Interactions on record — worth a quick check against your medications. Based on 1 of 6 ingredients. Check your meds →
Dietary supplement

Probiotic 3 Ingredients & Drug Interactions

by AOR Advanced Orthomolecular Research Ultra

Probiotic 3 label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic 3 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic 3 is a dietary supplement by AOR Advanced Orthomolecular Research Ultra with 6 active ingredients. Its ingredients are commonly taken for digestive health and bloating, diarrhea support, immune support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus subtilis TO-A. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic 3 by AOR Advanced Orthomolecular Research Ultra

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic 3 by AOR Advanced Orthomolecular Research Ultra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic 3 by AOR Advanced Orthomolecular Research Ultra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.

This product contains six active bacterial ingredients: three distinct strains of beneficial bacteria meant to support digestion and gut health. Two strains appear twice in the formula.

The main one we have interaction and effectiveness data for is Bacillus subtilis TO-A, a live probiotic organism. Inactive ingredients include the capsule material itself, plus lactose, potato starch, polyvinyl alcohol, and polyvinylpyrrolidone as binding and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy intestinal flora and digestion.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Dyspepsia, Flatulence — and 4 related terms.
  • The strongest evidence on file: Bacillus Subtilis is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Bacillus Subtilis is rated "Insufficient Reliable Evidence To Rate" for Constipation, Diarrhea, Dyspepsia, Flatulence, and more.

Bacillus subtilis in this product is possibly effective for antibiotic-associated diarrhea — the loose stools that can happen when antibiotics disrupt your gut bacteria. For other uses listed in the data — athletic performance, cirrhosis, constipation, atopic dermatitis (eczema), and diabetes — the evidence isn't established well enough to rate it.

For the other bacterial strains in this product, we hold no effectiveness data.

The evidence, ingredient by ingredient Bacillus Subtilis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus subtilis is generally well tolerated in healthy adults, though quality and safety can vary depending on the product and strain. That said, the safety data overall is limited, so it's worth checking with your doctor before starting this supplement.

In clinical trials, one case of headache was reported. Diarrhea has been reported rarely.

There are also rare cases of serious bloodstream infections and meningitis linked to frequent consumption of natto (fermented soybeans containing a related Bacillus strain), mostly in people with weakened immune systems, advanced age, or other serious conditions. The pregnancy and lactation safety information is not on file for this ingredient.

Side effects, ingredient by ingredient Bacillus Subtilis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, separate them from this probiotic — taking them at the same time may reduce how well the probiotic works. We could not check three of the six bacterial strains for interactions, so use the medication checker below for your complete list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic might help with diarrhea caused by antibiotics. If you're on antibiotics, time the doses apart — don't take them together.

If you have a weakened immune system or serious health conditions, talk to your doctor first. Always check your medications against the tool on this page before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic 3, straight from the product label.

Brand AOR Advanced Orthomolecular Research Ultra
Barcode (UPC) 624917089998
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 214882
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic 3 by AOR Advanced Orthomolecular Research Ultra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
45
UPC/BARCODE
624917089998
IngredientAmount% DV
Enterococcus faecium T-1100 NP--
Clostridium butyricum TO-A0 NP--
Bacillus subtilis TO-A0 NP--
Enterococcus faecium T-1100 NP--
Clostridium butyricum TO-A0 NP--
Bacillus subtilis TO-A0 NP--

Other ingredients: Capsule, Lactose, Potato Starch, Polyvinyl Alcohol, Polyvinylpyrrolidone

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

GMP Manufacturing Quality assured Independent testing

Probiotic formula for healthy digestion

Vegetarian

Non-GMO Gluten free

AOR guarantees that all ingredients have been declared on the label.

Made without wheat, gluten, corn, nuts, peanuts, sesame seeds, sulfites, mustard, soy, eggs, fish or shellfish.

Precautions

Do not use if safety seal is broken

Warning: Consult your physician before use if you are pregnant, lactating, have a medical condition, or if you’re taking any medication.

Keep out of reach of children.

Caution: Consult a health care practitioner prior to use if you have fever, vomiting, bloody diarrhea, severe abdominal pain, or if these symptoms occur discontinue use and consult a health care practitioner.

Contains: milk (lactose).

To report a serious adverse event or obtain product information, call 1-866-215-0450

Storage

Once opened, store in the refrigerator to maintain optimal potency

Formula

Discussion: The enterobacteria contained in Probiotic-3 act in symbiosis and supports a healthy intestinal flora. Lactic acid and butyric acid-producing probiotics inhibit the growth of non beneficial bacteria while promoting the growth of the beneficial Bifidobacterium strain.

Suggested/Recommended/Usage/Directions

Directions: Take 2-3 capsules daily with/without food, or as directed by a qualified health care practitioner. Take at least 2-3 hours before or after taking antibiotics. Refrigerate after opening.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

MyBlueprint

Product of Canada

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic 3 by AOR Advanced Orthomolecular Research Ultra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic 3 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic 3 by AOR Advanced Orthomolecular Research Ultra

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Enterococcus faecium T-110

0 NP per serving

Clostridium butyricum TO-A

0 NP per serving

Bacillus subtilis TO-A

Interacts with
182 drugs
0 NP per serving

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and diges...

Bacillus subtilis TO-A monograph & interactions

Enterococcus faecium T-110

0 NP per serving

Clostridium butyricum TO-A

0 NP per serving

Bacillus subtilis TO-A

Interacts with
182 drugs
0 NP per serving

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and diges...

Bacillus subtilis TO-A monograph & interactions

Other (inactive) ingredients: Capsule, Lactose, Potato Starch, Polyvinyl Alcohol, Polyvinylpyrrolidone. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic 3 by AOR Advanced Orthomolecular Research Ultra Drug Interactions

Want to check YOUR meds against Probiotic 3?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus subtilis TO-A 182

Individual Drug Interactions

The ingredients in Probiotic 3 interact with 182 drugs. Click any drug to see the details.

1 of the 6 ingredients in Probiotic 3 interact with drugs. Each result below shows which ingredient is responsible. Bacillus subtilis TO-A

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic 3 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus subtilis TO-A1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bacillus subtilis TO-A full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic 3, from the product label.

AOR Advanced Orthomolecular Research Ultra

See all AOR Advanced Orthomolecular Research Ultra products
Name
AOR Inc.
Street Address
30 Industrial West
City
Clifton
State
NJ
ZipCode
07012
Phone Number
1-866-215-0450
Pharmacist Counseling Corner

Probiotic 3 by AOR Advanced Orthomolecular Research Ultra: Common Questions

Does Probiotic 3 by AOR Advanced Orthomolecular Research Ultra interact with any medications?
Yes. Based on its ingredients, Probiotic 3 has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic 3 contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on an antibiotic?
You can, but time them apart. Taking antibiotics and this probiotic at the same time might reduce the probiotic's effectiveness because the antibiotic can kill the live organisms. Ask your pharmacist how far apart to space them — usually several hours is recommended.
Will this help my constipation?
The evidence for Bacillus subtilis and constipation isn't established well enough for us to rate it. If that's your main reason for trying it, talk to your doctor about whether this is a good fit for you.
What are these bacterial strains actually for?
They're beneficial bacteria meant to support your gut health and digestion. Bacillus subtilis is the one we have the most data on — it's possibly effective for diarrhea caused by antibiotics. The other strains are included for their potential probiotic role, though we don't have established evidence on file for them.
Are there any side effects I should know about?
In trials, one case of headache was reported, and diarrhea has been reported rarely. Generally well tolerated in healthy adults, though safety data is limited, so check with your doctor before starting if you have any health concerns.
Is this safe if I have a weakened immune system?
There are rare reports of serious infections linked to related Bacillus strains in people with weakened immune systems or serious health conditions. You should talk to your doctor before taking this if that applies to you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic 3 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic 3 label
Go deeper

The Full Monographs Behind Probiotic 3’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph →
Sources

Sources & How We Checked

Probiotic 3's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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