Famotidine Injection

Generic name: Pronounced as (fa moe' ti deen)
Brand names
  • Pepcid
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 06/15/2016

Famotidine injection is used in people who are hospitalized to treat certain conditions in which the stomach produces too much acid or to treat ulcers (sores in the lining of the stomach or intestine) that were not successfully treated with other medications. Famotidine injection is also used on a short-term basis in people who cannot take oral medication

  • to treat ulcers,

  • to prevent ulcers from returning after they have healed,

  • to treat gastroesophageal reflux disease (GERD, a condition in which backward flow of acid from the stomach causes heartburn and injury of the esophagus [tube between the throat and the stomach]),

  • and to treat conditions where the stomach produces too much acid, such as Zollinger-Ellison syndrome (tumors in the pancreas and small intestine that caused increased production of stomach acid).

Famotidine injection is in a class of medications called H2 blockers. It works by decreasing the amount of acid made in the stomach.

Famotidine injection comes as a solution (liquid) to be mixed with another fluid and injected intravenously (into a vein) over 2 to 30 minutes. It also is available as a premixed product to inject intravenously over 15 to 30 minutes. It is usually given every 12 hours.

You may receive famotidine injection in a hospital or you may administer the medication at home. If you will be receiving famotidine injection at home, your healthcare provider will show you how to use the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving famotidine injection,

  • tell your doctor and pharmacist if you are allergic to famotidine, cimetidine, nizatidine (Axid), ranitidine (Zantac), any other medications, or any of the ingredients in famotidine injection. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving famotidine injection, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

  • Famotidine injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • dizziness

    • constipation

    • diarrhea

    • pain or swelling in the area where the medication was injected

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment

    • hives

    • rash

    • itching

    • difficulty breathing or swallowing

    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

    • hoarseness

  • Famotidine injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The risk or severity of QTc prolongation can be increased when Famotidine is combined with Moxifloxacin.
Leflunomide Leflunomide The metabolism of Leflunomide can be decreased when combined with Famotidine.
Delavirdine Delavirdine Famotidine can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dolasetron Dolasetron The risk or severity of QTc prolongation can be increased when Famotidine is combined with Dolasetron.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Famotidine.
Anagrelide Anagrelide The metabolism of Anagrelide can be decreased when combined with Famotidine.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Famotidine.
Cilostazol Cilostazol The risk or severity of QTc prolongation can be increased when Famotidine is combined with Cilostazol.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Famotidine.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The risk or severity of QTc prolongation can be increased when Famotidine is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The excretion of Famotidine can be decreased when combined with Conjugated estrogens.
Mycophenolate Mycophenolate Famotidine can cause a decrease in the absorption of Mycophenolic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Penbutolol Penbutolol The risk or severity of QTc prolongation can be increased when Famotidine is combined with Acebutolol.
Ranitidine Ranitidine The serum concentration of Ranitidine can be increased when it is combined with Famotidine.
Reserpine Reserpine The serum concentration of Reserpine can be increased when it is combined with Famotidine.
Tacrolimus Tacrolimus The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Famotidine.
Tizanidine Tizanidine The serum concentration of Famotidine can be increased when it is combined with Tizanidine.
Zolmitriptan Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Famotidine.
Fluconazole Injection Fluconazole Injection Famotidine can cause a decrease in the absorption of Fluconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Foscarnet Injection Foscarnet Injection The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Famotidine.
Levofloxacin Injection Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Levofloxacin.
Metoclopramide Injection Metoclopramide Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The risk or severity of QTc prolongation can be increased when Metronidazole is combined with Famotidine.
Zidovudine Injection Zidovudine Injection The excretion of Famotidine can be decreased when combined with Zidovudine.
Altretamine Altretamine Amphetamine may decrease the sedative and stimulatory activities of Famotidine.
Cefuroxime Cefuroxime Famotidine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ondansetron Ondansetron The risk or severity of QTc prolongation can be increased when Famotidine is combined with Ondansetron.
Granisetron Granisetron The risk or severity of QTc prolongation can be increased when Famotidine is combined with Granisetron.
Olanzapine Olanzapine The risk or severity of QTc prolongation can be increased when Olanzapine is combined with Famotidine.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Famotidine.
Dofetilide Dofetilide The serum concentration of Dofetilide can be increased when it is combined with Famotidine.
Hydroxychloroquine Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Hydroxychloroquine.
Pantoprazole Pantoprazole The excretion of Famotidine can be decreased when combined with Pantoprazole.
Risedronate Risedronate Famotidine can cause an increase in the absorption of Risedronic acid resulting in an increased serum concentration and potentially a worsening of adverse effects.
Desloratadine Desloratadine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Desloratadine.
Trimipramine Trimipramine The risk or severity of QTc prolongation can be increased when Trimipramine is combined with Famotidine.
Tenofovir Tenofovir The excretion of Tenofovir can be decreased when combined with Famotidine.
Epinephrine Injection Epinephrine Injection The serum concentration of Epinephrine can be increased when it is combined with Famotidine.
Escitalopram Escitalopram The risk or severity of QTc prolongation can be increased when Famotidine is combined with Escitalopram.
Zonisamide Zonisamide The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Famotidine.
Aripiprazole Aripiprazole The risk or severity of QTc prolongation can be increased when Famotidine is combined with Aripiprazole.
Atomoxetine Atomoxetine The risk or severity of QTc prolongation can be increased when Atomoxetine is combined with Famotidine.
Dexmethylphenidate Dexmethylphenidate The therapeutic efficacy of Dexmethylphenidate can be decreased when used in combination with Famotidine.
Atazanavir Atazanavir Famotidine can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mefloquine Mefloquine The risk or severity of QTc prolongation can be increased when Mefloquine is combined with Famotidine.
Rosuvastatin Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Famotidine.
Vardenafil Vardenafil The risk or severity of QTc prolongation can be increased when Vardenafil is combined with Famotidine.
Alfuzosin Alfuzosin The risk or severity of QTc prolongation can be increased when Alfuzosin is combined with Famotidine.
Memantine Memantine Famotidine may decrease the excretion rate of Memantine which could result in a higher serum level.
Fosamprenavir Fosamprenavir Famotidine can cause a decrease in the absorption of Fosamprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be decreased when combined with Famotidine.
Gemifloxacin Gemifloxacin The risk or severity of QTc prolongation can be increased when Famotidine is combined with Gemifloxacin.
Apomorphine Injection Apomorphine Injection The risk or severity of QTc prolongation can be increased when Apomorphine is combined with Famotidine.
Protriptyline Protriptyline The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Famotidine.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Famotidine.
Cefditoren Cefditoren The excretion of Cefdinir can be decreased when combined with Famotidine.
Cinacalcet Cinacalcet The metabolism of Cinacalcet can be decreased when combined with Famotidine.
Erlotinib Erlotinib Famotidine can cause a decrease in the absorption of Erlotinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ganciclovir Ganciclovir The excretion of Famotidine can be decreased when combined with Ganciclovir.
Solifenacin Solifenacin The risk or severity of QTc prolongation can be increased when Famotidine is combined with Solifenacin.
Voriconazole Voriconazole Famotidine can cause a decrease in the absorption of Voriconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the sedative and stimulatory activities of Famotidine.
Entecavir Entecavir The metabolism of Entecavir can be decreased when combined with Famotidine.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Famotidine.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Famotidine.
Pregabalin Pregabalin The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Famotidine.
Tipranavir Tipranavir Famotidine can cause a decrease in the absorption of Tipranavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Felbamate Felbamate The risk or severity of QTc prolongation can be increased when Famotidine is combined with Felbamate.
Ranolazine Ranolazine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Ranolazine.
Rasagiline Rasagiline The metabolism of Rasagiline can be decreased when combined with Famotidine.
Imatinib Imatinib The risk or severity of QTc prolongation can be increased when Famotidine is combined with Imatinib.
Sitagliptin Sitagliptin The excretion of Sitagliptin can be decreased when combined with Famotidine.
Varenicline Varenicline The excretion of Varenicline can be decreased when combined with Famotidine.
Gefitinib Gefitinib Famotidine can cause a decrease in the absorption of Gefitinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Albuterol Albuterol The risk or severity of QTc prolongation can be increased when Famotidine is combined with Salbutamol.
Paliperidone Paliperidone The risk or severity of QTc prolongation can be increased when Famotidine is combined with Paliperidone.
Bortezomib Bortezomib The risk or severity of QTc prolongation can be increased when Bortezomib is combined with Famotidine.
Clofarabine Injection Clofarabine Injection The serum concentration of Clofarabine can be increased when it is combined with Famotidine.
Oxaliplatin Injection Oxaliplatin Injection The serum concentration of Oxaliplatin can be increased when it is combined with Famotidine.
Posaconazole Posaconazole Famotidine can cause a decrease in the absorption of Posaconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Primaquine Primaquine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Primaquine.
Darunavir Darunavir Famotidine can cause a decrease in the absorption of Darunavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pemetrexed Injection Pemetrexed Injection The excretion of Pemetrexed can be decreased when combined with Famotidine.
Dimenhydrinate Dimenhydrinate The risk or severity of QTc prolongation can be increased when Famotidine is combined with Dimenhydrinate.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may decrease the sedative and stimulatory activities of Famotidine.
Vorinostat Vorinostat The risk or severity of QTc prolongation can be increased when Famotidine is combined with Vorinostat.
Sorafenib Sorafenib The metabolism of Famotidine can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The risk or severity of QTc prolongation can be increased when Famotidine is combined with Sunitinib.
Lapatinib Lapatinib The risk or severity of QTc prolongation can be increased when Famotidine is combined with Lapatinib.
Levocetirizine Levocetirizine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Levocetirizine.
Dasatinib Dasatinib Famotidine can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Famotidine.
Nilotinib Nilotinib Famotidine can cause a decrease in the absorption of Nilotinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Toremifene Toremifene The risk or severity of QTc prolongation can be increased when Famotidine is combined with Toremifene.
Raltegravir Raltegravir Famotidine can cause an increase in the absorption of Raltegravir resulting in an increased serum concentration and potentially a worsening of adverse effects.
Budesonide Budesonide Famotidine can cause a decrease in the absorption of Budesonide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Doripenem Injection Doripenem Injection The excretion of Doripenem can be decreased when combined with Famotidine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Arsenic trioxide.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Famotidine.
Leucovorin Injection Leucovorin Injection The excretion of Famotidine can be decreased when combined with Leucovorin.
Flecainide Flecainide The risk or severity of QTc prolongation can be increased when Famotidine is combined with Flecainide.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Famotidine.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Famotidine.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Degarelix.
Betaxolol Betaxolol The risk or severity of QTc prolongation can be increased when Famotidine is combined with Betaxolol.
Iloperidone Iloperidone The risk or severity of QTc prolongation can be increased when Famotidine is combined with Iloperidone.
Dronedarone Dronedarone The risk or severity of QTc prolongation can be increased when Famotidine is combined with Dronedarone.
Saxagliptin Saxagliptin The excretion of Saxagliptin can be decreased when combined with Famotidine.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Telavancin.
Romidepsin Injection Romidepsin Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Romidepsin.
Pazopanib Pazopanib The therapeutic efficacy of Pazopanib can be decreased when used in combination with Famotidine.
Asenapine Asenapine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Asenapine.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Famotidine.
Dalfampridine Dalfampridine The serum concentration of Dalfampridine can be increased when it is combined with Famotidine.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Eribulin.
Lurasidone Lurasidone The risk or severity of QTc prolongation can be increased when Famotidine is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Famotidine.
Terbutaline Injection Terbutaline Injection The risk or severity of QTc prolongation can be increased when Terbutaline is combined with Famotidine.
Linagliptin Linagliptin The serum concentration of Linagliptin can be increased when it is combined with Famotidine.
Rilpivirine Rilpivirine Famotidine can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Triptorelin.
Vandetanib Vandetanib The risk or severity of QTc prolongation can be increased when Famotidine is combined with Vandetanib.
Vemurafenib Vemurafenib The risk or severity of QTc prolongation can be increased when Famotidine is combined with Vemurafenib.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Famotidine.
Crizotinib Crizotinib The risk or severity of QTc prolongation can be increased when Famotidine is combined with Crizotinib.
Mirabegron Mirabegron The risk or severity of QTc prolongation can be increased when Famotidine is combined with Mirabegron.
Bosutinib Bosutinib Famotidine can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Teriflunomide Teriflunomide The excretion of Famotidine can be decreased when combined with Teriflunomide.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Famotidine is combined with Bedaquiline.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Famotidine.
Dabrafenib Dabrafenib Famotidine can cause a decrease in the absorption of Dabrafenib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dolutegravir Dolutegravir The excretion of Famotidine can be decreased when combined with Dolutegravir.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Famotidine.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Famotidine.
Iron Sucrose Injection Iron Sucrose Injection Famotidine can cause a decrease in the absorption of Iron sucrose resulting in a reduced serum concentration and potentially a decrease in efficacy.
Apremilast Apremilast The metabolism of Apremilast can be decreased when combined with Famotidine.
Ceritinib Ceritinib The risk or severity of QTc prolongation can be increased when Famotidine is combined with Ceritinib.
Iron Dextran Injection Iron Dextran Injection Famotidine can cause a decrease in the absorption of Iron Dextran resulting in a reduced serum concentration and potentially a decrease in efficacy.
Testosterone Injection Testosterone Injection The excretion of Famotidine can be increased when combined with Testosterone.
Methamphetamine Methamphetamine Metamfetamine may decrease the sedative and stimulatory activities of Famotidine.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Famotidine.
Riociguat Riociguat Famotidine can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Famotidine.
Risperidone Injection Risperidone Injection The risk or severity of QTc prolongation can be increased when Risperidone is combined with Famotidine.
Palbociclib Palbociclib The absorption of Palbociclib can be decreased when combined with Famotidine.
Lenvatinib Lenvatinib The risk or severity of QTc prolongation can be increased when Famotidine is combined with Lenvatinib.
Panobinostat Panobinostat The risk or severity of QTc prolongation can be increased when Famotidine is combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Haloperidol.
Ivabradine Ivabradine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Ivabradine.
Isavuconazonium Injection Isavuconazonium Injection Famotidine can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Ziprasidone.
Eluxadoline Eluxadoline The excretion of Eluxadoline can be decreased when combined with Famotidine.
Dexamethasone Injection Dexamethasone Injection The excretion of Dexamethasone can be decreased when combined with Famotidine.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Diphenhydramine.
Furosemide Injection Furosemide Injection The excretion of Famotidine can be decreased when combined with Furosemide.
Rucaparib Rucaparib The excretion of Famotidine can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The risk or severity of QTc prolongation can be increased when Famotidine is combined with Ribociclib.
Doxepin (Insomnia) Doxepin (Insomnia) The risk or severity of QTc prolongation can be increased when Famotidine is combined with Doxepin.
Deutetrabenazine Deutetrabenazine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Deutetrabenazine.
Edaravone Injection Edaravone Injection The excretion of Edaravone can be decreased when combined with Famotidine.
Enasidenib Enasidenib The metabolism of Famotidine can be decreased when combined with Enasidenib.
Delafloxacin Delafloxacin The risk or severity of QTc prolongation can be increased when Famotidine is combined with Delafloxacin.
Letermovir Letermovir The excretion of Famotidine can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Tetrabenazine.
Apalutamide Apalutamide The excretion of Famotidine can be decreased when combined with Apalutamide.
Avatrombopag Avatrombopag The excretion of Famotidine can be decreased when combined with Avatrombopag.
Baricitinib Baricitinib The excretion of Baricitinib can be decreased when combined with Famotidine.
Lofexidine Lofexidine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Lofexidine.
Eliglustat Eliglustat The risk or severity of QTc prolongation can be increased when Famotidine is combined with Eliglustat.
Encorafenib Encorafenib The risk or severity of QTc prolongation can be increased when Famotidine is combined with Encorafenib.
Binimetinib Binimetinib The metabolism of Binimetinib can be decreased when combined with Famotidine.
Ivosidenib Ivosidenib The risk or severity of QTc prolongation can be increased when Famotidine is combined with Ivosidenib.
Stiripentol Stiripentol The metabolism of Stiripentol can be decreased when combined with Famotidine.
Gilteritinib Gilteritinib The risk or severity of QTc prolongation can be increased when Famotidine is combined with Gilteritinib.
Glasdegib Glasdegib The risk or severity of QTc prolongation can be increased when Famotidine is combined with Glasdegib.
Acyclovir Ophthalmic Acyclovir Ophthalmic The excretion of Famotidine can be decreased when combined with Acyclovir.
Esomeprazole Injection Esomeprazole Injection The excretion of Famotidine can be decreased when combined with Esomeprazole.
Solriamfetol Solriamfetol The serum concentration of Solriamfetol can be increased when it is combined with Famotidine.
Triclabendazole Triclabendazole The risk or severity of QTc prolongation can be increased when Famotidine is combined with Triclabendazole.
Entrectinib Entrectinib The risk or severity of QTc prolongation can be increased when Famotidine is combined with Entrectinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Famotidine.
Pitolisant Pitolisant Famotidine may increase the QTc-prolonging activities of Pitolisant.
Lefamulin Lefamulin Lefamulin may increase the QTc-prolonging activities of Famotidine.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Famotidine.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Famotidine.
Daratumumab and Hyaluronidase-fihj Injection Daratumumab and Hyaluronidase-fihj Injection The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Famotidine.
Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf Injection Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf Injection The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Famotidine.
Octreotide Octreotide Octreotide can cause a decrease in the absorption of Famotidine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Relugolix Relugolix The risk or severity of QTc prolongation can be increased when Famotidine is combined with Relugolix.
Cabotegravir Cabotegravir The excretion of Famotidine can be decreased when combined with Cabotegravir.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Famotidine.
Indomethacin Indomethacin The excretion of Famotidine can be decreased when combined with Indomethacin.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Famotidine.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Famotidine.
Methotrexate Injection Methotrexate Injection The excretion of Famotidine can be decreased when combined with Methotrexate.
Methsuximide Methsuximide The risk or severity of QTc prolongation can be increased when Famotidine is combined with Methsuximide.
Diethylpropion Diethylpropion Diethylpropion may decrease the sedative and stimulatory activities of Famotidine.
Chlorpromazine Chlorpromazine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Chlorpromazine.
Carmustine Carmustine The metabolism of Carmustine can be decreased when combined with Famotidine.
Amantadine Amantadine The serum concentration of Amantadine can be increased when it is combined with Famotidine.
Tetracycline Tetracycline The excretion of Famotidine can be decreased when combined with Tetracycline.
Minocycline Minocycline The excretion of Famotidine can be decreased when combined with Minocycline.
Prochlorperazine Prochlorperazine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Prochlorperazine.
Thioridazine Thioridazine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Thioridazine.
Trifluoperazine Trifluoperazine The metabolism of Trifluoperazine can be decreased when combined with Famotidine.
Methadone Methadone The risk or severity of QTc prolongation can be increased when Famotidine is combined with Methadone.
Benztropine Benztropine The risk or severity of QTc prolongation can be increased when Benzatropine is combined with Famotidine.
Maprotiline Maprotiline The risk or severity of QTc prolongation can be increased when Famotidine is combined with Maprotiline.
Orphenadrine Orphenadrine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Orphenadrine.
Perphenazine Perphenazine The metabolism of Perphenazine can be decreased when combined with Famotidine.
Azathioprine Azathioprine The metabolism of Azathioprine can be decreased when combined with Famotidine.
Phentermine Phentermine Phentermine may decrease the sedative and stimulatory activities of Famotidine.
Methylphenidate Methylphenidate The therapeutic efficacy of Methylphenidate can be decreased when used in combination with Famotidine.
Amoxapine Amoxapine The risk or severity of QTc prolongation can be increased when Amoxapine is combined with Famotidine.
Hydrocortisone Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Famotidine.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Famotidine.
Prazosin Prazosin The serum concentration of Prazosin can be increased when it is combined with Famotidine.
Cimetidine Cimetidine The excretion of Famotidine can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Warfarin can be decreased when combined with Famotidine.
Loperamide Loperamide The risk or severity of QTc prolongation can be increased when Famotidine is combined with Loperamide.
Promethazine Promethazine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Promethazine.
Methenamine Methenamine The therapeutic efficacy of Methenamine can be decreased when used in combination with Famotidine.
Digoxin Digoxin The risk or severity of QTc prolongation can be increased when Digoxin is combined with Famotidine.
Chloroquine Chloroquine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Chloroquine.
Quinine Quinine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of QTc prolongation can be increased when Ethosuximide is combined with Famotidine.
Triamterene Triamterene The metabolism of Triamterene can be decreased when combined with Famotidine.
Desipramine Desipramine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Desipramine.
Amitriptyline Amitriptyline The risk or severity of QTc prolongation can be increased when Famotidine is combined with Amitriptyline.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Famotidine.
Probenecid Probenecid The excretion of Famotidine can be decreased when combined with Probenecid.
Quinidine Quinidine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Quinidine.
Procainamide Procainamide The serum concentration of Procainamide can be increased when it is combined with Famotidine.
Rifampin Rifampin Famotidine can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Disopyramide Disopyramide The risk or severity of QTc prolongation can be increased when Famotidine is combined with Disopyramide.
Valproic Acid Valproic Acid The excretion of Valproic acid can be decreased when combined with Famotidine.
Tamoxifen Tamoxifen The metabolism of Famotidine can be decreased when combined with Tamoxifen.
Levothyroxine Levothyroxine Famotidine can cause a decrease in the absorption of Levothyroxine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Liothyronine Liothyronine The excretion of Famotidine can be decreased when combined with Liothyronine.
Dinoprostone Dinoprostone The excretion of Famotidine can be decreased when combined with Dinoprostone.
Cyclobenzaprine Cyclobenzaprine The metabolism of Cyclobenzaprine can be decreased when combined with Famotidine.
Doxylamine Doxylamine The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Famotidine.
Cyproheptadine Cyproheptadine The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Famotidine.
Clemastine Clemastine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Clemastine.
Chlorpheniramine Chlorpheniramine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of QTc prolongation can be increased when Dexbrompheniramine is combined with Famotidine.
Hydrochlorothiazide Hydrochlorothiazide The excretion of Hydrochlorothiazide can be decreased when combined with Famotidine.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Famotidine.
Disulfiram Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Famotidine.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The risk or severity of QTc prolongation can be increased when Famotidine is combined with Propranolol.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may decrease the sedative and stimulatory activities of Famotidine.
Nortriptyline Nortriptyline The serum concentration of Famotidine can be increased when it is combined with Nortriptyline.
Mercaptopurine Mercaptopurine The excretion of Mercaptopurine can be decreased when combined with Famotidine.
Allopurinol Allopurinol The excretion of Allopurinol can be decreased when combined with Famotidine.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Famotidine.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Papaverine.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Famotidine.
Cefaclor Cefaclor The excretion of Famotidine can be decreased when combined with Cefaclor.
Cefadroxil Cefadroxil The excretion of Famotidine can be decreased when combined with Cefadroxil.
Cefazolin Injection Cefazolin Injection The excretion of Cefazolin can be decreased when combined with Famotidine.
Cephalexin Cephalexin The excretion of Famotidine can be decreased when combined with Cephalexin.
Dacarbazine Dacarbazine The metabolism of Dacarbazine can be decreased when combined with Famotidine.
Cefotaxime Injection Cefotaxime Injection The excretion of Famotidine can be decreased when combined with Cefotaxime.
Iron Supplements Iron Supplements Famotidine can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ketoconazole Ketoconazole Famotidine can cause a decrease in the absorption of Ketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Captopril Captopril Famotidine can cause a decrease in the absorption of Captopril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Famotidine.
Thiothixene Thiothixene The risk or severity of QTc prolongation can be increased when Famotidine is combined with Thiothixene.
Aspirin Aspirin The excretion of Famotidine can be decreased when combined with Acetylsalicylic acid.
Hyoscyamine Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Famotidine.
Diltiazem Diltiazem The risk or severity of QTc prolongation can be increased when Famotidine is combined with Diltiazem.
Nifedipine Nifedipine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Nifedipine.
Timolol Timolol The risk or severity of QTc prolongation can be increased when Timolol is combined with Famotidine.
Verapamil Verapamil The metabolism of Verapamil can be decreased when combined with Famotidine.
Cisplatin Injection Cisplatin Injection The serum concentration of Cisplatin can be increased when it is combined with Famotidine.
Piroxicam Piroxicam The excretion of Famotidine can be decreased when combined with Piroxicam.
Bumetanide Bumetanide The excretion of Famotidine can be decreased when combined with Bumetanide.
Etoposide Etoposide The metabolism of Etoposide can be decreased when combined with Famotidine.
Indapamide Indapamide The risk or severity of QTc prolongation can be increased when Indapamide is combined with Famotidine.
Pentoxifylline Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Famotidine.
Pentamidine Injection Pentamidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Pentamidine.
Ceftriaxone Injection Ceftriaxone Injection The excretion of Famotidine can be decreased when combined with Ceftriaxone.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Leuprolide.
Gemfibrozil Gemfibrozil The excretion of Famotidine can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The metabolism of Guanabenz can be decreased when combined with Famotidine.
Ketoprofen Ketoprofen The excretion of Famotidine can be decreased when combined with Ketoprofen.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Famotidine.
Enalapril Enalapril The excretion of Famotidine can be decreased when combined with Enalapril.
Amiodarone Amiodarone The risk or severity of QTc prolongation can be increased when Famotidine is combined with Amiodarone.
Ciprofloxacin Ciprofloxacin The risk or severity of QTc prolongation can be increased when Famotidine is combined with Ciprofloxacin.
Mesalamine Mesalamine Famotidine can cause a decrease in the absorption of Mesalazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Diclofenac Diclofenac The excretion of Famotidine can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Fluoxetine.
Nimodipine Nimodipine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Nimodipine.
Clozapine Clozapine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Clozapine.
Ofloxacin Ofloxacin The risk or severity of QTc prolongation can be increased when Famotidine is combined with Ofloxacin.
Clarithromycin Clarithromycin The risk or severity of QTc prolongation can be increased when Famotidine is combined with Clarithromycin.
Felodipine Felodipine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Felodipine.
Nabumetone Nabumetone The metabolism of Nabumetone can be decreased when combined with Famotidine.
Pravastatin Pravastatin The excretion of Famotidine can be decreased when combined with Pravastatin.
Quinapril Quinapril The excretion of Quinapril can be decreased when combined with Famotidine.
Itraconazole Itraconazole Famotidine can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sotalol Sotalol The risk or severity of QTc prolongation can be increased when Famotidine is combined with Sotalol.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Famotidine.
Isradipine Isradipine The risk or severity of QTc prolongation can be increased when Isradipine is combined with Famotidine.
Cisapride Cisapride The risk or severity of QTc prolongation can be increased when Famotidine is combined with Cisapride.
Venlafaxine Venlafaxine The risk or severity of QTc prolongation can be increased when Venlafaxine is combined with Famotidine.
Fluvoxamine Fluvoxamine The metabolism of Fluvoxamine can be decreased when combined with Famotidine.
Lamotrigine Lamotrigine The risk or severity of QTc prolongation can be increased when Lamotrigine is combined with Famotidine.
Losartan Losartan The risk or severity of QTc prolongation can be increased when Losartan is combined with Famotidine.
Valacyclovir Valacyclovir The excretion of Valaciclovir can be decreased when combined with Famotidine.
Moexipril Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Famotidine.
Lansoprazole Lansoprazole The excretion of Famotidine can be decreased when combined with Lansoprazole.
Alprostadil Urogenital Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Famotidine.
Nicardipine Nicardipine The risk or severity of QTc prolongation can be increased when Nicardipine is combined with Famotidine.
Saquinavir Saquinavir Famotidine can cause an increase in the absorption of Saquinavir resulting in an increased serum concentration and potentially a worsening of adverse effects.
Metformin Metformin The serum concentration of Metformin can be increased when it is combined with Famotidine.
Lamivudine Lamivudine The serum concentration of Lamivudine can be increased when it is combined with Famotidine.
Riluzole Riluzole The metabolism of Riluzole can be decreased when combined with Famotidine.
Indinavir Indinavir Famotidine can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ritonavir Ritonavir Famotidine can cause a decrease in the absorption of Ritonavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Famotidine.
Mirtazapine Mirtazapine The risk or severity of QTc prolongation can be increased when Mirtazapine is combined with Famotidine.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Famotidine.
Pramipexole Pramipexole The serum concentration of Pramipexole can be increased when it is combined with Famotidine.
Nelfinavir Nelfinavir Famotidine can cause a decrease in the absorption of Nelfinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fexofenadine Fexofenadine The excretion of Fexofenadine can be decreased when combined with Famotidine.
Azithromycin Azithromycin The risk or severity of QTc prolongation can be increased when Famotidine is combined with Azithromycin.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Famotidine.
Flutamide Flutamide The metabolism of Flutamide can be decreased when combined with Famotidine.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Famotidine.
Propafenone Propafenone The risk or severity of QTc prolongation can be increased when Famotidine is combined with Propafenone.
Ropinirole Ropinirole The metabolism of Ropinirole can be decreased when combined with Famotidine.
Quetiapine Quetiapine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Quetiapine.
Cefpodoxime Cefpodoxime Famotidine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cetirizine Cetirizine The risk or severity of QTc prolongation can be increased when Cetirizine is combined with Famotidine.
Paroxetine Paroxetine The metabolism of Paroxetine can be decreased when combined with Famotidine.
Citalopram Citalopram The risk or severity of QTc prolongation can be increased when Famotidine is combined with Citalopram.
Efavirenz Efavirenz The risk or severity of QTc prolongation can be increased when Famotidine is combined with Efavirenz.
Tolterodine Tolterodine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Tolterodine.
Oseltamivir Oseltamivir The excretion of Oseltamivir can be decreased when combined with Famotidine.
Galantamine Galantamine The risk or severity of QTc prolongation can be increased when Galantamine is combined with Famotidine.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Famotidine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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