PM Formula By Integrative Therapeutics Overview & Drug Interactions

Valerian (Valeriana officinalis) is a perennial herb native to Europe and Asia. The plant is known for its strong, distinctive odor and its purported medicinal effects. Valerian contains a number of active compounds, including valerenic acid and valepotriates, which are believed to have a sedative effect on the body and are may to be helpful in the treatment of insomnia and anxiety. Valerian is also believed to have mild tranquilizing and muscle-relaxing properties and may be helpful in the treatment of muscle spasms and other muscle disorders. The root of the valerian plant is most commonly utilized in dietary supplements and is often standardized for valerenic acid content.

Hops are the female flowers (also known as cones) of the hop plant, Humulus lupulus, and a member of the Cannabaceae family. Hops are native to Europe and are widely cultivated in many parts of the world. Hops have a variety of applications, such as for food flavoring and brewing beer. Hops extract has been used in topical medicinal preparations and as a dietary supplement.

Theanine, often referred to as L-theanine as that is the predominant isomer of theanine, is an amino acid commonly found in tea leaves, particularly in green tea. It is purported to increase levels of GABA, serotonin, and dopamine in the brain, which can help to reduce stress and anxiety. L-theanine may also promote a sense of calm and improve overall well-being. Some studies have also suggested that it may improve cognitive function, although more research is needed. Most reported drug interactions with theanine are due to its sedative effects.

Black cohosh (Actaea racemosa) is a perennial plant native to North America and is sometimes referred to as "black snakeroot" or "bugbane". Black cohosh is often taken as a supplement to help with menopause symptoms, such as hot flashes, night sweats, and mood changes. It is also sometimes used to help with premenstrual syndrome (PMS) and other menstrual issues. Black cohosh supplements are typically standardized for their triterpene glycoside content.