Sweet Zap Mint Ingredients & Drug Interactions
by Seynani
What is this page for?
First and foremost: checking Sweet Zap Mint against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sweet Zap Mint is a dietary supplement by Seynani with 2 active ingredients. Its ingredients are commonly taken for blood sugar support, type 2 diabetes, sugar cravings.Based on those ingredients, 920 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gymnema sylvestre extract, Holy Basil extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sweet Zap Mint by Seynani
Ask about any prescription or over-the-counter medication and we check it for interactions with Sweet Zap Mint by Seynani — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Sweet Zap Mint by Seynani
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Sweet Zap Mint contains 2 active ingredients: gymnema sylvestre extract and holy basil extract. Gymnema is traditionally used in herbal medicine for blood sugar support, and holy basil (also called tulsi) is used for stress and inflammation.
The product also contains inactive ingredients — purified water, vegetable glycerin, peppermint oil, potassium sorbate, and silicon dioxide — which serve as the base, preservative, and flavoring.
Does it work?
Not established
The evidence for both active ingredients in this product is currently insufficient to rate. Gymnema sylvestre has been studied for diabetes, obesity, and prediabetes, but we don't have established reliable evidence that it works for these conditions.
Holy basil has been studied for anxiety, asthma, headaches, respiratory infections, dental plaque, and diabetes, but the evidence is not established in our data either. That doesn't mean they're ineffective — just that the research isn't solid enough yet for us to say they work.
How safe is it?
Well-documented data
Gymnema sylvestre is generally well tolerated in the short term, though quality varies between products and it can lower blood sugar. There is a reported case of liver inflammation (hepatitis) in someone who drank gymnema tea heavily — they recovered after treatment, but this is a concern.
Holy basil is generally well tolerated short-term, with loose stools and nausea reported by a small number of trial participants. However, long-term safety data are limited.
Do not use this product during pregnancy — gymnema safety data are not adequate, and holy basil is rated possibly unsafe. Do not use while breastfeeding — both ingredients have insufficient safety information for nursing.
Meds to double-check
Moderate interaction found
Check your exact medications against these drug types before taking Sweet Zap Mint: antidiabetes drugs (Moderate risk of low blood sugar), anticoagulants and antiplatelet drugs like warfarin or clopidogrel (Moderate risk of bleeding), drugs broken down by CYP1A2 and CYP2C9 enzymes (Moderate risk of level changes), pentobarbital or other sedatives (Moderate risk of increased sedation), and drugs metabolized by CYP3A4 (Minor risk of level increases).
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product is worth a conversation with your pharmacist, especially if you take diabetes medications, blood thinners, or sedatives. The ingredient quality matters — gymnema's effects vary between brands.
If you're pregnant or breastfeeding, skip this product. Talk to your pharmacist or doctor before starting it if you're on any prescription medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sweet Zap Mint, straight from the product label.
| Brand | Seynani |
|---|---|
| Barcode (UPC) | 697691508726 |
| Net contents | 0.27 Fluid Ounce(s); 8 mL |
| Market status | On market |
| Date entered into DSLD | Jan 22, 2021 |
| DSLD ID | 242602 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sweet Zap Mint by Seynani, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1.23 mg | -- |
| Gymnema sylvestre extract | 0 NP | -- |
| Holy Basil extract | 0 NP | -- |
Other ingredients: purified Water, Vegetable Glycerin, Peppermint Oil, Potassium Sorbate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Retrain Your Brain When you spray Sweet Zap on your tongue, the natural blend fills the sweet receptors located on the taste buds. Sweet Zap works on both sugar and artificial sweeteners by safely and temporarily blocking your ability to taste sweet. By blocking your ability to taste sweet, Sweet Zap can help retrain your brain to stop eating sweets altogether. Transitioning to a low or no-sugar diet reduces hunger and cravings, helps you burn fat, increases energy level, and reduces inflammation.
Sugar blocker mint spray
All natural no artificial flavors non-stimulant Gluten free Made with non-GMO ingredients
Suggested/Recommended/Usage/Directions
Sweet Zap is a conditioning tool. To increase your success: 1. Spray Sweet Zap on the tongue 2. Try the sweet you're craving
For regular use: Use 2-3 times daily or as often as needed. Sweet Zap is a conditioning tool. Suggested routine for success: If you eat sweets after breakfast or have sweets for breakfast, spray Sweet Zap and try that treat again. If you eat sweet treats after lunch, spray Sweet Zap after lunch and try that treat again. If you eat sweet treats after lunch, spray Sweet Zap after dinner or after you eat some of that dessert and try the dessert to avoid overeating.
Suggested Use: As a dietary supplement, spray Sweet Zap (1-2 times) directly on the tongue ensuring you cover the tip. Use Sweet Zap as often as needed to avoid cravings from sugar and artificial sweeteners and help maintain a healthy diet.
General Statements
End sugar cravings
Up to 77 servings
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to cure, diagnose, treat or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sweet Zap Mint by Seynani label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sweet Zap Mint by Seynani
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.104 mL Dosage formLiquid Servings per container77 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Other (inactive) ingredients: Purified Water, Vegetable Glycerin, Peppermint Oil, Potassium Sorbate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Sweet Zap Mint by Seynani Drug Interactions
HelloPharmacist Interaction Report
Sweet Zap Mint by Seynani contains gymnema sylvestre extract and holy basil extract, both of which interact with medications.
The most serious interaction we've documented is with antidiabetes drugs — both ingredients can lower blood sugar, and when combined with diabetes medications, this raises the risk of low blood sugar (hypoglycemia). Gymnema also affects how your liver processes certain medications through the CYP1A2 and CYP2C9 enzyme systems, which could raise or lower levels of those drugs; it may specifically increase phenacetin levels or decrease tolbutamide levels.
Read the full breakdown — every affected drug type, severity by severity
Holy basil extract carries a separate Moderate concern with blood thinners (anticoagulants and antiplatelet drugs) — animal data suggest it may increase bleeding time, though we don't know if this happens in people. It also has a documented interaction with pentobarbital (a sedative), where it might enhance sedation.
Gymnesia carries a Minor interaction with drugs metabolized by the CYP3A4 enzyme system, where it might theoretically raise their levels — though human evidence is mixed. Altogether, these interactions span 909 individual medications.
If you take any prescription medications, especially diabetes drugs, blood thinners, or sedatives, run them through the interaction checker below before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sweet Zap Mint?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sweet Zap Mint interact with 920 drugs. Click any drug to see the details.
2 of the 2 ingredients in Sweet Zap Mint interact with drugs. Each result below shows which ingredient is responsible. Gymnema sylvestre extract Holy Basil extract
AbciximabReoPro
How Abciximab interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Read the full Gymnema Sylvestre Extract + Abrocitinib interactionHoly Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Holy Basil ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Holy Basil Extract + Acarbose interactionGymnema Sylvestre ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Gymnema Sylvestre Extract + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Aspirin interactionHoly Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Sweet Zap Mint — through 2 ingredients. Tap an ingredient for the detail:
Holy Basil ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Holy Basil Extract + Acetaminophen, Aspirin, Caffeine interactionGymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Sweet Zap Mint — through 1 ingredient. Tap an ingredient for the detail:
Gymnema Sylvestre ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
Read the full Gymnema Sylvestre Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sweet Zap Mint with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Gymnema sylvestre extract
Antidiabetes Drugs
Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.
Phenacetin
Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.
Tolbutamide (Orinase)
Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.
Holy Basil extract
Anticoagulant/Antiplatelet Drugs
Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal research shows that holy basil seed oil can prolong bleeding time, possibly due to inhibition of platelet aggregation. However, it is not known if this occurs in humans.
Antidiabetes Drugs
Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that taking holy basil can decrease fasting blood glucose and other measures of glycemic control in patients with type 2 diabetes.
Pentobarbital (Nembutal)
Theoretically, holy basil seed oil might increase the sedative effects of pentobarbital.
Animal research shows that holy basil seed oil increases pentobarbitone-induced sleeping time. However, it is not known if this occurs in humans or if this applies to other barbiturates or sedatives.
Brand information
Manufacturer and brand details for Sweet Zap Mint, from the product label.
Seynani
See all Seynani products- Name
- Seynani, LLC
- Street Address
- PO Box 909
- City
- Falls Church
- State
- VA
- ZipCode
- 22046
Sweet Zap Mint by Seynani: Common Questions
Does Sweet Zap Mint by Seynani interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Sweet Zap Mint if I'm on diabetes medication?
What does gymnema sylvestre do?
Is it safe to take during pregnancy?
What's holy basil extract supposed to do?
What are the side effects I should watch for?
Can I take this with blood thinners like warfarin?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Sweet Zap Mint is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Sweet Zap Mint’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Gymnema
Interacts with 851 drugsGymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...
Read the full Gymnema monograph → Herb & supplement monographHoly Basil
Interacts with 212 drugsHoly basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and preliminary. It is generally well tolerat...
Read the full Holy Basil monograph →Sources & How We Checked
Sweet Zap Mint's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 20 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Gymnema 12 references
- Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-94. PubMed
- Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990;30:295-300.
- Kamble B, Gupta A, Moothedath I, Khatal L, Janrao S, Jadhav A, et al. Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats. Chem Biol Interact. 2016;245:30-8. PubMed
- Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014; 2014:830285.
- Fabio GD, Romanucci V, De Marco A, Zarrelli A. Triterpenoids from Gymnema sylvestre and their pharmacological activities. Molecules. 2014;19(8):10956-81. PubMed
- Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci. 2010;340(6):514-7. PubMed
- Zuniga LY, Gonzalez-Ortiz M, Martinez-Abundis E. Effect of gymnema sylvestre administration on metabolic syndrome, insulin sensitivity, and insulin secretion. J Med Food. 2017 Aug;20(8):750-54.
- Rammohan B, Samit K, Chinmoy D, et al. Human cytochrome P450 enzyme modulation by gymnema sylvestre: a predictive safety evaluation by LC-MS/MS. Pharmacogn Mag. 2016 Jul;12(Suppl 4):S389-S394.
- Vaghela M, Sahu N, Kharkar P, Pandita N. In vivo pharmacokinetic interaction by ethanolic extract of gymnema sylvestre with CYP2C9 (tolbutamide), CYP3A4 (amlodipine) and CYP1A2 (phenacetin) in rats. Chem Biol Interact. 2017 Dec 25;278:141-151. PubMed
- Vaghela M, Iyer K, Pandita N. In vitro inhibitory effect of gymnema sylvestre extracts and total gymnemic acids fraction on select cytochrome P450 activities in rat liver microsomes. Eur J Drug Metab Pharmacokinet. 2017 Oct 10. PubMed
- Gaytán Martínez LA, Sánchez-Ruiz LA, Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance. J Med Food. 2021;
- Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed
Holy Basil 8 references
- Agrawal P, Rai V, Singh RB. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus. Int J Clin Pharmacol Ther 1996;34:406-9.
- Sakina MR, Dandiya PC, Hamdard ME, Hameed A. Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract. J Ethnopharmacol 1990;28:143-50. PubMed
- Singh S, Rehan HM, Majumdar DK. Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time. J Ethnopharmacol 2001;78:139-43. PubMed
- Mondal, S., Varma, S., Bamola, V. D., Naik, S. N., Mirdha, B. R., Padhi, M. M., Mehta, N., and Mahapatra, S. C. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. J PubMed
- Agarwal, P. and Nagesh, L. Comparative evaluation of efficacy of 0.2% Chlorhexidine, Listerine and Tulsi extract mouth rinses on salivary Streptococcus mutans count of high school children--RCT. Contemp.Clin Trials 2011;32(6):802-808. PubMed
- Vohora, S. B., Garg, S. K., and Chaudhury, R. R. Antifertility screening of plants. 3. Effect of six indigenous plants on early pregnancy in albino rats. Indian J Med Res 1969;57(5):893-899.
- Khanna S, Gupta SR, Grover JK. Effect of long term feeding of tulsi (Ocimum sanctum Linn) on reproductive performance of adult albino rats. Indian J Exp Biol 1986;24(5):302-4.
- Somasundaram G, Manimekalai K, Salwe KJ, Pandiamunian J. Evaluation of the antidiabetic effect of Ocimum sanctum in type 2 diabetes patients. Int J Life Sci Pharma Res 2012;2(3):75-81.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC