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Dietary supplement

Ostivone Ingredients & Drug Interactions

by Integrative Therapeutics

Ostivone label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ostivone against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ostivone is a dietary supplement by Integrative Therapeutics with 1 active ingredient. Its ingredients are commonly taken for bone density and osteoporosis, postmenopausal bone loss, athletic performance.Based on those ingredients, 391 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ipriflavone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ostivone by Integrative Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Ostivone by Integrative Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ostivone by Integrative Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Ostivone contains one active ingredient: ipriflavone, a compound related to the isoflavones found in soy. It's designed to support bone density and strength.

The capsule itself is made from vegetable material, with magnesium stearate and silicon dioxide as inactive ingredients — these are standard binders and anti-caking agents with no pharmacological role.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support bone mineral density and healthy bones.
  • We looked for evidence on: Osteoporosis, bone loss, postmenopausal bone health, bone strength.
  • The strongest evidence on file: Ipriflavone is rated "Likely Effective" for Osteoporosis (Natural Medicines).

Ipriflavone is rated likely effective for osteoporosis and Paget disease based on the data we hold. This means there's solid evidence it can help slow bone loss and support bone health in these conditions, though we'd defer to your doctor about whether it's right for your specific situation.

The evidence, ingredient by ingredient Ipriflavone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ipriflavone is generally well tolerated, but some people experience epigastric pain (stomach discomfort), diarrhea, or dizziness. One concern flagged in the data is that prolonged use — at least 6 months — can potentially lower white blood cell counts (a condition called lymphocytopenia), so monitoring may be needed if you take it long-term.

The safety data for pregnancy is insufficient — there isn't enough information to know whether it's safe, so talk with your doctor or pharmacist about whether to use it if you're pregnant or planning to become pregnant. For breastfeeding, the data advises against use due to lack of reliable safety information.

Side effects, ingredient by ingredient Ipriflavone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ipriflavone.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 391 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Ostivone, check with your doctor or pharmacist if you take any drugs metabolized by your liver's CYP1A2 or CYP2C9 enzyme systems — this includes many antidepressants, anti-anxiety medications, and pain relievers. Also flag theophylline (used for asthma or COPD) and any immunosuppressant medications, which shouldn't be combined with ipriflavone without close medical supervision.

The interaction checker on this page will help you verify your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ostivone may be worth considering if you have osteoporosis or Paget disease and your doctor thinks ipriflavone is a good fit. Because it interacts with a large number of common medications and can lower white blood cell counts with long-term use, it's not one to start without clearing it first with your doctor or pharmacist — especially if you take any prescription drugs or have concerns about immune function.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ostivone, straight from the product label.

Brand Integrative Therapeutics
Barcode (UPC) 871791001756
Net contents 90 Veg Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2013
DSLD ID 24194
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ostivone by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
871791001756
IngredientAmount% DV
Ipriflavone200 mg--

Other ingredients: Vegetable Capsule, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Ostivone(R) bone formula features ipriflavone, which has been shown in more than 60 studies to support bone mineral density. Ostivone is best when used in conjunction with multi-nutrient bone support products with extra calcium such as our OsteoPrime(R) Forte.

Ostivone(R) is a registered trademark of Technical Sourcing International, Inc.

Suggested/Recommended/Usage/Directions

Recommendations: Take 1 capsule three times daily with meals, or as recommended by your healthcare practitioner.

Seals/Symbols

Ostivone A foundation for healthy bones

VEGETARIAN

General

LI77659.A03

FDA Disclaimer Statement

THIS STATEMENT HAS NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

General Statements

EVIDENCE-BASED

Enhances the body's absorption and use of calcium

This product contains natural ingredients; color variations are normal.

(Ipriflavone)

FDA Statement of Identity

Dietary Supplement

Precautions

WARNING: Ostivone(R) (ipriflavone) may slow the metabolism of theophylline (a prescription drug for asthma). Please consult your healthcare practitioner before using this product in conjunction with theophylline. If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

Formulation

Contains no sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, preservatives, or ingredients of animal origin.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ostivone by Integrative Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ostivone label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ostivone by Integrative Therapeutics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Ipriflavone

Interacts with
391 drugs
200 mg per serving

Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably preven...

Ipriflavone monograph & interactions

Other (inactive) ingredients: Vegetable Capsule, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ostivone by Integrative Therapeutics Drug Interactions

Want to check YOUR meds against Ostivone?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
391Drugs
391 Moderate

Ingredients driving the most interactions

Ipriflavone 391

Individual Drug Interactions

The ingredients in Ostivone interact with 391 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ostivone interact with drugs. Each result below shows which ingredient is responsible. Ipriflavone

Each ingredient & the kinds of drugs it affects

For each ingredient in Ostivone with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ipriflavone4 drug types · 391 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2). Theoretically, concurrent use of ipriflavone and drugs metabolized by these enzymes might result in decreased drug elimination, increased serum levels, and potential toxicity. Some drugs metabolized by CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), Pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline (Slo-bid, Theo-Dur, others), zileuton (Zyflo), Zolmitriptan (Zomig), and others.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Ipriflavone is thought to competitively inhibit cytochrome P450 2C9 (CYP2C9). Theoretically, concurrent use of ipriflavone and drugs metabolized by these enzymes might result in decreased drug elimination, increased serum levels, and potential toxicity. Some drugs metabolized by CYP2C9 include amitriptyline (Elavil), diazepam (Valium), estradiol (Estrace), tacrine (Cognex), verapamil (Calan), warfarin (Coumadin), zileuton (Zyflo), and others.

Likelihood Possible Evidence D
Immunosuppressants

Concurrent use of ipriflavone and immunosuppressant drugs might have additive effects on inhibiting immune function. Some patients taking ipriflavone experience subclinical lymphocytopenia; avoid concurrent use. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).

Likelihood Possible Evidence A
Theophylline

Concomitant use of theophylline and ipriflavone can increase serum theophylline levels. Increased theophylline levels have occurred in two cases after patients started taking ipriflavone. Ipriflavone is thought to decrease theophylline metabolism through competitive inhibition of the cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence D
Ipriflavone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ostivone, from the product label.

Integrative Therapeutics

See all Integrative Therapeutics products
Name
Integrative Therapeutics, Inc.
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1.800.931.1709
Web Address
www.integrativeinc.com
Pharmacist Counseling Corner

Ostivone by Integrative Therapeutics: Common Questions

Does Ostivone by Integrative Therapeutics interact with any medications?
Yes. Based on its ingredients, Ostivone has a known interaction with 391 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ostivone contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is ipriflavone, and what's it supposed to do?
Ipriflavone is a compound structurally similar to isoflavones from soy, designed to support bone density. It's rated likely effective for osteoporosis and Paget disease — two conditions where bone loss or abnormal bone growth is a concern.
Will Ostivone affect my blood pressure, cholesterol, or other common conditions?
The data we hold doesn't cover those specific health conditions. The main safety flags are about white blood cell counts with long-term use and stomach upset in some people. If you have other health concerns, run them by your doctor or pharmacist before starting.
Can I take this if I'm pregnant?
There isn't enough safety data to know whether ipriflavone is safe in pregnancy. Talk with your doctor or pharmacist about whether it's right for you if you're pregnant or planning to conceive.
What are the most common side effects?
Some people experience epigastric pain, diarrhea, or dizziness. There's also a concern that long-term use (at least 6 months) can lower white blood cell counts, which is why monitoring may be important if you plan to take it for a while.
Is this product safe to use long-term?
The data notes limited long-term safety information, and prolonged use carries the risk of low white blood cell counts. If you're thinking about taking it for an extended period, discuss monitoring and duration with your doctor or pharmacist.
Can I take this while breastfeeding?
No, the data advises against use while breastfeeding due to lack of reliable safety information. Talk with your doctor or pharmacist if you're breastfeeding and considering bone health support.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ostivone is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ostivone label
Go deeper

The Full Monographs Behind Ostivone’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ipriflavone

Interacts with 391 drugs

Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably prevents fractures or builds strong bone. Beca...

Read the full Ipriflavone monograph →
Sources

Sources & How We Checked

Ostivone's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ipriflavone 6 references
  1. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
  2. Alexandersen P, Toussaint A, Christiansen C, et al. Ipriflavone in the treatment of postmenopausal osteoporosis: A randomized controlled trial. JAMA 2001;285:1482-8.
  3. Agnusdei D, Camporeale A, Gonnelli S, et al. Short-term treatment of Paget's disease of bone with ipriflavone. Bone Miner 1992;19 Suppl 1:S35-42. PubMed
  4. Monostory K, Vereczkey L, Levai F, et al. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol 1998;123:605-10. PubMed
  5. Takahashi J, Kawakatsu K, Wakayama T, Sawaoka H. Elevation of serum theophylline levels by ipriflavone in a patient with chronic obstructive pulmonary disease. Eur J Clin Pharmacol 1992;43:207-8. PubMed
  6. Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed

See these in context on the Ipriflavone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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