Interactions on record — worth a quick check against your medications. Based on 4 of 11 ingredients. Check your meds →
Dietary supplement

SIBOZyme Ingredients & Drug Interactions

by Priority One Nutritional Supplements

SIBOZyme label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SIBOZyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

SIBOZyme is a dietary supplement by Priority One Nutritional Supplements with 11 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against SIBOZyme by Priority One Nutritional Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with SIBOZyme by Priority One Nutritional Supplements — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of SIBOZyme by Priority One Nutritional Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 8 of its 11 active ingredients.
  • “Pancreatin” is listed as a grouped ingredient — the label gives one combined amount (400 mg) without saying how much of each component you get.

SIBOZyme contains 11 active ingredients designed to support carbohydrate and fat digestion. The digestive enzymes include amylase (breaks down carbs), protease (breaks down protein), lipase (breaks down fats), lactase (breaks down milk sugar), maltase (breaks down malt sugar), and sucrase (breaks down table sugar).

It also contains pancreatin (a blend of multiple enzymes), betaine hydrochloride (increases stomach acid), ox bile (aids fat digestion), prolyl endopeptidase (a specialized protein-digesting enzyme), and L-glutamic acid. The product is delivered in a capsule and contains inactive ingredients of rice flour, hypromellose, and purified water.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive enzyme support for nutrient absorption.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, Diarrhea, Bloating and gas, Indigestion, Fat malabsorption.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Diarrhea, Dyspepsia.

The evidence we hold is limited. Lactase is rated Effective for lactose intolerance—if you have trouble digesting milk sugar, this ingredient may help.

For the other active ingredients (lipase for digestive upset or inflammatory bowel disease, betaine hydrochloride for digestive symptoms or other conditions, and protease), the evidence in our data is insufficient to rate them—meaning reliable studies backing their use for these purposes aren't established yet. We have no effectiveness data on file for the remaining ingredients.

The evidence, ingredient by ingredient Lactase Betaine Hydrochloride Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease is generally well tolerated but may cause digestive upset or allergic reactions in some people. Rarely, occupational exposure to similar proteolytic enzymes has caused allergic reactions of the nose, eyes, or airways.

Lipase is generally well tolerated in supplement form, though people with serious digestive conditions should use it only under medical guidance. Lactase is generally well tolerated when used as directed, though rare allergic reactions have been reported in workers exposed to powdered forms.

Betaine hydrochloride may irritate the stomach and is not safe for people with ulcers, gastritis, or acid reflux—it could theoretically worsen ulcers or cause heartburn. During pregnancy, safety data is sparse or absent for most of these ingredients.

Protease should be avoided unless prescribed; lipase and betaine hydrochloride should be used only if your doctor advises it. Lactase is likely safe in pregnancy.

During breastfeeding, protease and lipase have little safety data and are not recommended without medical advice; lactase safety while breastfeeding has not been well studied, so check with your healthcare provider first. Betaine hydrochloride should be avoided during breastfeeding.

Side effects, ingredient by ingredient Lactase Betaine Hydrochloride Proteolytic Enzymes (proteases) Lipase

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 4 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take H2-blockers, antacids, or proton pump inhibitors (PPIs) for acid reflux or stomach protection, flag this product with your pharmacist before starting—betaine hydrochloride may reduce how well these medications work. For all other medications you take, use the interaction checker on this page to confirm there are no surprises.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

SIBOZyme is a multi-enzyme digestive formula that may be worth considering if you have trouble digesting carbs, fats, or proteins—especially if you're lactose intolerant, since lactase is rated effective for that. If you take stomach acid–reducing medications (H2-blockers, antacids, or PPIs), or if you have ulcers or acid reflux, talk with your doctor or pharmacist before starting it.

The same goes if you're pregnant or breastfeeding—check with your healthcare provider about whether this product is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SIBOZyme, straight from the product label.

Brand Priority One Nutritional Supplements
Barcode (UPC) 815354021720
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 310784
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SIBOZyme by Priority One Nutritional Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Vegetarian Capsule(s)
Maximum serving Sizes:
3 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
815354021720
IngredientAmount% DV
Amylase0 NP--
L-Glutamic Acid220 mg--
Protease0 NP--
Lipase0 NP--
Lactase100 mg--
Maltase100 mg--
Betaine Hydrochloride220 mg--
Pancreatin400 mg--
Sucrase100 mg--
Ox Bile300 mg--
Prolyl Endopeptidase25 mg--
Amylase60 mg--

Other ingredients: Rice Flour, Hypromellose, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: If you are pregnant or breast feeding, consult your physician before using this product.

Keep out of reach of children.

For professional use only

Suggested/Recommended/Usage/Directions

Recommendations: Take three (3) capsules two times daily before meals or as directed by your physician.

Storage

Keep container tightly closed, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Contains no preservatives. Bisphenol-A (BPA) & Phthalate free

Non-GMO

General Statements

Formulated by: Dr. Mona Morstein

FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

Tolerase G is a trademark of DSM

Priority One Nutritional Supplements Inc. Since 1988

Seals/Symbols

GMP Certified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SIBOZyme by Priority One Nutritional Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SIBOZyme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SIBOZyme by Priority One Nutritional Supplements

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamic Acid

220 mg per serving

Lactase

No known
interactions
100 mg per serving

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...

Lactase monograph & interactions

Maltase

100 mg per serving

Betaine Hydrochloride

Interacts with
36 drugs
220 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Pancreatin

400 mg per serving

Sucrase

100 mg per serving

Ox Bile

300 mg per serving

Prolyl Endopeptidase

25 mg per serving Form: Aspergillus niger

Amylase

60 mg per serving

Other (inactive) ingredients: Rice Flour, Hypromellose, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

SIBOZyme by Priority One Nutritional Supplements Drug Interactions

Want to check YOUR meds against SIBOZyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in SIBOZyme interact with 36 drugs. Click any drug to see the details.

1 of the 11 ingredients in SIBOZyme interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in SIBOZyme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SIBOZyme, from the product label.

Priority One Nutritional Supplements

See all Priority One Nutritional Supplements products
Name
Priority One Nutritional Supplements, Inc.
Web Address
www.priorityonevitamins.com
Pharmacist Counseling Corner

SIBOZyme by Priority One Nutritional Supplements: Common Questions

Does SIBOZyme by Priority One Nutritional Supplements interact with any medications?
Yes. Based on its ingredients, SIBOZyme has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SIBOZyme contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my lactose intolerance?
Lactase, one of the ingredients in SIBOZyme, is rated Effective for lactose intolerance. Whether the full product helps depends on your individual digestion, but lactase itself has solid evidence behind it.
Can I take this if I have an ulcer or acid reflux?
No. Betaine hydrochloride in this product increases stomach acid and may irritate or worsen ulcers and gastritis. If you have acid reflux, ulcers, or gastritis, avoid this product unless your doctor clears it.
Is it safe during pregnancy?
Safety data during pregnancy is limited or absent for most of these ingredients. Lactase is likely safe, but betaine hydrochloride should be avoided. Talk with your doctor or pharmacist about your specific situation before using it.
Can I breastfeed while taking this?
Safety data during breastfeeding is sparse for most ingredients. Check with your doctor or pharmacist first—they can help you decide whether it's right for you and your baby.
What does the ox bile do?
Ox bile is included to help with the digestion and absorption of fats. It works alongside the lipase enzyme to break down dietary fat.
Are there any fillers in this?
The capsule contains rice flour, hypromellose (a capsule material), and purified water as inactive ingredients. These are standard excipients that hold the formula together and make the capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if SIBOZyme is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SIBOZyme label
Go deeper

The Full Monographs Behind SIBOZyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Sources

Sources & How We Checked

SIBOZyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team