Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Menopause Support Ingredients & Drug Interactions

by Adaptogen Research

Menopause Support label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Menopause Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Menopause Support is a dietary supplement by Adaptogen Research with 5 active ingredients. Its ingredients are commonly taken for hemorrhoids, varicose veins and poor circulation, leg swelling (venous insufficiency).Based on those ingredients, 1,605 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sage, Hesperidin Methyl Chalcone, Black Cohosh extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Menopause Support by Adaptogen Research

Ask about any prescription or over-the-counter medication and we check it for interactions with Menopause Support by Adaptogen Research — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Menopause Support by Adaptogen Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 9 active ingredients.
  • “Hesperidin Methyl Chalcone” is listed as a grouped ingredient — the label gives one combined amount (150 mg) without saying how much of each component you get.

Menopause Support contains 9 active ingredients chosen to address menopausal changes. The main players are sage, black cohosh extract, and gamma-oryzanol — all backed by some evidence for menopausal symptom relief.

The product also includes citrus ingredients: lemon, lime, tangerine, and orange, which contribute flavonoids and other plant compounds, plus hesperidin methyl chalcone (a flavonoid blend) and lignan extract, both of which may support overall wellness during this life stage. Three inactive ingredients — vegetarian capsule, L-leucine, and silicon dioxide — serve as the capsule shell and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support for menopausal symptoms in women.
  • We looked for evidence on: Menopausal symptoms, Anxiety, Depression, Dysmenorrhea, Premenstrual syndrome (PMS), hot flashes — and 2 related terms.
  • The strongest evidence on file: Sage is rated "Possibly Effective" for Menopausal symptoms (Natural Medicines).
  • Also on file: Black Cohosh is rated "Possibly Effective" for Menopausal symptoms.
  • Also on file: Sage is rated "Insufficient Reliable Evidence To Rate" for Androgen deprivation therapy (ADT)-associated hot flashes.

Sage and black cohosh extract are both rated possibly effective for menopausal symptoms based on the evidence we hold. Gamma-oryzanol is possibly effective for dyslipidemia (high cholesterol and triglycerides), which can shift during menopause.

The citrus ingredients — lemon, lime, and tangerine — have insufficient evidence in our data to rate their effectiveness for the conditions studied. For the specific uses this product claims, sage and black cohosh carry the strongest data, though neither is proven.

The evidence, ingredient by ingredient Hesperidin Sweet Orange Lemon Lime Tangerine Grapefruit Sage Gamma-oryzanol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sage is generally well tolerated as a food or short-term tea, but concentrated extracts used medicinally can cause nausea, vomiting, diarrhea, dizziness, or abdominal pain in some people. Rare serious effects (like seizures) are linked to thujone, a sage compound.

Black cohosh is generally well tolerated in typical short-term doses and commonly causes mild side effects like breast tenderness, headache, or dizziness; however, rare liver concerns have been reported, so medical guidance is wise. Grapefruit and its juice are generally well tolerated as food, though concentrated supplements should be avoided — consuming large amounts daily has been linked to a potential breast cancer risk.

Lemon and lime in food amounts are safe for most people but may cause heartburn or gastrointestinal upset in some. Gamma-oryzanol is generally well tolerated, though long-term safety data are sparse.

Tangerine fruit is safe as food; essential oil is less studied. We hold no pregnancy or breastfeeding safety data for most of these ingredients in our files — talk with your doctor or pharmacist before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Hesperidin Sweet Orange Lemon Lime Tangerine Grapefruit Sage Gamma-oryzanol

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 8 matched ingredients can interact with medications — Sage, Lemon, Lime, Black Cohosh, Sweet Orange, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,558 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check if you use heart rhythm drugs (amiodarone), immunosuppressants (cyclosporine), anti-anxiety medications (buspirone), cough suppressants (dextromethorphan), blood pressure drugs, antidepressants or other serotonergic drugs, or anything metabolized by your liver — grapefruit and sage can both change how your body processes these. Also flag any antifungal (itraconazole), liver-metabolized CYP3A4 drugs, photosensitizing drugs, or estrogen therapy.

Run your exact medications through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may help ease menopausal symptoms, especially if you respond to sage or black cohosh. However, the grapefruit content and sage's liver-enzyme effects mean you need to check your medications first — especially blood pressure drugs, heart medications, antidepressants, and any drug your liver processes heavily.

If you're pregnant, nursing, or have liver concerns, discuss it with your pharmacist or doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Menopause Support, straight from the product label.

Brand Adaptogen Research
Barcode (UPC) 828054705050
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 247130
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult Female (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Menopause Support by Adaptogen Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
828054705050
IngredientAmount% DV
Hesperidin Methyl Chalcone150 mg--
Sage60 mg--
Orange0 NP--
Lemon0 NP--
Lime0 NP--
Tangerine0 NP--
Grapefruit0 NP--
Gamma-Oryzanol150 mg--
Black Cohosh extract20 mg--
Lignan extract25 mg--

Other ingredients: Vegetarian Capsule, L-Leucine, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formula

For Women

General Statements

Professional Use Only

Precautions

Report any adverse reactions to (302) 213-0030.

Do not use if shrinkwrap is broken or missing.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 capsule, 2 times daily with food or as directed by a healthcare practitioner.

Brand IP Statement(s)

HMRlignan brand, a trademark of Linnea SA

Storage

Store in a cool, dry place (59 degrees F-85 degrees F) away from direct light.

Formulation

Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.

Notice: Color, size or shape may appear different between lots.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Menopause Support by Adaptogen Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Menopause Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Menopause Support by Adaptogen Research

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Hesperidin Methyl Chalcone

Interacts with
702 drugs
150 mg per serving

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and v...

Hesperidin Methyl Chalcone monograph & interactions

Sage

Interacts with
1,296 drugs
60 mg per serving

Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and memory. Some...

Sage monograph & interactions

Gamma-Oryzanol

No known
interactions
150 mg per serving Form: Rice Bran Oil extract

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The...

Gamma-Oryzanol monograph & interactions

Black Cohosh extract

Interacts with
652 drugs
20 mg per serving Form: Triterpene Glycosides

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It...

Black Cohosh extract monograph & interactions

Lignan extract

25 mg per serving Form: 7-Hydroxymatairesinol, Norway Spruce

Other (inactive) ingredients: Vegetarian Capsule, L-Leucine, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Menopause Support by Adaptogen Research Drug Interactions

Want to check YOUR meds against Menopause Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,605Drugs
777 Major 828 Moderate

Ingredients driving the most interactions

Sage 1,296
Hesperidin Methyl Chalcone 702
Black Cohosh extract 652

Individual Drug Interactions

The ingredients in Menopause Support interact with 1,605 drugs. Click any drug to see the details.

3 of the 5 ingredients in Menopause Support interact with drugs. Each result below shows which ingredient is responsible. Sage Hesperidin Methyl Chalcone Black Cohosh extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Menopause Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sage14 drug types · 1,296 drugs

Anticholinergic Drugs

Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.

Likelihood Possible Evidence D
Anticonvulsants

Theoretically, sage might interfere with the clinical effects of anticonvulsant drugs.
Some species of sage can cause convulsions when consumed in large quantities.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking sage with antidiabetes drugs might increase the risk of hypoglycemia.
In patients with polycystic ovary syndrome (PCOS) or inadequately controlled type 2 diabetes, common sage (Salvia officinalis) has demonstrated hypoglycemic activity. However, other clinical research in patients with inadequately controlled type 2 diabetes shows that common sage extract does not lower fasting blood glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, sage might increase or decrease the effects of antihypertensive drugs.
Animal research suggests that common sage (Salvia officinalis) can cause prolonged blood pressure reduction. However, clinical research suggests that Spanish sage (Salvia lavandulaefolia) can increase blood pressure in some people with hypertension. Until more is known, use with caution.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking sage might increase the sedative and adverse effects of benzodiazepines.
In vitro evidence suggests that certain components of common sage (Salvia officinalis) can bind to benzodiazepine receptors. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, sage might have additive effects when used with cholinergic drugs.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Some constituents of sage have CNS depressant activity.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C19.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C9.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2D6. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Animal research suggests that drinking common sage (Salvia officinalis) tea increases the expression of CYP2E1. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP3A4. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, sage might interfere with hormone therapy.
In vitro evidence suggests that geraniol, a constituent of Spanish sage (Salvia lavandulaefolia), exerts estrogenic activity. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, sage might increase levels of drugs transported by P-glycoprotein.
In vitro research suggests that common sage (Salvia officinalis) can inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Sage full monograph & interactions

Hesperidin Methyl Chalcone7 drug types · 702 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Animal research suggests that hesperetin, a bioflavonoid aglycone derivative of hesperidin, may have antiplatelet activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Some clinical and animal research shows that hesperidin can decrease blood pressure. However, other clinical research shows that hesperidin does not affect blood pressure.

Likelihood Possible Evidence D
Celiprolol (Celicard)

Theoretically, hesperidin may decrease the levels and clinical effects of celiprolol.
Animal research shows that concomitant use of hesperidin may reduce the plasma area under the curve of celiprolol by up to 75%. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Animal studies show that hesperidin has sedative effects, due to opioid receptor activity and can increase sedation when used with diazepam. This effect has not been reported in humans.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hesperidin may increase the levels and clinical effects of diltiazem.
Animal research suggests that hesperidin may enhance the bioavailability of diltiazem, increasing the plasma area under the curve of diltiazem by up to 65.3%. This effect has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
In vitro research shows that hesperidin can inhibit P-glycoprotein efflux. This effect has not been reported in humans.

Likelihood Possible Evidence D
Verapamil (Calan, Others)

Theoretically, hesperidin might increase the levels and clinical effects of verapamil.
Animal research suggests that hesperidin may enhance the bioavailability of verapamil, increasing the plasma area under the curve of verapamil by 96.8%. This effect has not been reported in humans

Likelihood Possible Evidence D
Hesperidin Methyl Chalcone full monograph & interactions

Black Cohosh extract7 drug types · 652 drugs

Atorvastatin (Lipitor)

Taking black cohosh with atorvastatin might increase the risk for elevated liver function tests.
In one case report, a patient taking atorvastatin (Lipitor) developed significantly elevated liver function enzymes after starting black cohosh 100 mg four times daily. Liver enzymes returned to normal when black cohosh was discontinued. It is unclear whether the elevated liver enzymes were due to black cohosh itself or an interaction between atorvastatin and black cohosh.

Likelihood Possible Evidence D
Cisplatin (Platinol-Aq)

Theoretically, black cohosh may reduce the clinical effects of cisplatin.
Animal research suggests that black cohosh might decrease the cytotoxic effect of cisplatin on breast cancer cells.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Some clinical research suggests that black cohosh might modestly inhibit CYP2D6 and increase levels of drugs metabolized by this enzyme. However, contradictory clinical research shows a specific black cohosh product (Remifemin, Enzymatic Therapy) 40 mg twice daily does not significantly inhibit metabolism of a CYP2D6 substrate in healthy study volunteers. Until more is known, use black cohosh cautiously in patients taking drugs metabolized by CYP2D6.

Likelihood Possible Evidence B
Estrogens

Theoretically, black cohosh may alter the effects of estrogen therapy.
Some research suggests that black cohosh has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
There is concern that black cohosh might be linked to cases of liver failure and autoimmune hepatitis.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.
Black cohosh might increase the risk of serotonin syndrome when combined with other serotonergic drugs. Black cohosh acts as an agonist at several serotonin receptor subtypes and might interact with other serotonergic medications. In one case, a 55-year-old female who had been on stable treatment with sertraline 50 mg and duloxetine 60 mg daily developed serotonin syndrome after taking black cohosh extract 40 mg daily for 3 days.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Black cohosh may inhibit one form of OATP, OATP2B1, which could reduce the bioavailability and clinical effects of OATP2B1 substrates.
In vitro research shows that black cohosh modestly inhibits OATP2B1. OATPs are expressed in the small intestine and liver and are responsible for the uptake of drugs and other compounds into the body. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Black Cohosh extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Menopause Support, from the product label.

Adaptogen Research

See all Adaptogen Research products
Name
Adaptogen Research
Street Address
625 Barksdale Road, Suite 113
City
Newark
State
DE
ZipCode
19711
Phone Number
302-213-0030
Pharmacist Counseling Corner

Menopause Support by Adaptogen Research: Common Questions

Does Menopause Support by Adaptogen Research interact with any medications?
Yes. Based on its ingredients, Menopause Support has a known interaction with 1,605 medications, including 777 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Menopause Support contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this help with hot flashes?
Sage and black cohosh are both rated possibly effective for menopausal symptoms, which includes hot flashes. That said, the evidence is not definitive — response varies person to person, and you should talk with your doctor about what to expect.
Is it safe to take if I'm on blood pressure medication?
Possibly not — sage can theoretically increase or decrease the effects of blood pressure drugs, and the result depends on which type you take and which sage product is in this capsule. Check your specific blood pressure medication in the interaction checker below before starting.
Can I take it while pregnant?
We hold no pregnancy safety data on file for most of these ingredients, including sage, black cohosh, and the citrus components. Talk with your doctor or pharmacist for personalized advice before using it during pregnancy.
What's the difference between this and other menopause supplements?
This one combines sage and black cohosh — both possibly effective for menopausal symptoms — along with citrus flavonoids and gamma-oryzanol, which may support lipid health. The exact blend and potency differ from other brands, so compare labels if you're choosing between products.
Will it interact with my antidepressant?
Black cohosh can theoretically interact with serotonergic drugs (including many antidepressants) and increase serotonin effects. Sage may also affect liver-metabolized drugs. Check your specific antidepressant in the interaction tool below before you start.
What are the most common side effects?
Sage can cause nausea, vomiting, abdominal pain, diarrhea, or dizziness. Black cohosh commonly causes breast tenderness, headache, or dizziness. Lemon and lime may trigger heartburn or stomach upset in some people. Serious side effects are rare at typical doses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Menopause Support label
Go deeper

The Full Monographs Behind Menopause Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hesperidin

Interacts with 702 drugs

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and varicose veins. Some evidence supports th...

Read the full Hesperidin monograph → Herb & supplement monograph

Sweet Orange

Interacts with 246 drugs

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and...

Read the full Sweet Orange monograph → Herb & supplement monograph

Lemon

Interacts with 1 drug

Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it can support hydration and a healthy diet...

Read the full Lemon monograph → Herb & supplement monograph

Lime

Interacts with 886 drugs

Lime is a common citrus fruit and a good natural source of vitamin C and plant antioxidants. As a food it is generally safe and enjoyed by most people, but evidence that lime treats any spec...

Read the full Lime monograph → Herb & supplement monograph

Tangerine

Interacts with 643 drugs

Tangerine is a sweet citrus fruit that is a good source of vitamin C and other nutrients, and is widely enjoyed as food. While the peel and essential oil are used in traditional medicine and...

Read the full Tangerine monograph → Herb & supplement monograph

Grapefruit

Interacts with 990 drugs

Grapefruit is a nutritious citrus fruit rich in vitamin C and other nutrients, and it is generally safe to eat. However, grapefruit is famous for serious interactions with many prescription...

Read the full Grapefruit monograph → Herb & supplement monograph

Sage

Interacts with 1,296 drugs

Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and memory. Some early research is encouraging for sore...

Read the full Sage monograph → Herb & supplement monograph

Gamma-oryzanol

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The evidence is limited and mostly comes fro...

Read the full Gamma-oryzanol monograph → Herb & supplement monograph

Black Cohosh

Interacts with 652 drugs

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It is generally well tolerated for short-t...

Read the full Black Cohosh monograph →
Sources

Sources & How We Checked

Menopause Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 308 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hesperidin 14 references
  1. Fernandez, S. P., Wasowski, C., Paladini, A. C., and Marder, M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur.J.Pharmacol. 4-11-2005;512(2-3):189-198. PubMed
  2. Jin, Y. R., Han, X. H., Zhang, Y. H., Lee, J. J., Lim, Y., Chung, J. H., and Yun, Y. P. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. Atherosclerosis 200
  3. Loscalzo, L. M., Wasowski, C., Paladini, A. C., and Marder, M. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur.J.Pharmacol. 2-12-2008;580(3):306-313. PubMed
  4. Yamamoto, M., Suzuki, A., Jokura, H., Yamamoto, N., and Hase, T. Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats. Nutrition 2008;24(5):470-476. PubMed
  5. El-Readi, M. Z., Hamdan, D., Farrag, N., El-Shazly, A., and Wink, M. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. Eur.J.Pharmacol. 1-25-2010;626(2-3):139-145 PubMed
  6. Buckshee, K., Takkar, D., and Aggarwal, N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet 1997;57(2):145-151. PubMed
  7. Uesawa, Y. and Mohri, K. Hesperidin in orange juice reduces the absorption of celiprolol in rats. Biopharm Drug Dispos. 2008;29(3):185-188. PubMed
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Sweet Orange 17 references
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Lemon 2 references
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Tangerine 3 references
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See these in context on the Grapefruit monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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