Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

ZAP2X Appetite Control Ingredients & Drug Interactions

by Pro-Nutra

ZAP2X Appetite Control label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ZAP2X Appetite Control against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ZAP2X Appetite Control is a dietary supplement by Pro-Nutra with 4 active ingredients. Its ingredients are commonly taken for antioxidant support, heart and circulation health, vein problems (such as varicose veins).Based on those ingredients, 1,194 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitis vinifera, Crocus sativus, Phaseolus vulgaris. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against ZAP2X Appetite Control by Pro-Nutra

Ask about any prescription or over-the-counter medication and we check it for interactions with ZAP2X Appetite Control by Pro-Nutra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ZAP2X Appetite Control by Pro-Nutra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “ZAP2X(TM) APPETITE CONTROL MATRIX (Proprietary Blend)” is a proprietary blend — the label gives one combined amount (355 mg) without saying how much of each component you get.

ZAP2X Appetite Control contains 4 active ingredients. Vitis vinifera (grape seed and fruit extract) is a plant compound studied for supporting vein health.

Crocus sativus (saffron) is a spice traditionally used in herbal medicine. Cassia nomame is a plant extract included in the formula.

Phaseolus vulgaris (white kidney bean) is a legume extract. The capsule also contains inactive ingredients: gelatin, microcrystalline cellulose, magnesium stearate, and food colorings (FD&C Red No.

3, FD&C Yellow No. 6, and titanium dioxide).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: appetite control and metabolism enhancement.
  • We looked for evidence on: Obesity, Metabolic syndrome, Impaired glucose tolerance (prediabetes), Diabetes, weight management, satiety — and 2 related terms.
  • The strongest evidence on file: Phaseolus Vulgaris is rated "Possibly Effective" for Obesity (Natural Medicines).
  • Also on file: Grape is rated "Possibly Ineffective" for Obesity.
  • Also on file: Grape is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Metabolic syndrome.

The evidence for appetite control specifically is not established in our data. Grape extract is possibly effective for chronic venous insufficiency (poor circulation in the legs), though it's possibly ineffective for chemotherapy-related nausea and obesity.

Saffron shows possibly effective evidence for chemotherapy-related nerve damage and Alzheimer disease. Phaseolus vulgaris (white kidney bean) is possibly effective for obesity, but evidence is insufficient to rate it for colorectal cancer, diabetes, or high cholesterol.

None of the ingredients carry strong evidence for appetite suppression itself.

The evidence, ingredient by ingredient Grape Saffron Cassia Nomame Phaseolus Vulgaris

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Grape extract is generally well tolerated, though the most common side effects are abdominal pain, diarrhea, dry mouth, indigestion, headache, joint pain, and nausea. Rare serious reactions including anaphylaxis to grape skin have been reported.

Saffron is also generally well tolerated at typical doses but causes gastrointestinal complaints, nausea, sedation, and vomiting in some users; rare anaphylaxis is possible. High saffron doses can be toxic.

Phaseolus vulgaris extract may cause constipation, diarrhea, bloating, nausea, stomach pain, and vomiting; hypersensitivity reactions including anaphylaxis are rare. Cassia nomame has limited safety data and should be used cautiously.

Side effects, ingredient by ingredient Grape Saffron Cassia Nomame Phaseolus Vulgaris

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Grape, Phaseolus Vulgaris, Saffron.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,195 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take ZAP2X Appetite Control, check with us if you're on blood thinners or antiplatelet drugs (Moderate risk of increased bleeding from grape), diabetes medications (Moderate risk of low blood sugar from saffron and Phaseolus vulgaris), CNS depressants or sedatives (Moderate risk of extra drowsiness from saffron), blood pressure medications (Moderate risk of additive lowering from saffron), or cyclosporine (Moderate risk of reduced absorption from grape). Grape also theoretically affects drugs processed by CYP1A2, CYP2D6, CYP3A4, and CYP2E1 enzymes, and may reduce midazolam effectiveness with long-term use.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners, diabetes medications, sedatives, or blood pressure drugs, you need to check your exact prescriptions with our tool before starting this product — grape and saffron both interact with these types of medications. The ingredients are generally well tolerated, though digestive upset is common.

Talk to your pharmacist about whether this product fits your health plan.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ZAP2X Appetite Control, straight from the product label.

Brand Pro-Nutra
Barcode (UPC) 851330004103
Net contents 60 Cap(s)
Market status On market
Date entered into DSLD Oct 25, 2012
DSLD ID 12545
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ZAP2X Appetite Control by Pro-Nutra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
851330004103
IngredientAmount% DV
Vitis vinifera0 NP--
Crocus sativus0 NP--
Cassia nomame0 NP--
ZAP2X(TM) APPETITE CONTROL MATRIX (Proprietary Blend)355 mg--
Phaseolus vulgaris0 NP--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, FD&C Red No. 3, FD&C Yellow No. 6, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

METABOLIC ENHANCER Promotes enhanced metabolism through upregulation of thermogenic capacity.

INCREASED SENSE OF FULLNESS Creates enhanced satiety for reduced intake of food and calories.

CONTROL APPETITE SUPPRESSANT

METABOLIC ENHANCER INCREASED SENSE OF FULLNESS

PHYSICIAN RECOMMENDED

Please read entire label before use.

APPETITE CONTROL Helps to manage cravings and support decreased food and caloric intake.

POWERFUL APPETITE SUPPRESSANT GREATER THAN 25% REDUCTION IN FOOD CONSUMPTION (chart) FOOD CONSUMPTION (g/kg) 0 10 20 30 40 50 60 Placebo White Kidney Bean Ext. (Phaseolus vulgaris) 25%+ REDUCTION Pytother Res. 2012 May 8, doi: 10.1002/ptr.4704. [Epub ahead of print].

When combined with a proper exercise and nutrition regimen. Statements based on early-stage independent 3rd party in vivo and / or in vitro model scientific research data findings.

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

KEEP OUT OF REACH OF CHILDREN.

DO NOT USE IF SAFETY SEAL IS BROKEN.

Warnings: Not intended for individuals under age of 18, unless instructed by a doctor.

Consult your physician prior to use if you have high blood pressure or heart problems or are taking prescription drugs.

Do not exceed the recommended daily intake. Seed the advice of a healthcare professional before beginning any supplement or exercise program. Improper use of this product will not improve results and is not advised.

Suggested/Recommended/Usage/Directions

Suggested Use: Take one (1) capsule in the morning and one (1) capsule in the afternoon, or as recommended by a qualified healthcare practitioner. This product can be taken with or without foot.

FDA Disclaimer Statement

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

General

Rev. 01-001-ZAP001 05/12

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ZAP2X Appetite Control by Pro-Nutra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ZAP2X Appetite Control label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ZAP2X Appetite Control by Pro-Nutra

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

ZAP2X(TM) APPETITE CONTROL MATRIX (Proprietary Blend)

355 mg per serving

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, FD&C Red No. 3, FD&C Yellow No. 6, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

ZAP2X Appetite Control by Pro-Nutra Drug Interactions

Want to check YOUR meds against ZAP2X Appetite Control?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,194Drugs
1,177 Moderate 17 Minor

Ingredients driving the most interactions

Vitis vinifera 910
Crocus sativus 521
Phaseolus vulgaris 86

Individual Drug Interactions

The ingredients in ZAP2X Appetite Control interact with 1,194 drugs. Click any drug to see the details.

3 of the 4 ingredients in ZAP2X Appetite Control interact with drugs. Each result below shows which ingredient is responsible. Vitis vinifera Crocus sativus Phaseolus vulgaris

Each ingredient & the kinds of drugs it affects

For each ingredient in ZAP2X Appetite Control with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitis vinifera9 drug types · 910 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D
Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D
Vitis vinifera full monograph & interactions

Crocus sativus4 drug types · 521 drugs

Antidiabetes Drugs

Theoretically, concomitant use of saffron with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that taking saffron extract reduces fasting levels of glucose when used in addition to hypoglycemic agents. However, saffron powder itself has not been shown to reduce fasting glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.
Animal and human research suggests that saffron extract can decrease blood pressure.

Likelihood Possible Evidence D
Caffeine

Theoretically, saffron might inhibit the metabolism of caffeine.
A small clinical study suggests that taking saffron powder 300 mg in 150 mL water daily for 5 days and then taking caffeine 200 mg seems to reduce caffeine metabolite levels in the saliva and urine in males, but not females. Theoretically, this may be due to the inhibition of cytochrome P450 1A2 by saffron.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Clinical research shows that taking saffron extract 60 mg orally daily for 26 weeks can cause drowsiness and sedation. Animal research suggests that adding saffron to hexobarbital further increases sleeping and slows motor activity.

Likelihood Possible Evidence D
Crocus sativus full monograph & interactions

Phaseolus vulgaris1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Phaseolus vulgaris might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Phaseolus vulgaris beans or bean pods, ingested alone or along with white mulberry leaf and bilberry, reduce blood glucose levels in some patients with diabetes.

Likelihood Possible Evidence D
Phaseolus vulgaris full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ZAP2X Appetite Control, from the product label.

Pro-Nutra

See all Pro-Nutra products
Name
Pro-Nutra
City
For Lauderdale
ZipCode
33301
Pharmacist Counseling Corner

ZAP2X Appetite Control by Pro-Nutra: Common Questions

Does ZAP2X Appetite Control by Pro-Nutra interact with any medications?
Yes. Based on its ingredients, ZAP2X Appetite Control has a known interaction with 1,194 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ZAP2X Appetite Control contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take ZAP2X Appetite Control during pregnancy?
No. Grape concentrates and saffron supplements should be avoided in pregnancy — there isn't enough safety data, and saffron may stimulate the uterus. Cassia nomame and Phaseolus vulgaris extracts are also not well studied in pregnancy. Talk with your doctor or pharmacist before considering this product if you're pregnant or planning to be.
What about taking it while breastfeeding?
There isn't enough reliable data on concentrated grape, saffron, Cassia nomame, or Phaseolus vulgaris supplements during breastfeeding. Use caution and check with your pharmacist before starting.
Does grape extract in this product work for appetite control?
Our data doesn't establish effectiveness for appetite control. Grape is possibly effective for chronic venous insufficiency (poor circulation), but possibly ineffective for obesity and nausea.
What are the most common side effects I might feel?
Digestive upset is the main concern — abdominal pain, diarrhea, nausea, bloating, constipation, and stomach pain. Grape may also cause dry mouth, headache, or joint pain. Saffron can cause drowsiness at the doses used in this formula. A small number of users reported allergic reactions including anaphylaxis, though that's rare.
Why are there so many medication interactions listed?
Grape and saffron affect how your body breaks down and uses several classes of drugs. Grape can change levels of medications processed by multiple liver enzymes, and both grape and saffron interact with blood thinners, diabetes drugs, blood pressure drugs, and sedatives separately. That's why checking your exact prescriptions is important.
What is Cassia nomame, and is it safe?
Cassia nomame is a plant extract included in this formula. It has limited human safety data available, so the recommendation is to use it cautiously and under guidance. Avoid it during pregnancy and breastfeeding due to insufficient safety information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ZAP2X Appetite Control label
Go deeper

The Full Monographs Behind ZAP2X Appetite Control’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Grape

Interacts with 910 drugs

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...

Read the full Grape monograph → Herb & supplement monograph

Saffron

Interacts with 521 drugs

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research uses small trials, so results are not defi...

Read the full Saffron monograph → Herb & supplement monograph

Cassia Nomame

Cassia nomame is a legume plant traditionally used in parts of Asia and now marketed mainly in weight-loss supplements for its supposed ability to block fat absorption. Human evidence is ver...

Read the full Cassia Nomame monograph → Herb & supplement monograph

Phaseolus Vulgaris

Interacts with 86 drugs

Phaseolus vulgaris, the common bean, is widely eaten as food, and a concentrated white bean extract is marketed as a 'carb blocker' for weight loss. Some small studies suggest it may modestl...

Read the full Phaseolus Vulgaris monograph →
Sources

Sources & How We Checked

ZAP2X Appetite Control's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 70 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Grape 34 references
  1. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
  2. Xiao Dong S, Zhi Ping Z, Zhong Xiao W, et al. Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects. Br J Clin Pharmacol 1999;48:638-40. PubMed
  3. Vaswani SK, Hamilton RG, Carey RN, et al. Anaphylaxis recurrent urticaria and angioedema from grape hypersensitivity. J Allergy Clin Immunol 1998;101:S31.
  4. Chevallier A. The Encyclopedia of Medicinal Plants. London, UK: Dorling Kindersley, Ltd., 1996.
  5. Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8.. PubMed
  6. Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
  7. Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. PubMed
  8. Ray, S. D., Parikh, H., Hickey, E., Bagchi, M., and Bagchi, D. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome 4502E1-dependent aniline hydroxylation. Mol Cell B PubMed
  9. O'Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374.
  10. Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschun PubMed
  11. Nishikawa, M., Ariyoshi, N., Kotani, A., Ishii, I., Nakamura, H., Nakasa, H., Ida, M., Nakamura, H., Kimura, N., Kimura, M., Hasegawa, A., Kusu, F., Ohmori, S., Nakazawa, K., and Kitada, M. Effects of continuous ingestion of green tea or grape seed extra
  12. de Lange, D. W., Scholman, W. L., Kraaijenhagen, R. J., Akkerman, J. W., and van de Wiel, A. Alcohol and polyphenolic grape extract inhibit platelet adhesion in flowing blood. Eur.J Clin.Invest 2004;34(12):818-824. PubMed
  13. Samet, J. M. and Coultas, D. B. Reduced forced vital capacity in California grape workers. What does it mean? Am Rev.Respir.Dis 1992;145(2 Pt 1):255-256. PubMed
  14. Gamsky, T. E., McCurdy, S. A., Samuels, S. J., and Schenker, M. B. Reduced FVC among California grape workers. Am Rev.Respir.Dis 1992;145(2 Pt 1):257-262. PubMed
  15. de Lange, D. W., Verhoef, S., Gorter, G., Kraaijenhagen, R. J., van de Wiel, A., and Akkerman, J. W. Polyphenolic grape extract inhibits platelet activation through PECAM-1: an explanation for the French paradox. Alcohol Clin.Exp.Res 2007;31(8):1308-1314 PubMed
  16. Etheridge, A. S., Black, S. R., Patel, P. R., So, J., and Mathews, J. M. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constitu
  17. Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., and Joseph, J. A. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010;103(5):730-734. PubMed
  18. Ingersoll, G. L., Wasilewski, A., Haller, M., Pandya, K., Bennett, J., He, H., Hoffmire, C., and Berry, C. Effect of concord grape juice on chemotherapy-induced nausea and vomiting: results of a pilot study. Oncol.Nurs.Forum 2010;37(2):213-221. PubMed
  19. Oliveira-Freitas, V. L., Dalla, Costa T., Manfro, R. C., Cruz, L. B., and Schwartsmann, G. Influence of purple grape juice in cyclosporine bioavailability. J Ren Nutr. 2010;20(5):309-313. PubMed
  20. Hollis, J. H., Houchins, J. A., Blumberg, J. B., and Mattes, R. D. Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults. J Am Coll.Nutr. 2009;28(5):574-582. PubMed
  21. Dohadwala, M. M., Hamburg, N. M., Holbrook, M., Kim, B. H., Duess, M. A., Levit, A., Titas, M., Chung, W. B., Vincent, F. B., Caiano, T. L., Frame, A. A., Keaney, J. F., Jr., and Vita, J. A. Effects of Concord grape juice on ambulatory blood pressure in
  22. Rabe, E., Stucker, M., Esperester, A., Schafer, E., and Ottillinger, B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur.J Vasc.Endovasc. PubMed
  23. Trotta, M., Cesaretti, M., Conzi, R., Derchi, L. E., and Borgonovo, G. Elderly male with mesogastric pain. Small bowel obstruction caused by an intact fresh grape. Ann.Emerg.Med 2011;58(4):e1-e2. PubMed
  24. McCurdy, S. A., Wiggins, P., Schenker, M. B., Munn, S., Shaieb, A. M., Weinbaum, Z., Goldsmith, D., McGillis, S. T., Berman, B., and Samuels, S. Assessing dermatitis in epidemiologic studies: occupational skin disease among California grape and tomato ha
  25. Winter, C. K. and Kurtz, P. H. Factors influencing grape worker susceptibility to skin rashes. Bull.Environ.Contam Toxicol. 1985;35(3):418-426. PubMed
  26. Yamasaki, R., Dekio, S., and Jidoi, J. Contact dermatitis from grape bud. Contact Dermatitis 1985;12(4):226-227. PubMed
  27. Cox, J. and Grigg, M. Small bowel obstruction by an intact grape. J Am Geriatr.Soc 1986;34(7):550. PubMed
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Saffron 22 references
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  11. Zhang, Y., Shoyama, Y., Sugiura, M., and Saito, H. Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biol.Pharm Bull. 1994;17(2):217-221. PubMed
  12. Wuthrich, B., Schmid-Grendelmeyer, P., and Lundberg, M. Anaphylaxis to saffron. Allergy 1997;52(4):476-477. PubMed
  13. Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi A. Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and plac
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Cassia Nomame 3 references
  1. Dietary Supplements for Weight Loss — NIH Office of Dietary Supplements Source
  2. Herbs at a Glance — NIH NCCIH Source
  3. Dietary Supplements — MedlinePlus Source

See these in context on the Cassia Nomame monograph →

Phaseolus Vulgaris 11 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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