Irinotecan Injection

Irinotecan is used alone or in combination with other medications to treat colon or rectal cancer (cancer that begins in the large intestine). Irinotecan is in a class of antineoplastic medications called topoisomerase I inhibitors. It works by stopping the growth of cancer cells.

Irinotecan comes as a liquid to be given over 90 minutes intravenously (into a vein) by a doctor or nurse. It is usually given not more often than once a week, according to a schedule that alternates one or more weeks when you receive irinotecan with one or more weeks when you do not receive the medication. Your doctor will choose the schedule that will work best for you.

Your doctor may need to delay your treatment and adjust your dose if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with irinotecan.

Your doctor may give you medication to prevent nausea, vomiting before you receive each dose of irinotecan. Your doctor may also give you other medication(s) to prevent or treat other side effects.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Irinotecan is also sometimes used along with other medications to treat small cell lung cancer. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving irinotecan,

• tell your doctor and pharmacist if you are allergic to irinotecan, sorbitol, or any other medications.

• tell your doctor if you are taking ketoconazole (Nizoral). Your doctor will probably tell you not to take ketoconazole for one week before you begin your treatment with irinotecan or during your treatment.

• tell your doctor if you are taking St. John's wort. You should not take St. John's wort for 2 weeks before you begin your treatment with irinotecan or during your treatment.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Be sure to mention any of the following: atazanavir (Reyataz); gemfibrozil (Lopid); medications for seizures such as carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital (Luminal), phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane, in Rifamate and Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor if you have or have ever had diabetes; fructose intolerance (inability to digest the natural sugar found in fruit); or liver, lung, or kidney disease.

• tell your doctor if you are pregnant, plan to become pregnant, or plan to father a child. You or your partner should not become pregnant while you are receiving irinotecan. You will need to have a negative pregnancy test before you begin receiving this medication. If you are female, use effective birth control during your treatment and for 6 months after your final dose. If you are a male and your partner can become pregnant, you should use effective birth control (condoms) during your treatment and for 3 months after your final dose. If you or your partner become pregnant while receiving irinotecan, call your doctor. Irinotecan may harm the fetus.

• tell your doctor if you are breastfeeding. You should not breastfeed while you are receiving irinotecan injection, and for 7 days after your final dose.

• you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of receiving irinotecan injection.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving irinotecan.

• you should know that irinotecan may make you dizzy or affect your vision, especially during the first 24 hours after you receive a dose. Do not drive a car or operate machinery until you know how this medication affects you.

• talk to your doctor before you receive any vaccinations during your treatment with irinotecan.

Your doctor will tell you about a special diet to follow to help control diarrhea during your treatment. Follow these instructions carefully.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while receiving this medicine.

• Irinotecan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea

  • vomiting

  • constipation

  • swelling and sores in the mouth

  • heartburn

  • loss of appetite

  • weight loss

  • hair loss

  • weakness

  • sleepiness

  • pain, especially back pain

• Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

  • chest pain

  • yellowing of the skin or eyes

  • swollen stomach

  • unexpected or unusual weight gain

  • swelling of the arms, hands, feet, ankles, or lower legs

  • rash

  • hives

  • itching

  • difficulty breathing or swallowing

• Some people who received irinotecan developed blood clots in their legs, lungs, brains, or hearts. There is not enough information to tell whether irinotecan caused the blood clots. Talk to your doctor about the risks of receiving irinotecan.

• Irinotecan may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• sore throat, fever, chills, cough and other signs of infection

• severe diarrhea

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

• CPT-11

Drug	Interaction
Repaglinide	Repaglinide The excretion of Repaglinide can be decreased when combined with Irinotecan.
Leflunomide	Leflunomide The risk or severity of adverse effects can be increased when Irinotecan is combined with Leflunomide.
Delavirdine	Delavirdine The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Delavirdine.
Nevirapine	Nevirapine The metabolism of Irinotecan can be increased when combined with Nevirapine.
Atorvastatin	Atorvastatin The excretion of Atorvastatin can be decreased when combined with Irinotecan.
Anagrelide	Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Irinotecan.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Irinotecan.
Clopidogrel	Clopidogrel The metabolism of Irinotecan can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The metabolism of Erythromycin can be decreased when combined with Irinotecan.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) The excretion of Conjugated estrogens can be decreased when combined with Irinotecan.
Fenofibrate	Fenofibrate The metabolism of Irinotecan can be decreased when combined with Fenofibrate.
Methylergonovine	Methylergonovine The metabolism of Irinotecan can be decreased when combined with Methylergometrine.
Mycophenolate	Mycophenolate The risk or severity of adverse effects can be increased when Irinotecan is combined with Mycophenolic acid.
Prednisone	Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Irinotecan.
Reserpine	Reserpine The metabolism of Irinotecan can be increased when combined with Reserpine.
Sumatriptan	Sumatriptan The excretion of Sumatriptan can be decreased when combined with Irinotecan.
Tacrolimus	Tacrolimus Tacrolimus may increase the immunosuppressive activities of Irinotecan.
Triamcinolone	Triamcinolone The metabolism of Irinotecan can be increased when combined with Triamcinolone.
Doxycycline Injection	Doxycycline Injection The metabolism of Irinotecan can be decreased when combined with Doxycycline.
Fluconazole Injection	Fluconazole Injection The metabolism of Irinotecan can be decreased when combined with Fluconazole.
Interferon Beta-1b Injection	Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Irinotecan.
Interferon Gamma-1b Injection	Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Irinotecan.
Meperidine Injection	Meperidine Injection The metabolism of Irinotecan can be increased when combined with Meperidine.
Methylprednisolone Injection	Methylprednisolone Injection The metabolism of Methylprednisolone can be increased when combined with Irinotecan.
Metoclopramide Injection	Metoclopramide Injection Metoclopramide may increase the neuromuscular blocking activities of Irinotecan.
Metronidazole Injection	Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Irinotecan.
Zidovudine Injection	Zidovudine Injection The metabolism of Irinotecan can be increased when combined with Zidovudine.
Cyclosporine	Cyclosporine Irinotecan may increase the immunosuppressive activities of Cyclosporine.
Ondansetron	Ondansetron The metabolism of Ondansetron can be decreased when combined with Irinotecan.
Enoxaparin Injection	Enoxaparin Injection The risk or severity of bleeding can be increased when Enoxaparin is combined with Irinotecan.
Torsemide	Torsemide The excretion of Torasemide can be decreased when combined with Irinotecan.
Hydroxychloroquine	Hydroxychloroquine The risk or severity of adverse effects can be increased when Irinotecan is combined with Hydroxychloroquine.
Orlistat	Orlistat The metabolism of Irinotecan can be increased when combined with Orlistat.
Oxcarbazepine	Oxcarbazepine The metabolism of Irinotecan can be increased when combined with Oxcarbazepine.
Pantoprazole	Pantoprazole Pantoprazole may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Telmisartan	Telmisartan Telmisartan may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Temozolomide	Temozolomide The risk or severity of adverse effects can be increased when Irinotecan is combined with Temozolomide.
Zaleplon	Zaleplon The metabolism of Zaleplon can be decreased when combined with Irinotecan.
Anakinra	Anakinra The metabolism of Irinotecan can be increased when combined with Anakinra.
Linezolid	Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Irinotecan.
Pentosan Polysulfate	Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Irinotecan.
Rivastigmine	Rivastigmine Rivastigmine may increase the neuromuscular blocking activities of Irinotecan.
Trimipramine	Trimipramine The metabolism of Irinotecan can be decreased when combined with Trimipramine.
Etanercept Injection	Etanercept Injection The metabolism of Irinotecan can be increased when combined with Etanercept.
Modafinil	Modafinil The metabolism of Irinotecan can be increased when combined with Modafinil.
Tenofovir	Tenofovir The metabolism of Irinotecan can be decreased when combined with Tenofovir.
Sirolimus	Sirolimus The metabolism of Sirolimus can be decreased when combined with Irinotecan.
Dutasteride	Dutasteride The metabolism of Dutasteride can be decreased when combined with Irinotecan.
Epinephrine Injection	Epinephrine Injection The metabolism of Irinotecan can be decreased when combined with Epinephrine.
Epirubicin	Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Irinotecan.
Eplerenone	Eplerenone The metabolism of Irinotecan can be decreased when combined with Eplerenone.
Zonisamide	Zonisamide The metabolism of Zonisamide can be decreased when combined with Irinotecan.
Adalimumab Injection	Adalimumab Injection The metabolism of Irinotecan can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Irinotecan.
Ezetimibe	Ezetimibe The excretion of Ezetimibe can be decreased when combined with Irinotecan.
Glatiramer Injection	Glatiramer Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Glatiramer.
Atazanavir	Atazanavir The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Atazanavir.
Mefloquine	Mefloquine The metabolism of Irinotecan can be decreased when combined with Mefloquine.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Irinotecan.
Vardenafil	Vardenafil The metabolism of Vardenafil can be decreased when combined with Irinotecan.
Aprepitant	Aprepitant The metabolism of Irinotecan can be decreased when combined with Aprepitant.
Memantine	Memantine The metabolism of Irinotecan can be decreased when combined with Memantine.
Tadalafil	Tadalafil The metabolism of Tadalafil can be decreased when combined with Irinotecan.
Progesterone	Progesterone The metabolism of Irinotecan can be increased when combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The metabolism of Irinotecan can be decreased when combined with Apomorphine.
Darbepoetin Alfa Injection	Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Irinotecan.
Infliximab Injection	Infliximab Injection The metabolism of Irinotecan can be increased when combined with Infliximab.
Rifaximin	Rifaximin The metabolism of Irinotecan can be increased when combined with Rifaximin.
Duloxetine	Duloxetine The metabolism of Irinotecan can be decreased when combined with Duloxetine.
Norethindrone	Norethindrone The metabolism of Irinotecan can be decreased when combined with Norethisterone.
Bosentan	Bosentan The metabolism of Bosentan can be increased when combined with Irinotecan.
Natalizumab Injection	Natalizumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Natalizumab.
Erlotinib	Erlotinib The risk or severity of neutropenia can be increased when Erlotinib is combined with Irinotecan.
Palifermin	Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Irinotecan.
Voriconazole	Voriconazole The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Voriconazole.
Peginterferon Alfa-2a Injection	Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Irinotecan.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Irinotecan.
Fentanyl	Fentanyl The metabolism of Fentanyl can be decreased when combined with Irinotecan.
Deferasirox	Deferasirox The risk or severity of neutropenia can be increased when Deferasirox is combined with Irinotecan.
Tipranavir	Tipranavir The serum concentration of SN-38, an active metabolite of Tipranavir, can be increased when used in combination with Irinotecan.
Felbamate	Felbamate The metabolism of Irinotecan can be increased when combined with Felbamate.
Ranolazine	Ranolazine The metabolism of Irinotecan can be decreased when combined with Ranolazine.
Abatacept Injection	Abatacept Injection The metabolism of Irinotecan can be increased when combined with Abatacept.
Imatinib	Imatinib The metabolism of Irinotecan can be decreased when combined with Imatinib.
Bevacizumab Injection	Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Irinotecan.
Gefitinib	Gefitinib The metabolism of Irinotecan can be decreased when combined with Gefitinib.
Paliperidone	Paliperidone The metabolism of Paliperidone can be decreased when combined with Irinotecan.
Bortezomib	Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Irinotecan.
Clofarabine Injection	Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Irinotecan.
Hepatitis B Vaccine	Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Irinotecan.
Influenza Vaccine, Inactivated or Recombinant	Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Irinotecan.
Influenza Vaccine, Live Intranasal	Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Irinotecan.
Live Shingles (Zoster) Vaccine (ZVL)	Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Irinotecan.
Oxaliplatin Injection	Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Irinotecan.
Posaconazole	Posaconazole The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Posaconazole.
Primaquine	Primaquine The metabolism of Irinotecan can be decreased when combined with Primaquine.
Rituximab Injection	Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Irinotecan.
Darunavir	Darunavir The serum concentration of SN-38, an active metabolite of Darunavir, can be increased when used in combination with Irinotecan.
Pemetrexed Injection	Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Irinotecan.
Vorinostat	Vorinostat The risk or severity of adverse effects can be increased when Irinotecan is combined with Vorinostat.
Sorafenib	Sorafenib The risk or severity of neutropenia can be increased when Sorafenib is combined with Irinotecan.
Sunitinib	Sunitinib The metabolism of Sunitinib can be decreased when combined with Irinotecan.
Dronabinol	Dronabinol Dronabinol may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Lapatinib	Lapatinib The metabolism of Lapatinib can be decreased when combined with Irinotecan.
Dasatinib	Dasatinib The metabolism of Dasatinib can be decreased when combined with Irinotecan.
Mexiletine	Mexiletine The metabolism of Irinotecan can be decreased when combined with Mexiletine.
Armodafinil	Armodafinil The metabolism of Irinotecan can be increased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Azacitidine.
Ivermectin	Ivermectin The metabolism of Irinotecan can be increased when combined with Ivermectin.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Irinotecan.
Nelarabine Injection	Nelarabine Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Nelarabine.
Lenalidomide	Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Irinotecan.
Nilotinib	Nilotinib The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Nilotinib.
Bexarotene	Bexarotene The metabolism of Irinotecan can be increased when combined with Bexarotene.
Budesonide	Budesonide The metabolism of Irinotecan can be increased when combined with Budesonide.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Irinotecan can be decreased when combined with Chloramphenicol.
Decitabine Injection	Decitabine Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Decitabine.
Betaine	Betaine Glycine betaine may increase the neuromuscular blocking activities of Irinotecan.
Etravirine	Etravirine The metabolism of Irinotecan can be increased when combined with Etravirine.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Arsenic trioxide.
Mitoxantrone Injection	Mitoxantrone Injection The metabolism of Mitoxantrone can be decreased when combined with Irinotecan.
Desvenlafaxine	Desvenlafaxine The metabolism of Irinotecan can be decreased when combined with Desvenlafaxine.
Tretinoin	Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Irinotecan.
Bendamustine Injection	Bendamustine Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Bendamustine.
Pilocarpine	Pilocarpine The metabolism of Irinotecan can be decreased when combined with Pilocarpine.
Certolizumab Injection	Certolizumab Injection The metabolism of Irinotecan can be increased when combined with Certolizumab pegol.
Ixabepilone Injection	Ixabepilone Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Ixabepilone.
Estramustine	Estramustine The risk or severity of adverse effects can be increased when Irinotecan is combined with Estramustine.
Praziquantel	Praziquantel The metabolism of Praziquantel can be decreased when combined with Irinotecan.
Mitotane	Mitotane The metabolism of Irinotecan can be increased when combined with Mitotane.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia)	Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Irinotecan.
Rufinamide	Rufinamide The metabolism of Irinotecan can be increased when combined with Rufinamide.
Midazolam	Midazolam The metabolism of Irinotecan can be decreased when combined with Midazolam.
Dexrazoxane Injection	Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Irinotecan.
Eltrombopag	Eltrombopag The risk or severity of neutropenia can be increased when Eltrombopag is combined with Irinotecan.
Ibritumomab Injection	Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Irinotecan.
Milnacipran	Milnacipran The metabolism of Irinotecan can be decreased when combined with Milnacipran.
Iloperidone	Iloperidone The metabolism of Iloperidone can be decreased when combined with Irinotecan.
Prasugrel	Prasugrel The metabolism of Prasugrel can be decreased when combined with Irinotecan.
Lacosamide	Lacosamide The metabolism of Irinotecan can be decreased when combined with Lacosamide.
Everolimus	Everolimus The risk or severity of adverse effects can be increased when Irinotecan is combined with Everolimus.
Dronedarone	Dronedarone The metabolism of Irinotecan can be decreased when combined with Dronedarone.
Pralatrexate Injection	Pralatrexate Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Pralatrexate.
Saxagliptin	Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Irinotecan.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Irinotecan.
Topotecan	Topotecan The metabolism of Topotecan can be increased when combined with Irinotecan.
Golimumab Injection	Golimumab Injection The metabolism of Irinotecan can be increased when combined with Golimumab.
Pazopanib	Pazopanib The risk or severity of neutropenia can be increased when Pazopanib is combined with Irinotecan.
Pitavastatin	Pitavastatin The excretion of Pitavastatin can be decreased when combined with Irinotecan.
Albendazole	Albendazole The metabolism of Irinotecan can be decreased when combined with Albendazole.
Levonorgestrel	Levonorgestrel The metabolism of Irinotecan can be decreased when combined with Levonorgestrel.
Denosumab Injection	Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Irinotecan.
Dabigatran	Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Irinotecan.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Irinotecan can be increased when combined with Tocilizumab.
Fingolimod	Fingolimod Irinotecan may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection	Eribulin Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Eribulin.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Irinotecan.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Irinotecan can be increased when combined with Acetaminophen.
Denileukin Diftitox Injection	Denileukin Diftitox Injection The metabolism of Irinotecan can be decreased when combined with Aldesleukin.
Sipuleucel-T Injection	Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Irinotecan.
Terbutaline Injection	Terbutaline Injection Terbutaline may increase the neuromuscular blocking activities of Irinotecan.
Belimumab Injection	Belimumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Belimumab.
Busulfan Injection	Busulfan Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Busulfan.
Roflumilast	Roflumilast Roflumilast may increase the immunosuppressive activities of Irinotecan.
Linagliptin	Linagliptin The metabolism of Irinotecan can be decreased when combined with Linagliptin.
Rilpivirine	Rilpivirine The metabolism of Rilpivirine can be decreased when combined with Irinotecan.
Telaprevir	Telaprevir The risk or severity of neutropenia can be increased when Glecaprevir is combined with Irinotecan.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Irinotecan can be increased when combined with Cyclophosphamide.
Rivaroxaban	Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Irinotecan.
Ticagrelor	Ticagrelor The metabolism of Irinotecan can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Irinotecan.
Ruxolitinib	Ruxolitinib The risk or severity of adverse effects can be increased when Irinotecan is combined with Ruxolitinib.
Vandetanib	Vandetanib Vandetanib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Clobazam	Clobazam The metabolism of Irinotecan can be increased when combined with Clobazam.
Vemurafenib	Vemurafenib The metabolism of Irinotecan can be increased when combined with Vemurafenib.
Vismodegib	Vismodegib Vismodegib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Belatacept Injection	Belatacept Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Belatacept.
Ivacaftor	Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Irinotecan.
Basiliximab Injection	Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Irinotecan.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Irinotecan.
Crizotinib	Crizotinib The metabolism of Irinotecan can be decreased when combined with Crizotinib.
Melphalan Injection	Melphalan Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Melphalan.
Cabergoline	Cabergoline The metabolism of Irinotecan can be decreased when combined with Cabergoline.
Naloxone Injection	Naloxone Injection The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Naloxone.
Ambrisentan	Ambrisentan The excretion of Ambrisentan can be decreased when combined with Irinotecan.
Eculizumab Injection	Eculizumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Eculizumab.
Fondaparinux Injection	Fondaparinux Injection The risk or severity of bleeding can be increased when Fondaparinux is combined with Irinotecan.
Carfilzomib Injection	Carfilzomib Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Carfilzomib.
Iloprost	Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Irinotecan.
Enzalutamide	Enzalutamide The metabolism of Irinotecan can be increased when combined with Enzalutamide.
Mirabegron	Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Irinotecan.
Regorafenib	Regorafenib The risk or severity of neutropenia can be increased when Regorafenib is combined with Irinotecan.
Bosutinib	Bosutinib The metabolism of Bosutinib can be decreased when combined with Irinotecan.
Corticotropin, Repository Injection	Corticotropin, Repository Injection The metabolism of Corticotropin can be increased when combined with Irinotecan.
Teriflunomide	Teriflunomide The risk or severity of adverse effects can be increased when Irinotecan is combined with Teriflunomide.
Icosapent Ethyl	Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Irinotecan.
Tofacitinib	Tofacitinib Irinotecan may increase the immunosuppressive activities of Tofacitinib.
Dimethyl Fumarate	Dimethyl Fumarate The risk or severity of adverse effects can be increased when Irinotecan is combined with Dimethyl fumarate.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Irinotecan.
Pomalidomide	Pomalidomide The risk or severity of adverse effects can be increased when Irinotecan is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Irinotecan.
Apixaban	Apixaban The metabolism of Apixaban can be decreased when combined with Irinotecan.
Dabrafenib	Dabrafenib The metabolism of Irinotecan can be increased when combined with Dabrafenib.
Ospemifene	Ospemifene The metabolism of Ospemifene can be decreased when combined with Irinotecan.
Trametinib	Trametinib The metabolism of Irinotecan can be increased when combined with Trametinib.
Afatinib	Afatinib Afatinib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Irinotecan.
Perampanel	Perampanel The metabolism of Perampanel can be increased when combined with Irinotecan.
Ibrutinib	Ibrutinib The risk or severity of adverse effects can be increased when Irinotecan is combined with Ibrutinib.
Lomitapide	Lomitapide The metabolism of Irinotecan can be decreased when combined with Lomitapide.
Obinutuzumab Injection	Obinutuzumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Obinutuzumab.
Simeprevir	Simeprevir The metabolism of Irinotecan can be decreased when combined with Simeprevir.
Apremilast	Apremilast The metabolism of Irinotecan can be increased when combined with Apremilast.
Ceritinib	Ceritinib The metabolism of Irinotecan can be decreased when combined with Ceritinib.
Siltuximab Injection	Siltuximab Injection The metabolism of Irinotecan can be increased when combined with Siltuximab.
Eslicarbazepine	Eslicarbazepine The metabolism of Irinotecan can be increased when combined with Eslicarbazepine.
Vedolizumab Injection	Vedolizumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Vedolizumab.
Belinostat Injection	Belinostat Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Belinostat.
Idelalisib	Idelalisib The risk or severity of adverse effects can be increased when Irinotecan is combined with Idelalisib.
Testosterone Injection	Testosterone Injection The metabolism of Irinotecan can be increased when combined with Testosterone.
Oritavancin Injection	Oritavancin Injection The metabolism of Irinotecan can be increased when combined with Oritavancin.
Vorapaxar	Vorapaxar The metabolism of Irinotecan can be decreased when combined with Vorapaxar.
Hydrocodone	Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Irinotecan.
Suvorexant	Suvorexant The metabolism of Irinotecan can be decreased when combined with Suvorexant.
Edoxaban	Edoxaban The risk or severity of bleeding can be increased when Edoxaban is combined with Irinotecan.
Peginterferon Beta-1a Injection	Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Peginterferon beta-1a.
Olaparib	Olaparib The metabolism of Olaparib can be decreased when combined with Irinotecan.
Blinatumomab Injection	Blinatumomab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Blinatumomab.
Caspofungin Injection	Caspofungin Injection The excretion of Caspofungin can be decreased when combined with Irinotecan.
Tasimelteon	Tasimelteon The metabolism of Irinotecan can be decreased when combined with Tasimelteon.
Lanreotide Injection	Lanreotide Injection The metabolism of Irinotecan can be decreased when combined with Lanreotide.
Pirfenidone	Pirfenidone The risk or severity of adverse effects can be increased when Irinotecan is combined with Pirfenidone.
Nintedanib	Nintedanib The metabolism of Irinotecan can be decreased when combined with Nintedanib.
Secukinumab Injection	Secukinumab Injection The metabolism of Irinotecan can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The metabolism of Irinotecan can be decreased when combined with Risperidone.
Palbociclib	Palbociclib The metabolism of Palbociclib can be decreased when combined with Irinotecan.
Lenvatinib	Lenvatinib The metabolism of Irinotecan can be increased when combined with Lenvatinib.
Panobinostat	Panobinostat The risk or severity of adverse effects can be increased when Irinotecan is combined with Panobinostat.
Dinutuximab Injection	Dinutuximab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Dinutuximab.
Haloperidol Injection	Haloperidol Injection The serum concentration of Irinotecan can be increased when it is combined with Haloperidol.
Isavuconazonium Injection	Isavuconazonium Injection The metabolism of Irinotecan can be increased when combined with Isavuconazonium.
Rolapitant	Rolapitant Rolapitant may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Prednisolone	Prednisolone The metabolism of Prednisolone can be increased when combined with Irinotecan.
Daclatasvir	Daclatasvir Daclatasvir may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Ziprasidone Injection	Ziprasidone Injection The metabolism of Irinotecan can be decreased when combined with Ziprasidone.
Eluxadoline	Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Irinotecan.
Cobimetinib	Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Irinotecan.
Mepolizumab Injection	Mepolizumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Mepolizumab.
Trabectedin Injection	Trabectedin Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Trabectedin.
Osimertinib	Osimertinib The metabolism of Irinotecan can be increased when combined with Osimertinib.
Alectinib	Alectinib Alectinib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Rifapentine	Rifapentine The metabolism of Irinotecan can be increased when combined with Rifapentine.
Lesinurad	Lesinurad The metabolism of Irinotecan can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection The metabolism of Irinotecan can be decreased when combined with Amphotericin B.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Irinotecan can be increased when combined with Dexamethasone.
Defibrotide Injection	Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Irinotecan.
Ixekizumab Injection	Ixekizumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Ixekizumab.
Brivaracetam Injection	Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Irinotecan.
Venetoclax	Venetoclax The metabolism of Irinotecan can be decreased when combined with Venetoclax.
Cobicistat	Cobicistat The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Cobicistat.
Selexipag	Selexipag The excretion of Selexipag can be decreased when combined with Irinotecan.
Rucaparib	Rucaparib The risk or severity of neutropenia can be increased when Rucaparib is combined with Irinotecan.
Ribociclib	Ribociclib The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Ribociclib.
Brodalumab Injection	Brodalumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Brodalumab.
Brigatinib	Brigatinib The metabolism of Irinotecan can be increased when combined with Brigatinib.
Deutetrabenazine	Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Irinotecan.
Valbenazine	Valbenazine The metabolism of Valbenazine can be decreased when combined with Irinotecan.
Deflazacort	Deflazacort The metabolism of Deflazacort can be increased when combined with Irinotecan.
Safinamide	Safinamide Safinamide may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Ocrelizumab Injection	Ocrelizumab Injection Ocrelizumab may increase the immunosuppressive activities of Irinotecan.
Sarilumab Injection	Sarilumab Injection The metabolism of Sarilumab can be increased when combined with Irinotecan.
Midostaurin	Midostaurin The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Midostaurin.
Guselkumab Injection	Guselkumab Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Guselkumab.
Enasidenib	Enasidenib The risk or severity of neutropenia can be increased when Enasidenib is combined with Irinotecan.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The metabolism of Irinotecan can be increased when combined with Fosaprepitant.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Irinotecan.
Abemaciclib	Abemaciclib Abemaciclib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Betrixaban	Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Irinotecan.
Acalabrutinib	Acalabrutinib The metabolism of Irinotecan can be decreased when combined with Acalabrutinib.
Gemtuzumab Ozogamicin Injection	Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Irinotecan.
Letermovir	Letermovir The metabolism of Irinotecan can be decreased when combined with Letermovir.
Ertugliflozin	Ertugliflozin The risk or severity of neutropenia can be increased when Ertugliflozin is combined with Irinotecan.
Buprenorphine Injection	Buprenorphine Injection The metabolism of Irinotecan can be decreased when combined with Buprenorphine.
Apalutamide	Apalutamide The metabolism of Irinotecan can be increased when combined with Apalutamide.
Penicillamine	Penicillamine The risk or severity of adverse effects can be increased when Irinotecan is combined with Penicillamine.
Fostamatinib	Fostamatinib The risk or severity of neutropenia can be increased when Fostamatinib is combined with Irinotecan.
Avatrombopag	Avatrombopag Avatrombopag may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Baricitinib	Baricitinib The risk or severity of adverse effects can be increased when Irinotecan is combined with Baricitinib.
Ivosidenib	Ivosidenib The metabolism of Irinotecan can be increased when combined with Ivosidenib.
Elagolix	Elagolix The excretion of Elagolix can be decreased when combined with Irinotecan.
Doravirine	Doravirine The metabolism of Doravirine can be decreased when combined with Irinotecan.
Cannabidiol	Cannabidiol Cannabidiol may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Dacomitinib	Dacomitinib The risk or severity of neutropenia can be increased when Dacomitinib is combined with Irinotecan.
Duvelisib	Duvelisib The metabolism of Irinotecan can be decreased when combined with Duvelisib.
Stiripentol	Stiripentol The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Stiripentol.
Gilteritinib	Gilteritinib The metabolism of Irinotecan can be decreased when combined with Gilteritinib.
Glasdegib	Glasdegib Glasdegib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be increased when combined with Irinotecan.
Methoxy Polyethylene Glycol-Epoetin Beta Injection	Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Irinotecan.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Irinotecan.
Rifamycin	Rifamycin The metabolism of Irinotecan can be increased when combined with Rifamycin.
Prucalopride	Prucalopride The metabolism of Irinotecan can be decreased when combined with Prucalopride.
Ravulizumab-cwvz Injection	Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Ravulizumab.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Irinotecan can be increased when combined with Emapalumab.
Siponimod	Siponimod The risk or severity of adverse effects can be increased when Irinotecan is combined with Siponimod.
Caplacizumab-yhdp Injection	Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Irinotecan.
Risankizumab-rzaa Injection	Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Risankizumab.
Alpelisib	Alpelisib The metabolism of Irinotecan can be increased when combined with Alpelisib.
Cladribine	Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Irinotecan.
Darolutamide	Darolutamide Darolutamide may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Triclabendazole	Triclabendazole The metabolism of Irinotecan can be decreased when combined with Triclabendazole.
Pexidartinib	Pexidartinib The risk or severity of neutropenia can be increased when Pexidartinib is combined with Irinotecan.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Irinotecan.
Pitolisant	Pitolisant The serum concentration of Irinotecan can be decreased when it is combined with Pitolisant.
Fedratinib	Fedratinib Fedratinib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Lefamulin	Lefamulin The serum concentration of Irinotecan can be increased when it is combined with Lefamulin.
Phenytoin Injection	Phenytoin Injection The metabolism of Irinotecan can be increased when combined with Phenytoin.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Irinotecan can be increased when combined with Fosphenytoin.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Irinotecan.
Voxelotor	Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Irinotecan.
Lasmiditan	Lasmiditan The serum concentration of Irinotecan can be increased when it is combined with Lasmiditan.
Tazemetostat	Tazemetostat The metabolism of Irinotecan can be decreased when combined with Tazemetostat.
Cenobamate	Cenobamate The serum concentration of Irinotecan can be decreased when it is combined with Cenobamate.
Ozanimod	Ozanimod The risk or severity of adverse effects can be increased when Irinotecan is combined with Ozanimod.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Irinotecan.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Irinotecan.
Remdesivir Injection	Remdesivir Injection The excretion of Remdesivir can be decreased when combined with Irinotecan.
Ripretinib	Ripretinib Ripretinib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Capmatinib	Capmatinib The serum concentration of Irinotecan can be increased when it is combined with Capmatinib.
Lemborexant	Lemborexant The serum concentration of Irinotecan can be decreased when it is combined with Lemborexant.
Fostemsavir	Fostemsavir Fostemsavir may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Octreotide	Octreotide The serum concentration of Irinotecan can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection	Belantamab Mafodotin-blmf Injection The excretion of Belantamab mafodotin can be decreased when combined with Irinotecan.
Pralsetinib	Pralsetinib The metabolism of Irinotecan can be increased when combined with Pralsetinib.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Irinotecan can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Irinotecan can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol)	Vitamin E (Alpha-Tocopherol) The metabolism of Irinotecan can be increased when combined with Vitamin E.
Indomethacin	Indomethacin The risk or severity of neutropenia can be increased when Indomethacin is combined with Irinotecan.
Mefenamic Acid	Mefenamic Acid The metabolism of Irinotecan can be decreased when combined with Mefenamic acid.
Trazodone	Trazodone The metabolism of Irinotecan can be decreased when combined with Trazodone.
Hydroxyurea	Hydroxyurea The risk or severity of adverse effects can be increased when Irinotecan is combined with Hydroxyurea.
Floxuridine	Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Irinotecan.
Phenobarbital	Phenobarbital The metabolism of Irinotecan can be increased when combined with Phenobarbital.
Methotrexate Injection	Methotrexate Injection The risk or severity of adverse effects can be increased when Methotrexate is combined with Irinotecan.
Primidone	Primidone The metabolism of Irinotecan can be increased when combined with Primidone.
Chlorpromazine	Chlorpromazine The metabolism of Irinotecan can be increased when combined with Chlorpromazine.
Diazepam	Diazepam The metabolism of Diazepam can be decreased when combined with Irinotecan.
Lorazepam	Lorazepam The metabolism of Irinotecan can be decreased when combined with Lorazepam.
Carmustine	Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Irinotecan.
Bromocriptine	Bromocriptine The metabolism of Irinotecan can be decreased when combined with Bromocriptine.
Tranylcypromine	Tranylcypromine The metabolism of Irinotecan can be decreased when combined with Tranylcypromine.
Phenelzine	Phenelzine The metabolism of Irinotecan can be decreased when combined with Phenelzine.
Procarbazine	Procarbazine The risk or severity of adverse effects can be increased when Irinotecan is combined with Procarbazine.
Tetracycline	Tetracycline The metabolism of Irinotecan can be decreased when combined with Tetracycline.
Thioguanine	Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Irinotecan.
Prochlorperazine	Prochlorperazine The metabolism of Irinotecan can be decreased when combined with Prochlorperazine.
Bleomycin	Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Irinotecan.
Dapsone	Dapsone The metabolism of Irinotecan can be decreased when combined with Dapsone.
Oxycodone	Oxycodone The metabolism of Irinotecan can be decreased when combined with Oxycodone.
Methadone	Methadone The metabolism of Irinotecan can be increased when combined with Methadone.
Oxybutynin	Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Irinotecan.
Orphenadrine	Orphenadrine The metabolism of Irinotecan can be decreased when combined with Orphenadrine.
Azathioprine	Azathioprine The risk or severity of adverse effects can be increased when Irinotecan is combined with Azathioprine.
Phentermine	Phentermine The metabolism of Irinotecan can be decreased when combined with Phentermine.
Sulfasalazine	Sulfasalazine The risk or severity of adverse effects can be increased when Irinotecan is combined with Sulfasalazine.
Hydrocortisone	Hydrocortisone The metabolism of Irinotecan can be increased when combined with Hydrocortisone.
Lomustine	Lomustine The risk or severity of adverse effects can be increased when Irinotecan is combined with Lomustine.
Doxorubicin	Doxorubicin The metabolism of Doxorubicin can be decreased when combined with Irinotecan.
Cytarabine	Cytarabine The risk or severity of adverse effects can be increased when Irinotecan is combined with Cytarabine.
Mechlorethamine	Mechlorethamine The risk or severity of adverse effects can be increased when Irinotecan is combined with Mechlorethamine.
Dactinomycin	Dactinomycin The risk or severity of adverse effects can be increased when Irinotecan is combined with Dactinomycin.
Pyridostigmine	Pyridostigmine Pyridostigmine may increase the neuromuscular blocking activities of Irinotecan.
Carbamazepine	Carbamazepine The metabolism of Irinotecan can be increased when combined with Carbamazepine.
Clonidine	Clonidine The metabolism of Irinotecan can be decreased when combined with Clonidine.
Hydralazine	Hydralazine The metabolism of Irinotecan can be decreased when combined with Hydralazine.
Cimetidine	Cimetidine The metabolism of Irinotecan can be decreased when combined with Cimetidine.
Warfarin	Warfarin The metabolism of Irinotecan can be increased when combined with Warfarin.
Loperamide	Loperamide The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Loperamide.
Promethazine	Promethazine The metabolism of Promethazine can be decreased when combined with Irinotecan.
Daunorubicin	Daunorubicin The metabolism of Irinotecan can be decreased when combined with Daunorubicin.
Griseofulvin	Griseofulvin The metabolism of Irinotecan can be increased when combined with Griseofulvin.
Digoxin	Digoxin The excretion of Digoxin can be decreased when combined with Irinotecan.
Chloroquine	Chloroquine The metabolism of Irinotecan can be decreased when combined with Chloroquine.
Quinine	Quinine The metabolism of Irinotecan can be increased when combined with Quinine.
Calcitriol	Calcitriol The metabolism of Irinotecan can be increased when combined with Calcitriol.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Irinotecan can be increased when combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Chlorothiazide is combined with Irinotecan.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Irinotecan.
Secobarbital	Secobarbital The metabolism of Irinotecan can be increased when combined with Secobarbital.
Desipramine	Desipramine The metabolism of Desipramine can be decreased when combined with Irinotecan.
Amitriptyline	Amitriptyline The risk or severity of neutropenia can be increased when Amitriptyline is combined with Irinotecan.
Imipramine	Imipramine The metabolism of Irinotecan can be decreased when combined with Imipramine.
Probenecid	Probenecid The risk or severity of neutropenia can be increased when Probenecid is combined with Irinotecan.
Quinidine	Quinidine The metabolism of Quinidine can be decreased when combined with Irinotecan.
Procainamide	Procainamide Procainamide may increase the neuromuscular blocking activities of Irinotecan.
Isoniazid	Isoniazid The metabolism of Irinotecan can be decreased when combined with Isoniazid.
Rifampin	Rifampin The metabolism of Irinotecan can be increased when combined with Rifampicin.
Valproic Acid	Valproic Acid The risk or severity of neutropenia can be increased when Valproic acid is combined with Irinotecan.
Tamoxifen	Tamoxifen The metabolism of Irinotecan can be decreased when combined with Tamoxifen.
Mitomycin	Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Irinotecan.
Liothyronine	Liothyronine The excretion of Liothyronine can be decreased when combined with Irinotecan.
Methimazole	Methimazole The serum concentration of SN-38, an active metabolite of Methimazole, can be increased when used in combination with Irinotecan.
Propylthiouracil	Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Irinotecan.
Dextromethorphan	Dextromethorphan The metabolism of Irinotecan can be decreased when combined with Dextromethorphan.
Dinoprostone	Dinoprostone The excretion of Dinoprostone can be decreased when combined with Irinotecan.
Niacin	Niacin The metabolism of Irinotecan can be decreased when combined with Niacin.
Chlorpheniramine	Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Irinotecan.
Brompheniramine	Brompheniramine The metabolism of Brompheniramine can be decreased when combined with Irinotecan.
Methyclothiazide	Methyclothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Methyclothiazide is combined with Irinotecan.
Hydrochlorothiazide	Hydrochlorothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Irinotecan.
Danazol	Danazol The metabolism of Irinotecan can be decreased when combined with Danazol.
Disulfiram	Disulfiram The metabolism of Disulfiram can be decreased when combined with Irinotecan.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The metabolism of Irinotecan can be decreased when combined with Propranolol.
Amphotericin B Injection	Amphotericin B Injection The metabolism of Irinotecan can be decreased when combined with Amphotericin B.
Mercaptopurine	Mercaptopurine The risk or severity of adverse effects can be increased when Irinotecan is combined with Mercaptopurine.
Allopurinol	Allopurinol The risk or severity of adverse effects can be increased when Allopurinol is combined with Irinotecan.
Fluorouracil Injection	Fluorouracil Injection The risk or severity of adverse effects can be increased when Fluorouracil is combined with Irinotecan.
Colchicine	Colchicine The metabolism of Irinotecan can be increased when combined with Colchicine.
Cephalexin	Cephalexin The metabolism of Irinotecan can be decreased when combined with Cephalexin.
Dacarbazine	Dacarbazine The risk or severity of adverse effects can be increased when Irinotecan is combined with Dacarbazine.
Acetazolamide	Acetazolamide The metabolism of Irinotecan can be decreased when combined with Acetazolamide.
Bacillus Calmette-Guerin (BCG) Vaccine	Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Irinotecan.
Ketoconazole	Ketoconazole The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Ketoconazole.
Thiotepa Injection	Thiotepa Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Thiotepa.
Vincristine Injection	Vincristine Injection The metabolism of Irinotecan can be decreased when combined with Vincristine.
Dipyridamole	Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Irinotecan.
Vinblastine	Vinblastine The metabolism of Irinotecan can be increased when combined with Vinblastine.
Metoprolol	Metoprolol The metabolism of Irinotecan can be decreased when combined with Metoprolol.
Hydroxyzine	Hydroxyzine The metabolism of Irinotecan can be decreased when combined with Hydroxyzine.
Aspirin	Aspirin The risk or severity of bleeding can be increased when Acetylsalicylic acid is combined with Irinotecan.
Chlorambucil	Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Irinotecan.
Alprazolam	Alprazolam The metabolism of Irinotecan can be decreased when combined with Alprazolam.
Triazolam	Triazolam The metabolism of Triazolam can be decreased when combined with Irinotecan.
Diltiazem	Diltiazem The metabolism of Irinotecan can be decreased when combined with Diltiazem.
Nifedipine	Nifedipine The metabolism of Nifedipine can be increased when combined with Irinotecan.
Verapamil	Verapamil The metabolism of Irinotecan can be decreased when combined with Verapamil.
Cisplatin Injection	Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Irinotecan.
Diflunisal	Diflunisal The metabolism of Irinotecan can be decreased when combined with Diflunisal.
Streptozocin	Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Irinotecan.
Etoposide	Etoposide The metabolism of Etoposide can be decreased when combined with Irinotecan.
Glyburide	Glyburide The metabolism of Glyburide can be decreased when combined with Irinotecan.
Dicloxacillin	Dicloxacillin The metabolism of Irinotecan can be increased when combined with Dicloxacillin.
Nafcillin Injection	Nafcillin Injection The metabolism of Irinotecan can be increased when combined with Nafcillin.
Pentoxifylline	Pentoxifylline The risk or severity of bleeding can be increased when Pentoxifylline is combined with Irinotecan.
Pentamidine Injection	Pentamidine Injection The metabolism of Irinotecan can be decreased when combined with Pentamidine.
Gemfibrozil	Gemfibrozil The risk or severity of neutropenia can be increased when Gemfibrozil is combined with Irinotecan.
Pimozide	Pimozide The metabolism of Pimozide can be decreased when combined with Irinotecan.
Enalapril	Enalapril The excretion of Enalapril can be decreased when combined with Irinotecan.
Flurbiprofen	Flurbiprofen The risk or severity of neutropenia can be increased when Flurbiprofen is combined with Irinotecan.
Amiodarone	Amiodarone The metabolism of Irinotecan can be decreased when combined with Amiodarone.
Buspirone	Buspirone The metabolism of Irinotecan can be decreased when combined with Buspirone.
Lovastatin	Lovastatin The metabolism of Lovastatin can be decreased when combined with Irinotecan.
Ciprofloxacin	Ciprofloxacin The metabolism of Irinotecan can be decreased when combined with Ciprofloxacin.
Diclofenac	Diclofenac The metabolism of Irinotecan can be decreased when combined with Diclofenac.
Fluoxetine	Fluoxetine The metabolism of Irinotecan can be decreased when combined with Fluoxetine.
Interferon Alfa-2b Injection	Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Irinotecan.
Clozapine	Clozapine The risk or severity of neutropenia can be increased when Irinotecan is combined with Clozapine.
Idarubicin	Idarubicin The risk or severity of adverse effects can be increased when Irinotecan is combined with Idarubicin.
Fludarabine Injection	Fludarabine Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Fludarabine.
Pentostatin Injection	Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Irinotecan.
Clarithromycin	Clarithromycin The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Clarithromycin.
Felodipine	Felodipine The metabolism of Felodipine can be decreased when combined with Irinotecan.
Pravastatin	Pravastatin Pravastatin may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Simvastatin	Simvastatin The metabolism of Simvastatin can be increased when combined with Irinotecan.
Epoetin Alfa, Injection	Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Irinotecan.
Teniposide Injection	Teniposide Injection The metabolism of Irinotecan can be decreased when combined with Teniposide.
Itraconazole	Itraconazole The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Itraconazole.
Rifabutin	Rifabutin The metabolism of Irinotecan can be increased when combined with Rifabutin.
Doxazosin	Doxazosin The metabolism of Irinotecan can be decreased when combined with Doxazosin.
Isradipine	Isradipine The metabolism of Irinotecan can be decreased when combined with Isradipine.
Omeprazole	Omeprazole The metabolism of Irinotecan can be increased when combined with Omeprazole.
Cisapride	Cisapride The metabolism of Irinotecan can be decreased when combined with Cisapride.
Fluvastatin	Fluvastatin The metabolism of Irinotecan can be decreased when combined with Fluvastatin.
Venlafaxine	Venlafaxine Venlafaxine may increase the excretion rate of Irinotecan which could result in a lower serum level and potentially a reduction in efficacy.
Nizatidine	Nizatidine Nizatidine may increase the neuromuscular blocking activities of Irinotecan.
Famciclovir	Famciclovir The metabolism of Irinotecan can be decreased when combined with Famciclovir.
Fluvoxamine	Fluvoxamine The metabolism of Irinotecan can be decreased when combined with Fluvoxamine.
Nefazodone	Nefazodone The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Nefazodone.
Lamotrigine	Lamotrigine The metabolism of Irinotecan can be increased when combined with Lamotrigine.
Losartan	Losartan The metabolism of Irinotecan can be decreased when combined with Losartan.
Tramadol	Tramadol The metabolism of Irinotecan can be decreased when combined with Tramadol.
Vinorelbine Injection	Vinorelbine Injection The risk or severity of adverse effects can be increased when Vinorelbine is combined with Irinotecan.
Carboplatin Injection	Carboplatin Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Carboplatin.
Lansoprazole	Lansoprazole The metabolism of Irinotecan can be increased when combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Irinotecan.
Pegaspargase Injection	Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Irinotecan.
Nicardipine	Nicardipine The metabolism of Irinotecan can be decreased when combined with Nicardipine.
Bupropion	Bupropion The metabolism of Bupropion can be decreased when combined with Irinotecan.
Ticlopidine	Ticlopidine The metabolism of Irinotecan can be decreased when combined with Ticlopidine.
Saquinavir	Saquinavir The serum concentration of SN-38, an active metabolite of Saquinavir, can be increased when used in combination with Irinotecan.
Dalteparin Injection	Dalteparin Injection The risk or severity of bleeding can be increased when Dalteparin is combined with Irinotecan.
Nisoldipine	Nisoldipine The metabolism of Irinotecan can be decreased when combined with Nisoldipine.
Gemcitabine Injection	Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Irinotecan.
Indinavir	Indinavir The risk or severity of neutropenia can be increased when Irinotecan is combined with Indinavir.
Ritonavir	Ritonavir The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Irinotecan.
Clomipramine	Clomipramine The metabolism of Clomipramine can be decreased when combined with Irinotecan.
Zafirlukast	Zafirlukast The metabolism of Irinotecan can be decreased when combined with Zafirlukast.
Mirtazapine	Mirtazapine The metabolism of Irinotecan can be decreased when combined with Mirtazapine.
Topiramate	Topiramate The metabolism of Irinotecan can be increased when combined with Topiramate.
Valsartan	Valsartan The excretion of Valsartan can be decreased when combined with Irinotecan.
Donepezil	Donepezil Donepezil may increase the neuromuscular blocking activities of Irinotecan.
Nelfinavir	Nelfinavir The metabolism of Irinotecan can be increased when combined with Nelfinavir.
Fexofenadine	Fexofenadine The excretion of Fexofenadine can be decreased when combined with Irinotecan.
Azithromycin	Azithromycin The metabolism of Irinotecan can be decreased when combined with Azithromycin.
Flutamide	Flutamide The metabolism of Irinotecan can be decreased when combined with Flutamide.
Selegiline	Selegiline The metabolism of Selegiline can be decreased when combined with Irinotecan.
Bicalutamide	Bicalutamide The metabolism of Irinotecan can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The metabolism of Irinotecan can be decreased when combined with Sertraline.
Raloxifene	Raloxifene The metabolism of Irinotecan can be decreased when combined with Raloxifene.
Irbesartan	Irbesartan The metabolism of Irinotecan can be decreased when combined with Irbesartan.
Finasteride	Finasteride The metabolism of Finasteride can be decreased when combined with Irinotecan.
Quetiapine	Quetiapine The metabolism of Quetiapine can be decreased when combined with Irinotecan.
Paroxetine	Paroxetine The metabolism of Irinotecan can be decreased when combined with Paroxetine.
Citalopram	Citalopram The metabolism of Irinotecan can be decreased when combined with Citalopram.
Capecitabine	Capecitabine The risk or severity of adverse effects can be increased when Irinotecan is combined with Capecitabine.
Efavirenz	Efavirenz The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Efavirenz.
Sildenafil	Sildenafil The metabolism of Irinotecan can be decreased when combined with Sildenafil.
Trastuzumab Injection	Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Irinotecan.
Thalidomide	Thalidomide The risk or severity of adverse effects can be increased when Irinotecan is combined with Thalidomide.
Nateglinide	Nateglinide The metabolism of Irinotecan can be decreased when combined with Nateglinide.
Galantamine	Galantamine Galantamine may increase the neuromuscular blocking activities of Irinotecan.
Rabeprazole	Rabeprazole The metabolism of Irinotecan can be decreased when combined with Rabeprazole.
Terbinafine	Terbinafine The metabolism of Irinotecan can be increased when combined with Terbinafine.