Sodium Fluoride Drops 0.5 mg/mL Grape Flavored Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Sodium Fluoride Drops 0.5 mg/mL Grape Flavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sodium Fluoride Drops 0.5 mg/mL Grape Flavored is a dietary supplement by Sancilio & Company with 1 active ingredient. Its ingredients are commonly taken for preventing tooth decay (cavities), strengthening tooth enamel, dental care for children in low-fluoride areas.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Sodium Fluoride Drops 0.5 mg/mL Grape Flavored by Sancilio & Company
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: fluoride at a concentration of 0.5 mg per milliliter, delivered as a grape-flavored liquid. Fluoride is a mineral that helps strengthen tooth enamel and prevent cavities.
The inactive ingredients are water, glycerin, xylitol, propylene glycol, natural grape flavor, sucralose, methyl paraben, and propyl paraben—these are the carriers, sweeteners, and preservatives that make up the liquid base.
Does it work?
Strong evidence
Fluoride in this formulation is effective for preventing dental cavities (tooth decay). It's also possibly effective for reducing dental plaque, helping with gingivitis (gum inflammation), and strengthening bones in cases of osteoporosis.
The evidence is strongest for cavity prevention; the other uses show promise but need more research to pin down how well they really work.
How safe is it?
Well-documented data
Fluoride at the recommended dental dose is generally well tolerated, with most people experiencing no problems. The most common side effect when taken by mouth is gastrointestinal upset.
Rare serious reactions include allergic responses—hives, skin rashes, lip swelling, or respiratory symptoms—and in very rare cases, a sore mouth. Fluorosis (tooth staining or spotting) can happen with topical products if you use too much.
Pregnancy and breastfeeding data is mixed. Routine prenatal fluoride supplements aren't recommended; normal dietary intake and fluoridated water are generally considered sufficient.
Some observational research has raised questions about very high fluoride exposure during pregnancy or childhood and brain development, but these findings are still being studied and we don't yet know if any risk applies at typical exposure levels. Talk with your doctor or pharmacist about what's right for your situation.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we hold on file. That's good news, but it's still worth confirming with your own doctor or pharmacist that there's nothing to watch for with your specific medications.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
This product is an effective way to help prevent cavities in children or adults when used at the recommended dose. It's well tolerated in most people, though gastrointestinal upset and rare allergic reactions are possible.
If you're pregnant or nursing, or if you're giving this to a child, check with your doctor or pharmacist first to make sure the dose fits your family's overall fluoride intake—you want to stay in the safe range and avoid excess.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sodium Fluoride Drops 0.5 mg/mL Grape Flavored, straight from the product label.
| Brand | Sancilio & Company |
|---|---|
| Barcode (UPC) | 344946103280 |
| Net contents | 1.6 Fluid Ounce(s); 50 Milliliter(s) |
| Market status | On market |
| Date entered into DSLD | Dec 18, 2021 |
| DSLD ID | 264209 |
| Product type | Mineral |
| Supplement form | Liquid |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Children (All), Infants/Baby (0 - 1 Year), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sodium Fluoride Drops 0.5 mg/mL Grape Flavored by Sancilio & Company, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Fluoride | 0.5 mg | -- |
Other ingredients: Water, Glycerin, Xylitol, Propylene Glycol, natural Grape flavor, Sucralose, Methyl Paraben, Propyl Paraben
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
SCI Developing Good Science into Great Medicine
Formula
(Sodium Fluoride Oral Solution, USP)
Formulation
No dyes, artificial flavors or sugar Saccharin and gluten free
Precautions
Dispense under a physician's order
Caution: Should be used only when the fluoride content of the drinking water supply is known to be 0.6 parts per million or less.
Do not exceed recommended dosage.
Keep this product out of the reach of children. If overdosage is suspected, seek professional assistance or contact a poison control center immediately 1-800-222-1222.
The manufacturer of this product requires that it be dispensed only under the order of a physician or licensed medical practitioner.
FDA Statement of Identity
Dietary Supplement
General Statements
Adds a negligible amount of sugar
The numeric identifier on this product's labeling is an assigned product code for use with pharmacy-level, health-insurance and state level reimbursement programs and is not intended to denote registration with the FDA.
44946-1032-8
Suggested/Recommended/Usage/Directions
Indications and Usage: As a supplemental source of fluoride. Dosage and Administration: Daily oral dose: (in areas where the drinking water contains less than 0.3 ppm F); 6 months to age 3: one half dropperful (1/2 mL); age 3-6: one dropperful (1 mL); age 6-16: two dropperfuls (2mL). When drinking water is partially fluoridated (0.3 to 0.6 ppm F inclusive) dose as follows: 6 months to age 3: Fluoride supplementation not indicated; age 3-6: one half dropperful (1/2 mL); age 6-16: one dropperful (1mL).
Dispense in original container.
Storage
Keep tightly closed.
Store at controlled room temperature 15 degrees to 30 degrees C (59 degrees to 86 degrees F).
Seals/Symbols
Made in the USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sodium Fluoride Drops 0.5 mg/mL Grape Flavored by Sancilio & Company label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sodium Fluoride Drops 0.5 mg/mL Grape Flavored by Sancilio & Company
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container50 Amounts shown are per serving.
Fluoride
No knowninteractions
Fluoride is a mineral best known for preventing cavities and strengthening tooth enamel, and it is widely used in toothpaste, mouth rinses, and commun...
Fluoride monograph & interactionsOther (inactive) ingredients: Water, Glycerin, Xylitol, Propylene Glycol, Natural Grape flavor, Sucralose, Methyl Paraben, Propyl Paraben. These complete the product’s ingredient list but are not active constituents.
Sodium Fluoride Drops 0.5 mg/mL Grape Flavored by Sancilio & Company Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Sodium Fluoride Drops 0.5 mg/mL Grape Flavored. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Sodium Fluoride Drops 0.5 mg/mL Grape Flavored, from the product label.
Sancilio & Company
See all Sancilio & Company products- Name
- Sancilio & Company, Inc.
- Street Address
- 3874 Fiscal Court
- City
- Riviera Beach
- State
- FL
- ZipCode
- 33404
- Phone Number
- (800) 724-8711
Sodium Fluoride Drops 0.5 mg/mL Grape Flavored by Sancilio & Company: Common Questions
Does Sodium Fluoride Drops 0.5 mg/mL Grape Flavored by Sancilio & Company interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe to use while pregnant or breastfeeding?
Can my child take this, or is there a risk of fluorosis?
What are the common side effects?
Is this effective for cavities?
Does this product have any fillers or extra ingredients I should know about?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Sodium Fluoride Drops 0.5 mg/mL Grape Flavored is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Sodium Fluoride Drops 0.5 mg/mL Grape Flavored’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Sodium Fluoride Drops 0.5 mg/mL Grape Flavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 39 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Fluoride 39 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press, 1999. Available at: http://books.nap.edu/books/0309063507/html/index.html.
- Position of the American Dietetic Association: the impact of fluoride on health. J Am Diet Assoc 2001;101:126-32.. PubMed
- Brown JP, Josse RG, et al. 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ 2002;167:S1-S34..
- Haguenauer D, Welch V, Shea B, et al. Fluoride for treating postmenopausal osteoporosis.(Cochrane Review). Cochrane Database Syst Rev 2002;(4):CD002825.. PubMed
- Choi AL, Sun G, Zhang Y, Grandjean P. Developmental fluoride neurotoxicity: a systematic review and meta-analysis. Environ Health Perspect. 2012 Oct;120(10):1362-8. PubMed
- Enamandram M, Das S, Chaney KS. Cheilitis and urticaria associated with stannous fluoride in toothpaste. J Am Acad Dermatol. 2014 Sep;71(3):e75-6. PubMed
- Foti C, Romita P, Ficco D, Bonamonte D, Angelini G. Allergic contact cheilitis to amine fluoride in a toothpaste. Dermatitis. 2014 Jul-Aug;25(4):209. PubMed
- Grey A, Garg S, Dray M, Purvis L, Horne A, Callon K, Gamble G, Bolland M, Reid IR, Cundy T. Low-dose fluoride in postmenopausal women: a randomized controlled trial. J Clin Endocrinol Metab. 2013 Jun;98(6):2301-7. PubMed
- Peters P, Drummond C. Perioral dermatitis from high fluoride dentifrice: a case report and review of literature. Aust Dent J. 2013 Sep;58(3):371-2. PubMed
- Sälzer S, Slot DE, Dörfer CE, Van der Weijden GA. Comparison of triclosan and stannous fluoride dentifrices on parameters of gingival inflammation and plaque scores: a systematic review and meta-analysis. Int J Dent Hyg. 2015 Feb;13(1):1-17.
- Till C, Green R, Flora D, et al. Fluoride exposure from infant formula and child IQ in a Canadian birth cohort. Environ Int. 2020;134:105315. PubMed
- Seddek AL, Ghallab A. Fluoride: No evidence of developmental neurotoxicity due to current exposure levels in Europe. Arch Toxicol. 2020;94(7):2543-2544. PubMed
- Green R, Lanphear B, Hornung R, et al. Association between maternal fluoride exposure during pregnancy and IQ scores in offspring in Canada. JAMA Pediatr. 2019;173(10):940-8. PubMed
- Guth S, Hüser S, Roth A, et al. Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses. Arch Toxicol. 2020;94(5):1375-1415. PubMed
- Canadian Dental Association. CDA position on use of fluorides in caries prevention. March 2012. Available at: https://www.cda-adc.ca/_files/position_statements/fluoride.pdf. Accessed December 9, 2020.
- Bellinger DC. Is fluoride potentially neurotoxic? JAMA Pediatr. 2019. PubMed
- Till C, Green R, Lanphear B. Association between maternal fluoride exposure and child IQ-reply. JAMA Pediatr. 2020;174(2):216-217. PubMed
- Bledsoe J, Breiger D, McKeever J. Association between maternal fluoride exposure and child IQ. JAMA Pediatr. 2020;174(2):213. PubMed
- Gong CX, James NE. Association between maternal fluoride exposure and child IQ. JAMA Pediatr. 2020;174(2):212-213. PubMed
- Bashash M, Marchand M, Hu H, et al. Prenatal fluoride exposure and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12?years of age in Mexico City. Environ Int. 2018;121(Pt 1):658-666. PubMed
- Riddell JK, Malin AJ, Flora D, McCague H, Till C. Association of water fluoride and urinary fluoride concentrations with attention deficit hyperactivity disorder in Canadian youth. Environ Int. 2019;133(Pt B):105190. PubMed
- Wei Y, Zhu J, Wetzstein SA. Plasma and water fluoride levels and hyperuricemia among adolescents: A cross-sectional study of a nationally representative sample of the United States for 2013-2016. Ecotoxicol Environ Saf 2021;208:111670. PubMed
- Davoudi M, Barjasteh-Askari F, Sarmadi M, et al. Relationship of fluoride in drinking water with blood pressure and essential hypertension prevalence: a systematic review and meta-analysis. Int Arch Occup Environ Health 2021;94(6):1137-1146. PubMed
- Veneri F, Vinceti M, Generali L, et al. Fluoride exposure and cognitive neurodevelopment: Systematic review and dose-response meta-analysis. Environ Res 2023;221:115239. PubMed
- Iamandii I, De Pasquale L, Giannone ME, et al. Does fluoride exposure affect thyroid function? A systematic review and dose-response meta-analysis. Environ Res 2024;242:117759. PubMed
- Mou Y, Qu T, Wang R, Zhang Y, He Z, Gu S. The association of high-fluoride and high-iodine combined exposure with dental fluorosis and goiter: a meta-analysis. Environ Geochem Health 2023;45(6):3143-3153. PubMed
- Hall M, Lanphear B, Chevrier J, Hornung R, Green R, Goodman C, et al. Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort. Sci Total Environ 2023;869:161149. PubMed
- Malin AJ, Riddell J, McCague H, Till C. Fluoride exposure and thyroid function among adults living in Canada: Effect modification by iodine status. Environ Int 2018;121(Pt 1):667-674. PubMed
- Do LG, Sawyer A, John Spencer A, et al. Early Childhood Exposures to Fluorides and Cognitive Neurodevelopment: A Population-Based Longitudinal Study. J Dent Res 2024; Dec. PubMed
- Do LG, Spencer AJ, Sawyer A, et al. Early Childhood Exposures to Fluorides and Child Behavioral Development and Executive Function: A Population-Based Longitudinal Study. J Dent Res 2023;102(1):28-36. PubMed
- Farmus L, Till C, Green R, et al. Critical windows of fluoride neurotoxicity in Canadian children. Environ Res 2021;200:111315. PubMed
- Grandjean P, Meddis A, Nielsen F, et al. Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies. Eur J Public Health 2024;34(1):143-149. PubMed
- Griebel-Thompson AK, Sands S, Chollet-Hinton L, et al. A Scoping Review of Iodine and Fluoride in Pregnancy in Relation to Maternal Thyroid Function and Offspring Neurodevelopment. Adv Nutr 2023;14(2):317-338. PubMed
- Kumar JV, Moss ME, Liu H, Fisher-Owens S. Association between low fluoride exposure and children's intelligence: a meta-analysis relevant to community water fluoridation. Public Health 2023;219:73-84. PubMed
- Levy SM. Caution Needed in Interpreting the Evidence Base on Fluoride and IQ. JAMA Pediatr 2025. PubMed
- Taylor KW, Eftim SE, Sibrizzi CA, et al. Fluoride Exposure and Children's IQ Scores: A Systematic Review and Meta-Analysis. JAMA Pediatr 2025. PubMed
- Goodman CV, Hall M, Green R, et al. Iodine Status Modifies the Association between Fluoride Exposure in Pregnancy and Preschool Boys' Intelligence. Nutrients 2022;14(14):2920. PubMed
- Castiblanco-Rubio GA, Muñoz-Rocha TV, Téllez-Rojo MM, et al. Dietary Influences on Urinary Fluoride over the Course of Pregnancy and at One-Year Postpartum. Biol Trace Elem Res 2022;200(4):1568-1579. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC