Palmitoylethanolamide and Luteolin Ingredients & Drug Interactions
by Mirica
What is this page for?
First and foremost: checking Palmitoylethanolamide and Luteolin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Palmitoylethanolamide and Luteolin is a dietary supplement by Mirica with 3 active ingredients. Its ingredients are commonly taken for high cholesterol, liver health, brain and memory support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Palmitoylethanolamide and Luteolin by Mirica
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Mirica contains 3 active ingredients. Sunflower lecithin is a fatty substance made from sunflower seeds, often used as an emulsifier (something that helps keep ingredients mixed together).
Palmitoylethanolamide, also called PEA, is a compound your body naturally produces; it's being studied for joint pain and inflammation. Luteolin is a plant flavonoid (a type of antioxidant) found in many vegetables and herbs.
The capsule also contains cellulose as an inactive ingredient.
Does it work?
Not established
Palmitoylethanolamide shows possibly effective evidence for osteoarthritis — meaning some studies suggest it may help, but the evidence isn't definitive yet. For other uses like migraine headaches, carpal tunnel syndrome, and autism spectrum disorder, there isn't enough reliable evidence to say whether it works.
Sunflower lecithin has been studied for Alzheimer disease and age-related cognitive decline, but the evidence doesn't support it for Alzheimer disease, and there's insufficient evidence for cognitive decline. Luteolin's effectiveness hasn't been established in the data we hold.
How safe is it?
Well-documented data
Sunflower lecithin is generally well tolerated, though it can cause stomach pain, diarrhea, bloating, or nausea in some people — and it may trigger allergic skin reactions in anyone with egg or soy allergies. It's likely safe in pregnancy and breastfeeding.
Palmitoylethanolamide is generally well tolerated in studies, with nausea being the main side effect reported rarely. However, long-term safety data are limited.
The safety data advises against use during pregnancy and breastfeeding. Luteolin safety information isn't on file for this product.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. However, because we have no interaction data for luteolin, you should confirm with your pharmacist that it's safe to combine Mirica with any medications you take.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
Mirica may be worth considering if you're looking into palmitoylethanolamide for osteoarthritis, though the evidence is still emerging. Because one ingredient hasn't been checked for drug interactions and another has limited long-term safety data, talk with your doctor or pharmacist before starting — especially if you're pregnant, breastfeeding, or take any medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Palmitoylethanolamide and Luteolin, straight from the product label.
| Brand | Mirica |
|---|---|
| Barcode (UPC) | 863968000402 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 270032 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Palmitoylethanolamide and Luteolin by Mirica, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Sunflower Lecithin | 100 mg | -- |
| Luteolin | 24 mg | -- |
| Palmitoylethanolamide | 630 mg | -- |
Other ingredients: Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Synergistic combination of PEA & Luteolin Contains clinically-studied Levagen PEA
Formulation
Promotes healthy nervous & immune systems
Free of yeast, soy, gluten, peanut, egg, wheat, chemicals, preservatives, binders or fillers. 100% vegan and non-GMO
100% vegan and non-GMO
This product has been manufactured in a cGMP registered, FDA registered facility in the USA.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement. Starting dose: Take 2 capsules in the morning and 2 capsules in the evening for four weeks. Maintenance dose: Take 1 capsule twice daily.
Precautions
Caution: Not intended for use by women who are pregnant or breastfeeding.
Keep out of the reach of children.
Brand IP Statement(s)
Levagen is a registered trademark of Gencor used under license by Young Nutraceuticals.
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
GMP Good Manufacturing Practice
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Palmitoylethanolamide and Luteolin by Mirica label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Palmitoylethanolamide and Luteolin by Mirica
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sunflower Lecithin
No knowninteractions
Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting...
Sunflower Lecithin monograph & interactionsLuteolin
Palmitoylethanolamide
No knowninteractions
Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...
Palmitoylethanolamide monograph & interactionsOther (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.
Palmitoylethanolamide and Luteolin by Mirica Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Palmitoylethanolamide and Luteolin. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Palmitoylethanolamide and Luteolin, from the product label.
Mirica
See all Mirica products- Name
- Young Nutraceuticals
- Street Address
- 708 SW C St., Suite 3
- City
- Bentonville
- State
- AR
- ZipCode
- 72712
- Phone Number
- 479-553-7700
- Web Address
- YoungNutra.com
Palmitoylethanolamide and Luteolin by Mirica: Common Questions
Does Palmitoylethanolamide and Luteolin by Mirica interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Mirica if I'm pregnant or breastfeeding?
What's palmitoylethanolamide, and what does it do?
Will Mirica cause side effects?
What is luteolin?
Is Mirica safe to use long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Palmitoylethanolamide and Luteolin is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Palmitoylethanolamide and Luteolin’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lecithin
Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting most of its health claims is limited, t...
Read the full Lecithin monograph → Herb & supplement monographPalmitoylethanolamide (pea)
Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it may help certain types of chronic and ne...
Read the full Palmitoylethanolamide (pea) monograph →Sources & How We Checked
Palmitoylethanolamide and Luteolin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 13 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lecithin 9 references
- Buchman AL, Dubin M, Jenden D, et al. Lecithin increases plasma free choline and decreases hepatic steatosis in long-term total parenteral nutrition patients. Gastroenterology 1992;102:1363-70.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Chatellier G, Lacomblez L. Tacrine (tetrahydroaminoacridine; THA) and lecithin in senile dementia of the Alzheimer type: a multicentre trial. Groupe Francais d'Etude de la Tetrahydroaminoacridine. BMJ 1990;300:495-9.
- Gelenberg AJ, Dorer DJ, Wojcik JD, et al. A crossover study of lecithin treatment of tardive dyskinesia. J Clin Psychiatry 1990;51:149-53.
- Little A, Levy R, Chuaqui-Kidd P, Hand D. A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease. J Neurol Neurosurg Psychiatry 1985;48:736-42. PubMed
- Palm M, Moneret-Vautrin DA, Kanny G, et al. Food allergy to egg and soy lecithins. Allergy 1999;54:1116-7. PubMed
- Drachman DA, Glosser G, Fleming P, et al. Memory decline in the aged: treatment with lecithin and physostigmine. Neurology 1982;32:944-50. PubMed
- Gelenberg, A. J., Doller-Wojcik, J. C., and Growdon, J. H. Choline and lecithin in the treatment of tardive dyskinesia: preliminary results from a pilot study. Am J Psychiatry 1979;136(6):772-776. PubMed
- Electronic Code of Federal Regulations. Title 21, Chapter 1, Subchapter B, Part 184: Direct food substances affirmed as Generally Recognized as Safe. Subpart B - listing of specific substances affirmed as GRAS. Sec. 184.1400 Lecithin. Available at: https:
Palmitoylethanolamide (pea) 4 references
- Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
- Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
- Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
- Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed
See these in context on the Palmitoylethanolamide (pea) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC