Irinotecan Injection

Generic name: Pronounced as (ir in oh tee' kan )
Brand names
  • Camptosar®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 04/15/2020

Irinotecan injection must be given under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer.

You may experience the following symptoms while you are receiving a dose of irinotecan or for up to 24 hours afterward: runny nose, increased saliva, shrinking pupils (black circles in the middle of the eyes), watery eyes, sweating, flushing, diarrhea (sometimes called 'early diarrhea'), and stomach cramps. Tell your doctor if you experience any of these symptoms. Your doctor can give you medication to prevent or treat these symptoms.

You may also experience severe diarrhea (sometimes called ''late diarrhea'') more than 24 hours after you receive irinotecan. This type of diarrhea can be life threatening since it can last a long time and lead to dehydration, infection, kidney failure, and other problems. Tell your doctor if you have or have ever had a bowel obstruction (blockage in your intestine). Tell your doctor and pharmacist if you are taking any of the following medications: other chemotherapy medications for cancer; diuretics ('water pills'); or laxatives such as bisacodyl (Dulcolax) or senna (in Correctol, Ex-Lax, Peri-Colace, Senokot).

Before you begin your treatment with irinotecan, talk to your doctor about what to do if you have late diarrhea. Your doctor will probably tell you to keep loperamide (Imodium AD) on hand so that you can begin to take it right away if you develop late diarrhea. Your doctor will probably tell you to take loperamide at regular intervals throughout the day and night. Be sure to follow your doctor's directions for taking loperamide; these will be different than the directions printed on the package label of loperamide. Your doctor will also tell you which foods you should eat and which foods you should avoid to control diarrhea during your treatment. Drink plenty of fluids and follow this diet carefully.

Call your doctor right away the first time you have diarrhea during your treatment. Also call your doctor immediately if you experience any of the following symptoms: fever (temperature higher than 100.4°F); shaking chills; black or bloody stools; diarrhea that does not stop within 24 hours; lightheadedness, dizziness, or fainting; or severe nausea and vomiting that stops you from drinking anything. Your doctor will watch you carefully and may treat you with fluids or antibiotics if needed.

Irinotecan may cause a decrease in the number of blood cells made by your bone marrow. Tell your doctor if you have or have ever had a blood disease or Gilbert's syndrome (decreased ability to break down bilirubin, a natural substance in the body) and if you are being treated with radiation to your stomach or pelvis (area between the hip bones) or if you have ever been treated with this type of radiation. If you experience any of the following symptoms, call your doctor immediately: fever, chills, cough, or other signs of infection; shortness of breath; fast heartbeat; headache; dizziness; pale skin; confusion; extreme tiredness, or unusual bleeding or bruising.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to irinotecan.

Talk to your doctor about the risks of using irinotecan.

Irinotecan is used alone or in combination with other medications to treat colon or rectal cancer (cancer that begins in the large intestine). Irinotecan is in a class of antineoplastic medications called topoisomerase I inhibitors. It works by stopping the growth of cancer cells.

Irinotecan comes as a liquid to be given over 90 minutes intravenously (into a vein) by a doctor or nurse. It is usually given not more often than once a week, according to a schedule that alternates one or more weeks when you receive irinotecan with one or more weeks when you do not receive the medication. Your doctor will choose the schedule that will work best for you.

Your doctor may need to delay your treatment and adjust your dose if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with irinotecan.

Your doctor may give you medication to prevent nausea, vomiting before you receive each dose of irinotecan. Your doctor may also give you other medication(s) to prevent or treat other side effects.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Irinotecan is also sometimes used along with other medications to treat small cell lung cancer. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving irinotecan,

  • tell your doctor and pharmacist if you are allergic to irinotecan, sorbitol, or any other medications.

  • tell your doctor if you are taking ketoconazole (Nizoral). Your doctor will probably tell you not to take ketoconazole for one week before you begin your treatment with irinotecan or during your treatment.

  • tell your doctor if you are taking St. John's wort. You should not take St. John's wort for 2 weeks before you begin your treatment with irinotecan or during your treatment.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Be sure to mention any of the following: atazanavir (Reyataz); gemfibrozil (Lopid); medications for seizures such as carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital (Luminal), phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane, in Rifamate and Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had diabetes; fructose intolerance (inability to digest the natural sugar found in fruit); or liver, lung, or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or plan to father a child. You or your partner should not become pregnant while you are receiving irinotecan. You will need to have a negative pregnancy test before you begin receiving this medication. If you are female, use effective birth control during your treatment and for 6 months after your final dose. If you are a male and your partner can become pregnant, you should use effective birth control (condoms) during your treatment and for 3 months after your final dose. If you or your partner become pregnant while receiving irinotecan, call your doctor. Irinotecan may harm the fetus.

  • tell your doctor if you are breastfeeding. You should not breastfeed while you are receiving irinotecan injection, and for 7 days after your final dose.

  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of receiving irinotecan injection.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving irinotecan.

  • you should know that irinotecan may make you dizzy or affect your vision, especially during the first 24 hours after you receive a dose. Do not drive a car or operate machinery until you know how this medication affects you.

  • talk to your doctor before you receive any vaccinations during your treatment with irinotecan.

Your doctor will tell you about a special diet to follow to help control diarrhea during your treatment. Follow these instructions carefully.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while receiving this medicine.

  • Irinotecan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • constipation

    • swelling and sores in the mouth

    • heartburn

    • loss of appetite

    • weight loss

    • hair loss

    • weakness

    • sleepiness

    • pain, especially back pain

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

    • chest pain

    • yellowing of the skin or eyes

    • swollen stomach

    • unexpected or unusual weight gain

    • swelling of the arms, hands, feet, ankles, or lower legs

    • rash

    • hives

    • itching

    • difficulty breathing or swallowing

  • Some people who received irinotecan developed blood clots in their legs, lungs, brains, or hearts. There is not enough information to tell whether irinotecan caused the blood clots. Talk to your doctor about the risks of receiving irinotecan.

  • Irinotecan may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • sore throat, fever, chills, cough and other signs of infection

  • severe diarrhea

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The excretion of Repaglinide can be decreased when combined with Irinotecan.
Leflunomide Leflunomide The risk or severity of adverse effects can be increased when Irinotecan is combined with Leflunomide.
Delavirdine Delavirdine The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Delavirdine.
Nevirapine Nevirapine The metabolism of Irinotecan can be increased when combined with Nevirapine.
Atorvastatin Atorvastatin The excretion of Atorvastatin can be decreased when combined with Irinotecan.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Irinotecan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Irinotecan.
Clopidogrel Clopidogrel The metabolism of Irinotecan can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Erythromycin can be decreased when combined with Irinotecan.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The excretion of Conjugated estrogens can be decreased when combined with Irinotecan.
Fenofibrate Fenofibrate The metabolism of Irinotecan can be decreased when combined with Fenofibrate.
Methylergonovine Methylergonovine The metabolism of Irinotecan can be decreased when combined with Methylergometrine.
Mycophenolate Mycophenolate The risk or severity of adverse effects can be increased when Irinotecan is combined with Mycophenolic acid.
Prednisone Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Irinotecan.
Reserpine Reserpine The metabolism of Irinotecan can be increased when combined with Reserpine.
Sumatriptan Sumatriptan The excretion of Sumatriptan can be decreased when combined with Irinotecan.
Tacrolimus Tacrolimus Tacrolimus may increase the immunosuppressive activities of Irinotecan.
Triamcinolone Triamcinolone The metabolism of Irinotecan can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Irinotecan can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The metabolism of Irinotecan can be decreased when combined with Fluconazole.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Irinotecan.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Irinotecan.
Meperidine Injection Meperidine Injection The metabolism of Irinotecan can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Methylprednisolone can be increased when combined with Irinotecan.
Metoclopramide Injection Metoclopramide Injection Metoclopramide may increase the neuromuscular blocking activities of Irinotecan.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Irinotecan.
Zidovudine Injection Zidovudine Injection The metabolism of Irinotecan can be increased when combined with Zidovudine.
Cyclosporine Cyclosporine Irinotecan may increase the immunosuppressive activities of Cyclosporine.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Irinotecan.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding can be increased when Enoxaparin is combined with Irinotecan.
Torsemide Torsemide The excretion of Torasemide can be decreased when combined with Irinotecan.
Hydroxychloroquine Hydroxychloroquine The risk or severity of adverse effects can be increased when Irinotecan is combined with Hydroxychloroquine.
Orlistat Orlistat The metabolism of Irinotecan can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Irinotecan can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Temozolomide Temozolomide The risk or severity of adverse effects can be increased when Irinotecan is combined with Temozolomide.
Zaleplon Zaleplon The metabolism of Zaleplon can be decreased when combined with Irinotecan.
Anakinra Anakinra The metabolism of Irinotecan can be increased when combined with Anakinra.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Irinotecan.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Irinotecan.
Rivastigmine Rivastigmine Rivastigmine may increase the neuromuscular blocking activities of Irinotecan.
Trimipramine Trimipramine The metabolism of Irinotecan can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Irinotecan can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Irinotecan can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Irinotecan can be decreased when combined with Tenofovir.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Irinotecan.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Irinotecan.
Epinephrine Injection Epinephrine Injection The metabolism of Irinotecan can be decreased when combined with Epinephrine.
Epirubicin Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Irinotecan.
Eplerenone Eplerenone The metabolism of Irinotecan can be decreased when combined with Eplerenone.
Zonisamide Zonisamide The metabolism of Zonisamide can be decreased when combined with Irinotecan.
Adalimumab Injection Adalimumab Injection The metabolism of Irinotecan can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Irinotecan.
Ezetimibe Ezetimibe The excretion of Ezetimibe can be decreased when combined with Irinotecan.
Glatiramer Injection Glatiramer Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Glatiramer.
Atazanavir Atazanavir The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Atazanavir.
Mefloquine Mefloquine The metabolism of Irinotecan can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Irinotecan.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Irinotecan.
Aprepitant Aprepitant The metabolism of Irinotecan can be decreased when combined with Aprepitant.
Memantine Memantine The metabolism of Irinotecan can be decreased when combined with Memantine.
Tadalafil Tadalafil The metabolism of Tadalafil can be decreased when combined with Irinotecan.
Progesterone Progesterone The metabolism of Irinotecan can be increased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Irinotecan can be decreased when combined with Apomorphine.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Irinotecan.
Infliximab Injection Infliximab Injection The metabolism of Irinotecan can be increased when combined with Infliximab.
Rifaximin Rifaximin The metabolism of Irinotecan can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Irinotecan can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Irinotecan can be decreased when combined with Norethisterone.
Bosentan Bosentan The metabolism of Bosentan can be increased when combined with Irinotecan.
Natalizumab Injection Natalizumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Natalizumab.
Erlotinib Erlotinib The risk or severity of neutropenia can be increased when Erlotinib is combined with Irinotecan.
Palifermin Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Irinotecan.
Voriconazole Voriconazole The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Voriconazole.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Irinotecan.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Irinotecan.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Irinotecan.
Deferasirox Deferasirox The risk or severity of neutropenia can be increased when Deferasirox is combined with Irinotecan.
Tipranavir Tipranavir The serum concentration of SN-38, an active metabolite of Tipranavir, can be increased when used in combination with Irinotecan.
Felbamate Felbamate The metabolism of Irinotecan can be increased when combined with Felbamate.
Ranolazine Ranolazine The metabolism of Irinotecan can be decreased when combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Irinotecan can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Irinotecan can be decreased when combined with Imatinib.
Bevacizumab Injection Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Irinotecan.
Gefitinib Gefitinib The metabolism of Irinotecan can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The metabolism of Paliperidone can be decreased when combined with Irinotecan.
Bortezomib Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Irinotecan.
Clofarabine Injection Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Irinotecan.
Hepatitis B Vaccine Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Irinotecan.
Influenza Vaccine, Inactivated or Recombinant Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Irinotecan.
Influenza Vaccine, Live Intranasal Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Irinotecan.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Irinotecan.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Irinotecan.
Posaconazole Posaconazole The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Posaconazole.
Primaquine Primaquine The metabolism of Irinotecan can be decreased when combined with Primaquine.
Rituximab Injection Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Irinotecan.
Darunavir Darunavir The serum concentration of SN-38, an active metabolite of Darunavir, can be increased when used in combination with Irinotecan.
Pemetrexed Injection Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Irinotecan.
Vorinostat Vorinostat The risk or severity of adverse effects can be increased when Irinotecan is combined with Vorinostat.
Sorafenib Sorafenib The risk or severity of neutropenia can be increased when Sorafenib is combined with Irinotecan.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Irinotecan.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Irinotecan.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Irinotecan.
Mexiletine Mexiletine The metabolism of Irinotecan can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Irinotecan can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Azacitidine.
Ivermectin Ivermectin The metabolism of Irinotecan can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Irinotecan.
Nelarabine Injection Nelarabine Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Nelarabine.
Lenalidomide Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Irinotecan.
Nilotinib Nilotinib The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Nilotinib.
Bexarotene Bexarotene The metabolism of Irinotecan can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Irinotecan can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Irinotecan can be decreased when combined with Chloramphenicol.
Decitabine Injection Decitabine Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Decitabine.
Betaine Betaine Glycine betaine may increase the neuromuscular blocking activities of Irinotecan.
Etravirine Etravirine The metabolism of Irinotecan can be increased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Arsenic trioxide.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Mitoxantrone can be decreased when combined with Irinotecan.
Desvenlafaxine Desvenlafaxine The metabolism of Irinotecan can be decreased when combined with Desvenlafaxine.
Tretinoin Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Irinotecan.
Bendamustine Injection Bendamustine Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Bendamustine.
Pilocarpine Pilocarpine The metabolism of Irinotecan can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Irinotecan can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Ixabepilone.
Estramustine Estramustine The risk or severity of adverse effects can be increased when Irinotecan is combined with Estramustine.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Irinotecan.
Mitotane Mitotane The metabolism of Irinotecan can be increased when combined with Mitotane.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Irinotecan.
Rufinamide Rufinamide The metabolism of Irinotecan can be increased when combined with Rufinamide.
Midazolam Midazolam The metabolism of Irinotecan can be decreased when combined with Midazolam.
Dexrazoxane Injection Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Irinotecan.
Eltrombopag Eltrombopag The risk or severity of neutropenia can be increased when Eltrombopag is combined with Irinotecan.
Ibritumomab Injection Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Irinotecan.
Milnacipran Milnacipran The metabolism of Irinotecan can be decreased when combined with Milnacipran.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Irinotecan.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Irinotecan.
Lacosamide Lacosamide The metabolism of Irinotecan can be decreased when combined with Lacosamide.
Everolimus Everolimus The risk or severity of adverse effects can be increased when Irinotecan is combined with Everolimus.
Dronedarone Dronedarone The metabolism of Irinotecan can be decreased when combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Pralatrexate.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Irinotecan.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Irinotecan.
Topotecan Topotecan The metabolism of Topotecan can be increased when combined with Irinotecan.
Golimumab Injection Golimumab Injection The metabolism of Irinotecan can be increased when combined with Golimumab.
Pazopanib Pazopanib The risk or severity of neutropenia can be increased when Pazopanib is combined with Irinotecan.
Pitavastatin Pitavastatin The excretion of Pitavastatin can be decreased when combined with Irinotecan.
Albendazole Albendazole The metabolism of Irinotecan can be decreased when combined with Albendazole.
Levonorgestrel Levonorgestrel The metabolism of Irinotecan can be decreased when combined with Levonorgestrel.
Denosumab Injection Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Irinotecan.
Dabigatran Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Irinotecan.
Tocilizumab Injection Tocilizumab Injection The metabolism of Irinotecan can be increased when combined with Tocilizumab.
Fingolimod Fingolimod Irinotecan may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Eribulin.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Irinotecan.
Acetaminophen Injection Acetaminophen Injection The metabolism of Irinotecan can be increased when combined with Acetaminophen.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Irinotecan can be decreased when combined with Aldesleukin.
Sipuleucel-T Injection Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Irinotecan.
Terbutaline Injection Terbutaline Injection Terbutaline may increase the neuromuscular blocking activities of Irinotecan.
Belimumab Injection Belimumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Belimumab.
Busulfan Injection Busulfan Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Busulfan.
Roflumilast Roflumilast Roflumilast may increase the immunosuppressive activities of Irinotecan.
Linagliptin Linagliptin The metabolism of Irinotecan can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Rilpivirine can be decreased when combined with Irinotecan.
Telaprevir Telaprevir The risk or severity of neutropenia can be increased when Glecaprevir is combined with Irinotecan.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Irinotecan can be increased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Irinotecan.
Ticagrelor Ticagrelor The metabolism of Irinotecan can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Irinotecan.
Ruxolitinib Ruxolitinib The risk or severity of adverse effects can be increased when Irinotecan is combined with Ruxolitinib.
Vandetanib Vandetanib Vandetanib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Clobazam Clobazam The metabolism of Irinotecan can be increased when combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Irinotecan can be increased when combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Belatacept Injection Belatacept Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Belatacept.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Irinotecan.
Basiliximab Injection Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Irinotecan.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Irinotecan.
Crizotinib Crizotinib The metabolism of Irinotecan can be decreased when combined with Crizotinib.
Melphalan Injection Melphalan Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Melphalan.
Cabergoline Cabergoline The metabolism of Irinotecan can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Naloxone.
Ambrisentan Ambrisentan The excretion of Ambrisentan can be decreased when combined with Irinotecan.
Eculizumab Injection Eculizumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Eculizumab.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding can be increased when Fondaparinux is combined with Irinotecan.
Carfilzomib Injection Carfilzomib Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Carfilzomib.
Iloprost Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Irinotecan.
Enzalutamide Enzalutamide The metabolism of Irinotecan can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Irinotecan.
Regorafenib Regorafenib The risk or severity of neutropenia can be increased when Regorafenib is combined with Irinotecan.
Bosutinib Bosutinib The metabolism of Bosutinib can be decreased when combined with Irinotecan.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Corticotropin can be increased when combined with Irinotecan.
Teriflunomide Teriflunomide The risk or severity of adverse effects can be increased when Irinotecan is combined with Teriflunomide.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Irinotecan.
Tofacitinib Tofacitinib Irinotecan may increase the immunosuppressive activities of Tofacitinib.
Dimethyl Fumarate Dimethyl Fumarate The risk or severity of adverse effects can be increased when Irinotecan is combined with Dimethyl fumarate.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Irinotecan.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Irinotecan is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Irinotecan.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Irinotecan.
Dabrafenib Dabrafenib The metabolism of Irinotecan can be increased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Irinotecan.
Trametinib Trametinib The metabolism of Irinotecan can be increased when combined with Trametinib.
Afatinib Afatinib Afatinib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Irinotecan.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Irinotecan.
Ibrutinib Ibrutinib The risk or severity of adverse effects can be increased when Irinotecan is combined with Ibrutinib.
Lomitapide Lomitapide The metabolism of Irinotecan can be decreased when combined with Lomitapide.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Obinutuzumab.
Simeprevir Simeprevir The metabolism of Irinotecan can be decreased when combined with Simeprevir.
Apremilast Apremilast The metabolism of Irinotecan can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Irinotecan can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Irinotecan can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Irinotecan can be increased when combined with Eslicarbazepine.
Vedolizumab Injection Vedolizumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Vedolizumab.
Belinostat Injection Belinostat Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Belinostat.
Idelalisib Idelalisib The risk or severity of adverse effects can be increased when Irinotecan is combined with Idelalisib.
Testosterone Injection Testosterone Injection The metabolism of Irinotecan can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Irinotecan can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Irinotecan can be decreased when combined with Vorapaxar.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Irinotecan.
Suvorexant Suvorexant The metabolism of Irinotecan can be decreased when combined with Suvorexant.
Edoxaban Edoxaban The risk or severity of bleeding can be increased when Edoxaban is combined with Irinotecan.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Irinotecan.
Blinatumomab Injection Blinatumomab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Blinatumomab.
Caspofungin Injection Caspofungin Injection The excretion of Caspofungin can be decreased when combined with Irinotecan.
Tasimelteon Tasimelteon The metabolism of Irinotecan can be decreased when combined with Tasimelteon.
Lanreotide Injection Lanreotide Injection The metabolism of Irinotecan can be decreased when combined with Lanreotide.
Pirfenidone Pirfenidone The risk or severity of adverse effects can be increased when Irinotecan is combined with Pirfenidone.
Nintedanib Nintedanib The metabolism of Irinotecan can be decreased when combined with Nintedanib.
Secukinumab Injection Secukinumab Injection The metabolism of Irinotecan can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Irinotecan can be decreased when combined with Risperidone.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Irinotecan.
Lenvatinib Lenvatinib The metabolism of Irinotecan can be increased when combined with Lenvatinib.
Panobinostat Panobinostat The risk or severity of adverse effects can be increased when Irinotecan is combined with Panobinostat.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Dinutuximab.
Haloperidol Injection Haloperidol Injection The serum concentration of Irinotecan can be increased when it is combined with Haloperidol.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Irinotecan can be increased when combined with Isavuconazonium.
Rolapitant Rolapitant Rolapitant may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Prednisolone Prednisolone The metabolism of Prednisolone can be increased when combined with Irinotecan.
Daclatasvir Daclatasvir Daclatasvir may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Ziprasidone Injection Ziprasidone Injection The metabolism of Irinotecan can be decreased when combined with Ziprasidone.
Eluxadoline Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Irinotecan.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Irinotecan.
Mepolizumab Injection Mepolizumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Mepolizumab.
Trabectedin Injection Trabectedin Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Trabectedin.
Osimertinib Osimertinib The metabolism of Irinotecan can be increased when combined with Osimertinib.
Alectinib Alectinib Alectinib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Irinotecan can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Irinotecan can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Irinotecan can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Irinotecan can be increased when combined with Dexamethasone.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Irinotecan.
Ixekizumab Injection Ixekizumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Ixekizumab.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Irinotecan.
Venetoclax Venetoclax The metabolism of Irinotecan can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Cobicistat.
Selexipag Selexipag The excretion of Selexipag can be decreased when combined with Irinotecan.
Rucaparib Rucaparib The risk or severity of neutropenia can be increased when Rucaparib is combined with Irinotecan.
Ribociclib Ribociclib The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Ribociclib.
Brodalumab Injection Brodalumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Brodalumab.
Brigatinib Brigatinib The metabolism of Irinotecan can be increased when combined with Brigatinib.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Irinotecan.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Irinotecan.
Deflazacort Deflazacort The metabolism of Deflazacort can be increased when combined with Irinotecan.
Safinamide Safinamide Safinamide may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Ocrelizumab Injection Ocrelizumab Injection Ocrelizumab may increase the immunosuppressive activities of Irinotecan.
Sarilumab Injection Sarilumab Injection The metabolism of Sarilumab can be increased when combined with Irinotecan.
Midostaurin Midostaurin The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Midostaurin.
Guselkumab Injection Guselkumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Guselkumab.
Enasidenib Enasidenib The risk or severity of neutropenia can be increased when Enasidenib is combined with Irinotecan.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Irinotecan can be increased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Irinotecan.
Abemaciclib Abemaciclib Abemaciclib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Irinotecan.
Acalabrutinib Acalabrutinib The metabolism of Irinotecan can be decreased when combined with Acalabrutinib.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Irinotecan.
Letermovir Letermovir The metabolism of Irinotecan can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin The risk or severity of neutropenia can be increased when Ertugliflozin is combined with Irinotecan.
Buprenorphine Injection Buprenorphine Injection The metabolism of Irinotecan can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Irinotecan can be increased when combined with Apalutamide.
Penicillamine Penicillamine The risk or severity of adverse effects can be increased when Irinotecan is combined with Penicillamine.
Fostamatinib Fostamatinib The risk or severity of neutropenia can be increased when Fostamatinib is combined with Irinotecan.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Baricitinib Baricitinib The risk or severity of adverse effects can be increased when Irinotecan is combined with Baricitinib.
Ivosidenib Ivosidenib The metabolism of Irinotecan can be increased when combined with Ivosidenib.
Elagolix Elagolix The excretion of Elagolix can be decreased when combined with Irinotecan.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Irinotecan.
Cannabidiol Cannabidiol Cannabidiol may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Dacomitinib Dacomitinib The risk or severity of neutropenia can be increased when Dacomitinib is combined with Irinotecan.
Duvelisib Duvelisib The metabolism of Irinotecan can be decreased when combined with Duvelisib.
Stiripentol Stiripentol The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Stiripentol.
Gilteritinib Gilteritinib The metabolism of Irinotecan can be decreased when combined with Gilteritinib.
Glasdegib Glasdegib Glasdegib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be increased when combined with Irinotecan.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Irinotecan.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Irinotecan.
Rifamycin Rifamycin The metabolism of Irinotecan can be increased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Irinotecan can be decreased when combined with Prucalopride.
Ravulizumab-cwvz Injection Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Ravulizumab.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Irinotecan can be increased when combined with Emapalumab.
Siponimod Siponimod The risk or severity of adverse effects can be increased when Irinotecan is combined with Siponimod.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Irinotecan.
Risankizumab-rzaa Injection Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Risankizumab.
Alpelisib Alpelisib The metabolism of Irinotecan can be increased when combined with Alpelisib.
Cladribine Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Irinotecan.
Darolutamide Darolutamide Darolutamide may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Triclabendazole Triclabendazole The metabolism of Irinotecan can be decreased when combined with Triclabendazole.
Pexidartinib Pexidartinib The risk or severity of neutropenia can be increased when Pexidartinib is combined with Irinotecan.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Irinotecan.
Pitolisant Pitolisant The serum concentration of Irinotecan can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib Fedratinib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Lefamulin Lefamulin The serum concentration of Irinotecan can be increased when it is combined with Lefamulin.
Phenytoin Injection Phenytoin Injection The metabolism of Irinotecan can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Irinotecan can be increased when combined with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Irinotecan.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Irinotecan.
Lasmiditan Lasmiditan The serum concentration of Irinotecan can be increased when it is combined with Lasmiditan.
Tazemetostat Tazemetostat The metabolism of Irinotecan can be decreased when combined with Tazemetostat.
Cenobamate Cenobamate The serum concentration of Irinotecan can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The risk or severity of adverse effects can be increased when Irinotecan is combined with Ozanimod.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Irinotecan.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Irinotecan.
Remdesivir Injection Remdesivir Injection The excretion of Remdesivir can be decreased when combined with Irinotecan.
Ripretinib Ripretinib Ripretinib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Capmatinib Capmatinib The serum concentration of Irinotecan can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Irinotecan can be decreased when it is combined with Lemborexant.
Fostemsavir Fostemsavir Fostemsavir may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Octreotide Octreotide The serum concentration of Irinotecan can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The excretion of Belantamab mafodotin can be decreased when combined with Irinotecan.
Pralsetinib Pralsetinib The metabolism of Irinotecan can be increased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Irinotecan can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Irinotecan can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Irinotecan can be increased when combined with Vitamin E.
Indomethacin Indomethacin The risk or severity of neutropenia can be increased when Indomethacin is combined with Irinotecan.
Mefenamic Acid Mefenamic Acid The metabolism of Irinotecan can be decreased when combined with Mefenamic acid.
Trazodone Trazodone The metabolism of Irinotecan can be decreased when combined with Trazodone.
Hydroxyurea Hydroxyurea The risk or severity of adverse effects can be increased when Irinotecan is combined with Hydroxyurea.
Floxuridine Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Irinotecan.
Phenobarbital Phenobarbital The metabolism of Irinotecan can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The risk or severity of adverse effects can be increased when Methotrexate is combined with Irinotecan.
Primidone Primidone The metabolism of Irinotecan can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Irinotecan can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Irinotecan.
Lorazepam Lorazepam The metabolism of Irinotecan can be decreased when combined with Lorazepam.
Carmustine Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Irinotecan.
Bromocriptine Bromocriptine The metabolism of Irinotecan can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Irinotecan can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Irinotecan can be decreased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Irinotecan is combined with Procarbazine.
Tetracycline Tetracycline The metabolism of Irinotecan can be decreased when combined with Tetracycline.
Thioguanine Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Irinotecan.
Prochlorperazine Prochlorperazine The metabolism of Irinotecan can be decreased when combined with Prochlorperazine.
Bleomycin Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Irinotecan.
Dapsone Dapsone The metabolism of Irinotecan can be decreased when combined with Dapsone.
Oxycodone Oxycodone The metabolism of Irinotecan can be decreased when combined with Oxycodone.
Methadone Methadone The metabolism of Irinotecan can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Irinotecan.
Orphenadrine Orphenadrine The metabolism of Irinotecan can be decreased when combined with Orphenadrine.
Azathioprine Azathioprine The risk or severity of adverse effects can be increased when Irinotecan is combined with Azathioprine.
Phentermine Phentermine The metabolism of Irinotecan can be decreased when combined with Phentermine.
Sulfasalazine Sulfasalazine The risk or severity of adverse effects can be increased when Irinotecan is combined with Sulfasalazine.
Hydrocortisone Hydrocortisone The metabolism of Irinotecan can be increased when combined with Hydrocortisone.
Lomustine Lomustine The risk or severity of adverse effects can be increased when Irinotecan is combined with Lomustine.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be decreased when combined with Irinotecan.
Cytarabine Cytarabine The risk or severity of adverse effects can be increased when Irinotecan is combined with Cytarabine.
Mechlorethamine Mechlorethamine The risk or severity of adverse effects can be increased when Irinotecan is combined with Mechlorethamine.
Dactinomycin Dactinomycin The risk or severity of adverse effects can be increased when Irinotecan is combined with Dactinomycin.
Pyridostigmine Pyridostigmine Pyridostigmine may increase the neuromuscular blocking activities of Irinotecan.
Carbamazepine Carbamazepine The metabolism of Irinotecan can be increased when combined with Carbamazepine.
Clonidine Clonidine The metabolism of Irinotecan can be decreased when combined with Clonidine.
Hydralazine Hydralazine The metabolism of Irinotecan can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Irinotecan can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Irinotecan can be increased when combined with Warfarin.
Loperamide Loperamide The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Loperamide.
Promethazine Promethazine The metabolism of Promethazine can be decreased when combined with Irinotecan.
Daunorubicin Daunorubicin The metabolism of Irinotecan can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Irinotecan can be increased when combined with Griseofulvin.
Digoxin Digoxin The excretion of Digoxin can be decreased when combined with Irinotecan.
Chloroquine Chloroquine The metabolism of Irinotecan can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Irinotecan can be increased when combined with Quinine.
Calcitriol Calcitriol The metabolism of Irinotecan can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Irinotecan can be increased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Chlorothiazide is combined with Irinotecan.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Irinotecan.
Secobarbital Secobarbital The metabolism of Irinotecan can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Irinotecan.
Amitriptyline Amitriptyline The risk or severity of neutropenia can be increased when Amitriptyline is combined with Irinotecan.
Imipramine Imipramine The metabolism of Irinotecan can be decreased when combined with Imipramine.
Probenecid Probenecid The risk or severity of neutropenia can be increased when Probenecid is combined with Irinotecan.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Irinotecan.
Procainamide Procainamide Procainamide may increase the neuromuscular blocking activities of Irinotecan.
Isoniazid Isoniazid The metabolism of Irinotecan can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Irinotecan can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The risk or severity of neutropenia can be increased when Valproic acid is combined with Irinotecan.
Tamoxifen Tamoxifen The metabolism of Irinotecan can be decreased when combined with Tamoxifen.
Mitomycin Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Irinotecan.
Liothyronine Liothyronine The excretion of Liothyronine can be decreased when combined with Irinotecan.
Methimazole Methimazole The serum concentration of SN-38, an active metabolite of Methimazole, can be increased when used in combination with Irinotecan.
Propylthiouracil Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Irinotecan.
Dextromethorphan Dextromethorphan The metabolism of Irinotecan can be decreased when combined with Dextromethorphan.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Irinotecan.
Niacin Niacin The metabolism of Irinotecan can be decreased when combined with Niacin.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Irinotecan.
Brompheniramine Brompheniramine The metabolism of Brompheniramine can be decreased when combined with Irinotecan.
Methyclothiazide Methyclothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Methyclothiazide is combined with Irinotecan.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Irinotecan.
Danazol Danazol The metabolism of Irinotecan can be decreased when combined with Danazol.
Disulfiram Disulfiram The metabolism of Disulfiram can be decreased when combined with Irinotecan.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Irinotecan can be decreased when combined with Propranolol.
Amphotericin B Injection Amphotericin B Injection The metabolism of Irinotecan can be decreased when combined with Amphotericin B.
Mercaptopurine Mercaptopurine The risk or severity of adverse effects can be increased when Irinotecan is combined with Mercaptopurine.
Allopurinol Allopurinol The risk or severity of adverse effects can be increased when Allopurinol is combined with Irinotecan.
Fluorouracil Injection Fluorouracil Injection The risk or severity of adverse effects can be increased when Fluorouracil is combined with Irinotecan.
Colchicine Colchicine The metabolism of Irinotecan can be increased when combined with Colchicine.
Cephalexin Cephalexin The metabolism of Irinotecan can be decreased when combined with Cephalexin.
Dacarbazine Dacarbazine The risk or severity of adverse effects can be increased when Irinotecan is combined with Dacarbazine.
Acetazolamide Acetazolamide The metabolism of Irinotecan can be decreased when combined with Acetazolamide.
Bacillus Calmette-Guerin (BCG) Vaccine Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Irinotecan.
Ketoconazole Ketoconazole The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Ketoconazole.
Thiotepa Injection Thiotepa Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Thiotepa.
Vincristine Injection Vincristine Injection The metabolism of Irinotecan can be decreased when combined with Vincristine.
Dipyridamole Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Irinotecan.
Vinblastine Vinblastine The metabolism of Irinotecan can be increased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Irinotecan can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine The metabolism of Irinotecan can be decreased when combined with Hydroxyzine.
Aspirin Aspirin The risk or severity of bleeding can be increased when Acetylsalicylic acid is combined with Irinotecan.
Chlorambucil Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Irinotecan.
Alprazolam Alprazolam The metabolism of Irinotecan can be decreased when combined with Alprazolam.
Triazolam Triazolam The metabolism of Triazolam can be decreased when combined with Irinotecan.
Diltiazem Diltiazem The metabolism of Irinotecan can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Nifedipine can be increased when combined with Irinotecan.
Verapamil Verapamil The metabolism of Irinotecan can be decreased when combined with Verapamil.
Cisplatin Injection Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Irinotecan.
Diflunisal Diflunisal The metabolism of Irinotecan can be decreased when combined with Diflunisal.
Streptozocin Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Irinotecan.
Etoposide Etoposide The metabolism of Etoposide can be decreased when combined with Irinotecan.
Glyburide Glyburide The metabolism of Glyburide can be decreased when combined with Irinotecan.
Dicloxacillin Dicloxacillin The metabolism of Irinotecan can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Irinotecan can be increased when combined with Nafcillin.
Pentoxifylline Pentoxifylline The risk or severity of bleeding can be increased when Pentoxifylline is combined with Irinotecan.
Pentamidine Injection Pentamidine Injection The metabolism of Irinotecan can be decreased when combined with Pentamidine.
Gemfibrozil Gemfibrozil The risk or severity of neutropenia can be increased when Gemfibrozil is combined with Irinotecan.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Irinotecan.
Enalapril Enalapril The excretion of Enalapril can be decreased when combined with Irinotecan.
Flurbiprofen Flurbiprofen The risk or severity of neutropenia can be increased when Flurbiprofen is combined with Irinotecan.
Amiodarone Amiodarone The metabolism of Irinotecan can be decreased when combined with Amiodarone.
Buspirone Buspirone The metabolism of Irinotecan can be decreased when combined with Buspirone.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Irinotecan.
Ciprofloxacin Ciprofloxacin The metabolism of Irinotecan can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Irinotecan can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The metabolism of Irinotecan can be decreased when combined with Fluoxetine.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Irinotecan.
Clozapine Clozapine The risk or severity of neutropenia can be increased when Irinotecan is combined with Clozapine.
Idarubicin Idarubicin The risk or severity of adverse effects can be increased when Irinotecan is combined with Idarubicin.
Fludarabine Injection Fludarabine Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Fludarabine.
Pentostatin Injection Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Irinotecan.
Clarithromycin Clarithromycin The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Clarithromycin.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Irinotecan.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Simvastatin can be increased when combined with Irinotecan.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Irinotecan.
Teniposide Injection Teniposide Injection The metabolism of Irinotecan can be decreased when combined with Teniposide.
Itraconazole Itraconazole The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Itraconazole.
Rifabutin Rifabutin The metabolism of Irinotecan can be increased when combined with Rifabutin.
Doxazosin Doxazosin The metabolism of Irinotecan can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Irinotecan can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Irinotecan can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Irinotecan can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Irinotecan can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may increase the excretion rate of Irinotecan which could result in a lower serum level and potentially a reduction in efficacy.
Nizatidine Nizatidine Nizatidine may increase the neuromuscular blocking activities of Irinotecan.
Famciclovir Famciclovir The metabolism of Irinotecan can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Irinotecan can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Nefazodone.
Lamotrigine Lamotrigine The metabolism of Irinotecan can be increased when combined with Lamotrigine.
Losartan Losartan The metabolism of Irinotecan can be decreased when combined with Losartan.
Tramadol Tramadol The metabolism of Irinotecan can be decreased when combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The risk or severity of adverse effects can be increased when Vinorelbine is combined with Irinotecan.
Carboplatin Injection Carboplatin Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Carboplatin.
Lansoprazole Lansoprazole The metabolism of Irinotecan can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Irinotecan.
Pegaspargase Injection Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Irinotecan.
Nicardipine Nicardipine The metabolism of Irinotecan can be decreased when combined with Nicardipine.
Bupropion Bupropion The metabolism of Bupropion can be decreased when combined with Irinotecan.
Ticlopidine Ticlopidine The metabolism of Irinotecan can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The serum concentration of SN-38, an active metabolite of Saquinavir, can be increased when used in combination with Irinotecan.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding can be increased when Dalteparin is combined with Irinotecan.
Nisoldipine Nisoldipine The metabolism of Irinotecan can be decreased when combined with Nisoldipine.
Gemcitabine Injection Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Irinotecan.
Indinavir Indinavir The risk or severity of neutropenia can be increased when Irinotecan is combined with Indinavir.
Ritonavir Ritonavir The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Irinotecan.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Irinotecan.
Zafirlukast Zafirlukast The metabolism of Irinotecan can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Irinotecan can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Irinotecan can be increased when combined with Topiramate.
Valsartan Valsartan The excretion of Valsartan can be decreased when combined with Irinotecan.
Donepezil Donepezil Donepezil may increase the neuromuscular blocking activities of Irinotecan.
Nelfinavir Nelfinavir The metabolism of Irinotecan can be increased when combined with Nelfinavir.
Fexofenadine Fexofenadine The excretion of Fexofenadine can be decreased when combined with Irinotecan.
Azithromycin Azithromycin The metabolism of Irinotecan can be decreased when combined with Azithromycin.
Flutamide Flutamide The metabolism of Irinotecan can be decreased when combined with Flutamide.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Irinotecan.
Bicalutamide Bicalutamide The metabolism of Irinotecan can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Irinotecan can be decreased when combined with Sertraline.
Raloxifene Raloxifene The metabolism of Irinotecan can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Irinotecan can be decreased when combined with Irbesartan.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Irinotecan.
Quetiapine Quetiapine The metabolism of Quetiapine can be decreased when combined with Irinotecan.
Paroxetine Paroxetine The metabolism of Irinotecan can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Irinotecan can be decreased when combined with Citalopram.
Capecitabine Capecitabine The risk or severity of adverse effects can be increased when Irinotecan is combined with Capecitabine.
Efavirenz Efavirenz The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Efavirenz.
Sildenafil Sildenafil The metabolism of Irinotecan can be decreased when combined with Sildenafil.
Trastuzumab Injection Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Irinotecan.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Irinotecan is combined with Thalidomide.
Nateglinide Nateglinide The metabolism of Irinotecan can be decreased when combined with Nateglinide.
Galantamine Galantamine Galantamine may increase the neuromuscular blocking activities of Irinotecan.
Rabeprazole Rabeprazole The metabolism of Irinotecan can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Irinotecan can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists