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Dietary supplement

SuperCissus RX Ingredients & Drug Interactions

by USPlabs

SuperCissus RX label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SuperCissus RX against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SuperCissus RX is a dietary supplement by USPlabs with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are SuperCissus(TM). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against SuperCissus RX by USPlabs

Ask about any prescription or over-the-counter medication and we check it for interactions with SuperCissus RX by USPlabs — and tell you which ingredient is responsible.

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Computed from our clinical databases

HelloPharmacist Scorecard of SuperCissus RX by USPlabs

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The stated purpose hasn't been mapped to our evidence data yet.

Why this rating?
  • We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.
Known Interaction Concern
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Safety Information
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SuperCissus RX, straight from the product label.

Brand USPlabs
Net contents 150 Capsule(s)
Market status Off market
Date entered into DSLD Dec 23, 2011
DSLD ID 3429
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SuperCissus RX by USPlabs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
150
IngredientAmount% DV
SuperCissus(TM)800 mg--

Other ingredients: Gelatin, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Directions for use: As a dietary supplement, take 1-2 capsules with meals. For best results, take 4-5 capsules per day. For more immediate results, begin with a 14 – 21 day “loading phase” of three (3) capsules, three times per day with meals, followed by a maintenance phase of three (3) capsules with morning meal and two (2) capsules with last meal of the day.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Pregnant or nursing women should not use this product. Consult with your health care provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement product or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAO-B inhibitor or any other medication. Discontinue use and immediately consult your health care professional if you experience any adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing.

Warning: This product is only intended to be consumed by healthy adults 18 years of age or older.

FDA Disclaimer Statement

†These statements have not been evaluated by the Food and Drug administration. This product is not intended to treat, diagnose, cure or prevent any disease.

General Statements

*In comparison to original 90 count version

AWARD WINNING JOINT FORMULA

BONUS SIZE - 67% MORE FREE!*

Patent Pending 60/595630

Brand IP Statement(s)

SuperCissus RX(TM) has quickly established itself among customers & industry insiders alike. In fact, it has won numerous awards including Planet Muscle Magazine’s “Platinum #1 Joint Product for 2008-2009”!†

SuperCissus RX(TM) is THE Original patent-pending Cissus Quadrangularis joint product. † SuperCissus RX(TM) has earned numerous “Joint Product of The Year” awards since its inception. Do not accept inferior imitations - Demand the best, SuperCissus RX(TM).† The key ingredient in SuperCissus RX(TM), Cissus Quadrangularis: Contains compounds that may work to promote tendon and ligament health.† Is Shellfish-free.† Supported by centuries of use in Ayurvedic Medicinal system.† Subject of numerous scientific studies.† Does not contain Glucosamine, Chondroitin or MSM.†

Seals/Symbols

PLATINUM WINNER #1 Voted #1 Joint Formula

USPlabs(TM) Ultra-Premium Supplements

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SuperCissus RX by USPlabs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SuperCissus RX label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SuperCissus RX by USPlabs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container150 Amounts shown are per serving.

SuperCissus(TM)

Interacts with
86 drugs
800 mg per serving

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

SuperCissus(TM) monograph & interactions

Other (inactive) ingredients: Gelatin, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

SuperCissus RX by USPlabs Drug Interactions

SuperCissus RX contains a single active ingredient, and it has known interactions with 86 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against SuperCissus RX?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

SuperCissus(TM) 86

Individual Drug Interactions

The ingredients in SuperCissus RX interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in SuperCissus RX interact with drugs. Each result below shows which ingredient is responsible. SuperCissus(TM)

Each ingredient & the kinds of drugs it affects

For each ingredient in SuperCissus RX with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

SuperCissus(TM)1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
SuperCissus(TM) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SuperCissus RX, from the product label.

USPlabs

See all USPlabs products
Phone Number
1-800-890-3067
Web Address
www.usplabsdirect.com
Pharmacist Counseling Corner

SuperCissus RX by USPlabs: Common Questions

Does SuperCissus RX by USPlabs interact with any medications?
Yes. Based on its ingredients, SuperCissus RX has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SuperCissus RX contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if SuperCissus RX is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SuperCissus RX label
Go deeper

The Full Monographs Behind SuperCissus RX’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

SuperCissus RX's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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