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Calcium, Magnesium, Potassium, and Sodium Oxybate

Calcium, magnesium, potassium, and sodium oxybate is a central nervous system depressant used to treat cataplexy and excessive daytime sleepiness in narcolepsy, and to treat idiopathic hypersomnia in adults.

Brand name Xywav
Drug class Central Nervous System Depressant
Rx Schedule CIII Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 1 clinical label set within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 6, 2026
Calcium, Magnesium, Potassium, and Sodium Oxybate at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Xywav is a specialist medicine for cataplexy (sudden muscle weakness triggered by emotion) and excessive daytime sleepiness in narcolepsy, and for idiopathic hypersomnia (severe sleepiness with no known cause) in adults; its oxybate (GHB) helps consolidate nighttime sleep, and since about 2020 it has been the lower-sodium, brand-only alternative to the older Xyrem. Most people tolerate it reasonably well, though nausea, dizziness, headache and night sweats are common. Its boxed warning covers slowed or stopped breathing and abuse or misuse, so it comes only through a restricted pharmacy program and must never be combined with alcohol or sleep aids. Report low mood, sleepwalking or odd nighttime behavior promptly.

Clinical pearls

  • Leave at least two hours between your last meal and a dose, since food sharply cuts how much gets absorbed.
  • Take each dose already in bed, lie down right away, and skip driving or machinery for at least six hours.
  • Opioids, benzodiazepines, muscle relaxants and general anesthesia all deepen breathing risk, so tell every prescriber and surgeon you take Xywav.
  • Divalproex (Depakote) raises oxybate levels and mental slowing, so a lower Xywav dose is recommended if both are needed.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Xywav carries two serious black box warnings — the FDA's strongest safety alert.

First, Xywav is a central nervous system (CNS) depressant that can slow or stop breathing, even at normal prescribed doses. This risk is highest when combined with alcohol, sleep aids, or other medications that cause drowsiness. Never drink alcohol or take sleep aids while using Xywav.

Second, the active ingredient — oxybate (GHB) — has been widely abused as an illicit drug. Misuse of GHB is linked to seizures, loss of consciousness, coma, and death. Because of these risks, Xywav is only available through a tightly controlled program. It will only be dispensed by specially certified pharmacies to patients who are enrolled and have agreed to safe-use conditions.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asOral solution
Earliest FDA record2020
Companies listing it with the FDA1
FDA label last updatedJul 1, 2025
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Calcium, Magnesium, Potassium, and Sodium Oxybate, written from its FDA label.

What Calcium, Magnesium, Potassium, and Sodium Oxybate is used for

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Xywav (calcium, magnesium, potassium, and sodium oxybate) oral solution is approved for two distinct sleep-related conditions.

  • Narcolepsy (age 7 and older): Xywav treats cataplexy — the sudden, brief loss of muscle control often triggered by strong emotions — and excessive daytime sleepiness (EDS) in patients aged 7 and older who have narcolepsy.
  • Idiopathic hypersomnia in adults: Xywav treats idiopathic hypersomnia (IH), a condition marked by severe, persistent excessive sleepiness that cannot be explained by another disorder. This use is approved for adults only.

How Calcium, Magnesium, Potassium, and Sodium Oxybate works

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Xywav contains oxybate — the same molecule as gamma-hydroxybutyrate (GHB), a compound the brain naturally produces in small amounts as a byproduct of the neurotransmitter GABA. Scientists believe Xywav works by activating GABA-B receptors in brain circuits that involve norepinephrine, dopamine, and the thalamus — regions that regulate the transition between sleep stages and daytime alertness. By acting on these pathways during sleep, it is thought to consolidate and stabilize nighttime sleep, which then reduces symptoms like cataplexy and excessive daytime sleepiness. The exact mechanism, however, has not been fully confirmed.

Calcium, Magnesium, Potassium, and Sodium Oxybate dosage

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Xywav oral solution is taken at night, in bed, and must be prepared ahead of time by mixing each dose with roughly a quarter cup of water in the special containers provided by the pharmacy. It should always be taken at least 2 hours after your last meal, because eating — especially a high-fat meal — meaningfully reduces the amount of medicine that reaches your bloodstream.

