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Dietary supplement

Probiotic Solutions Prenatal 20 Billion CFUs Ingredients & Drug Interactions

by GNC Probiotic Solutions

Probiotic Solutions Prenatal 20 Billion CFUs label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic Solutions Prenatal 20 Billion CFUs against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic Solutions Prenatal 20 Billion CFUs is a dietary supplement by GNC Probiotic Solutions with 2 active ingredients. Its ingredients are commonly taken for digestive health and regularity, constipation relief, immune support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium animalis subsp. lactis. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Prenatal Probiotic blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This prenatal probiotic contains 2 active ingredients: Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis, delivering 20 billion colony-forming units (CFUs) per dose. Both are live, beneficial bacteria meant to support digestive and immune health during pregnancy.

The capsule also contains several inactive ingredients — maltodextrin, vegetarian capsule shell, microcrystalline cellulose, silicon dioxide, magnesium stearate, and titanium dioxide — which serve as fillers and binding agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and probiotic support for pregnancy.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Pregnancy-induced nausea and vomiting, Gut microbiome balance, Maternal-fetal health.
  • The strongest evidence on file: Bifidobacterium Animalis Subsp. Lactis is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bifidobacterium Animalis Subsp. Lactis is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Pregnancy-induced nausea and vomiting.

Bifidobacterium lactis is rated Possibly Effective for respiratory tract infections, irritable bowel syndrome (IBS), and constipation based on available evidence. That means some studies suggest a benefit, but more research is needed to be sure.

We could not check effectiveness data for Lactobacillus rhamnosus GG, so we can't say what the evidence shows for that ingredient in this product.

The evidence, ingredient by ingredient Bifidobacterium Animalis Subsp. Lactis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bifidobacterium lactis is generally well tolerated by most healthy people when taken as directed. The most common side effect reported is diarrhea; bloating, flatulence, abdominal pain, and stomach upset have been reported rarely.

In very uncommon cases, probiotics may cause infections in certain people, though this is not well established. Pregnancy and lactation safety data for these ingredients is not on file in our data.

Because you're taking this during pregnancy, talk with your doctor or pharmacist about whether it's right for you before starting.

Side effects, ingredient by ingredient Bifidobacterium Animalis Subsp. Lactis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bifidobacterium Animalis Subsp. Lactis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check any antibiotic medications you're using with your doctor or pharmacist. Antibiotic drugs can reduce how well Bifidobacterium lactis works, so separating doses is important.

No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This prenatal probiotic may help with digestive health and immune support during pregnancy, but the evidence is still limited. The main caution is timing it away from antibiotics — they can reduce its effectiveness.

If you're pregnant, on any medications, or have a weakened immune system, check with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Solutions Prenatal 20 Billion CFUs, straight from the product label.

Brand GNC Probiotic Solutions
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 21, 2017
DSLD ID 76803
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Pregnant Women, Lactating, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Pregnant and Lactating
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Lactobacillus rhamnosus GG0 NP--
Bifidobacterium animalis subsp. lactis0 NP--
Prenatal Probiotic blend0 NP--

Other ingredients: Maltodextrin, Vegetarian Capsule Shell, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General

CODE 424555 IRG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one serving daily with food. You may take this product throughout pregnancy and breastfeeding.

Upon completion of breastfeeding, you may continue to take this product or consider switching to another high-quality GNC probiotic.

Formula

Contains: Milk.

Clinically studied in pregnant & breastfeeding women

Precautions

Contains: Milk.

Keep out of reach of children.

Formulation

Gluten free, lactose free.

General Statements

Contains an insignificant amount of lactose.

Taken throughout pregnancy and for up to six months postnatally when breastfeeding. Pregnant women also received dietary counseling focusing on dietary fat intake.

Actual size

Made in the UK

Potency guaranteed 20 billion CFUs

20 billion active cultures

Guaranteed potency Probiotics Solutions Prenatal has been tested to ensure the full 20 billion cultures in each dose are live and active when used by the expiration date.

Seals/Symbols

Gf Gluten free

FDA Statement of Identity

Why GNC Probiotic Solutions Prenatal? Multiple strains of live, active probiotic cultures Probiotic strains clinically studied in women throughout pregnancy and during breastfeeding Guaranteed potency through expiration date

Dietary Supplement

Storage

No refrigeration necessary

Store in a cool, dry place. No refrigeration required.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic Solutions Prenatal 20 Billion CFUs label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Prenatal Probiotic blend

0 NP per serving

Other (inactive) ingredients: Maltodextrin, Vegetarian Capsule Shell, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions Drug Interactions

Want to check YOUR meds against Probiotic Solutions Prenatal 20 Billion CFUs?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium animalis subsp. lactis 182

Individual Drug Interactions

The ingredients in Probiotic Solutions Prenatal 20 Billion CFUs interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Probiotic Solutions Prenatal 20 Billion CFUs interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium animalis subsp. lactis

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Solutions Prenatal 20 Billion CFUs with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium animalis subsp. lactis1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B. lactis.
Since B. lactis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. lactis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium animalis subsp. lactis full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic Solutions Prenatal 20 Billion CFUs, from the product label.

GNC Probiotic Solutions

See all GNC Probiotic Solutions products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions: Common Questions

Does Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions interact with any medications?
Yes. Based on its ingredients, Probiotic Solutions Prenatal 20 Billion CFUs has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Solutions Prenatal 20 Billion CFUs contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
The safety data for these specific probiotic strains in pregnancy isn't established in our data. Because you're pregnant, talk with your doctor or pharmacist before starting — they can give you personalized advice based on your health and any other medications you take.
What's the difference between the two bacteria in this product?
Both Lactobacillus rhamnosus GG and Bifidobacterium lactis are live beneficial bacteria meant to support your gut and immune health. We could not check effectiveness data for the L. rhamnosus GG strain, but B. lactis shows possibly effective evidence for respiratory infections, IBS, and constipation.
What if I'm taking antibiotics?
Antibiotics can kill the live organisms in this probiotic, making it less effective. Separate your doses by at least 2–3 hours — take your antibiotic at one time and the probiotic several hours later or earlier. Ask your doctor or pharmacist for the best timing for your specific antibiotic.
Will this cause side effects?
Most people tolerate it well, but diarrhea is the most commonly reported side effect. Bloating, flatulence, abdominal pain, and stomach upset have been reported rarely. If you experience any of these, talk with your doctor or pharmacist.
Can I breastfeed while taking this?
Safety data for breastfeeding is not on file for these ingredients. Talk with your doctor or pharmacist to decide if it's right for you while nursing.
Does this actually work for constipation and digestive issues?
Bifidobacterium lactis is rated Possibly Effective for constipation and IBS, meaning some studies show benefit but the evidence is still limited. Results may vary from person to person.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic Solutions Prenatal 20 Billion CFUs is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Solutions Prenatal 20 Billion CFUs label
Go deeper

The Full Monographs Behind Probiotic Solutions Prenatal 20 Billion CFUs’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Animalis Subsp. Lactis

Interacts with 182 drugs

Bifidobacterium animalis subsp. lactis is a well-studied probiotic bacterium commonly added to supplements and yogurts to support digestion and gut health. It appears generally safe for most...

Read the full Bifidobacterium Animalis Subsp. Lactis monograph →
Sources

Sources & How We Checked

Probiotic Solutions Prenatal 20 Billion CFUs's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Animalis Subsp. Lactis 8 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Phuapradit P, Varavithya W, Vathanophas K, et al. Reduction of rotavirus infection in children receiving bifidobacteria-supplemented formula. J Med Assoc Thai 1999;82:S43-8.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  5. Taipale TJ, Pienihäkkinen K, Isolauri E, Jokela JT, Söderling EM. Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in early childhood. Pediatr Res. 2016;79(1-1):65-9. PubMed
  6. Amat-Bou M, Garcia-Ribera S, Climent E, et al. Effects of Bifidobacterium animalis Subsp. lactis (BPL1) supplementation in children and adolescents with prader-willi syndrome: A randomized crossover trial. Nutrients. 2020;12(10):3123. PubMed
  7. Mäkelä SM, Forssten SD, Kailajärvi M, et al. Effects of Bifidobacterium animalis ssp. lactis 420 on gastrointestinal inflammation induced by a nonsteroidal anti-inflammatory drug: A randomized, placebo-controlled, double-blind clinical trial. Br J Clin Ph
  8. Wildt S, Munck LK, Vinter-Jensen L, et al. Probiotic treatment of collagenous colitis: a randomized, double-blind, placebo-controlled trial with Lactobacillus acidophilus and Bifidobacterium animalis subsp. Lactis. Inflamm Bowel Dis 2006;12(5):395-401. PubMed

See these in context on the Bifidobacterium Animalis Subsp. Lactis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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