Interactions on record — worth a quick check against your medications. Based on 6 of 7 ingredients. Check your meds →
Dietary supplement

Spice Syrup Ingredients & Drug Interactions

by Dr. Clark Research Association Dr. Clark Zentrum

Spice Syrup label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Spice Syrup against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Spice Syrup is a dietary supplement by Dr. Clark Research Association Dr. Clark Zentrum with 7 active ingredients. Its ingredients are commonly taken for digestive upset and bloating, infant colic, menstrual cramps.Based on those ingredients, 1,396 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Clove essential oil, Peppermint essential Oil, Fennel Essential Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Spice Syrup by Dr. Clark Research Association Dr. Clark Zentrum

Ask about any prescription or over-the-counter medication and we check it for interactions with Spice Syrup by Dr. Clark Research Association Dr. Clark Zentrum — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Spice Syrup by Dr. Clark Research Association Dr. Clark Zentrum

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Essential Oils” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Spice Syrup is a liquid blend of 7 ingredients, 6 of which are active: fennel essential oil, peppermint essential oil, clove essential oil, coriander essential oil, white thyme essential oil, and nutmeg essential oil. These are concentrated plant oils that give the syrup its flavor and aroma.

The product also contains maple syrup as a base and inactive ingredients (coriander, peppermint, clove, white thyme, nutmeg, and fennel), which are excipients that support the formulation.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Irritable bowel syndrome (IBS) — rated "Likely Effective" (Peppermint) (Natural Medicines).
  • On file: Ventilator-associated pneumonia (VAP) — rated "Possibly Effective" (Clove) (Natural Medicines).
  • On file: Dysmenorrhea — rated "Possibly Effective" (Fennel) (Natural Medicines).
  • On file: Barium enema-related colonic spasm — rated "Possibly Effective" (Peppermint) (Natural Medicines).
  • On file: Chemotherapy-induced nausea and vomiting (CINV) — rated "Possibly Effective" (Peppermint) (Natural Medicines).

The evidence we hold on effectiveness is mixed and mostly limited. Fennel is possibly effective for dysmenorrhea (painful periods), but the evidence for bronchitis, anxiety, nocturnal enuresis, and cholera is insufficient.

Peppermint is likely effective for irritable bowel syndrome (IBS) and possibly effective for indigestion, nausea from chemotherapy or medical procedures, and related digestive issues. Clove is possibly effective for ventilator-associated pneumonia, but evidence for cough, acute pain, and indigestion is insufficient.

Coriander, thyme, and nutmeg all lack sufficient reliable evidence for the conditions they're traditionally used for—including loss of appetite, anxiety, constipation, diabetes, diarrhea, and indigestion for coriander; bronchitis, aging skin, and hair loss for thyme; and dental caries, diarrhea, and bad breath for nutmeg. If you're considering this syrup for a specific reason, ask your pharmacist whether the evidence supports that use.

The evidence, ingredient by ingredient Fennel Peppermint Clove Coriander Thyme Nutmeg

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These essential oils are generally well tolerated in food amounts, but this product is a concentrated syrup—not a food seasoning—so safety depends on how much you take. Fennel can cause gastrointestinal discomfort, photosensitivity (reaction to sun exposure), and allergic reactions; seizures are rare but documented.

Peppermint is generally well tolerated but may cause abdominal pain, anal burning, diarrhea, dry mouth, heartburn, nausea, or vomiting; anaphylaxis is rare. Clove can cause burning, contact dermatitis, and other topical irritation; liver failure is rare, and clove oil in small amounts (5–10 mL) can be toxic in children.

Coriander is generally safe in food amounts and well tolerated; contact dermatitis is possible topically, and anaphylaxis is rare. Thyme is well tolerated but may cause allergic reactions, diarrhea, dizziness, headache, heartburn, nausea, or vomiting, and contact dermatitis topically.

Nutmeg is safe as a food spice but is toxic at high doses—serious poisoning can cause hallucinations, depression, cardiac and gastrointestinal problems, and death. Fennel is rated possibly unsafe in pregnancy and lactation due to limited safety data and possible hormone effects.

Peppermint is likely safe during pregnancy and lactation. Clove and thyme are likely safe in pregnancy and lactation.

Coriander has no safety rating on file for pregnancy and lactation. Nutmeg is rated likely safe in pregnancy but possibly unsafe (one source lists it that way), and likely safe during lactation.

Because this is a blend of concentrated essential oils and the dosage per use isn't specified here, talk with your doctor or pharmacist before using it if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Fennel Peppermint Clove Coriander Thyme Nutmeg

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Coriander, Clove, Fennel, Peppermint, Nutmeg, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,397 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check these medication types with your pharmacist: blood thinners (anticoagulants and antiplatelet drugs)—moderate severity; contraceptive drugs and hormone replacement therapy (estrogens)—moderate; blood sugar medications (antidiabetes drugs) and sedatives (CNS depressants)—moderate; blood pressure medications (antihypertensive drugs)—moderate; drugs your liver breaks down, especially via CYP3A4, CYP2C19, CYP2C9, CYP2D6, and CYP1A2 pathways—moderate; and drugs affecting acetylcholine (anticholinergic and cholinergic medications)—moderate. This is not an exhaustive list; run your complete medication list through the interaction checker.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Spice Syrup is a multi-ingredient essential oil blend with serious interaction potential—especially with blood thinners, hormonal drugs, diabetes medications, sedatives, and liver-processed medications. If you take any prescription or over-the-counter medications, check them against the interaction tool on this page before you start.

Peppermint oil is the most established ingredient for digestive issues (especially IBS), but the others lack robust evidence. Ask your pharmacist whether this product is right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Spice Syrup, straight from the product label.

Brand Dr. Clark Research Association Dr. Clark Zentrum
Barcode (UPC) 7640116929494
Net contents 120 mL; 4 Ounce(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 223457
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Spice Syrup by Dr. Clark Research Association Dr. Clark Zentrum, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 Teaspoon(s)
Maximum serving Sizes:
0.25 Teaspoon(s)
Servings per container
96
UPC/BARCODE
7640116929494
IngredientAmount% DV
Essential Oils0 NP--
Fennel Essential Oil0 NP--
Peppermint essential Oil0 NP--
Clove essential oil0 NP--
Maple syrup0 NP--
Coriander Essential Oil0 NP--
White thyme essential oil0 NP--
Nutmeg essential oil0 NP--

Other ingredients: Coriander, Peppermint, Clove, White Thyme, Nutmeg, Fennel

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement/Food Supplement

Suggested/Recommended/Usage/Directions

Adults and children 12 or more years of age: Take 1/4 tsp. as needed or as directed. Do not exceed 6 doses per day.

Precautions

Store out of reach of young children.

Dietary supplements/food supplements should not be used as a substitute for a varied diet. Do not exceed the stated recommended daily dose.

Storage

Store in a dry, cool place.

Formulation

Made in the USA.

General Statements

Nominal weight: 120 g % DV = % Daily Value

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Spice Syrup by Dr. Clark Research Association Dr. Clark Zentrum label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Spice Syrup label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Spice Syrup by Dr. Clark Research Association Dr. Clark Zentrum

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.25 Teaspoon(s) Dosage formLiquid Servings per container96 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Maple syrup

0 NP per serving

Other (inactive) ingredients: Coriander, Peppermint, Clove, White Thyme, Nutmeg, Fennel. These complete the product’s ingredient list but are not active constituents.

Interaction report

Spice Syrup by Dr. Clark Research Association Dr. Clark Zentrum Drug Interactions

Want to check YOUR meds against Spice Syrup?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,396Drugs
1,396 Moderate

Ingredients driving the most interactions

Clove essential oil 977
Peppermint essential Oil 796
Fennel Essential Oil 740
Coriander Essential Oil 717
Nutmeg essential oil 528

Individual Drug Interactions

The ingredients in Spice Syrup interact with 1,396 drugs. Click any drug to see the details.

6 of the 7 ingredients in Spice Syrup interact with drugs. Each result below shows which ingredient is responsible. Clove essential oil Peppermint essential Oil Fennel Essential Oil Coriander Essential Oil Nutmeg essential oil White thyme essential oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Spice Syrup with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Clove essential oil7 drug types · 977 drugs

Antidiabetes Drugs

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical and laboratory research suggest that polyphenol extracts from clove flower buds might lower blood glucose levels. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary when taken with clove. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP1A2 in a dose-dependent manner,. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2C9.
In vitro research shows that eugenol, the principal constituent of clove, inhibits CYP2C9 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP2D6 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP3A4 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that eugenol, a constituent of clove, has antiplatelet activity. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Ibuprofen (Advil, Others)

Theoretically, topical application of clove oil with ibuprofen might increase the absorption and side effects of topical ibuprofen.
Laboratory research shows that topical application of clove oil increases the absorption of topical ibuprofen. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Clove essential oil full monograph & interactions

Peppermint essential Oil5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
Peppermint essential Oil full monograph & interactions

Fennel Essential Oil6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel Essential Oil full monograph & interactions

Coriander Essential Oil4 drug types · 717 drugs

Antidiabetes Drugs

Theoretically, coriander might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Evidence from animal research suggests that coriander fruit and coriander extract can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Evidence from animal research suggests that coriander fruit can lower blood pressure.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Evidence from animal research suggests that coriander fruit extract has sedative effects.

Likelihood Possible Evidence D
Photosensitizing Drugs

Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Evidence from in vitro research suggests that coriandrin, a constituent of coriander, has photosensitizing effects.

Likelihood Possible Evidence D
Coriander Essential Oil full monograph & interactions

Nutmeg essential oil5 drug types · 528 drugs

Anticholinergic Drugs

Theoretically, concomitant use of nutmeg and anticholinergic drugs might decrease the effectiveness of either agent.
Animal research suggests that nutmeg extract can inhibit acetylcholinesterase and might increase acetylcholine levels.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concomitant use of nutmeg with other cholinergic drugs might have additive effects and increase the risk of cholinergic side effects.
Animal research suggests that nutmeg extract can inhibit acetylcholinesterase and might increase acetylcholine levels.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, nutmeg might increase the risk of additive sedation when taken with CNS depressants.
Animal studies suggest that nutmeg extracts and several volatile oils in nutmeg, such as methyleugenol, isoeugenol, safrole, myristicin, trimyristin, 1,8-cineole, and geranyl acetate, have sedative effects. One animal study shows that petroleum ether extracts of nutmeg can potentiate the effects of pentobarbital or phenobarbital. However, evidence from other animal research suggests that the nutmeg constituent myristicin can actually reduce sleeping time in rats pretreated with phenobarbital.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, nutmeg might decrease levels of drugs metabolized by CYP1A2.
Animal research suggests that intraperitoneal injections of myristicin, a constituent of nutmeg, can induce CYP1A2.

Likelihood Possible Evidence D
Phenobarbital (Luminal)

Theoretically, nutmeg might increase or decrease the effects and adverse effects of phenobarbital.
Some animal research suggests that myristicin, a constituent of nutmeg, can reduce sleeping time in rats pretreated with phenobarbital. However, other animal research suggests that petroleum ether extract of nutmeg can potentiate the effects of phenobarbital.

Likelihood Probable Evidence D
Nutmeg essential oil full monograph & interactions

White thyme essential oil4 drug types · 379 drugs

Anticholinergic Drugs

Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that thyme leaf extract has antiplatelet effects. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that thyme has estrogen receptor-binding activity and phytoestrogen content. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
White thyme essential oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Spice Syrup, from the product label.

Dr. Clark Research Association Dr. Clark Zentrum

See all Dr. Clark Research Association Dr. Clark Zentrum products
Name
Dr. Clark Zentrum Limited
Street Address
152 Naxxar Road #7, SGN 9030
City
San Gwann
State
Malta
Web Address
www.drclark.com
Pharmacist Counseling Corner

Spice Syrup by Dr. Clark Research Association Dr. Clark Zentrum: Common Questions

Does Spice Syrup by Dr. Clark Research Association Dr. Clark Zentrum interact with any medications?
Yes. Based on its ingredients, Spice Syrup has a known interaction with 1,396 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Spice Syrup contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to use while I'm pregnant or breastfeeding?
It depends on the ingredient. Fennel is rated possibly unsafe in pregnancy and lactation due to limited safety data and possible hormone-like effects—avoid medicinal or concentrated amounts. Peppermint, clove, and thyme are likely safe. Coriander and nutmeg lack enough data or have mixed ratings. Because this is a blend of concentrated essential oils and we don't know how much you'd take, talk with your doctor or pharmacist for personalized advice before you use it.
Can I use this if I take birth control pills?
No, not without checking with your pharmacist first. Fennel essential oil in this product may theoretically decrease the effects of contraceptive drugs by competing for estrogen receptors. This is a moderate-severity concern and means your birth control might not work as well. Talk to your pharmacist or doctor before starting.
What is this product supposed to help with?
The evidence we have is limited. Peppermint is likely effective for irritable bowel syndrome (IBS) and possibly effective for indigestion and nausea. Fennel is possibly effective for painful periods. For the other ingredients and uses—anxiety, cough, diarrhea, dental issues—the evidence is insufficient to rate. If you're considering it for a specific reason, ask your pharmacist whether the science supports that.
What are the most common side effects?
From the essential oils in this syrup, the most common side effects are gastrointestinal: abdominal pain, belching, diarrhea, heartburn, nausea, and vomiting (mainly from peppermint). Fennel may also cause photosensitivity (a reaction to sunlight) and allergic reactions in sensitive people. Clove can cause burning or irritation topically. Most people tolerate these oils well when used in food amounts, but this is a concentrated syrup—so start cautiously and stop if you notice discomfort.
Is there anything I should avoid taking with this product?
Yes—blood thinners (like warfarin), birth control pills, hormone therapy, blood pressure medications, blood sugar medications, sedatives, and any medication that's broken down by your liver are all concerns. Some interactions are moderate-severity. Use the medication checker on this page with your complete list, and ask your pharmacist before you start.
What ingredients does this syrup contain?
The active ingredients are six essential oils: fennel, peppermint, clove, coriander, white thyme, and nutmeg—all in a maple syrup base. We could not check maple syrup itself for interactions. The product also contains those same spice ingredients as inactive excipients to support the formulation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Spice Syrup label
Go deeper

The Full Monographs Behind Spice Syrup’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph → Herb & supplement monograph

Clove

Interacts with 977 drugs

Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main compound, eugenol. Food amounts are general...

Read the full Clove monograph → Herb & supplement monograph

Coriander

Interacts with 717 drugs

Coriander (also called cilantro) is a common cooking herb and spice that has long been used in traditional medicine for digestive complaints. As a food it is generally safe for most people,...

Read the full Coriander monograph → Herb & supplement monograph

Thyme

Interacts with 379 drugs

Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found in food, and some cough products that com...

Read the full Thyme monograph → Herb & supplement monograph

Nutmeg

Interacts with 528 drugs

Nutmeg is a popular cooking spice that has long been used in traditional medicine for digestion and other complaints, but there is little solid human research to support its medicinal use. I...

Read the full Nutmeg monograph →
Sources

Sources & How We Checked

Spice Syrup's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 143 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fennel 17 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
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Peppermint 41 references
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Clove 26 references
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Coriander 12 references
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Thyme 18 references
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See these in context on the Nutmeg monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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