Buprenorphine Injection

Generic name: Pronounced as (byoo pre nor' feen)
Brand names
  • Sublocade®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/15/2023

FDA Drug Safety Communication:

[Posted 4/13/2023]

  • As part of its ongoing efforts to address the nation's opioid crisis, FDA is requiring several updates to the prescribing information of opioid pain medicines. The changes are being made to provide additional guidance for safe use of these drugs while also recognizing the important benefits when used appropriately. The changes apply to both immediate-release (IR) and extended-release/long-acting preparations (ER/LA).

  • Updates to the IR opioids state that these drugs should not be used for an extended period unless the pain remains severe enough to require an opioid pain medicine and alternative treatment options are insufficient, and that many acute pain conditions treated in the outpatient setting require no more than a few days of an opioid pain medicine.

  • Updates to the ER/LA opioids recommend that these drugs be reserved for severe and persistent pain requiring an extended period of treatment with a daily opioid pain medicine and for which alternative treatment options are inadequate.

  • A new warning is being added about opioid-induced hyperalgesia (OIH) for both IR and ER/LA opioid pain medicines. This includes information describing the symptoms that differentiate OIH from opioid tolerance and withdrawal.

  • Information in the boxed warning for all IR and ER/LA opioid pain medicines will be updated and reordered to elevate the importance of warnings concerning life-threatening respiratory depression, and risks associated with using opioid pain medicines in conjunction with benzodiazepines or other medicines that depress the central nervous system (CNS).

  • Other changes will also be required in various other sections of the prescribing information to educate clinicians, patients, and caregivers about the risks of these drugs.

Buprenorphine extended-release injection is only available through a special distribution program called Sublocade REMS. Your doctor and your pharmacy must be enrolled in this program before you can receive buprenorphine injection. Ask your doctor for more information about this program and how you will receive your medication.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests before and during your treatment to check your body's response to buprenorphine extended-release injection.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with buprenorphine extended-release injection and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

Buprenorphine extended-release injection is used to treat opioid dependence (addiction to opioid drugs, including heroin and narcotic painkillers) in people who have received buccal or sublingual buprenorphine for at least 7 days. Buprenorphine extended-release injection is in a class of medications called opiate partial agonists. It works to prevent withdrawal symptoms when someone stops taking opioid drugs by producing similar effects to these drugs.

Buprenorphine extended-release (long-acting) injection comes as a solution (liquid) to be injected subcutaneously (just under the skin) by a health care provider into the stomach area. It is usually given once monthly with at least 26 days in between doses. Each buprenorphine injection slowly releases the drug into your body over a month.

After you receive a dose of buprenorphine extended-release injection, you may notice a lump at the injection site for several weeks, but it should decrease in size over time. Do not rub or massage the injection site. Be sure that your belt or waistband does not put pressure on the place where the medication was injected.

Your doctor may increase or decrease your dose depending on how well the medication works for you, and any side effects you experience. Be sure to tell your doctor how you are feeling during your treatment with buprenorphine extended-release injection.

If buprenorphine extended-release is to be discontinued, your doctor will probably decrease your dose gradually. You may experience withdrawal symptoms including restlessness, teary eyes, sweating, chills, widening of the pupils (black circles in the middle of the eyes), irritability, anxiety, backache, weakness, stomach cramps, difficulty falling asleep or staying asleep, nausea, loss of appetite, vomiting, diarrhea, fast breathing, or fast heartbeat. These withdrawal symptoms may occur 1 month or longer after your last buprenorphine extended-release injection dose.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving buprenorphine injection,

  • tell your doctor and pharmacist if you are allergic to buprenorphine, any other medications, or any of the ingredients in buprenorphine injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antihistamines; benzodiazepines such as such as alprazolam (Xanax), chlordiazepoxide (Librium, in Librax), clonazepam (Klonopin), diazepam (Valium), estazolam, flurazepam, lorazepam (Ativan), oxazepam, temazepam (Restoril), triazolam (Halcion); carbamazepine (Carbatrol, Tegretol, Teril, others); diuretics ('water pills'); erythromycin (E.E.S., Eryc, PCE, others); HIV medications such as atazanavir (Reyataz, in Evotaz), delavirdine (Rescriptor), efavirenz (Sustiva, in Atripla), etravirine (Intelence), indinavir (Crixivan), nevirapine (Viramune), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); certain medications for irregular heartbeat including amiodarone (Nexterone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), procainamide (Procanbid), quinidine (in Nuedexta), and sotalol (Betapace, Betapace AF, Sorine); medications for glaucoma, mental illness, motion sickness, Parkinson's disease, ulcers, or urinary problems; ketoconazole, other medications for pain; medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, in Treximet), and zolmitriptan (Zomig); muscle relaxants; phenobarbital; phenytoin (Dilantin, Phenytek); rifampin (Rifadin, Rimactane); sedatives; sleeping pills; 5HT3 serotonin blockers such as alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), ondansetron (Zofran, Zuplenz), or palonosetron (Aloxi); selective serotonin-reuptake inhibitors such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Prozac, Pexeva), and sertraline (Zoloft); serotonin and norepinephrine reuptake inhibitors such as duloxetine (Cymbalta), desvenlafaxine (Khedezla, Pristiq), milnacipran (Savella), and venlafaxine (Effexor); tramadol; tranquilizers; trazodone; or tricyclic antidepressants ('mood elevators') such as amitriptyline, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil). Also tell your doctor or pharmacist if you are taking or receiving the following monoamine oxidase (MAO) inhibitors or if you have stopped taking them within the past two weeks: isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with buprenorphine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you or a family member drinks or has ever drunk large amounts of alcohol or have or have ever had prolonged QT syndrome (condition that increases the risk of developing an irregular heartbeat that may cause loss of consciousness or sudden death). Also, tell your doctor if you have or have ever had low levels of potassium or magnesium in the blood; heart failure; a slow or irregular heartbeat; chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways); other lung diseases; a head injury; a brain tumor; any condition that increases the amount of pressure in your brain; adrenal problems such as Addison's disease (condition in which the adrenal gland produces less hormone than normal); benign prostatic hypertrophy (BPH, enlargement of the prostate gland); difficulty urinating; hallucinations (seeing things or hearing voices that do not exist); a curve in the spine that makes it hard to breathe; or thyroid, gallbladder, or liver disease.

  • tell your doctor if you are pregnant or plan to become pregnant. If you receive buprenorphine extended-release injection regularly during your pregnancy, your baby could experience life-threatening withdrawal symptoms after birth. Tell your baby's doctor right away if your baby experiences any of the following symptoms: irritability, hyperactivity, abnormal sleep, high-pitched cry, uncontrollable shaking of a part of the body, vomiting, diarrhea, or failure to gain weight.

  • tell your doctor if you are breastfeeding. Tell your baby's doctor right away if your baby is sleepier than usual or has trouble breathing while you are receiving this medication.

  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of using buprenorphine extended-release injection.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving buprenorphine extended-release injection.

  • you should know that buprenorphine extended-release injection may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

  • you should not drink alcohol or use street drugs during your treatment. Drinking alcohol, taking prescription or nonprescription medications that contain alcohol, or using street drugs during your treatment with buprenorphine injection increases the risk that you will experience serious and life-threatening breathing problems.

  • you should know that buprenorphine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

  • you should know that buprenorphine may cause constipation. Talk to your doctor about changing your diet or using other medications to prevent or treat constipation while you are using buprenorphine injection.

Unless your doctor tells you otherwise, continue your normal diet.

If you miss a scheduled buprenorphine extended-release injection dose, you should call your doctor to receive the dose as soon as possible. Your next dose should be given at least 26 days later.

  • Buprenorphine extended-release injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • headache

    • fatigue

    • pain, itching, swelling, discomfort, redness, bruising, or bumps in the injection site

  • Some side effects can be serious. If you experience any of these symptoms call your doctor immediately or get emergency medical treatment:

    • difficulty breathing

    • agitation, hallucinations (seeing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, slurred speech, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

    • nausea, vomiting, loss of appetite, weakness, or dizziness

    • inability to get or keep an erection

    • irregular menstruation

    • decreased sexual desire

    • rash

    • hives

    • itching

    • slurred speech

    • blurred vision

    • changes in heartbeat

    • pain in the upper right part of the stomach

    • yellowing of the skin or eyes

    • dark-colored urine

    • light-colored stools

  • Buprenorphine extended-release injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • narrowing or widening of the pupils (black circles in the center of the eye)

  • slowed or difficulty breathing

  • extreme sleepiness or drowsiness

  • coma (loss of consciousness for a period of time)

  • slow heartbeat

Before having any laboratory test (especially those that involve methylene blue), tell your doctor and the laboratory personnel that you are using buprenorphine injection.

In the case of an emergency, a family member or caregiver should tell the emergency medical staff that you are physically dependent on an opioid and are receiving treatment with buprenorphine extended-release injection.

Buprenorphine extended-release injection is a controlled substance. Be sure to schedule appointments with your doctor on a regular basis to receive your injections. Ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Buprenorphine can be decreased when combined with Repaglinide.
Montelukast Montelukast The metabolism of Buprenorphine can be decreased when combined with Montelukast.
Leflunomide Leflunomide Buprenorphine may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Delavirdine Delavirdine The metabolism of Buprenorphine can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Buprenorphine can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Buprenorphine.
Dolasetron Dolasetron Dolasetron may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Buprenorphine.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Buprenorphine.
Candesartan Candesartan The metabolism of Buprenorphine can be decreased when combined with Candesartan.
Cilostazol Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Buprenorphine.
Clopidogrel Clopidogrel Buprenorphine can cause a decrease in the absorption of Clopidogrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Diphenoxylate Diphenoxylate Diphenoxylate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Buprenorphine can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Buprenorphine may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate The metabolism of Buprenorphine can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine Guanfacine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Magnesium Hydroxide Magnesium Hydroxide The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Buprenorphine.
Magnesium Oxide Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Buprenorphine.
Naratriptan Naratriptan Naratriptan may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Paregoric Paregoric Morphine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Penbutolol Penbutolol The metabolism of Buprenorphine can be decreased when combined with Acebutolol.
Pentazocine Pentazocine Pentazocine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Buprenorphine.
Potassium Potassium The therapeutic efficacy of Potassium can be decreased when used in combination with Buprenorphine.
Psyllium Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Buprenorphine.
Ranitidine Ranitidine The metabolism of Buprenorphine can be decreased when combined with Ranitidine.
Reserpine Reserpine Reserpine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Rizatriptan Rizatriptan Rizatriptan may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Sumatriptan Sumatriptan Sumatriptan may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Buprenorphine.
Tizanidine Tizanidine Tizanidine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Triamcinolone Triamcinolone The metabolism of Buprenorphine can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Fluconazole Injection Fluconazole Injection The metabolism of Buprenorphine can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Meperidine Injection Meperidine Injection Meperidine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Metoclopramide Injection Metoclopramide Injection The therapeutic efficacy of Buprenorphine can be decreased when used in combination with Metoclopramide.
Metronidazole Injection Metronidazole Injection The metabolism of Buprenorphine can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection Morphine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Zidovudine Injection Zidovudine Injection The metabolism of Buprenorphine can be increased when combined with Zidovudine.
Altretamine Altretamine The risk or severity of serotonin syndrome and opioid toxicity can be increased when Buprenorphine is combined with Amphetamine.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Buprenorphine.
Ondansetron Ondansetron Ondansetron may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Granisetron Granisetron Granisetron may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Torsemide Torsemide The metabolism of Buprenorphine can be decreased when combined with Torasemide.
Olanzapine Olanzapine Olanzapine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Alosetron Alosetron Alosetron may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Buprenorphine.
Entacapone Entacapone Entacapone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Hydroxychloroquine Hydroxychloroquine The metabolism of Buprenorphine can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam The metabolism of Buprenorphine can be decreased when combined with Meloxicam.
Oxcarbazepine Oxcarbazepine Oxcarbazepine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Pantoprazole Pantoprazole The metabolism of Pantoprazole can be decreased when combined with Buprenorphine.
Zaleplon Zaleplon Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Anakinra Anakinra The metabolism of Buprenorphine can be increased when combined with Anakinra.
Desloratadine Desloratadine Desloratadine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Linezolid Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Buprenorphine.
Trimipramine Trimipramine Trimipramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Etanercept Injection Etanercept Injection The metabolism of Buprenorphine can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate The risk or severity of adverse effects can be increased when Buprenorphine is combined with Glycopyrronium.
Modafinil Modafinil The metabolism of Buprenorphine can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Buprenorphine.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Buprenorphine.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Buprenorphine.
Epinephrine Injection Epinephrine Injection The metabolism of Buprenorphine can be decreased when combined with Epinephrine.
Eplerenone Eplerenone The therapeutic efficacy of Buprenorphine can be decreased when used in combination with Eplerenone.
Escitalopram Escitalopram Escitalopram may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Zonisamide Zonisamide Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Adalimumab Injection Adalimumab Injection The metabolism of Buprenorphine can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Atomoxetine Atomoxetine Atomoxetine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Dexmethylphenidate Dexmethylphenidate Dexmethylphenidate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Ezetimibe Ezetimibe Buprenorphine may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Buprenorphine.
Almotriptan Almotriptan Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Eletriptan Eletriptan Eletriptan may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Mefloquine Mefloquine The metabolism of Buprenorphine can be decreased when combined with Mefloquine.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Buprenorphine.
Rosuvastatin Rosuvastatin Buprenorphine may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Buprenorphine.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Buprenorphine.
Aprepitant Aprepitant The metabolism of Buprenorphine can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The metabolism of Buprenorphine can be decreased when combined with Tegaserod.
Tadalafil Tadalafil The metabolism of Buprenorphine can be decreased when combined with Tadalafil.
Frovatriptan Frovatriptan Frovatriptan may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Progesterone Progesterone The metabolism of Buprenorphine can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection Apomorphine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Infliximab Injection Infliximab Injection The metabolism of Buprenorphine can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Buprenorphine can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Rifaximin Rifaximin The metabolism of Buprenorphine can be increased when combined with Rifaximin.
Duloxetine Duloxetine Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Norethindrone Norethindrone The metabolism of Buprenorphine can be decreased when combined with Norethisterone.
Trospium Trospium The risk or severity of adverse effects can be increased when Buprenorphine is combined with Trospium.
Bosentan Bosentan The metabolism of Buprenorphine can be increased when combined with Bosentan.
Cinacalcet Cinacalcet The metabolism of Buprenorphine can be decreased when combined with Cinacalcet.
Erlotinib Erlotinib The metabolism of Buprenorphine can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Solifenacin Solifenacin The risk or severity of adverse effects can be increased when Buprenorphine is combined with Solifenacin.
Voriconazole Voriconazole The metabolism of Buprenorphine can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine The risk or severity of serotonin syndrome and opioid toxicity can be increased when Buprenorphine is combined with Amphetamine.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Buprenorphine can be increased when combined with Peginterferon alfa-2b.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Isocarboxazid Isocarboxazid The risk or severity of serotonin syndrome and opioid toxicity can be increased when Buprenorphine is combined with Isocarboxazid.
Ramelteon Ramelteon Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Buprenorphine.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Buprenorphine.
Pregabalin Pregabalin Pregabalin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Deferasirox Deferasirox The metabolism of Buprenorphine can be decreased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Buprenorphine.
Felbamate Felbamate Felbamate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Ranolazine Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Buprenorphine.
Abatacept Injection Abatacept Injection The metabolism of Buprenorphine can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of serotonin syndrome and opioid toxicity can be increased when Buprenorphine is combined with Rasagiline.
Imatinib Imatinib The metabolism of Buprenorphine can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Buprenorphine.
Gefitinib Gefitinib Buprenorphine may decrease the excretion rate of Gefitinib which could result in a higher serum level.
Paliperidone Paliperidone Paliperidone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Bortezomib Bortezomib The metabolism of Buprenorphine can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Buprenorphine may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Lubiprostone Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Buprenorphine.
Oxaliplatin Injection Oxaliplatin Injection Buprenorphine may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Primaquine Primaquine The metabolism of Buprenorphine can be decreased when combined with Primaquine.
Darunavir Darunavir The serum concentration of Darunavir can be increased when it is combined with Buprenorphine.
Dimenhydrinate Dimenhydrinate Dimenhydrinate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may increase the analgesic activities of Buprenorphine.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Buprenorphine.
Sorafenib Sorafenib The metabolism of Buprenorphine can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Buprenorphine.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Lapatinib Lapatinib The metabolism of Buprenorphine can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Buprenorphine.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Buprenorphine.
Armodafinil Armodafinil The metabolism of Buprenorphine can be increased when combined with Armodafinil.
Ivermectin Ivermectin Buprenorphine may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Buprenorphine.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Buprenorphine.
Nilotinib Nilotinib The metabolism of Buprenorphine can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Buprenorphine can be decreased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Buprenorphine can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Buprenorphine can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin The risk or severity of hyponatremia can be increased when Buprenorphine is combined with Desmopressin.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection Botulinum toxin type A may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection Botulinum Toxin Type B may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Etravirine Etravirine The metabolism of Etravirine can be decreased when combined with Buprenorphine.
Mitoxantrone Injection Mitoxantrone Injection Buprenorphine may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine Desvenlafaxine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Cevimeline Cevimeline The metabolism of Cevimeline can be decreased when combined with Buprenorphine.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Buprenorphine.
Tretinoin Tretinoin The metabolism of Buprenorphine can be decreased when combined with Tretinoin.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Buprenorphine.
Certolizumab Injection Certolizumab Injection The metabolism of Buprenorphine can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Buprenorphine.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Buprenorphine.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Buprenorphine.
Alvimopan Alvimopan The risk or severity of adverse effects can be increased when Buprenorphine is combined with Alvimopan.
Methylnaltrexone Injection Methylnaltrexone Injection Buprenorphine may increase the opioid antagonism activities of Methylnaltrexone.
Rufinamide Rufinamide Rufinamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Buprenorphine.
Naltrexone Injection Naltrexone Injection The therapeutic efficacy of Buprenorphine can be decreased when used in combination with Naltrexone.
Eltrombopag Eltrombopag The metabolism of Buprenorphine can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Dexlansoprazole Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Buprenorphine.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Buprenorphine.
Fesoterodine Fesoterodine The risk or severity of adverse effects can be increased when Buprenorphine is combined with Fesoterodine.
Betaxolol Betaxolol The metabolism of Betaxolol can be decreased when combined with Buprenorphine.
Iloperidone Iloperidone Iloperidone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Buprenorphine.
Lacosamide Lacosamide Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Buprenorphine.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be decreased when combined with Buprenorphine.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Buprenorphine.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection Botulinum toxin type A may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Pralatrexate Injection Pralatrexate Injection Buprenorphine may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Buprenorphine.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Buprenorphine.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Topotecan Topotecan Buprenorphine may decrease the excretion rate of Topotecan which could result in a higher serum level.
Golimumab Injection Golimumab Injection The metabolism of Buprenorphine can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Buprenorphine.
Asenapine Asenapine Asenapine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Vigabatrin Vigabatrin Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Pitavastatin Pitavastatin Buprenorphine may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Buprenorphine.
Levonorgestrel Levonorgestrel The metabolism of Buprenorphine can be decreased when combined with Levonorgestrel.
Oxymorphone Oxymorphone Oxymorphone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Tocilizumab Injection Tocilizumab Injection The metabolism of Buprenorphine can be increased when combined with Tocilizumab.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection Botulinum toxin type A may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Buprenorphine.
Lurasidone Lurasidone Lurasidone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Buprenorphine.
Vilazodone Vilazodone Vilazodone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Buprenorphine.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Buprenorphine.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Buprenorphine.
Rilpivirine Rilpivirine The metabolism of Buprenorphine can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Buprenorphine can be decreased when combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Buprenorphine.
Abiraterone Abiraterone The metabolism of Buprenorphine can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban Buprenorphine may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor Ticagrelor can cause a decrease in the absorption of Buprenorphine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Buprenorphine.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Buprenorphine.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Buprenorphine.
Clobazam Clobazam Clobazam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be decreased when combined with Buprenorphine.
Vismodegib Vismodegib The metabolism of Buprenorphine can be decreased when combined with Vismodegib.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Buprenorphine.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Buprenorphine.
Crizotinib Crizotinib The metabolism of Buprenorphine can be decreased when combined with Crizotinib.
Cabergoline Cabergoline Cabergoline may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Buprenorphine.
Ezogabine Ezogabine Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be increased when combined with Buprenorphine.
Mirabegron Mirabegron The metabolism of Mirabegron can be decreased when combined with Buprenorphine.
Regorafenib Regorafenib The metabolism of Buprenorphine can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Buprenorphine can be decreased when combined with Bosutinib.
Linaclotide Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Buprenorphine.
Teriflunomide Teriflunomide Buprenorphine may decrease the excretion rate of Teriflunomide which could result in a higher serum level.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Buprenorphine.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Buprenorphine.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Buprenorphine.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Buprenorphine.
Pomalidomide Pomalidomide Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Buprenorphine.
Apixaban Apixaban Buprenorphine may decrease the excretion rate of Apixaban which could result in a higher serum level.
Canagliflozin Canagliflozin The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Buprenorphine.
Methazolamide Methazolamide The therapeutic efficacy of Methazolamide can be decreased when used in combination with Buprenorphine.
Dabrafenib Dabrafenib The metabolism of Buprenorphine can be decreased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Buprenorphine.
Trametinib Trametinib The metabolism of Buprenorphine can be decreased when combined with Trametinib.
Dolutegravir Dolutegravir Buprenorphine may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Afatinib Afatinib Buprenorphine may decrease the excretion rate of Afatinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran Levomilnacipran may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Vortioxetine Vortioxetine Vortioxetine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Buprenorphine.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Buprenorphine.
Ketorolac Injection Ketorolac Injection The metabolism of Buprenorphine can be decreased when combined with Ketorolac.
Simeprevir Simeprevir Buprenorphine may decrease the excretion rate of Simeprevir which could result in a higher serum level.
Sofosbuvir Sofosbuvir Buprenorphine may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The therapeutic efficacy of Dapagliflozin can be decreased when used in combination with Buprenorphine.
Apremilast Apremilast The metabolism of Buprenorphine can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Buprenorphine.
Siltuximab Injection Siltuximab Injection The metabolism of Buprenorphine can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine Eslicarbazepine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Buprenorphine.
Testosterone Injection Testosterone Injection Buprenorphine may decrease the excretion rate of Testosterone which could result in a higher serum level.
Oritavancin Injection Oritavancin Injection The metabolism of Buprenorphine can be decreased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Buprenorphine.
Hydrocodone Hydrocodone The therapeutic efficacy of Hydrocodone can be decreased when used in combination with Buprenorphine.
Suvorexant Suvorexant Buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Buprenorphine.
Methamphetamine Methamphetamine Metamfetamine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Tasimelteon Tasimelteon Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Riociguat Riociguat Buprenorphine may decrease the excretion rate of Riociguat which could result in a higher serum level.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Buprenorphine.
Secukinumab Injection Secukinumab Injection The metabolism of Buprenorphine can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection Risperidone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Buprenorphine.
Lenvatinib Lenvatinib Buprenorphine may decrease the excretion rate of Lenvatinib which could result in a higher serum level.
Naloxegol Naloxegol Buprenorphine may increase the opioid antagonism activities of Naloxegol.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Buprenorphine.
Haloperidol Injection Haloperidol Injection Haloperidol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Amiloride Amiloride The therapeutic efficacy of Amiloride can be decreased when used in combination with Buprenorphine.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Buprenorphine.
Flibanserin Flibanserin Flibanserin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Rolapitant Rolapitant The metabolism of Buprenorphine can be decreased when combined with Rolapitant.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Buprenorphine.
Brexpiprazole Brexpiprazole Brexpiprazole may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Ziprasidone Injection Ziprasidone Injection Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Cariprazine Cariprazine Cariprazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Eluxadoline Eluxadoline The risk or severity of constipation can be increased when Buprenorphine is combined with Eluxadoline.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Buprenorphine.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Buprenorphine.
Osimertinib Osimertinib The metabolism of Osimertinib can be decreased when combined with Buprenorphine.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Buprenorphine.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Buprenorphine.
Rifapentine Rifapentine The metabolism of Buprenorphine can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Buprenorphine.
Dexamethasone Injection Dexamethasone Injection The metabolism of Buprenorphine can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection Brivaracetam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Venetoclax Venetoclax The metabolism of Venetoclax can be decreased when combined with Buprenorphine.
Cobicistat Cobicistat The serum concentration of Buprenorphine can be increased when it is combined with Cobicistat.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Buprenorphine.
Pimavanserin Pimavanserin Pimavanserin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Diphenhydramine Injection Diphenhydramine Injection Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Furosemide can be decreased when used in combination with Buprenorphine.
Rucaparib Rucaparib The metabolism of Buprenorphine can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Ribociclib can be decreased when combined with Buprenorphine.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Buprenorphine.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Plecanatide Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Buprenorphine.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Buprenorphine.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Buprenorphine.
Deflazacort Deflazacort The metabolism of Buprenorphine can be increased when combined with Deflazacort.
Safinamide Safinamide The risk or severity of serotonin syndrome and opioid toxicity can be increased when Buprenorphine is combined with Safinamide.
Naldemedine Naldemedine The therapeutic efficacy of Buprenorphine can be decreased when used in combination with Naldemedine.
Midostaurin Midostaurin The metabolism of Buprenorphine can be decreased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Buprenorphine.
Enasidenib Enasidenib The metabolism of Buprenorphine can be decreased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be decreased when combined with Buprenorphine.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Buprenorphine.
Delafloxacin Delafloxacin Buprenorphine may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Buprenorphine.
Acalabrutinib Acalabrutinib The metabolism of Buprenorphine can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Buprenorphine can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Buprenorphine.
Ertugliflozin Ertugliflozin The metabolism of Buprenorphine can be decreased when combined with Ertugliflozin.
Apalutamide Apalutamide The metabolism of Buprenorphine can be decreased when combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Buprenorphine can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The metabolism of Buprenorphine can be increased when combined with Avatrombopag.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Buprenorphine.
Lofexidine Lofexidine The therapeutic efficacy of Buprenorphine can be increased when used in combination with Lofexidine.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Buprenorphine.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Buprenorphine.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Buprenorphine.
Lusutrombopag Lusutrombopag Buprenorphine may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Buprenorphine.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Buprenorphine.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Buprenorphine.
Cannabidiol Cannabidiol Cannabidiol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Dacomitinib Dacomitinib The metabolism of Buprenorphine can be decreased when combined with Dacomitinib.
Duvelisib Duvelisib Buprenorphine may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Stiripentol Stiripentol Stiripentol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Talazoparib Talazoparib Buprenorphine may decrease the excretion rate of Talazoparib which could result in a higher serum level.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Buprenorphine.
Glasdegib Glasdegib Buprenorphine may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Buprenorphine.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Buprenorphine.
Rifamycin Rifamycin The metabolism of Buprenorphine can be decreased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Buprenorphine.
Magnesium Citrate Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Buprenorphine.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Buprenorphine can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Buprenorphine.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Buprenorphine.
Esomeprazole Injection Esomeprazole Injection The metabolism of Esomeprazole can be decreased when combined with Buprenorphine.
Alpelisib Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Buprenorphine.
Brexanolone Injection Brexanolone Injection Brexanolone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Cladribine Cladribine Buprenorphine may decrease the excretion rate of Cladribine which could result in a higher serum level.
Solriamfetol Solriamfetol Solriamfetol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Darolutamide Darolutamide Buprenorphine may decrease the excretion rate of Darolutamide which could result in a higher serum level.
Triclabendazole Triclabendazole The metabolism of Buprenorphine can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Buprenorphine.
Pexidartinib Pexidartinib The metabolism of Buprenorphine can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Buprenorphine.
Pitolisant Pitolisant The serum concentration of Buprenorphine can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Buprenorphine.
Lefamulin Lefamulin The metabolism of Lefamulin can be decreased when combined with Buprenorphine.
Phenytoin Injection Phenytoin Injection Phenytoin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Fosphenytoin Injection Fosphenytoin Injection Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Buprenorphine.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Buprenorphine.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Buprenorphine.
Lumateperone Lumateperone Lumateperone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Lasmiditan Lasmiditan Lasmiditan may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Buprenorphine.
Tazemetostat Tazemetostat Buprenorphine may decrease the excretion rate of Tazemetostat which could result in a higher serum level.
Cenobamate Cenobamate The serum concentration of Buprenorphine can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod Buprenorphine may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib Selumetinib Buprenorphine may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Buprenorphine.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Buprenorphine.
Ripretinib Ripretinib Buprenorphine may decrease the excretion rate of Ripretinib which could result in a higher serum level.
Selpercatinib Selpercatinib The serum concentration of Buprenorphine can be increased when it is combined with Selpercatinib.
Lemborexant Lemborexant Buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Fenfluramine Fenfluramine Fenfluramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Pralsetinib Pralsetinib Buprenorphine may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Opicapone Opicapone The metabolism of Buprenorphine can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Buprenorphine can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Drospirenone can be decreased when used in combination with Buprenorphine.
Viloxazine Viloxazine Viloxazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Buprenorphine.
Indomethacin Indomethacin The metabolism of Buprenorphine can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The metabolism of Buprenorphine can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Buprenorphine can be decreased when combined with Naproxen.
Trazodone Trazodone Trazodone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Hydroxyurea Hydroxyurea The metabolism of Buprenorphine can be decreased when combined with Hydroxyurea.
Floxuridine Floxuridine The metabolism of Buprenorphine can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Metaxalone Metaxalone Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Buprenorphine.
Levorphanol Levorphanol Levorphanol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Primidone Primidone Primidone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Methsuximide Methsuximide Methsuximide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Diethylpropion Diethylpropion Diethylpropion may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Chlorpromazine Chlorpromazine Chlorpromazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Diazepam Diazepam Diazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Oxazepam Oxazepam Oxazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Flurazepam Flurazepam Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Clorazepate Clorazepate Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Lorazepam Lorazepam Lorazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Amantadine Amantadine The risk or severity of adverse effects can be increased when Amantadine is combined with Buprenorphine.
Codeine Codeine Codeine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Meprobamate Meprobamate Meprobamate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Chlordiazepoxide Chlordiazepoxide Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Bromocriptine Bromocriptine Bromocriptine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Tranylcypromine Tranylcypromine The risk or severity of serotonin syndrome and opioid toxicity can be increased when Buprenorphine is combined with Tranylcypromine.
Phenelzine Phenelzine The risk or severity of serotonin syndrome and opioid toxicity can be increased when Buprenorphine is combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of serotonin syndrome and opioid toxicity can be increased when Buprenorphine is combined with Procarbazine.
Ergoloid Mesylates Ergoloid Mesylates Ergoloid mesylate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Prochlorperazine Prochlorperazine Prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Thioridazine Thioridazine Thioridazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Trifluoperazine Trifluoperazine Trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Buprenorphine.
Sulfadiazine Sulfadiazine The metabolism of Buprenorphine can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone Oxycodone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Buprenorphine.
Oxybutynin Oxybutynin The risk or severity of adverse effects can be increased when Oxybutynin is combined with Buprenorphine.
Benztropine Benztropine The risk or severity of adverse effects can be increased when Buprenorphine is combined with Benzatropine.
Maprotiline Maprotiline Maprotiline may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Buprenorphine.
Trihexyphenidyl Trihexyphenidyl The risk or severity of adverse effects can be increased when Buprenorphine is combined with Trihexyphenidyl.
Orphenadrine Orphenadrine Orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Perphenazine Perphenazine Perphenazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Fluphenazine Fluphenazine Fluphenazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Phentermine Phentermine Phentermine may increase the analgesic activities of Buprenorphine.
Amoxapine Amoxapine Amoxapine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Sulfasalazine Sulfasalazine Buprenorphine may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Buprenorphine can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be decreased when combined with Buprenorphine.
Dactinomycin Dactinomycin Buprenorphine may decrease the excretion rate of Dactinomycin which could result in a higher serum level.
Carbamazepine Carbamazepine Carbamazepine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Molindone Molindone Molindone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Buprenorphine.
Prazosin Prazosin Buprenorphine may decrease the excretion rate of Prazosin which could result in a higher serum level.
Cimetidine Cimetidine The metabolism of Cimetidine can be decreased when combined with Buprenorphine.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Buprenorphine.
Clonazepam Clonazepam Clonazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Loperamide Loperamide The metabolism of Buprenorphine can be decreased when combined with Loperamide.
Promethazine Promethazine Promethazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Daunorubicin Daunorubicin Buprenorphine may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Buprenorphine may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Buprenorphine can be increased when combined with Griseofulvin.
Loxapine Loxapine Loxapine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Chloroquine Chloroquine The metabolism of Buprenorphine can be decreased when combined with Chloroquine.
Quinine Quinine Quinine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Ethosuximide Ethosuximide Ethosuximide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Triamterene Triamterene The therapeutic efficacy of Triamterene can be decreased when used in combination with Buprenorphine.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Buprenorphine.
Sulfinpyrazone Sulfinpyrazone The metabolism of Buprenorphine can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Buprenorphine.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Buprenorphine.
Metolazone Metolazone The therapeutic efficacy of Metolazone can be decreased when used in combination with Buprenorphine.
Isosorbide Isosorbide The therapeutic efficacy of Isosorbide can be decreased when used in combination with Buprenorphine.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Buprenorphine.
Secobarbital Secobarbital Secobarbital may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Desipramine Desipramine Desipramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Buprenorphine.
Imipramine Imipramine Imipramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Probenecid Probenecid The metabolism of Buprenorphine can be decreased when combined with Probenecid.
Quinidine Quinidine The risk or severity of adverse effects can be increased when Buprenorphine is combined with Quinidine.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Buprenorphine.
Isoniazid Isoniazid The metabolism of Buprenorphine can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Buprenorphine can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of adverse effects can be increased when Buprenorphine is combined with Disopyramide.
Valproic Acid Valproic Acid Valproic acid may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Buprenorphine.
Butabarbital Butabarbital Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Levothyroxine Levothyroxine The metabolism of Buprenorphine can be decreased when combined with Levothyroxine.
Methimazole Methimazole The metabolism of Buprenorphine can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide The metabolism of Buprenorphine can be decreased when combined with Chlorpropamide.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Buprenorphine.
Tolazamide Tolazamide The metabolism of Buprenorphine can be decreased when combined with Tolazamide.
Dextromethorphan Dextromethorphan Dextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Cyclobenzaprine Cyclobenzaprine Cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Niacin Niacin The metabolism of Buprenorphine can be decreased when combined with Niacin.
Baclofen Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Cyproheptadine Cyproheptadine Cyproheptadine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Clemastine Clemastine Clemastine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Chlorpheniramine Chlorpheniramine Chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Brompheniramine Brompheniramine Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Meclizine Meclizine Meclizine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Buprenorphine.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Buprenorphine.
Dantrolene Dantrolene Dantrolene may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Carisoprodol Carisoprodol Carisoprodol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Methocarbamol Methocarbamol Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Folic Acid Folic Acid Buprenorphine may decrease the excretion rate of Folic acid which could result in a higher serum level.
Disulfiram Disulfiram The metabolism of Buprenorphine can be decreased when combined with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propranolol can be increased when it is combined with Buprenorphine.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may increase the analgesic activities of Buprenorphine.
Nortriptyline Nortriptyline Nortriptyline may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Spironolactone Spironolactone The metabolism of Buprenorphine can be decreased when combined with Spironolactone.
Nadolol Nadolol The metabolism of Nadolol can be decreased when combined with Buprenorphine.
Butorphanol Injection Butorphanol Injection Butorphanol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Nalbuphine Injection Nalbuphine Injection Nalbuphine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Allopurinol Allopurinol Buprenorphine may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Trimethobenzamide Trimethobenzamide Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Flavoxate Flavoxate The risk or severity of adverse effects can be increased when Buprenorphine is combined with Flavoxate.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Buprenorphine.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Buprenorphine.
Cephalexin Cephalexin The metabolism of Buprenorphine can be decreased when combined with Cephalexin.
Acetazolamide Acetazolamide Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Ketoconazole Ketoconazole The metabolism of Buprenorphine can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel Pyrantel may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Buprenorphine.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Buprenorphine.
Vinblastine Vinblastine The metabolism of Buprenorphine can be decreased when combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Buprenorphine.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Buprenorphine.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Thiothixene Thiothixene Thiothixene may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Buprenorphine.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Buprenorphine.
Temazepam Temazepam Temazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Triazolam Triazolam Triazolam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Dicyclomine Dicyclomine The risk or severity of adverse effects can be increased when Buprenorphine is combined with Dicyclomine.
Hyoscyamine Hyoscyamine The risk or severity of adverse effects can be increased when Buprenorphine is combined with Hyoscyamine.
Propantheline Propantheline The risk or severity of adverse effects can be increased when Buprenorphine is combined with Propantheline.
Trimethoprim Trimethoprim The metabolism of Buprenorphine can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Buprenorphine can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Buprenorphine can be decreased when combined with Nifedipine.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Buprenorphine.
Verapamil Verapamil The metabolism of Buprenorphine can be decreased when combined with Verapamil.
Atenolol Atenolol The metabolism of Atenolol can be decreased when combined with Buprenorphine.
Pindolol Pindolol Pindolol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Cisplatin Injection Cisplatin Injection The metabolism of Buprenorphine can be decreased when combined with Cisplatin.
Diflunisal Diflunisal The metabolism of Buprenorphine can be decreased when combined with Diflunisal.
Piroxicam Piroxicam The metabolism of Buprenorphine can be decreased when combined with Piroxicam.
Bumetanide Bumetanide The therapeutic efficacy of Bumetanide can be decreased when used in combination with Buprenorphine.
Etoposide Etoposide The metabolism of Etoposide can be decreased when combined with Buprenorphine.
Glyburide Glyburide Buprenorphine may decrease the excretion rate of Glyburide which could result in a higher serum level.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Buprenorphine.
Indapamide Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Buprenorphine.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Buprenorphine.
Labetalol Labetalol The metabolism of Buprenorphine can be decreased when combined with Labetalol.
Gemfibrozil Gemfibrozil The metabolism of Buprenorphine can be decreased when combined with Gemfibrozil.
Ketoprofen Ketoprofen The metabolism of Buprenorphine can be decreased when combined with Ketoprofen.
Pimozide Pimozide Pimozide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Flurbiprofen Flurbiprofen The metabolism of Buprenorphine can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Buprenorphine.
Buspirone Buspirone The risk or severity of serotonin syndrome can be increased when Buspirone is combined with Buprenorphine.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Buprenorphine.
Ciprofloxacin Ciprofloxacin The metabolism of Buprenorphine can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Buprenorphine can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine Fluoxetine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Clozapine Clozapine Clozapine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Estazolam Estazolam Estazolam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Buprenorphine.
Clarithromycin Clarithromycin The metabolism of Buprenorphine can be decreased when combined with Clarithromycin.
Etodolac Etodolac The metabolism of Buprenorphine can be decreased when combined with Etodolac.
Felodipine Felodipine The metabolism of Buprenorphine can be decreased when combined with Felodipine.
Nabumetone Nabumetone The metabolism of Buprenorphine can be decreased when combined with Nabumetone.
Pravastatin Pravastatin Buprenorphine may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Buprenorphine can be decreased when combined with Simvastatin.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Buprenorphine.
Itraconazole Itraconazole The metabolism of Buprenorphine can be decreased when combined with Itraconazole.
Atovaquone Atovaquone The metabolism of Buprenorphine can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Buprenorphine can be increased when combined with Rifabutin.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Buprenorphine.
Zolpidem Zolpidem Zolpidem may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Buprenorphine.
Omeprazole Omeprazole The metabolism of Buprenorphine can be decreased when combined with Omeprazole.
Cisapride Cisapride Cisapride may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Gabapentin Gabapentin Gabapentin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Fluvastatin Fluvastatin The metabolism of Buprenorphine can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Famciclovir Famciclovir The metabolism of Buprenorphine can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine Fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Nefazodone Nefazodone Nefazodone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Lamotrigine Lamotrigine Lamotrigine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Losartan Losartan The metabolism of Buprenorphine can be decreased when combined with Losartan.
Tramadol Tramadol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Buprenorphine.
Vinorelbine Injection Vinorelbine Injection The metabolism of Buprenorphine can be decreased when combined with Vinorelbine.
Lansoprazole Lansoprazole The metabolism of Buprenorphine can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Buprenorphine can be decreased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Buprenorphine can be decreased when combined with Nicardipine.
Bupropion Bupropion Bupropion may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Ticlopidine Ticlopidine The metabolism of Buprenorphine can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Buprenorphine can be decreased when combined with Saquinavir.
Nisoldipine Nisoldipine The metabolism of Buprenorphine can be decreased when combined with Nisoldipine.
Lamivudine Lamivudine Buprenorphine may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole Riluzole may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Glimepiride Glimepiride The metabolism of Buprenorphine can be decreased when combined with Glimepiride.
Anastrozole Anastrozole The metabolism of Buprenorphine can be decreased when combined with Anastrozole.
Indinavir Indinavir The metabolism of Buprenorphine can be decreased when combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Buprenorphine can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Buprenorphine.
Clomipramine Clomipramine Clomipramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Zafirlukast Zafirlukast The metabolism of Buprenorphine can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine Buprenorphine may increase the serotonergic activities of Mirtazapine.
Topiramate Topiramate Topiramate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Zileuton Zileuton The metabolism of Buprenorphine can be decreased when combined with Zileuton.
Valsartan Valsartan The metabolism of Buprenorphine can be decreased when combined with Valsartan.
Pramipexole Pramipexole Buprenorphine may increase the sedative activities of Pramipexole.
Donepezil Donepezil Donepezil may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Nelfinavir Nelfinavir The metabolism of Nelfinavir can be decreased when combined with Buprenorphine.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Buprenorphine.
Loratadine Loratadine The metabolism of Buprenorphine can be decreased when combined with Loratadine.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Buprenorphine.
Nilutamide Nilutamide The metabolism of Buprenorphine can be decreased when combined with Nilutamide.
Flutamide Flutamide The metabolism of Buprenorphine can be decreased when combined with Flutamide.
Selegiline Selegiline The risk or severity of serotonin syndrome and opioid toxicity can be increased when Buprenorphine is combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Buprenorphine can be decreased when combined with Bicalutamide.
Sertraline Sertraline Sertraline may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Propafenone Propafenone The metabolism of Buprenorphine can be decreased when combined with Propafenone.
Raloxifene Raloxifene Buprenorphine may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Irbesartan Irbesartan The metabolism of Buprenorphine can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Buprenorphine.
Ropinirole Ropinirole Ropinirole may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Buprenorphine.
Quetiapine Quetiapine Quetiapine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Cetirizine Cetirizine Cetirizine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Paroxetine Paroxetine Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Tolcapone Tolcapone Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Citalopram Citalopram Citalopram may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Capecitabine Capecitabine The metabolism of Buprenorphine can be decreased when combined with Capecitabine.
Efavirenz Efavirenz Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Sildenafil Sildenafil The metabolism of Buprenorphine can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Buprenorphine can be decreased when combined with Pioglitazone.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Buprenorphine.
Rosiglitazone Rosiglitazone The metabolism of Buprenorphine can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The risk or severity of adverse effects can be increased when Buprenorphine is combined with Tolterodine.
Thalidomide Thalidomide Buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Nateglinide Nateglinide The metabolism of Buprenorphine can be decreased when combined with Nateglinide.
Galantamine Galantamine The metabolism of Galantamine can be decreased when combined with Buprenorphine.
Levetiracetam Levetiracetam Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Rabeprazole Rabeprazole The metabolism of Buprenorphine can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Buprenorphine can be decreased when combined with Terbinafine.

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