Copanlisib Injection

Generic name: Pronounced as (koe" pan lis' ib)
Brand names
  • Aliqopa®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 04/15/2020

Copanlisib injection is used to treat people with follicular lymphoma (FL; a slow-growing blood cancer) that has returned after being treated 2 or more times with other medications. Copanlisib injection is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

Copanlisib injection comes as a powder to be mixed with liquid and given through a needle or catheter placed into a vein. It is usually injected slowly over a period of 60 minutes on days 1,8, and 15 of a 28-day treatment cycle.

Copanlisib injection may cause high blood pressure for up to 8 hours after the infusion. Your doctor will check your blood pressure before you receive the infusion and for several hours after the infusion is completed. If you experience any of the following symptoms after you receive the medication tell your doctor immediately: dizziness, feeling faint, headache, or pounding heartbeat.

Your doctor may reduce your dose, delay or stop your treatment with copanlisib injection, or treat you with additional medications depending on your response to the medication and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving copanlisib injection,

  • tell your doctor and pharmacist if you are allergic to copanlisib, any other medications, or any of the ingredients in copanlisib injection. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Be sure to mention any of the following: boceprevir (Victrelis); carbamazepine (Carbatrol, Equetro, Tegretol, others), clarithromycin (Biaxin, in Prevpac), cobicistat (Tybost, in Evotaz, Genvoya, Prezcobix, Stribild), conivaptan (Vaprisol), diltiazem (Cardizem, Cartia XT, Diltzac, others), efavirenz (Sustiva), enzalutamide (Xtandi), idelalisib (Zydelig), indinavir (Crixivan) with ritonavir; itraconazole (Sporonox, Onmel), and ketoconazole, lopinavir with ritonavir (in Kaletra); mitotane (Lysodren), nefazodone, nelfinavir (Viracept), nevirapine (Viramune), paritaprevir, ritonavir, ombitasvir, and/or dasabuvir (Viekira Pak); phenobarbital, phenytoin (Dilantin, Phenytek), posaconazole (Noxafil), rifabutin (Mycobutin), rifampin (Rifadine, in Rifamate, Rifater), ritonavir (Norvir, in Kaletra, Technivie, Viekira Pak), saquinavir (Invirase), and tipranavir (Aptivus) with ritonavir; and voriconazole (Vfend). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with copanlisib injection, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have an infection or if you have or have ever had high blood sugar, diabetes, lung or breathing problems, high blood pressure, or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or plan to father a child. You should not become pregnant while you are receiving copanlisib injection. You will need to have a negative pregnancy test before you begin receiving this medication. Use effective birth control during your treatment with copanlisib injection and for 1 month after your final dose. If you are a male and your partner can become pregnant, you should use effective birth control during your treatment and for 1 month after your final dose. If you or your partner become pregnant while receiving copanlisib, call your doctor.

  • tell your doctor if you are breastfeeding. You should not breastfeed while you are receiving copanlisib injection, and for 1 month after your final dose.

  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of receiving copanlisib injection.

Do not drink grapefruit juice while receiving this medication.

Unless your doctor tells you otherwise, continue your normal diet.

  • Copanlisib injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • nausea

    • vomiting

    • mouth sores, ulcers, or pain

    • burning, prickling, tingling, or numb feeling on the skin

    • pain upon touch

    • swelling of nose, throat, or mouth

    • lack of strength or energy

  • Some side effects can be serious. If you experience any of these symptoms call your doctor immediately:

    • unusual bleeding or bruising

    • new or worsening cough, shortness of breath, or difficulty breathing

    • rash; or red, itching, peeling or swelling skin

    • fever, sore throat, chills, or other signs of infection

    • feeling very hungry or thirsty, headache, or frequent urination

  • Copanlisib injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to copanlisib injection.

Ask your pharmacist any questions you have about copanlisib injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The metabolism of Copanlisib can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Copanlisib can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Copanlisib can be decreased when combined with Atorvastatin.
Cilostazol Cilostazol The metabolism of Copanlisib can be decreased when combined with Cilostazol.
Clopidogrel Clopidogrel The metabolism of Copanlisib can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Copanlisib can be increased when it is combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Copanlisib can be decreased when combined with Fenofibrate.
Methylergonovine Methylergonovine The metabolism of Copanlisib can be decreased when combined with Methylergometrine.
Paregoric Paregoric The serum concentration of Copanlisib can be increased when it is combined with Morphine.
Reserpine Reserpine The serum concentration of Copanlisib can be increased when it is combined with Reserpine.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Copanlisib.
Triamcinolone Triamcinolone The metabolism of Copanlisib can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Copanlisib can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The serum concentration of Copanlisib can be increased when it is combined with Fluconazole.
Meperidine Injection Meperidine Injection The metabolism of Copanlisib can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Copanlisib can be increased when combined with Methylprednisolone.
Metronidazole Injection Metronidazole Injection The metabolism of Copanlisib can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The serum concentration of Copanlisib can be increased when it is combined with Morphine.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Copanlisib.
Ondansetron Ondansetron The metabolism of Copanlisib can be decreased when combined with Ondansetron.
Orlistat Orlistat The metabolism of Copanlisib can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Copanlisib can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Zaleplon Zaleplon The metabolism of Copanlisib can be decreased when combined with Zaleplon.
Anakinra Anakinra The metabolism of Copanlisib can be increased when combined with Anakinra.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Copanlisib.
Etanercept Injection Etanercept Injection The metabolism of Copanlisib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Copanlisib can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Copanlisib.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Copanlisib.
Dutasteride Dutasteride The metabolism of Copanlisib can be decreased when combined with Dutasteride.
Epinephrine Injection Epinephrine Injection The metabolism of Copanlisib can be decreased when combined with Epinephrine.
Eplerenone Eplerenone The metabolism of Copanlisib can be decreased when combined with Eplerenone.
Zonisamide Zonisamide The serum concentration of Copanlisib can be increased when it is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Copanlisib can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Copanlisib can be decreased when combined with Aripiprazole.
Atazanavir Atazanavir The metabolism of Copanlisib can be decreased when combined with Atazanavir.
Mefloquine Mefloquine The metabolism of Copanlisib can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Copanlisib can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil The serum concentration of Vardenafil can be increased when it is combined with Copanlisib.
Aprepitant Aprepitant The metabolism of Copanlisib can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The serum concentration of Copanlisib can be increased when it is combined with Tegaserod.
Tadalafil Tadalafil The metabolism of Copanlisib can be decreased when combined with Tadalafil.
Progesterone Progesterone The metabolism of Copanlisib can be increased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Copanlisib can be decreased when combined with Apomorphine.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Copanlisib.
Infliximab Injection Infliximab Injection The metabolism of Copanlisib can be increased when combined with Infliximab.
Rifaximin Rifaximin The metabolism of Copanlisib can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Copanlisib can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Copanlisib can be decreased when combined with Norethisterone.
Bosentan Bosentan The metabolism of Copanlisib can be increased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Copanlisib can be decreased when combined with Erlotinib.
Ganciclovir Ganciclovir The excretion of Ganciclovir can be decreased when combined with Copanlisib.
Voriconazole Voriconazole The metabolism of Copanlisib can be decreased when combined with Voriconazole.
Fentanyl Fentanyl The metabolism of Copanlisib can be decreased when combined with Fentanyl.
Deferasirox Deferasirox The metabolism of Copanlisib can be increased when combined with Deferasirox.
Tipranavir Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Copanlisib.
Felbamate Felbamate The metabolism of Copanlisib can be increased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Copanlisib can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Copanlisib can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Copanlisib can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Copanlisib can be increased when it is combined with Sitagliptin.
Gefitinib Gefitinib The metabolism of Copanlisib can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The serum concentration of Copanlisib can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The serum concentration of Copanlisib can be increased when it is combined with Bortezomib.
Posaconazole Posaconazole The metabolism of Copanlisib can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Copanlisib can be decreased when combined with Primaquine.
Darunavir Darunavir The serum concentration of Copanlisib can be increased when it is combined with Darunavir.
Sorafenib Sorafenib The serum concentration of Copanlisib can be increased when it is combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Copanlisib can be decreased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Lapatinib Lapatinib The serum concentration of Copanlisib can be increased when it is combined with Lapatinib.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Copanlisib.
Armodafinil Armodafinil The metabolism of Copanlisib can be increased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Copanlisib can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Copanlisib.
Nilotinib Nilotinib The serum concentration of Copanlisib can be increased when it is combined with Nilotinib.
Toremifene Toremifene The serum concentration of Copanlisib can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Copanlisib can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Copanlisib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Copanlisib can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The metabolism of Copanlisib can be increased when combined with Etravirine.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Copanlisib can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Copanlisib can be decreased when combined with Desvenlafaxine.
Tretinoin Tretinoin The metabolism of Copanlisib can be decreased when combined with Tretinoin.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Copanlisib.
Pilocarpine Pilocarpine The metabolism of Copanlisib can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Copanlisib can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection The metabolism of Copanlisib can be decreased when combined with Irinotecan.
Praziquantel Praziquantel The metabolism of Copanlisib can be decreased when combined with Praziquantel.
Mitotane Mitotane The metabolism of Copanlisib can be increased when combined with Mitotane.
Rufinamide Rufinamide The metabolism of Copanlisib can be increased when combined with Rufinamide.
Silodosin Silodosin The serum concentration of Copanlisib can be increased when it is combined with Silodosin.
Midazolam Midazolam The metabolism of Copanlisib can be decreased when combined with Midazolam.
Eltrombopag Eltrombopag Eltrombopag may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Milnacipran Milnacipran The metabolism of Copanlisib can be decreased when combined with Milnacipran.
Iloperidone Iloperidone The metabolism of Copanlisib can be decreased when combined with Iloperidone.
Lacosamide Lacosamide The metabolism of Copanlisib can be decreased when combined with Lacosamide.
Everolimus Everolimus The serum concentration of Copanlisib can be increased when it is combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Copanlisib.
Dronedarone Dronedarone The serum concentration of Dronedarone can be increased when it is combined with Copanlisib.
Saxagliptin Saxagliptin The metabolism of Copanlisib can be decreased when combined with Saxagliptin.
Romidepsin Injection Romidepsin Injection The metabolism of Copanlisib can be decreased when combined with Romidepsin.
Topotecan Topotecan The metabolism of Topotecan can be increased when combined with Copanlisib.
Golimumab Injection Golimumab Injection The metabolism of Copanlisib can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Copanlisib can be decreased when combined with Pazopanib.
Albendazole Albendazole The metabolism of Copanlisib can be decreased when combined with Albendazole.
Levonorgestrel Levonorgestrel The metabolism of Copanlisib can be decreased when combined with Levonorgestrel.
Tocilizumab Injection Tocilizumab Injection The metabolism of Copanlisib can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Copanlisib can be decreased when combined with Cabazitaxel.
Acetaminophen Injection Acetaminophen Injection The metabolism of Copanlisib can be increased when combined with Acetaminophen.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Copanlisib can be decreased when combined with Aldesleukin.
Roflumilast Roflumilast The metabolism of Copanlisib can be decreased when combined with Roflumilast.
Linagliptin Linagliptin The serum concentration of Copanlisib can be increased when it is combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Copanlisib can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The serum concentration of Copanlisib can be increased when it is combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Copanlisib can be increased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The metabolism of Copanlisib can be decreased when combined with Rivaroxaban.
Ticagrelor Ticagrelor The serum concentration of Ticagrelor can be increased when it is combined with Copanlisib.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Copanlisib can be decreased when combined with Brentuximab vedotin.
Vandetanib Vandetanib The serum concentration of Copanlisib can be increased when it is combined with Vandetanib.
Clobazam Clobazam The metabolism of Copanlisib can be increased when combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Copanlisib can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Ivacaftor Ivacaftor The serum concentration of Copanlisib can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The metabolism of Copanlisib can be decreased when combined with Axitinib.
Crizotinib Crizotinib The metabolism of Copanlisib can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Copanlisib can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Copanlisib can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan The metabolism of Copanlisib can be decreased when combined with Ambrisentan.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Copanlisib can be increased when it is combined with Carfilzomib.
Enzalutamide Enzalutamide The serum concentration of Copanlisib can be increased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Copanlisib can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The serum concentration of Copanlisib can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Copanlisib can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Copanlisib can be increased when combined with Corticotropin.
Teriflunomide Teriflunomide Teriflunomide may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Ponatinib Ponatinib The serum concentration of Copanlisib can be increased when it is combined with Ponatinib.
Pomalidomide Pomalidomide The serum concentration of Copanlisib can be increased when it is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Copanlisib can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The metabolism of Copanlisib can be decreased when combined with Apixaban.
Canagliflozin Canagliflozin The serum concentration of Copanlisib can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The metabolism of Copanlisib can be increased when combined with Dabrafenib.
Trametinib Trametinib The metabolism of Copanlisib can be increased when combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Copanlisib can be increased when it is combined with Dolutegravir.
Afatinib Afatinib The serum concentration of Copanlisib can be increased when it is combined with Afatinib.
Vortioxetine Vortioxetine The metabolism of Copanlisib can be decreased when combined with Vortioxetine.
Perampanel Perampanel The metabolism of Copanlisib can be increased when combined with Perampanel.
Ibrutinib Ibrutinib The metabolism of Copanlisib can be decreased when combined with Ibrutinib.
Lomitapide Lomitapide The serum concentration of Lomitapide can be increased when it is combined with Copanlisib.
Simeprevir Simeprevir The serum concentration of Copanlisib can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Copanlisib can be increased when it is combined with Sofosbuvir.
Apremilast Apremilast The metabolism of Copanlisib can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Copanlisib can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Copanlisib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Copanlisib can be increased when combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The serum concentration of Copanlisib can be increased when it is combined with Belinostat.
Idelalisib Idelalisib The metabolism of Copanlisib can be decreased when combined with Idelalisib.
Testosterone Injection Testosterone Injection The metabolism of Copanlisib can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Copanlisib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The serum concentration of Copanlisib can be increased when it is combined with Vorapaxar.
Suvorexant Suvorexant The serum concentration of Copanlisib can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Copanlisib can be increased when it is combined with Edoxaban.
Olaparib Olaparib The metabolism of Copanlisib can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Copanlisib can be decreased when combined with Tasimelteon.
Lanreotide Injection Lanreotide Injection The metabolism of Copanlisib can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The metabolism of Copanlisib can be decreased when combined with Nintedanib.
Secukinumab Injection Secukinumab Injection The metabolism of Copanlisib can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Copanlisib can be decreased when combined with Risperidone.
Palbociclib Palbociclib The serum concentration of Copanlisib can be increased when it is combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Copanlisib can be increased when combined with Lenvatinib.
Panobinostat Panobinostat The serum concentration of Copanlisib can be increased when it is combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The serum concentration of Copanlisib can be increased when it is combined with Haloperidol.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Copanlisib can be increased when it is combined with Isavuconazonium.
Flibanserin Flibanserin The serum concentration of Copanlisib can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Copanlisib can be increased when it is combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Copanlisib can be increased when combined with Prednisolone.
Daclatasvir Daclatasvir The serum concentration of Copanlisib can be increased when it is combined with Daclatasvir.
Ziprasidone Injection Ziprasidone Injection The metabolism of Copanlisib can be decreased when combined with Ziprasidone.
Cobimetinib Cobimetinib The metabolism of Copanlisib can be decreased when combined with Cobimetinib.
Osimertinib Osimertinib The metabolism of Copanlisib can be increased when combined with Osimertinib.
Alectinib Alectinib Alectinib may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Copanlisib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Copanlisib can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Copanlisib can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Copanlisib can be increased when combined with Dexamethasone.
Venetoclax Venetoclax The serum concentration of Copanlisib can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Copanlisib can be increased when it is combined with Cobicistat.
Selexipag Selexipag The serum concentration of Copanlisib can be increased when it is combined with Selexipag.
Rucaparib Rucaparib The serum concentration of Copanlisib can be increased when it is combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Copanlisib can be decreased when combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Copanlisib can be increased when combined with Brigatinib.
Deutetrabenazine Deutetrabenazine The metabolism of Copanlisib can be decreased when combined with Deutetrabenazine.
Valbenazine Valbenazine The metabolism of Copanlisib can be decreased when combined with Valbenazine.
Deflazacort Deflazacort The metabolism of Copanlisib can be increased when combined with Deflazacort.
Safinamide Safinamide The metabolism of Copanlisib can be decreased when combined with Safinamide.
Sarilumab Injection Sarilumab Injection The metabolism of Copanlisib can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Copanlisib can be increased when combined with Midostaurin.
Neratinib Neratinib The serum concentration of Copanlisib can be increased when it is combined with Neratinib.
Enasidenib Enasidenib The serum concentration of Copanlisib can be increased when it is combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Copanlisib can be increased when it is combined with Inotuzumab ozogamicin.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Copanlisib can be increased when combined with Fosaprepitant.
Abemaciclib Abemaciclib Abemaciclib may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Betrixaban Betrixaban The serum concentration of Copanlisib can be increased when it is combined with Betrixaban.
Acalabrutinib Acalabrutinib The metabolism of Copanlisib can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Copanlisib can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin The serum concentration of Copanlisib can be increased when it is combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection The metabolism of Copanlisib can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The serum concentration of Copanlisib can be decreased when it is combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Copanlisib can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Baricitinib Baricitinib The excretion of Baricitinib can be decreased when combined with Copanlisib.
Eliglustat Eliglustat The serum concentration of Copanlisib can be increased when it is combined with Eliglustat.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Copanlisib.
Ivosidenib Ivosidenib The serum concentration of Copanlisib can be increased when it is combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Copanlisib.
Elagolix Elagolix The serum concentration of Copanlisib can be increased when it is combined with Elagolix.
Doravirine Doravirine The metabolism of Copanlisib can be decreased when combined with Doravirine.
Cannabidiol Cannabidiol The metabolism of Copanlisib can be decreased when combined with Cannabidiol.
Dacomitinib Dacomitinib The serum concentration of Copanlisib can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Copanlisib can be decreased when combined with Duvelisib.
Omadacycline Omadacycline The serum concentration of Copanlisib can be increased when it is combined with Omadacycline.
Sarecycline Sarecycline The serum concentration of Copanlisib can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Copanlisib can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Copanlisib can be increased when it is combined with Talazoparib.
Gilteritinib Gilteritinib The metabolism of Copanlisib can be decreased when combined with Gilteritinib.
Glasdegib Glasdegib The serum concentration of Copanlisib can be increased when it is combined with Glasdegib.
Lorlatinib Lorlatinib The metabolism of Copanlisib can be decreased when combined with Lorlatinib.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Copanlisib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Copanlisib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Copanlisib.
Rifamycin Rifamycin The serum concentration of Copanlisib can be increased when it is combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Copanlisib can be decreased when combined with Prucalopride.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Copanlisib can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Copanlisib can be decreased when combined with Siponimod.
Acyclovir Ophthalmic Acyclovir Ophthalmic The excretion of Acyclovir can be decreased when combined with Copanlisib.
Erdafitinib Erdafitinib The serum concentration of Copanlisib can be increased when it is combined with Erdafitinib.
Alpelisib Alpelisib The metabolism of Copanlisib can be increased when combined with Alpelisib.
Darolutamide Darolutamide Darolutamide may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Triclabendazole Triclabendazole The metabolism of Copanlisib can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The serum concentration of Copanlisib can be increased when it is combined with Entrectinib.
Istradefylline Istradefylline The serum concentration of Copanlisib can be increased when it is combined with Istradefylline.
Pitolisant Pitolisant The serum concentration of Copanlisib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Copanlisib can be increased when it is combined with Fedratinib.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Copanlisib.
Phenytoin Injection Phenytoin Injection The metabolism of Copanlisib can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Copanlisib can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Copanlisib.
Voxelotor Voxelotor The serum concentration of Copanlisib can be increased when it is combined with Voxelotor.
Lasmiditan Lasmiditan The serum concentration of Copanlisib can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Copanlisib.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Copanlisib.
Cenobamate Cenobamate The serum concentration of Copanlisib can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The metabolism of Copanlisib can be decreased when combined with Selumetinib.
Rimegepant Rimegepant The serum concentration of Copanlisib can be increased when it is combined with Rimegepant.
Tucatinib Tucatinib Tucatinib may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Copanlisib can be increased when it is combined with Remdesivir.
Ripretinib Ripretinib The serum concentration of Copanlisib can be increased when it is combined with Ripretinib.
Capmatinib Capmatinib The serum concentration of Copanlisib can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The metabolism of Copanlisib can be decreased when combined with Lemborexant.
Fostemsavir Fostemsavir Fostemsavir may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Octreotide Octreotide The serum concentration of Copanlisib can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Copanlisib can be increased when it is combined with Belantamab mafodotin.
Pralsetinib Pralsetinib The serum concentration of Copanlisib can be increased when it is combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Copanlisib can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Copanlisib can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Copanlisib can be increased when combined with Vitamin E.
Trazodone Trazodone The serum concentration of Copanlisib can be decreased when it is combined with Trazodone.
Phenobarbital Phenobarbital The metabolism of Copanlisib can be increased when combined with Phenobarbital.
Primidone Primidone The metabolism of Copanlisib can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Copanlisib can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Copanlisib can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Copanlisib can be decreased when combined with Lorazepam.
Bromocriptine Bromocriptine The metabolism of Copanlisib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Copanlisib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Copanlisib can be decreased when combined with Phenelzine.
Tetracycline Tetracycline The metabolism of Copanlisib can be decreased when combined with Tetracycline.
Prochlorperazine Prochlorperazine The metabolism of Copanlisib can be decreased when combined with Prochlorperazine.
Dapsone Dapsone The metabolism of Copanlisib can be decreased when combined with Dapsone.
Oxycodone Oxycodone The metabolism of Copanlisib can be decreased when combined with Oxycodone.
Methadone Methadone The metabolism of Copanlisib can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Copanlisib can be decreased when combined with Oxybutynin.
Orphenadrine Orphenadrine The metabolism of Copanlisib can be decreased when combined with Orphenadrine.
Phentermine Phentermine The metabolism of Copanlisib can be decreased when combined with Phentermine.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Copanlisib can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Copanlisib can be decreased when combined with Doxorubicin.
Dactinomycin Dactinomycin The serum concentration of Copanlisib can be increased when it is combined with Dactinomycin.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Copanlisib.
Clonidine Clonidine The metabolism of Copanlisib can be decreased when combined with Clonidine.
Hydralazine Hydralazine The metabolism of Copanlisib can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Copanlisib can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Copanlisib can be increased when combined with Warfarin.
Loperamide Loperamide The metabolism of Copanlisib can be decreased when combined with Loperamide.
Daunorubicin Daunorubicin The metabolism of Copanlisib can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Copanlisib can be increased when combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Copanlisib.
Loxapine Loxapine The serum concentration of Copanlisib can be increased when it is combined with Loxapine.
Chloroquine Chloroquine The metabolism of Copanlisib can be decreased when combined with Chloroquine.
Quinine Quinine The serum concentration of Copanlisib can be increased when it is combined with Quinine.
Calcitriol Calcitriol The metabolism of Copanlisib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Copanlisib can be increased when combined with Sulfinpyrazone.
Clindamycin Injection Clindamycin Injection The metabolism of Copanlisib can be decreased when combined with Clindamycin.
Secobarbital Secobarbital The metabolism of Copanlisib can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Copanlisib can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The metabolism of Copanlisib can be decreased when combined with Amitriptyline.
Imipramine Imipramine The metabolism of Copanlisib can be decreased when combined with Imipramine.
Probenecid Probenecid The metabolism of Copanlisib can be increased when combined with Probenecid.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Copanlisib.
Procainamide Procainamide The excretion of Procainamide can be decreased when combined with Copanlisib.
Isoniazid Isoniazid The metabolism of Copanlisib can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Copanlisib can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Copanlisib can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The serum concentration of Copanlisib can be increased when it is combined with Tamoxifen.
Levothyroxine Levothyroxine The serum concentration of Copanlisib can be decreased when it is combined with Levothyroxine.
Methimazole Methimazole The metabolism of Copanlisib can be decreased when combined with Methimazole.
Dextromethorphan Dextromethorphan The metabolism of Copanlisib can be decreased when combined with Dextromethorphan.
Niacin Niacin The metabolism of Copanlisib can be decreased when combined with Niacin.
Chlorpheniramine Chlorpheniramine The metabolism of Copanlisib can be decreased when combined with Chlorpheniramine.
Danazol Danazol The metabolism of Copanlisib can be decreased when combined with Danazol.
Disulfiram Disulfiram The metabolism of Copanlisib can be decreased when combined with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Copanlisib can be decreased when combined with Propranolol.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Copanlisib.
Amphotericin B Injection Amphotericin B Injection The metabolism of Copanlisib can be decreased when combined with Amphotericin B.
Nadolol Nadolol The excretion of Nadolol can be decreased when combined with Copanlisib.
Clomiphene Clomiphene The serum concentration of Copanlisib can be increased when it is combined with Clomifene.
Colchicine Colchicine The metabolism of Copanlisib can be increased when combined with Colchicine.
Cephalexin Cephalexin The metabolism of Copanlisib can be decreased when combined with Cephalexin.
Acetazolamide Acetazolamide The metabolism of Copanlisib can be decreased when combined with Acetazolamide.
Ketoconazole Ketoconazole The serum concentration of Copanlisib can be increased when it is combined with Ketoconazole.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Copanlisib.
Vinblastine Vinblastine The metabolism of Copanlisib can be increased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Copanlisib can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine The metabolism of Copanlisib can be decreased when combined with Hydroxyzine.
Alprazolam Alprazolam The metabolism of Copanlisib can be decreased when combined with Alprazolam.
Triazolam Triazolam The metabolism of Copanlisib can be decreased when combined with Triazolam.
Diltiazem Diltiazem The metabolism of Copanlisib can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Copanlisib can be increased when combined with Nifedipine.
Verapamil Verapamil The serum concentration of Copanlisib can be increased when it is combined with Verapamil.
Etoposide Etoposide The metabolism of Copanlisib can be increased when combined with Etoposide.
Glyburide Glyburide The metabolism of Copanlisib can be decreased when combined with Glyburide.
Dicloxacillin Dicloxacillin The metabolism of Copanlisib can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Copanlisib can be increased when combined with Nafcillin.
Pentamidine Injection Pentamidine Injection The metabolism of Copanlisib can be decreased when combined with Pentamidine.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Copanlisib.
Amiodarone Amiodarone The serum concentration of Amiodarone can be increased when it is combined with Copanlisib.
Buspirone Buspirone The metabolism of Copanlisib can be decreased when combined with Buspirone.
Lovastatin Lovastatin The metabolism of Copanlisib can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Copanlisib can be decreased when combined with Ciprofloxacin.
Clozapine Clozapine The metabolism of Copanlisib can be increased when combined with Clozapine.
Clarithromycin Clarithromycin The serum concentration of Copanlisib can be increased when it is combined with Clarithromycin.
Felodipine Felodipine The metabolism of Copanlisib can be decreased when combined with Felodipine.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Simvastatin Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Copanlisib.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Copanlisib.
Teniposide Injection Teniposide Injection The metabolism of Copanlisib can be decreased when combined with Teniposide.
Itraconazole Itraconazole The serum concentration of Copanlisib can be increased when it is combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Copanlisib can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol The serum concentration of Copanlisib can be increased when it is combined with Bisoprolol.
Doxazosin Doxazosin The metabolism of Copanlisib can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Copanlisib can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Copanlisib can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Copanlisib can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Copanlisib can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may increase the excretion rate of Copanlisib which could result in a lower serum level and potentially a reduction in efficacy.
Famciclovir Famciclovir The metabolism of Copanlisib can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Copanlisib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Copanlisib can be decreased when combined with Nefazodone.
Losartan Losartan The metabolism of Copanlisib can be decreased when combined with Losartan.
Lansoprazole Lansoprazole The metabolism of Copanlisib can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Copanlisib can be increased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Copanlisib can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Copanlisib can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The serum concentration of Saquinavir can be increased when it is combined with Copanlisib.
Metformin Metformin The excretion of Metformin can be decreased when combined with Copanlisib.
Nisoldipine Nisoldipine The metabolism of Copanlisib can be decreased when combined with Nisoldipine.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Copanlisib can be increased when it is combined with Gemcitabine.
Indinavir Indinavir The metabolism of Copanlisib can be decreased when combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Copanlisib can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Copanlisib can be decreased when combined with Docetaxel.
Zafirlukast Zafirlukast The metabolism of Copanlisib can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Copanlisib can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Copanlisib can be increased when combined with Topiramate.
Nelfinavir Nelfinavir The metabolism of Copanlisib can be decreased when combined with Nelfinavir.
Fexofenadine Fexofenadine The serum concentration of Copanlisib can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The metabolism of Copanlisib can be decreased when combined with Azithromycin.
Carvedilol Carvedilol The serum concentration of Copanlisib can be increased when it is combined with Carvedilol.
Flutamide Flutamide The metabolism of Copanlisib can be decreased when combined with Flutamide.
Bicalutamide Bicalutamide The metabolism of Copanlisib can be decreased when combined with Bicalutamide.
Propafenone Propafenone The serum concentration of Copanlisib can be increased when it is combined with Propafenone.
Raloxifene Raloxifene The metabolism of Copanlisib can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Copanlisib can be decreased when combined with Irbesartan.
Finasteride Finasteride The metabolism of Copanlisib can be decreased when combined with Finasteride.
Quetiapine Quetiapine The metabolism of Copanlisib can be decreased when combined with Quetiapine.
Paroxetine Paroxetine The metabolism of Copanlisib can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Copanlisib can be decreased when combined with Citalopram.
Efavirenz Efavirenz The metabolism of Copanlisib can be increased when combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Copanlisib.
Thalidomide Thalidomide The metabolism of Copanlisib can be increased when combined with Thalidomide.
Nateglinide Nateglinide The metabolism of Copanlisib can be decreased when combined with Nateglinide.
Rabeprazole Rabeprazole The metabolism of Copanlisib can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Copanlisib can be increased when combined with Terbinafine.

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