Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

ProgestoMend Ingredients & Drug Interactions

by Douglas Laboratories

ProgestoMend label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ProgestoMend against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

ProgestoMend is a dietary supplement by Douglas Laboratories with 7 active ingredients. Its ingredients are commonly taken for kidney and adrenal support, anemia and blood building (traditional), inflammatory conditions.Based on those ingredients, 1,331 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Coleus forskohlii root extract, Passion Flower, Paeonia lactiflora root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against ProgestoMend by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with ProgestoMend by Douglas Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ProgestoMend by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “ProgestoMend A Phytocrine Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,440 mg) without saying how much of each component you get.

ProgestoMend contains 7 active herbal ingredients, each with a traditional role in women's health formulas. Rehmannia glutinosa root extract is used to support kidney and immune function; coleus forskohlii root extract contains forskolin, which research suggests may affect heart and metabolic function; bupleurum falcatum root extract is traditionally used for liver and respiratory support; wild yam root extract has been used traditionally for hormonal balance; paeonia lactiflora (peony) root extract is incorporated for circulatory and hormonal benefits; passion flower adds calming support; and vitex agnus-castus berry extract is traditionally used to support menstrual regularity and breast comfort.

The product also contains inactive ingredients—hydroxypropyl methylcellulose, dicalcium phosphate, vegetable stearate, and silica—which serve as capsule and tablet binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Menstrual and hormone balance support.
  • We looked for evidence on: Dysmenorrhea, Amenorrhea, Premenstrual syndrome (PMS), Premenstrual dysphoric disorder (PMDD), Mastalgia, Menopausal symptoms — and 4 related terms.
  • The strongest evidence on file: Vitex Agnus-castus is rated "Possibly Effective" for Mastalgia (Natural Medicines).
  • Also on file: Vitex Agnus-castus is rated "Possibly Effective" for Premenstrual syndrome (PMS).
  • Also on file: Wild Yam is rated "Possibly Ineffective" for Menopausal symptoms.

The evidence for ProgestoMend's ingredients is mixed and limited. Rehmannia is rated possibly effective for chronic kidney disease but has insufficient evidence for the other conditions it's traditionally used for, including diabetes and bone health.

Passion flower is possibly effective for insomnia and pre-procedural anxiety. Vitex agnus-castus is possibly effective for premenstrual syndrome and breast tenderness (mastalgia).

Coleus, bupleurum, wild yam, and peony all lack sufficient reliable evidence to rate their effectiveness for their traditional uses—the data we hold doesn't establish whether they work for these purposes.

The evidence, ingredient by ingredient Rehmannia Coleus Bupleurum Wild Yam Peony Passion Flower Vitex Agnus-castus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these herbs are generally well tolerated in the short term, though each carries cautions. Coleus can cause gastrointestinal side effects—a small number of trial participants reported diarrhea and loose stools—and may lower blood pressure.

Passion flower commonly causes drowsiness, dizziness, and confusion; one case report documented severe nausea, vomiting, and heart rhythm changes at very high doses. Peony may cause abdominal discomfort, diarrhea, and nausea; a rare case involved bleeding in a patient taking an herbal product containing peony while on warfarin.

Vitex can cause diarrhea, fatigue, headache, nausea, skin irritation, and changes in menstrual bleeding. Rehmannia, bupleurum, wild yam, and passion flower all lack sufficient safety data for long-term use.

Regarding pregnancy and breastfeeding: rehmannia, coleus, bupleurum, wild yam, peony, and passion flower are all rated as possibly unsafe or lacking enough data, so they should be avoided or discussed with your doctor during pregnancy and while breastfeeding. Vitex is rated possibly unsafe for both pregnancy and lactation.

Side effects, ingredient by ingredient Rehmannia Coleus Bupleurum Wild Yam Peony Passion Flower Vitex Agnus-castus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Peony, Bupleurum, Passion Flower, Vitex Agnus-castus, Wild Yam, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,332 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking ProgestoMend, double-check with your doctor or pharmacist if you take any of these: heart medications, especially nitrates or calcium channel blockers (Major risk with coleus); blood thinners or antiplatelet drugs like warfarin or aspirin; blood pressure medications; diabetes medications; sedative or anti-anxiety drugs; birth control pills or hormone replacement therapy; antipsychotics or dopamine agonists for Parkinson's disease; metoclopramide (Reglan); or any drugs metabolized by liver enzymes CYP1A2, CYP2C9, or CYP3A4. No interactions are documented in our data for the proprietary blend component itself.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

ProgestoMend is a traditional herbal blend that may appeal to you if you're interested in botanical support for hormonal balance and menstrual health, particularly if passion flower's calming effects and vitex's support for premenstrual symptoms match your needs. However, if you take any heart, blood pressure, diabetes, blood-thinning, antipsychotic, birth control, or sedative medications, or if you're pregnant or breastfeeding, talk with your doctor or pharmacist before starting—the interactions are significant.

Check your exact medications with the tool on this page, or review the product with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ProgestoMend, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539980286
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 274144
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ProgestoMend by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s), 4 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s), 4 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
310539980286
IngredientAmount% DV
Rehmannia glutinosa Root Extract0 NP, 0 NP--
Coleus forskohlii root extract0 NP, 0 NP--
Bupleurum falcatum root extract0 NP, 0 NP--
Wild Yam root extract0 NP, 0 NP--
Paeonia lactiflora root extract0 NP, 0 NP--
ProgestoMend A Phytocrine Proprietary Blend1440 mg, 2880 mg--
Passion Flower0 NP, 0 NP--
Vitex agnus-castus berry extract0 NP, 0 NP--

Other ingredients: Hydroxypropyl Methylcellulose, Dicalcium Phosphate, Vegetable Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 2-4 capsules daily or as directed by your health professional.

Precautions

Warning: Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

Storage

Store in a cool, dry place.

Formulation

Gluten-free, Non-GMO

Healthy progesterone production and function

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Scan to learn about our manufacturing excellence Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ProgestoMend by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ProgestoMend label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ProgestoMend by Douglas Laboratories

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Dicalcium Phosphate, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

ProgestoMend by Douglas Laboratories Drug Interactions

Want to check YOUR meds against ProgestoMend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,331Drugs
29 Major 1,279 Moderate 23 Minor

Ingredients driving the most interactions

Coleus forskohlii root extract 915
Passion Flower 836
Paeonia lactiflora root extract 811
Bupleurum falcatum root extract 327
Rehmannia glutinosa Root Extract 258

Individual Drug Interactions

The ingredients in ProgestoMend interact with 1,331 drugs. Click any drug to see the details.

7 of the 7 ingredients in ProgestoMend interact with drugs. Each result below shows which ingredient is responsible. Coleus forskohlii root extract Passion Flower Paeonia lactiflora root extract Bupleurum falcatum root extract Rehmannia glutinosa Root Extract Vitex agnus-castus berry extract Wild Yam root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in ProgestoMend with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Coleus forskohlii root extract7 drug types · 915 drugs

Calcium Channel Blockers

Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and calcium channel blockers both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Nitrates

Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and nitrates both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of coleus and anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro and animal research shows that forskolin, a constituent of coleus, can inhibit platelet aggregation and adhesion.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Animal research shows that forskolin, a constituent of coleus, may lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, taking coleus may affect drugs metabolized by CYP2C9 and increase the risk of adverse effects or reduce the effectiveness.
Research on the effect of coleus on CYP2C9 is conflicting. Some animal research shows that coleus extract can induce CYP2C9, while in vitro research shows that coleus can inhibit CYP2C9. Until more is known, advise patients that taking coleus might increase or decrease levels of drugs metabolized by CYP2C9.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
In vitro research shows that coleus can activate the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of coleus and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking coleus may affect the metabolism of warfarin and increase the risk of adverse effects or reduce the effectiveness.
Some animal research shows that coleus extract can induce cytochrome P450 2C9 (CYP2C9), an enzyme that metabolizes warfarin. However, other in vitro research shows that coleus can inhibit CYP2C9. Theoretically, taking coleus with drugs metabolized by CYP2C9 might affect drug levels and the risk of adverse effects. Until more is known, advise patients that taking coleus might increase or decrease levels of warfarin.

Likelihood Possible Evidence D
Coleus forskohlii root extract full monograph & interactions

Passion Flower3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Passion Flower full monograph & interactions

Paeonia lactiflora root extract7 drug types · 811 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, combining peony with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research suggests that peony might have antiplatelet, anticoagulant, and antithrombotic effects.

Likelihood Possible Evidence D
Clozapine (Clozaril)

Theoretically, peony might increase the levels and clinical effects of clozapine.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on cytochromes P450 (CYP) 1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, peony might interfere with contraceptive drugs due to competition for estrogen receptors.
In vitro and animal research shows that peony extract has estrogenic activity. Concomitant use might also increase the risk for estrogen-related adverse effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on CYP1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on CYP1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of peony might interfere with hormone replacement therapy and/or increase the risk for estrogen-related adverse effects.
In vitro and animal research shows that peony extract has estrogenic activity. Theoretically, peony might compete for estrogen receptors and/or cause additive estrogenic effects.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, peony might reduce the levels and clinical effects of phenytoin.
Animal research shows that taking peony root reduces levels of phenytoin. Some researchers suggest that peony root might affect cytochrome P450 (CYP) 2C9, which metabolizes phenytoin. However, preliminary research in humans shows that peony root does not alter levels of losartan (Cozaar), which is also metabolized by CYP2C9.

Likelihood Probable Evidence D
Paeonia lactiflora root extract full monograph & interactions

Bupleurum falcatum root extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bupleurum might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research suggests that saikosaponins, constituents of bupleurum, can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bupleurum might decrease the effects of antidiabetes drugs.
Animal research suggests that saikosaponins, constituents of bupleurum, can increase blood glucose.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, bupleurum might decrease the effects of immunosuppressants.
In vitro and animal research suggests that bupleurum might stimulate immune function.

Likelihood Possible Evidence D
Bupleurum falcatum root extract full monograph & interactions

Rehmannia glutinosa Root Extract2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that rehmannia may have hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that rehmannia may have hypotensive effects. Laboratory research shows that formulations of dried and processed rehmannia root inhibit angiotensin-converting enzyme (ACE).

Likelihood Possible Evidence D
Rehmannia glutinosa Root Extract full monograph & interactions

Vitex agnus-castus berry extract5 drug types · 121 drugs

Antipsychotic Drugs

Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as antipsychotic drugs due to its dopamine agonist effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Vitex agnus-castus might interfere with the efficacy of oral contraceptives due to possible hormone modulating activity.

Likelihood Possible Evidence B
Dopamine Agonists

Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Vitex agnus-castus might potentiate the actions of dopaminergic agonists due to possible dopaminergic effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Vitex agnus-castus has hormone modulating activity that can interfere with the efficacy of hormone replacement therapy.

Likelihood Probable Evidence D
Metoclopramide (Reglan)

Theoretically, dopaminergic effects of vitex agnus-castus could interfere with metoclopramide.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as metoclopramide due to its possible dopaminergic effects.

Likelihood Possible Evidence D
Vitex agnus-castus berry extract full monograph & interactions

Wild Yam root extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ProgestoMend, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Phone Number
1.800.245.4440
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

ProgestoMend by Douglas Laboratories: Common Questions

Does ProgestoMend by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, ProgestoMend has a known interaction with 1,331 medications, including 29 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ProgestoMend contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will ProgestoMend help with PMS and irregular periods?
Vitex agnus-castus, one of the ingredients, is rated possibly effective for premenstrual syndrome and breast tenderness, so it may help with some PMS symptoms. Passion flower in the blend is possibly effective for anxiety. However, the other ingredients lack enough evidence to say whether they work for menstrual or hormonal concerns. Results vary by person—talk with your healthcare provider about whether it's right for your situation.
Can I take ProgestoMend if I'm on birth control pills?
No, not without checking first. Both vitex and peony in this blend theoretically interfere with oral contraceptive effectiveness because they have hormone-modulating activity. Wild yam and peony may also increase or decrease estrogen effects. You must discuss this with your doctor or pharmacist before combining them.
Is it safe to take ProgestoMend while pregnant or breastfeeding?
No. Most of the ingredients—rehmannia, coleus, bupleurum, wild yam, peony, and passion flower—lack enough safety data and are advised against during pregnancy. Vitex is also rated possibly unsafe for both pregnancy and breastfeeding. Talk with your doctor or midwife before taking any supplement during these times.
Will ProgestoMend make me drowsy?
Passion flower in the blend commonly causes drowsiness, dizziness, and confusion, especially in sensitive individuals. If you take sedative drugs or need to stay alert, this is an important concern to discuss with your doctor or pharmacist.
Can I take ProgestoMend with my blood pressure medication?
Possibly not without caution. Both rehmannia and coleus may lower blood pressure, so taking them with blood pressure medications could cause your pressure to drop too much. Ask your doctor or pharmacist to review your specific medications and dose before starting.
What are the most common side effects?
The most frequently reported side effects are gastrointestinal: coleus can cause diarrhea and loose stools in some users; peony may cause diarrhea, nausea, and abdominal discomfort; and vitex can cause diarrhea and nausea. Passion flower commonly causes drowsiness. Vitex may also cause irregular menstrual bleeding and skin irritation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ProgestoMend label
Go deeper

The Full Monographs Behind ProgestoMend’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rehmannia

Interacts with 258 drugs

Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human evidence for most modern uses is limited, so i...

Read the full Rehmannia monograph → Herb & supplement monograph

Coleus

Interacts with 915 drugs

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. While early lab and small human studies are...

Read the full Coleus monograph → Herb & supplement monograph

Bupleurum

Interacts with 327 drugs

Bupleurum (Chai Hu) is a root used in traditional Chinese medicine, usually as part of multi-herb formulas, for liver, digestive, and fever-related complaints. High-quality human evidence fo...

Read the full Bupleurum monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph → Herb & supplement monograph

Peony

Interacts with 811 drugs

Peony root is a traditional Chinese medicine herb often used for menstrual problems, cramps, and inflammation, frequently as part of combination formulas. Human evidence for most uses is lim...

Read the full Peony monograph → Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph → Herb & supplement monograph

Vitex Agnus-castus

Interacts with 121 drugs

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS symptoms. It is generally well tolerated by ma...

Read the full Vitex Agnus-castus monograph →
Sources

Sources & How We Checked

ProgestoMend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 100 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rehmannia 3 references
  1. Zhang R, Zhou J, Jia Z, et al. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J Ethnopharmacol 2004;90:39-43. PubMed
  2. Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 2008;117(2):199-214. PubMed
  3. Chao CH, Hsu JL, Chen MF, et al. Anti-hypertensive effects of Radix Rehmanniae and its active ingredients. Nat Prod Res. 2020;34(11):1547-1552.

See these in context on the Rehmannia monograph →

Coleus 16 references
  1. Baumann G, Felix S, Sattelberger U, Klein G. Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestiv cardiomyopathy. A comparative study with dobutamine and sodium nitroprusside. J Cardiovasc Pharmacol 1990;16:93-100.
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Bupleurum 17 references
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Wild Yam 7 references
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Peony 15 references
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Passion Flower 19 references
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Vitex Agnus-castus 23 references
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