  • For narcolepsy (adults and children 7+): taken as two separate doses per night — the first at bedtime and the second 2.5 to 4 hours later. Some patients do better with unequal split doses.
  • For idiopathic hypersomnia in adults: may be taken either as a single dose at bedtime or split into two nightly doses, as directed by your prescriber.
  • Patients switching from Xyrem to Xywav start at the same total nightly dose, gram for gram.
  • Lie down immediately after each dose — Xywav works quickly and can cause sudden sedation.

Always follow your prescriber's exact instructions. Do not adjust your dose on your own.

Dosing details from the FDA-approved label

From the Calcium, Magnesium, Potassium, and Sodium Oxybate prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Adult Patients with Narcolepsy
    • Initiate at 4.5 g per night orally, divided into two doses (2.25 g at bedtime and 2.25 g taken 2.5 to 4 hours later)
    • Titrate to effect in increments of up to 1.5 g per night per week to the recommended range of 6 g to 9 g per night, divided into two doses
    • Doses may be divided equally or unequally
    • Maximum: Doses higher than 9 g per night have not been studied and ordinarily should not be administered
    • Take first dose at bedtime and second dose 2.5 to 4 hours later
  • Pediatric Patients with Narcolepsy (7 Years of Age and Older)
    • Administered orally twice per night
    • Recommended starting dosage, titration regimen, and maximum total nightly dosage are based on patient weight, as specified in Table 2
    • Maximum: Doses higher than 9 g per night have not been studied and ordinarily should not be administered
    • Weight-based; for patients under 20 kg a lower starting dosage, lower weekly increases and lower maximum should be considered
  • Adult Patients with Idiopathic Hypersomnia, twice nightly regimen
    • Initiate at 4.5 g or less per night orally, divided into two doses
    • Titrate to effect in increments of up to 1.5 g per night per week
    • Maximum: 9 g total nightly dose
  • Adult Patients with Idiopathic Hypersomnia, once nightly regimen
    • Initiate at 3 g or less per night orally, as one dose
    • Titrate to effect in increments of up to 1.5 g per night per week
    • Maximum: 6 g total nightly dose
  • Patients transitioning from Xyrem to XYWAV
    • Initiate at the same dose and regimen as Xyrem (gram for gram)
    • Titrate as needed based on efficacy and tolerability
  • Patients with Hepatic Impairment
    • Recommended starting dosage is one-half of the original dosage per night administered orally, divided into two doses
    • Starting dosage reduced by one-half
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION See Full Prescribing Information for complete dosing instructions ( 2.1 - 2.7 ). Dosage for Adult Patients with Narcolepsy • Initiate dosage at 4.5 g per night orally, divided into two doses ( 2.1 ). • Titrate to effect in increments of up to 1.5 g per night per week ( 2.1 ). • Recommended dosage range: 6 g to 9 g per night orally, divided into two doses ( 2.1 ). • Doses may be divided equally or unequally and the first dose taken at bedtime and the second dose taken 2.5 to 4 hours later ( 2.1 ). Dosage for Pediatric Patients with Narcolepsy (7 Years of Age and Older) • The recommended starting dosage, titration regimen, and maximum total nightly dosage are based on body weight (2.2 ). Dosage for Adult Patients with Idiopathic Hypersomnia • XYWAV can be administered as a twice or once nightly regimen in adults ( 2.3 ). • Twice nightly: Initiate dosage at 4.5 g or less per night orally, divided into two doses. Titrate to effect in increments of up to 1.5 g per night per week, up to 9 g total nightly dose ( 2.3 ). • Once nightly: Initiate dosage at 3 g or less per night orally, as one dose. Titrate to effect in increments of up to 1.5 g per night per week, up to 6 g total nightly dose ( 2.3 ). Important Administration Information • Administer XYWAV at least 2 hours after eating ( 2.4 ). • Prepare XYWAV prior to bedtime; dilute with approximately ¼ cup of water in pharmacy-provided containers ( 2.4 ). • Take XYWAV while in bed and lie down after dosing ( 2.4 ). For Patients Transitioning from Xyrem to XYWAV: Initiate at the same dose and regimen as Xyrem (gram for gram). Titrate as needed based on efficacy and tolerability ( 2.5 ). Patients with Hepatic Impairment Recommended starting dosage is one-half of the original dosage per night administered orally, divided into two doses ( 2.6 ). 2.1 Dosing Information in Adult Patients with Narcolepsy The recommended starting dosage is 4.5 grams (g) per night administered orally, divided into two doses: 2.25 g at bedtime and 2.25 g taken 2.5 to 4 hours later (see Table 1). Increase the dosage by up to 1.5 g per night per week (e.g., 0.75 g at bedtime and 0.75 g taken 2.5 to 4 hours later), to the recommended dosage range of 6 g to 9 g per night. The dosage may be gradually titrated based on efficacy and tolerability.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Calcium, Magnesium, Potassium, and Sodium Oxybate side effects

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Most side effects tend to appear early in treatment and improve over time. Common ones include:

Common side effects

  • Nausea or vomiting
  • Headache
  • Dizziness
  • Decreased appetite
  • Excessive sweating (hyperhidrosis) or night sweats
  • Anxiety
  • Diarrhea
  • Parasomnias (abnormal sleep behaviors such as sleepwalking or sleep talking)
  • Dry mouth
  • Fatigue

When to get medical help

  • Call 911 immediately if breathing slows, becomes shallow, or stops — this is a life-threatening emergency
  • Call your doctor if you notice increased sadness, hopelessness, or any thoughts of suicide or self-harm
  • Contact your doctor if you experience sleepwalking or other unusual behaviors during sleep
  • Seek help right away if you feel severely confused, disoriented, or have trouble thinking clearly
  • Tell your doctor immediately if you lose consciousness or are very difficult to wake up
  • Do not drive or operate machinery for at least 6 hours after taking Xywav — or longer until you know how it affects you

In children with narcolepsy (based on studies with the same active ingredient), bedwetting (enuresis) and sleepwalking were also commonly reported. Contact your doctor right away if you experience significant breathing changes, thoughts of suicide or self-harm, worsening depression, severe confusion, or any sleepwalking episodes.

Calcium, Magnesium, Potassium, and Sodium Oxybate warnings and precautions

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  • Breathing problems: Xywav can slow or suppress breathing, even at normal doses. The risk is highest in people with sleep apnea or other lung conditions, and when combined with alcohol or other sedating drugs. This can be life-threatening.
  • CNS depression: Deep sedation can occur. Do not drive, operate heavy machinery, or do anything requiring full alertness for at least 6 hours after taking Xywav.
  • Abuse and misuse: GHB is a federally controlled substance with known illicit use. Xywav is only available through a restricted REMS program and can only be dispensed by certified pharmacies.
  • Depression and suicidal thoughts: These have been reported in patients taking Xywav. Tell your doctor immediately about any mood changes or thoughts of self-harm.
  • Sleepwalking (parasomnias): Unusual sleep-related behaviors, including sleepwalking, have occurred. These should be evaluated by your doctor, as they may pose a safety risk.
  • Liver disease: Xywav is processed more slowly in people with liver problems, increasing drug levels in the body. A reduced starting dose is required.

Calcium, Magnesium, Potassium, and Sodium Oxybate interactions

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Xywav interacts with several substances that can dramatically increase the risk of serious harm:

  • Alcohol: Absolutely contraindicated — combining alcohol with Xywav greatly increases the risk of loss of consciousness, stopped breathing, and death.
  • Sedative hypnotics (sleep aids): Contraindicated — must not be taken together with Xywav under any circumstances.
  • Other CNS depressants (opioid pain medicines, benzodiazepines, sedating antidepressants or antipsychotics, anti-seizure drugs, muscle relaxants, general anesthesia): These increase the risk of dangerously slowed breathing and excessive sedation. Dose adjustments or stopping one of the medications may be needed.
  • Divalproex sodium (Depakote): Raises the blood level of oxybate and worsens mental impairment. If these must be used together, Xywav dose should be reduced and your response monitored closely.

Interactions listed in the FDA-approved label

From the Calcium, Magnesium, Potassium, and Sodium Oxybate prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Divalproex sodium: Concomitant use with sodium oxybate increases systemic exposure to GHB, which caused greater impairment on some tests of attention and working memory in a clinical study; a similar increase is expected with XYWAV. An initial reduction in XYWAV dose of at least 20% is recommended; monitor patient response closely and adjust dose accordingly.
  • Alcohol: XYWAV is contraindicated for use in combination with alcohol.
  • Sedative hypnotics: XYWAV is contraindicated for use in combination with sedative hypnotics.
  • Other CNS depressants: Use of other CNS depressants may potentiate the CNS-depressant effects of XYWAV.
Read the label’s full interactions text

7 DRUG INTERACTIONS • Concomitant use with divalproex sodium: An initial reduction in XYWAV dose of at least 20% is recommended ( 2.7 , 7.2 ). 7.1 Alcohol, Sedative Hypnotics, and CNS Depressants XYWAV is contraindicated for use in combination with alcohol or sedative hypnotics. Use of other CNS depressants may potentiate the CNS-depressant effects of XYWAV [see Warnings and Precautions ( 5.1 )] . 7.2 Divalproex Sodium Concomitant use of sodium oxybate with divalproex sodium results in an increase in systemic exposure to GHB, which was shown to cause a greater impairment on some tests of attention and working memory in a clinical study [see Clinical Pharmacology ( 12.3 )] . A similar increase in exposure is expected with concomitant use of XYWAV and divalproex sodium; therefore, an initial dose reduction of XYWAV is recommended when used concomitantly with divalproex sodium [see Dosage and Administration ( 2.7 )]. Prescribers are advised to monitor patient response closely and adjust dose accordingly if concomitant use of XYWAV and divalproex sodium is warranted.

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿23 supplements and herbs with documented Calcium, Magnesium, Potassium, and Sodium Oxybate interactions, ranked by severity Check Calcium, Magnesium, Potassium, and Sodium Oxybate against a supplement or herb →

Before taking Calcium, Magnesium, Potassium, and Sodium Oxybate

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  • Do not take Xywav if you have succinic semialdehyde dehydrogenase deficiency — a rare inherited metabolic disorder that prevents proper breakdown of GHB.
  • Tell your doctor about any history of depression, suicidal thoughts, or psychiatric illness before starting.
  • Tell your doctor if you have liver disease — your dose will need to be reduced because Xywav stays in your body longer.
  • Tell your doctor if you have sleep apnea or any breathing disorder — Xywav can increase central apneas and reduce oxygen levels during sleep.
  • If you are pregnant or trying to become pregnant, discuss risks with your doctor. Animal studies showed harm to offspring at doses relevant to humans, and GHB crosses the placenta rapidly.
  • GHB is found in breast milk after oxybate use. Discuss the risks with your doctor if you are breastfeeding.
  • Older adults should be started at low doses and monitored for confusion, falls, and other side effects, as they may be more sensitive.
  • Xywav is not approved for idiopathic hypersomnia in children; its use in narcolepsy is supported for ages 7 and older only.
  • You must be enrolled in the XYWAV and XYREM REMS program to receive this medication — your prescriber and pharmacy must also be certified.

Calcium, Magnesium, Potassium, and Sodium Oxybate overdose

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Taking too much Xywav — or GHB in general — can cause rapidly shifting levels of consciousness ranging from confusion and agitation to full coma, slowed or stopped breathing, seizures, slow heart rate, and low body temperature. Vomiting while partially sedated is especially dangerous. If an overdose is suspected, call 911 immediately and contact Poison Control at 1-800-222-1222. There is no specific reversal agent — treatment is supportive care focused on protecting the airway and breathing.

How your body processes Calcium, Magnesium, Potassium, and Sodium Oxybate

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After you take Xywav by mouth, oxybate (GHB) reaches peak levels in the blood in about 1.3 hours when taken on an empty stomach. Eating a high-fat meal just before taking it significantly reduces the peak concentration and overall exposure, which is why it must always be taken at least 2 hours after food. The body breaks down GHB almost entirely through normal metabolic pathways — primarily the Krebs cycle — converting it to carbon dioxide and water, which are exhaled. Very little of the drug leaves the body unchanged through urine. GHB has a short half-life of about 40 minutes, meaning it clears the body relatively quickly; however, its effects on the brain can outlast that window, so caution for at least 6 hours after dosing is warranted.

How to store Calcium, Magnesium, Potassium, and Sodium Oxybate

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Keep out of reach of children. stored between 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) (see USP Controlled Room Temperature). Dispense in tight containers.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

23

Supplements & herbs that interact with Calcium, Magnesium, Potassium, and Sodium Oxybate

23 supplements and herbal products have documented interactions with Calcium, Magnesium, Potassium, and Sodium Oxybate in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 1
  • Moderate · 13
  • Minor · 9
ACTIVATED CHARCOAL Major BIOFEEDBACK Moderate COFFEE CHARCOAL Moderate DENDROBIUM Moderate EUROPEAN MANDRAKE Moderate GINKGO Moderate GLUCOMANNAN Moderate GUAR GUM Moderate +15 more
Every supplement checked against Calcium, Magnesium, Potassium, and Sodium Oxybate — ranked by severity The full interaction hub: 1 major · 13 moderate · 9 minor · every one linked to its full report. Check Calcium, Magnesium, Potassium, and Sodium Oxybate against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Calcium, Magnesium, Potassium, and Sodium Oxybate: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Calcium, Magnesium, Potassium, and Sodium Oxybate — the kind of thing our pharmacy team would talk through with you at the counter.

Why do I have to take this medicine in the middle of the night? Can't I just take it all at once at bedtime?

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For narcolepsy, Xywav is designed to be split into two doses because it works during sleep to stabilize your sleep stages — and since it clears your system fairly quickly, a second dose a few hours later helps maintain that effect through the night. For idiopathic hypersomnia in adults, your prescriber may actually choose a once-nightly schedule depending on what works best for you. Either way, always follow the specific timing your prescriber has given you, and set an alarm if needed for that second dose.

I heard this medicine is basically the same as a date rape drug. Should I be worried about taking it?

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It's understandable that this concerns you. The active ingredient in Xywav — oxybate, or GHB — is the same substance that has been misused illicitly. However, when prescribed and taken exactly as directed for a legitimate medical condition, it's a very different situation. Xywav is tightly controlled: it's only available through a special restricted program, dispensed by certified pharmacies, and comes with strict safety monitoring. The key is sticking exactly to your prescription, never sharing it, and keeping it locked up safely at home.

Can I have a glass of wine in the evening before I take my dose?

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No — alcohol and Xywav must never be combined. This is one of the most important safety rules with this medication. Mixing them dramatically increases the risk of severely slowed or stopped breathing, loss of consciousness, and can be fatal. Avoid all alcohol on any day you are taking Xywav.

What side effects should I expect when I first start, and which ones should make me call my doctor?

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When you first start, nausea, headache, and dizziness are the most common side effects, and for most people they tend to improve after the first few weeks. More unusual sleep behaviors like sleepwalking can also occur. You should call your doctor right away if you experience significant breathing problems, episodes of sleepwalking, worsening depression, or any thoughts of harming yourself. And if someone ever cannot wake you or your breathing seems labored after a dose, that's a 911 situation.

Is it safe to take this if I'm pregnant or trying to get pregnant?

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This is definitely a conversation to have with your doctor before starting or continuing Xywav. Animal studies showed that oxybate at relevant doses increased the risk of stillbirth and reduced offspring survival. There's no solid safety data in human pregnancies. GHB also crosses the placenta quickly, so it can reach the baby. Your doctor will help you weigh the potential risks against the benefits of treating your condition.

I take Depakote (divalproex) for another condition. Is it okay to take that with Xywav?

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You'll want to tell your prescriber about the Depakote before starting Xywav. When the two are taken together, Depakote raises the level of oxybate in your blood, which can increase mental impairment — things like attention and memory problems. If your doctor decides both are necessary, they'll likely start you on a lower Xywav dose and watch you closely. Don't adjust either medication on your own.

Is Calcium, Magnesium, Potassium, and Sodium Oxybate available over the counter?

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No. Calcium, Magnesium, Potassium, and Sodium Oxybate is a prescription medicine: every Calcium, Magnesium, Potassium, and Sodium Oxybate product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

Is Calcium, Magnesium, Potassium, and Sodium Oxybate a controlled substance?

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Yes — Calcium, Magnesium, Potassium, and Sodium Oxybate is a federally controlled substance (Schedule III) in the United States, so how it is prescribed, refilled and dispensed is regulated by the DEA.

When was Calcium, Magnesium, Potassium, and Sodium Oxybate first available?

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The earliest FDA record we hold for Calcium, Magnesium, Potassium, and Sodium Oxybate is from 2020: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Calcium, Magnesium, Potassium, and Sodium Oxybate was first used.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Calcium, Magnesium, Potassium, and Sodium Oxybate on HelloPharmacist

📊Calcium, Magnesium, Potassium, and Sodium Oxybate supplement interactions23 checked — ranked by severity 🌿Drug & Supplement CheckerCalcium, Magnesium, Potassium, and Sodium Oxybate vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Calcium, Magnesium, Potassium, and Sodium Oxybate NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Calcium, Magnesium, Potassium, and Sodium Oxybate Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Calcium, Magnesium, Potassium, and Sodium Oxybate forms and strengths (how it comes)

Calcium, Magnesium, Potassium, and Sodium Oxybate is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Calcium, Magnesium, Potassium, and Sodium Oxybate inactive ingredients by manufacturer.

Oral solution

By mouth
Brands Xywav
How this form is used
What it may be used for
  • Xywav oral solution is used to treat cataplexy and excessive daytime sleepiness in patients aged 7 and older with narcolepsy
  • Xywav oral solution is used to treat idiopathic hypersomnia (IH) in adults
Important instructions
  • Xywav must be taken at least 2 hours after eating — food reduces how much medicine your body absorbs
  • Xywav oral solution is prepared before bedtime by diluting each dose with about a quarter cup of water in the pharmacy-provided containers
  • Xywav should be taken while already in bed; lie down immediately after swallowing each dose
  • For narcolepsy, Xywav is taken as two doses per night — the first at bedtime and the second 2.5 to 4 hours later; for idiopathic hypersomnia in adults, it may be taken once or twice nightly as directed by your prescriber
Available strengths 1 strength
0.5 g/mL / 0.5 g/mL / 0.5 g/mL / 0.5 g/mL
1 FDA-listed product record ⓘ

Calcium, Magnesium, Potassium, and Sodium Oxybate on the U.S. market: products, makers and brands

How Calcium, Magnesium, Potassium, and Sodium Oxybate appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

1 company lists 1 Calcium, Magnesium, Potassium, and Sodium Oxybate product record with the FDA, mostly as oral solution; the earliest marketing or approval year on record is 2020. Brand names on the directory include Xywav; the rest are generics.

1
Dose forms ⓘ
1
Labelers (makers, repackagers, distributors)
1
Brand names
1
FDA-listed product records ⓘ
2020
Earliest FDA record ⓘ

How widely Calcium, Magnesium, Potassium, and Sodium Oxybate is used (Medicaid data)

A general measure of how commonly Calcium, Magnesium, Potassium, and Sodium Oxybate is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Calcium, Magnesium, Potassium, and Sodium Oxybate is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

9,091
Medicaid prescriptions filled (Q1–Q4 2025)
$150.2M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Calcium, Magnesium, Potassium, and Sodium Oxybate prescribed? Of the 1,601 medications we measure, Calcium, Magnesium, Potassium, and Sodium Oxybate ranks #944 by Medicaid prescriptions — more than 41% of them.

Where Calcium, Magnesium, Potassium, and Sodium Oxybate ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #944 of 1,601
#939 Meperidine 9,802 Rx #940 Enzalutamide 9,669 Rx #941 Ethambutol 9,534 Rx #942 Potassium Chloride / S... 9,393 Rx #943 Vincristine Injection 9,198 Rx #944 Calcium, Magnesium, Po... 9,091 Rx #945 Aminophylline 9,002 Rx #946 Estradiol Topical 8,927 Rx #947 Eptinezumab-jjmr Injec... 8,909 Rx #948 Pitavastatin 8,812 Rx #949 Balsalazide 8,799 Rx

Utilization by Calcium, Magnesium, Potassium, and Sodium Oxybate product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

calcium oxybate 234 MG/ML / magnesium oxybate 96 MG/ML / potassium oxybate 130 MG/ML / sodium oxybate 40 MG/ML Oral Solution

9,091 Medicaid prescriptions (Q1–Q4 2025) 100% of Calcium, Magnesium, Potassium, and Sodium Oxybate prescriptions shown $150.2M gross reimbursement (before rebates) ≈ $16,521 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2393795

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Calcium, Magnesium, Potassium, and Sodium Oxybate, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 1 of 1 listed Calcium, Magnesium, Potassium, and Sodium Oxybate NDCs with Medicaid activity.

Compare Calcium, Magnesium, Potassium, and Sodium Oxybate products

A representative set of FDA-listed product records for Calcium, Magnesium, Potassium, and Sodium Oxybate — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Strength Route Manufacturer / Labeler Category ⓘ Details
💊Oral solution
SODIUM OXYBATE 0.5 g/mL; CALCIUM OXYBATE 0.5 g/mL; POTASSIUM OXYBATE 0.5 g/mL; MAGNESIUM OXYBATE 0.5 g/mL Oral Jazz Pharmaceuticals, Inc. NDA View NDC →

Showing 1 of 1 products — FDA National Drug Code Directory. See every product, package size and price: browse all 1 Calcium, Magnesium, Potassium, and Sodium Oxybate NDCs →

Calcium, Magnesium, Potassium, and Sodium Oxybate recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Calcium, Magnesium, Potassium, and Sodium Oxybate recalls since July 2021.

✅No Calcium, Magnesium, Potassium, and Sodium Oxybate recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

Calcium, Magnesium, Potassium, and Sodium Oxybate brand names

Calcium, Magnesium, Potassium, and Sodium Oxybate is sold under one brand name in the FDA directory — Xywav. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Xywav

Who makes Calcium, Magnesium, Potassium, and Sodium Oxybate: manufacturers and labelers

One company lists Calcium, Magnesium, Potassium, and Sodium Oxybate products with the FDA. By number of product records, the largest are Jazz Pharmaceuticals, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Jazz Pharmaceuticals, Inc. 1

Calcium, Magnesium, Potassium, and Sodium Oxybate drug class (RxNorm)

Calcium, Magnesium, Potassium, and Sodium Oxybate belongs to the Other general anesthetics class.

Drug family (ATC) Other general anesthetics, Other nervous system drugs

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Calcium, Magnesium, Potassium, and Sodium Oxybate page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jul 1, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Calcium, Magnesium, Potassium, and Sodium Oxybate.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
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Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Calcium, Magnesium, Potassium, and Sodium Oxybate after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
1
Finished products in the current FDA directory
1
Companies listing them (makers, repackagers, distributors)
1
FDA labeler codes behind them ⓘ
1
Linked representative label ⓘ
Jazz Pharmaceuticals, Inc.
Linked label effective
Jul 1, 2025
Composite sections available
25
Linked SPL Set ID
1e0ae43a-037f-42af-8e23-a0e51d75abe8
Linked SPL Document ID
6815ce2b-51e5-4d03-92a6-523718ab0d8c
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Jazz Pharmaceuticals, Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →