Major interaction on record — check this product against your medications before combining. Based on 6 of 12 ingredients. Check your meds →
Dietary supplement

Shred Matrix Ingredients & Drug Interactions

by MusclePharm

Shred Matrix label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Shred Matrix against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Shred Matrix is a dietary supplement by MusclePharm with 12 active ingredients. Its ingredients are commonly taken for hair growth and thinning hair, brittle nails, skin health.Based on those ingredients, 1,667 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Niacin, Magnesium, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Shred Matrix by MusclePharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Shred Matrix by MusclePharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Shred Matrix by MusclePharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 7 of its 21 active ingredients.
  • “8 Stage Weight Loss Proprietary Blend” is a proprietary blend — the label gives one combined amount (2,437.50 mg) without saying how much of each component you get.
  • “Stages 1 & 2: Energy & Fat Metabolism” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Shred Matrix contains 21 ingredients across multiple functional stages. The active ingredients include biotin and pantothenic acid (B vitamins), caffeine anhydrous and three caffeine-containing botanicals (yerba mate, guarana seed extract, green tea extract), niacin, chromium, magnesium, and whole herbs like eleuthero, olive leaf extract, fo-ti, cayenne, saw palmetto, and suma extract.

Several ingredients are grouped into proprietary blends labeled as stages for energy, appetite, mood, brain power, diuretic, and enzyme support; we hold no interaction data for these stage blends. The product also contains inactive ingredients: gelatin, magnesium stearate, and microcrystalline cellulose (a filler).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: fat loss and body composition.
  • We looked for evidence on: Athletic performance, Chromium deficiency, Metabolism, Body composition.
  • The strongest evidence on file: Chromium is rated "Likely Effective" for Chromium deficiency (Natural Medicines).
  • Also on file: Caffeine is rated "Likely Effective" for Athletic performance.
  • Also on file: Magnesium is rated "Possibly Ineffective" for Athletic performance.

The evidence for Shred Matrix's ingredients is mixed. Biotin is likely effective for biotin deficiency but has insufficient evidence for hair loss and is possibly ineffective for MS and seborrheic dermatitis.

Pantothenic acid is effective for pantothenic acid deficiency but insufficient for most other uses. Caffeine is effective for neonatal apnea and postoperative headache, and likely effective for mental alertness and athletic performance.

Niacin is likely effective for pellagra but only possibly effective for metabolic syndrome and HIV-related cholesterol issues. Chromium is likely effective for chromium deficiency and possibly effective for blood sugar, but possibly ineffective for prediabetes.

Cayenne is likely effective for nerve pain and diabetic neuropathy. Green tea extract is likely effective for HPV and possibly effective for cholesterol and ovarian cancer.

For yerba mate, guarana, eleuthero, fo-ti, saw palmetto, olive leaf, and suma, the evidence is insufficient or not established in the data we hold — their effectiveness for weight loss or the other claims on this product is not documented here.

The evidence, ingredient by ingredient Biotin Pantothenic Acid Niacin Olive Chromium Magnesium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 16 of the 16 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 16 of 16.
  • General safety write-ups exist for 16 of 16.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated at typical doses, though several carry cautions. Caffeine at high doses can cause anxiety, insomnia, jitteriness, nausea, and rarely stroke.

Niacin commonly causes flushing and gastrointestinal upset and rarely liver damage, especially in sustained-release form. Green tea extract has been linked to rare cases of liver injury at high doses.

Fo-ti carries the most serious safety concern — it has been associated with approximately 450 documented cases of hepatitis, ranging from mild to cirrhosis and liver failure, at a wide range of doses and formulations. Eleuthero, while often well tolerated short-term, has limited long-term safety data and has been linked to increased blood pressure and heart effects in some patients.

Yerba mate and guarana are high in caffeine and unsafe at high doses. Chromium and magnesium are generally safe at dietary levels but can cause gastrointestinal upset, and magnesium at high doses or long-term use carries rare risks.

Pregnancy and breastfeeding: biotin, pantothenic acid, niacin, and magnesium are likely safe or possibly safe in pregnancy at normal doses; caffeine and yerba mate should be limited; eleuthero, fo-ti, saw palmetto, guarana, and green tea extract should be avoided in pregnancy due to insufficient safety data or safety concerns.

Side effects, ingredient by ingredient Biotin Pantothenic Acid Niacin Olive Chromium Magnesium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 12 of the 16 matched ingredients can interact with medications — Yohimbe, Fo-ti, Yerba Mate, Niacin, Chromium, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,668 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications urgently if you take ephedrine (Major risk of life-threatening stimulant effects from caffeine and green tea). Also confirm with your pharmacist before using if you take: blood thinners or antiplatelet drugs (warfarin, aspirin); antidiabetes medications or insulin; antihypertensive or heart drugs (nadolol, atorvastatin, calcium channel blockers, ACE inhibitors); seizure medications (phenobarbital, carbamazepine, phenytoin, valproate, felbamate, ethosuximide); psychiatric medications (clozapine); or any drug metabolized by the liver's cytochrome P450 system.

No interactions are documented for the proprietary stage blends themselves, but their specific component ingredients are not identified on file.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Shred Matrix is a complex, multi-ingredient weight-loss formula with active compounds ranging from well-studied vitamins to botanicals with limited effectiveness evidence. The product carries significant interaction risks, most critically with ephedrine and blood thinners, and serious safety concerns with fo-ti (documented liver injury) and high caffeine content (1,615 medication interactions documented across ingredients).

If you take any prescription or over-the-counter medications, especially those for blood pressure, blood sugar, seizure control, heart rhythm, or blood clotting, talk with your pharmacist or doctor before using this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 16 of 21 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Shred Matrix, straight from the product label.

Brand MusclePharm
Barcode (UPC) 71812265798
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 18006
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Shred Matrix by MusclePharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
40
UPC/BARCODE
71812265798
IngredientAmount% DV
Biotin150 mcg50%
Pantothenic Acid3 mg30%
Caffeine Anhydrous150 mg--
Niacin3 mg15%
Yerba Mate0 NP--
Eleuthero0 NP--
Olive leaf extract1 mg6%
Fo-Ti0 NP--
Yohimbine HCl0 NP--
Chromium100 mcg83%
Guarana seed extract0 NP--
Cayenne0 NP--
Saw Palmetto0 NP--
8 Stage Weight Loss Proprietary Blend2437.5 mg--
Magnesium3.5 mg1%
Stages 1 & 2: Energy & Fat Metabolism0 NP--
Green Tea Extract0 NP--
Suma Extract0 NP--
Stages 3 & 4: Appetite Balancing & Weight Management Control0 NP--
Stage 5: Anti-Stress Mood Balancing Matrix0 NP--
Stage 6: Brain Power Matrix0 NP--
Stage 7: Diuretic Complex0 NP--
Stage 8: Sugar Stop(TM) & Enzyme Aid Matrix0 NP--

Other ingredients: Gelatin, Magnesium Stearate, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

WHAT IS SHRED MATRIX(TM)?

MADE IN A cGMP AND NSF(R) CERTIFIED FACILITY

Cory Gregory {signature} (R)

LIVE SHREDDED(TM)

SHRED MATRIX(TM)

MP MUSCLEPHARM(R) THE ATHLETE'S COMPANY(TM)

STAGES 1 AND 2: INCREASED ENERGY AND RAMP UP METABOLISM. SHRED MATRIX(TM) meticulously combines several carefully selected natural stimulant agents that have proven fat loss properties. These select herbs are the double-edged weapon against stored fat. These key ingredients support the mobilization and utilization of stored fats, to be used for energy. These same ingredients simultaneously deliver concentrated, sustained, performance-enhancing energy and focus without jitter or crash by speeding up metabolism and feeding the ramped up metabolic rate with fats pulled from the body’s fat stores. STAGES 3 AND 4: CRUSH HUNGER & BLOCK FAT FORMATION. SHRED MATRIX(TM) helps regulate blood sugar, which directly impacts the hunger sensation, appetite and energy levels. SHRED MATRIX(TM) also supports favorable nutrient repartitioning, which means increasing insulin sensitivity and facilitating the uptake of carbohydrates directly into muscle cells, away from fat storage areas, thus “blocking” fat formation. Better nutrient absorption means greater fat utilization for energy. STAGE 5: ANTI-STRESS (ADAPTOGEN), MOOD-BALANCING BLEND. SHRED MATRIX(TM) makes it easy for you to stick to your nutritional plan by including several key adaptogenic, mood-enhancing and balancing agents to help counter the irritability and mood swings that can be associated with dieting. These natural, herbal ingredients may contribute to an improved sense of well-being and enhance mood by supporting healthy brain chemistry. STAGE 6: RAZOR-SHARP MENTAL FOCUS, WITHOUT JITTER OR CRASH. SHRED MATRIX(TM) contains key herbal ingredients that help support natural brain chemistry, to enhance mental function and improve mood – very important to successful dieting! SHRED MATRIX(TM)’s sophisticated formula provides all-day energy without crash or jitter. Perform better with razor sharp focus and alertness using SHRED MATRIX(TM). STAGE 7: ELIMINATE EXCESS WATER. SHRED MATRIX’s diuretic complex will help maintain fluid balance to keep your physique LEAN and TIGHT. Keeping the water in the right places and maintaining healthy fluid balance, will help the body systems work more efficiently, resulting in the tight, lean appearance that we’re all after. STAGE 8: SUGAR STOP(TM) AND ENZYME AID MATRIX DESTROY SUGAR CRAVINGS. SHRED MATRIX(TM) addresses the problem of sugar/sweet cravings with the proprietary Sugar Stop Matrix(TM). Sugar Stop(TM) crushes the craving for sweets and sugar often associated with dieting for weight loss. The key enzymes in SHRED MATRIX(TM) help shuttle nutrients more efficiently into the bloodstream, maintaining better blood sugar maintenance for better control of cravings, and better use of ingested calories.

Precautions

Consult your physician prior to use if you have a medical condition, including but not limited to, heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma. Discontinue 2 weeks prior to surgery or if you experience rapid heart beat, dizziness, severe headache or shortness of breath.

KEEP OUT OF REACH OF CHILDREN.

ALLERGEN WARNING: This product was produced in a facility that may also process ingredients containing milk, egg, soybeans, shellfish, fish, tree nuts, and peanuts.

WARNING: Taking this product without adequate fluid may cause it to swell and block your throat or esophagus and may cause choking. Do not take this product if you have difficulty in swallowing. If you experience chest pain, vomiting, or difficulty in swallowing or breathing after taking this product, seek immediate medical attention. Not intended for use by persons under age 18. Do not exceed recommended dose. Do not consume synephrine or caffeine from other sources, including but not limited to, coffee, tea, soda and other dietary supplements or medications containing phenylephrine or caffeine. Contains caffeine. Do not use for more than 8 weeks.

Consult with your physician prior to use if you are pregnant or nursing, or if you are taking medication, including but not limited to MAO Inhibitors (MAOI), antidepressants, aspirin, nonsteroidal anti-inflammatory drugs or products containing phylephrine, ephedrine, pseudoephedrine, or other stimulants.

General Statements

-The most powerful fat loss system available! -IS COMPLETELY unique - utilizing the power of THE comprehensive, 8-STAGE FAT LOSS SYSTEM, formulated to help you achieve the tight, fit, lean and toned body you've been seeking. -Utilizes the body's multiple energy pathways to mobilize fat to become the body's primary fuel source. -Destroys cravings, curbs hunger, improves energy and alertness, and enhances mental focus and mood.

MADE IN USA

AS MUSCLEPHARM’S PRESIDENT, IT’S IMPORTANT TO ME THAT MUSCLEPHARM PRODUCTS PERFORM! OUR COMPANY WAS BUILT BY ATHLETES, FOR ATHLETES, SO IT’S IMPORTANT THAT I WALK THE WALK TOO! SO, I PUT MY MONEY WHERE MY MOUTH IS WHEN I DECIDED TO GET INTO THE BEST SHAPE OF MY LIFE. I USED SHRED MATRIXTM TO GET INTO MY BEST CONDITION EVER AND I’M JUST AMAZED WITH THE RESULTS! I WOULD WAKE UP EACH MORNING LEANER AND TIGHTER, ALMOST AS IF THE FAT WERE MELTING AWAY RIGHT BEFORE MY EYES! AND THE BEST THING I NOTICED ABOUT SHRED MATRIX(TM) - I WAS NEVER HUNGRY! AMAZING APPETITE CONTROL, AMAZING RESULTS! BUT DON'T TAKE MY WORD FOR IT GET SHRED MATRIXTM NOW AND SEE FOR YOURSELF! (TRUST ME, I’M THE PRESIDENT OF MUSCLEPHARM. - I WOULDN’T PUT MY PICTURE ON THE BOX IF I DIDN’T BELIEVE IN THIS PRODUCT!

PRESIDENT MUSCLEPHARM

GET THE FREE DIET & TRAINING GUIDE AND LIVE THE SHRED LIFESTYLE!

FREE DIET & TRAINING GUIDE AVAILABLE AT SHREDLIFESTYLE.COM

8-STAGE WEIGHT-LOSS SYSTEM • STRONGEST FORMULA AVAILABLE • PHYSICIAN-FORMULATED • VISIBLE CHANGES IN LESS THAN 2 WEEKS

SHRED LIFESTYLE SERIES

8-STAGE WEIGHT-LOSS SYSTEM SHRED MATRIX’S CAREFUL COMBINATION OF CLINICALLY PROVEN INGREDIENTS IS PHYSICIAN-FORMULATED, RESULTING IN ONE OF THE MOST COMPLETE, MOST EFFECTIVE FAT LOSS SYSTEMS AVAILABLE. SHRED MATRIX’S COMPREHENSIVE FORMULA ATTACKS FAT FROM ALL ANGLES, IN IT’S 8-STAGE WEIGHT LOSS SYSTEM. STAGE 1. INCREASE ENERGY STAGE 2. RAMP UP METABOLISM STAGE 3. CRUSH HUNGER STAGE 4. BLOCK FAT FORMATION STAGE 5. ANTI-STRESS MOOD BALANCING BLEND STAGE 6. RAZOR-SHARP MENTAL FOCUS, WITHOUT CRASH OR JITTER STAGE 7. ELIMINATE EXCESS WATER STAGE 8. DESTROY SUGAR CRAVINGS

Suggested/Recommended/Usage/Directions

SUGGESTED USE: Take one serving (3 capsules) with an 8 oz. glass of water twice daily. MORNING: Take three (3) capsules with 8 ounces of water 30-45 mins before breakfast. AFTERNOON: Take three (3) capsules with 8 ounces of water 30-45 mins before lunch. Drink a minimum of 1 gallon of water per day while on Shred Matrix *Shred Matrix should not be taken within 6 hours before bed.

General

Dom v8.2 20110117

FDA Statement of Identity

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

DIETARY SUPPLEMENT

Seals/Symbols

MP MUSCLEPHARM(R)

Authentic OFFICIAL MUSCLEPHARM PRODUCT(TM)

Formulation

THIS PRODUCT CONTAINS NO BANNED SUBSTANCES

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Shred Matrix by MusclePharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Shred Matrix label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Shred Matrix by MusclePharm

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Biotin

No known
interactions
150 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Pantothenic Acid

No known
interactions
3 mg per serving Form: D-Calcium Pantothenate

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nea...

Pantothenic Acid monograph & interactions

Niacin

Interacts with
727 drugs
3 mg per serving Form: Niacinamide

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Niacin monograph & interactions

Olive leaf extract

No known
interactions
1 mg per serving Form: Oleuropein

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

Olive leaf extract monograph & interactions

Chromium

Interacts with
178 drugs
100 mcg per serving Form: {chromium} chelate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

8 Stage Weight Loss Proprietary Blend

2437.5 mg per serving
  • › Stages 1 & 2: Energy & Fat Metabolism
  • › Stages 3 & 4: Appetite Balancing & Weight Management Control
  • › Stage 5: Anti-Stress Mood Balancing Matrix
  • › Stage 6: Brain Power Matrix
  • › Stage 7: Diuretic Complex
  • › Stage 8: Sugar Stop(TM) & Enzyme Aid Matrix

Magnesium

Interacts with
295 drugs
3.5 mg per serving Form: Magnesium Gluconate

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...

Magnesium monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Shred Matrix by MusclePharm Drug Interactions

Want to check YOUR meds against Shred Matrix?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,667Drugs
28 Major 1,619 Moderate 20 Minor

Ingredients driving the most interactions

Niacin 727
Magnesium 295
Chromium 178

Individual Drug Interactions

The ingredients in Shred Matrix interact with 1,667 drugs. Click any drug to see the details.

3 of the 12 ingredients in Shred Matrix interact with drugs. Each result below shows which ingredient is responsible. Niacin Magnesium Chromium

Each ingredient & the kinds of drugs it affects

For each ingredient in Shred Matrix with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Niacin15 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D
Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B
Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D
Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D
Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B
Niacin full monograph & interactions

Magnesium15 drug types · 295 drugs

Levodopa/Carbidopa (Sinemet)

Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.

Likelihood Probable Evidence B
Aminoglycoside Antibiotics

Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.

Likelihood Possible Evidence D
Antacids

Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.

Likelihood Possible Evidence D
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.

Likelihood Probable Evidence B
Calcium Channel Blockers

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.

Likelihood Possible Evidence D
Digoxin

Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.

Likelihood Possible Evidence B
Potassium-Sparing Diuretics

Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.

Likelihood Probable Evidence D
Quinolone Antibiotics

Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.

Likelihood Probable Evidence A
Sulfonylureas

Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.

Likelihood Unlikely Evidence B
Gabapentin (Neurontin)

Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Unlikely Evidence B
Sevelamer (Renagel, Renvela)

Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.

Likelihood Possible Evidence B
Magnesium full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Shred Matrix, from the product label.

MusclePharm

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Web Address
MUSCLEPHARM.COM
Pharmacist Counseling Corner

Shred Matrix by MusclePharm: Common Questions

Does Shred Matrix by MusclePharm interact with any medications?
Yes. Based on its ingredients, Shred Matrix has a known interaction with 1,667 medications, including 28 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Shred Matrix contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have caffeine, and how much?
Yes. Shred Matrix contains caffeine anhydrous plus three additional caffeine-containing botanicals — yerba mate, guarana seed extract, and green tea extract — making it a high-caffeine product. The label or product details should specify total caffeine per serving; check that amount against your daily caffeine limit, especially if you also consume coffee, tea, or energy drinks.
Can I take this while on blood thinners like warfarin?
No — do not start this product without talking to your pharmacist or doctor first. Fo-ti in this formula has been associated with cases of acute liver failure that dangerously elevated blood thinner levels, and several other ingredients (cayenne, niacin, saw palmetto, eleuthero) may also affect bleeding risk or interact with blood thinners.
Is it safe during pregnancy?
No. Several ingredients should be avoided in pregnancy: eleuthero, fo-ti, saw palmetto, guarana, and green tea extract all lack adequate safety data or have safety concerns. The high caffeine content also exceeds safe limits in pregnancy. Talk with your doctor or pharmacist before considering any weight-loss product while pregnant.
What is fo-ti, and why is it concerning?
Fo-ti is a traditional Chinese herb included in this formula. The medical literature documents approximately 450 cases of liver damage — ranging from mild hepatitis to cirrhosis and complete liver failure — linked to both processed and unprocessed fo-ti at many different doses. Liver injury is rare but serious and unpredictable.
Does this product work for weight loss?
The ingredients have insufficient or unstudied evidence for weight loss as a primary outcome in humans. Caffeine and green tea extract have some evidence for supporting metabolic rate and fat loss, but the effectiveness of the full formula, the proprietary blends, and several botanicals is not established in the data we hold. Weight loss claims should be verified with your doctor or a registered dietitian.
What side effects should I watch for?
Most common: caffeine-related effects (jitteriness, insomnia, anxiety, nausea, headache, diarrhea), flushing and stomach upset from niacin, and gastrointestinal distress from magnesium. Serious but rare: caffeine toxicity (stroke, heart problems), liver damage (fo-ti, green tea), and dangerous interactions if you take certain medications. Stop and contact your doctor if you experience chest pain, severe headache, palpitations, or signs of liver damage (yellowing skin/eyes, dark urine, abdominal pain).

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Shred Matrix label
Go deeper

The Full Monographs Behind Shred Matrix’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph → Herb & supplement monograph

Pantothenic Acid

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nearly all foods, and most people meet thei...

Read the full Pantothenic Acid monograph → Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph → Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Magnesium

Interacts with 295 drugs

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...

Read the full Magnesium monograph →
Sources

Sources & How We Checked

Shred Matrix's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1,142 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Biotin 4 references
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  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. PubMed
  4. Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. PubMed

See these in context on the Biotin monograph →

Pantothenic Acid 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  4. Schmuth, M., Wimmer, M. A., Hofer, S., Sztankay, A., Weinlich, G., Linder, D. M., Elias, P. M., Fritsch, P. O., and Fritsch, E. Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study. Br.J.Dermatol. 2 PubMed
  5. Schreck, U., Paulsen, F., Bamberg, M., and Budach, W. Intraindividual comparison of two different skin care conceptions in patients undergoing radiotherapy of the head-and-neck region. Creme or powder? Strahlenther.Onkol. 2002;178(6):321-329. PubMed
  6. Herbst, R. A., Uter, W., Pirker, C., Geier, J., and Frosch, P. J. Allergic and non-allergic periorbital dermatitis: patch test results of the Information Network of the Departments of Dermatology during a 5-year period. Contact Dermatitis 2004;51(1):13-1 PubMed
  7. Champault, G. and Patel, J. C. [Treatment of constipation with Bepanthene]. Med.Chir Dig. 1977;6(1):57-59.
  8. Scott LN, Fiume M, Bergfeld WF, et al. Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics. Int J Toxicol 2022;41(3_suppl):77-128. PubMed
  9. Han J, Warshaw EM. Allergic Contact Dermatitis to Panthenol in "Hypoallergenic" Products. Dermatitis 2023;34(1):62-63. PubMed
  10. Blanchard G, Kerre S, Walker A, et al. Allergic contact dermatitis from pantolactone and dexpanthenol in wound healing creams. Contact Dermatitis 2022;87(5):468-471. PubMed
  11. Peltier E, Trapp S, de Salvo R, et al. A new dexpanthenol-containing liquid cleanser for atopic-prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function. J Cosme PubMed

See these in context on the Pantothenic Acid monograph →

Caffeine 236 references
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See these in context on the Magnesium monograph →

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See these in context on the Suma monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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