamine is generally well tolerated but may cause bloating, constipation, diarrhea, nausea, or heartburn in some people; rare allergic reactions and asthma flare-ups have been reported. Boswellia serrata extract is generally well tolerated short-term and is likely safe in pregnancy, though quality varies widely.

Avocado from food is safe for most people but concentrated supplements are not well studied. Chondroitin sulfate is generally well tolerated for short-term use.

Glycine is generally well tolerated at typical doses but has limited long-term safety data. There is not enough safety information on glucosamine or chondroitin for pregnancy, so those ingredients should be avoided during pregnancy.

Safety during breastfeeding is also unclear for both.

Side effects, ingredient by ingredient Sodium Glucosamine Chondroitin Sulfate Boswellia Serrata

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Boswellia Serrata, Chondroitin Sulfate, Glucosamine, Avocado, Vitamin E, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications; lithium.
  • For scale: 1,237 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you use warfarin or other blood thinners—glucosamine, vitamin E, avocado, and chondroitin all carry Major or Moderate bleeding risks with these drugs. Also confirm use if you take blood pressure medications, corticosteroids, lithium, chemotherapy drugs, clozapine, cyclosporine, or any drugs metabolized by your liver's CYP enzymes (CYP2D6, CYP2C19, CYP1A2, CYP2C9, or CYP3A4).

No interactions are documented for soy protein isolate, the one ingredient we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may help with osteoarthritis, the primary condition it's formulated for, though quality and individual results vary. If you take warfarin or other blood thinners, diabetes medications, blood pressure drugs, lithium, clozapine, or medications metabolized by your liver, you'll need to clear this product with your doctor or pharmacist before starting—the sodium and several plant compounds here interact with those drugs.

Pregnant or breastfeeding people should avoid it due to insufficient safety data for glucosamine and chondroitin. Talk with your own healthcare provider about whether it's right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Maximum Strength Cosamin ASU, straight from the product label.

Brand Nutramax Laboratories Consumer Care
Barcode (UPC) 755970820140
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Dec 23, 2015
DSLD ID 54981
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
60
UPC/BARCODE
755970820140
IngredientAmount% DV
Calories15 {Calories}--
Total Carbohydrates1 Gram(s)1%
Sodium70 mg3%
Protein1 Gram(s)--
Mixed Tocopherols0 NP--
Soy Protein isolate0 NP--
Glucosamine HCl1.5 Gram(s)--
Avocado/Soybean Unsaponifiables (ASU) powder0 NP--
Soy (Glycine maximus) Unsaponifiables0 NP--
Avocado (Persea gratissima) Unsaponifiables0 NP--
Sodium Chondroitin Sulfate0 NP--
AKBA Complex0 NP--
Boswellia extracts0 NP--
Proprietary Chondroitin Sulfate, ASU Powder, and AKBA Complex750 mg--

Other ingredients: Gelatin, Contains <2% of:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions for Use: Take 3 capsules daily until desired comfort level is reached. Then gradually reduce number of capsules taken daily to maintain comfort level. Capsules may be taken all at once or divided with meals throughout the day.*

Precautions

If you have any condition that requires medical attention, always consult your physician before taking any dietary supplement.

Important: Tamper evident seal under cap. Do not use if seal is broken or missing.

Contains: Glucosamine derived from crab and shrimp. Contains: Soy.

Storage

Keep in a cool, dry place.

Formulation

Gluten-Free.

General Statements

{CAPSULE} COS ASU

Psalm 86:12

For more information visit CosaminASU.com or call Customer Service at 1-877-COSAMIN (1-877-267-2646).

Tested and Certified by NSF.

JOINT HEALTH SUPPLEMENT*

ADVANCED FORMULA NEW & IMPROVED

Brand IP Statement(s)

U.S. Patent Nos. 6,797,289. Additional Patent Pending.

2014 Nutramax Laboratories, Inc.

General

10-1072-00

Seals/Symbols

NSF Contents Tested & Certified www.nsf.org

#1 RESEARCHED Glucosamin/Chondroitin Brand

FDA Statement of Identity

Dietary Supplement

Formula

Glucosamine HCI Chondroitin Sulfate ASU AKBA

Contains: Glucosamine derived from crab and shrimp. Contains: Soy.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Maximum Strength Cosamin ASU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
70 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Protein

1 Gram(s) per serving

Glucosamine HCl

Interacts with
170 drugs
1.5 Gram(s) per serving

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

Glucosamine HCl monograph & interactions

Proprietary Chondroitin Sulfate, ASU Powder, and AKBA Complex

750 mg per serving

Other (inactive) ingredients: Gelatin, Contains <2% of:. These complete the product’s ingredient list but are not active constituents.

Interaction report

Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care Drug Interactions

Want to check YOUR meds against Maximum Strength Cosamin ASU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,236Drugs
2 Major 1,164 Moderate 70 Minor

Ingredients driving the most interactions

AKBA Complex 952
Sodium 205
Glucosamine HCl 170
Sodium Chondroitin Sulfate 2

Individual Drug Interactions

The ingredients in Maximum Strength Cosamin ASU interact with 1,236 drugs. Click any drug to see the details.

4 of the 6 ingredients in Maximum Strength Cosamin ASU interact with drugs. Each result below shows which ingredient is responsible. AKBA Complex Sodium Glucosamine HCl Sodium Chondroitin Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Maximum Strength Cosamin ASU with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

AKBA Complex6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
AKBA Complex full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Glucosamine HCl4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
Glucosamine HCl full monograph & interactions

Sodium Chondroitin Sulfate1 drug type · 2 drugs

Warfarin (Coumadin)

Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin. However, the effect of chondroitin alone is unclear.
There have been multiple reports of increased international normalized ratio (INR) in patients taking warfarin with glucosamine, with or without chondroitin. The lack of reports with chondroitin alone seem to suggest that the interactions occurring in these reports may have been due to glucosamine. In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in INR in patients previously stabilized on warfarin. Additionally, 20 voluntary case reports to the US Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone, without chondroitin, to increased INR in patients taking warfarin.

Likelihood Unlikely Evidence D
Sodium Chondroitin Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Maximum Strength Cosamin ASU, from the product label.

Nutramax Laboratories Consumer Care

See all Nutramax Laboratories Consumer Care products
Name
Nutramax Laboratories Consumer Care, Inc.
City
Edgewood
State
MD
ZipCode
21040
Phone Number
1-800-925-5187
Web Address
NutramaxLabs.com
Pharmacist Counseling Corner

Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care: Common Questions

Does Maximum Strength Cosamin ASU by Nutramax Laboratories Consumer Care interact with any medications?
Yes. Based on its ingredients, Maximum Strength Cosamin ASU has a known interaction with 1,236 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Maximum Strength Cosamin ASU contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
The safety data advises against glucosamine and chondroitin during pregnancy, so this product should not be used. Safety while breastfeeding is also unknown for these two ingredients. Talk with your doctor or pharmacist before considering it.
Will this actually help my osteoarthritis?
Glucosamine is likely effective for osteoarthritis, and boswellia and chondroitin are possibly effective. That said, results vary from person to person, and quality differences exist between products. Your doctor can advise whether a trial is worth attempting.
What side effects might I experience?
The most common are stomach-related: bloating, constipation, diarrhea, nausea, and heartburn. Headache is possible with boswellia. Rare but serious effects include allergic reactions (including anaphylaxis in very rare cases) and asthma flare-ups.
Can I take this with my blood thinner?
No—do not take this product with warfarin or other blood thinners without your doctor's approval. Glucosamine, vitamin E, and the avocado compounds in this formula can increase bleeding risk. Your doctor or pharmacist must review it first.
Why is there sodium in a joint supplement?
Sodium is an essential electrolyte, and some formulations include it as a stabilizer or buffer. However, high sodium intake can raise blood pressure and interfere with blood pressure medications and other drugs like lithium. If you're on those medications or have salt restrictions, flag this product with your pharmacist.
Is the vitamin E in here enough to cause bleeding on its own?
Vitamin E alone from a single supplement is unlikely to cause bleeding at typical doses. The risk increases with higher doses and especially when combined with blood thinners. Combined with glucosamine and other compounds in this product that also carry bleeding risks, the cumulative effect is why checking with your doctor matters if you take blood thinners.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Maximum Strength Cosamin ASU label
Go deeper

The Full Monographs Behind Maximum Strength Cosamin ASU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph → Herb & supplement monograph

Chondroitin Sulfate

Interacts with 2 drugs

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...

Read the full Chondroitin Sulfate monograph → Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph →
Sources

Sources & How We Checked

Maximum Strength Cosamin ASU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 213 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
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Glycine 5 references
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Avocado 10 references
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See these in context on the Avocado monograph →

Chondroitin Sulfate 22 references
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See these in context on the Chondroitin Sulfate monograph →

Boswellia Serrata 16 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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