Isavuconazonium Injection

Generic name: Pronounced as (eye'' sa vue koe'' na zoe' nee um)
Brand names
  • Cresemba® I.V.
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 03/15/2017

Isavuconazonium injection is used to treat serious fungal infections such as invasive aspergillosis (a fungal infection that begins in the lungs and spreads through the bloodstream to other organs) and invasive mucormycosis (a fungal infection that usually begins in the sinuses, brain, or lungs). Isavuconazonium injection is in a class of medications called azole antifungals. It works by slowing the growth of fungi that cause infection.

Isavuconazonium injection comes as a powder to be mixed with liquid and injected intravenously (into a vein). It is usually given over at least 1 hour every 8 hours for the first six doses and then once a day. The length of your treatment depends on your general health, the type of infection that you have, and how well you respond to the medication. You may receive isavuconazonium injection in a hospital or you may administer the medication at home. If you will be receiving isavuconazonium injection at home, your healthcare provider will show you how to use the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving isavuconazonium injection,

  • tell your doctor and pharmacist if you are allergic to isavuconazonium, fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole, any other medications, or any of the ingredients in isavuconazonium injection. Ask your pharmacist for a list of the ingredients.

  • tell your doctor if you are taking carbamazepine (Carbatrol, Tegretol), ketoconazole (Nizoral), phenobarbital, rifampin (Rifadin, Rifamate), ritonavir (Norvir, in Kaletra), or St. John's wort. Your doctor will probably tell you not to use isavuconazonium injection if you are taking one or more of these medications.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: atorvastatin (Lipitor), bupropion (Aplenzin, Forfivo XL, Wellbutrin, Zyban), cyclosporine (Gengraf, Neoral, Sandimmune), digoxin (Digitek, Lanoxicaps, Lanoxin), midazolam, mycophenolate mofetil (CellCept), sirolimus (Rapamune), or tacrolimus (Prograf). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with isavuconazonium, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you or anyone in your family has or has ever had short QT syndrome (condition that increases the risk of irregular heartbeat, dizziness, fainting, or sudden death). Your doctor will probably tell you not to receive isavuconazonium injection.

  • tell your doctor if you have or have ever had heart or liver problems.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while receiving isavuconazonium injection, call your doctor.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while receiving this medication.

  • Isavuconazonium injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • constipation

    • headache

    • back pain

    • cough

    • difficulty falling asleep or staying asleep

    • anxiety

    • agitation

    • confusion

    • decreased appetite

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • hives

    • rash

    • itching

    • peeling or blistering skin

    • nausea

    • vomiting

    • yellowing of the skin or eyes

    • extreme tiredness

    • flu-like symptoms

    • muscle aches, cramps, or weakness

    • irregular heartbeat

    • swelling of the hands, feet, arms or legs

    • difficulty breathing or swallowing

    • fainting

    • blurred vision

    • dizziness

    • chills

    • numbness, burning, or tingling in the hands, arms, feet, or legs

    • changes in your sense of touch

  • Isavuconazonium injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • headache

  • dizziness

  • pain, burning, or tingling in the hands or feet

  • drowsiness

  • difficulty focusing

  • change in sense of taste

  • dry mouth

  • numbness in the mouth

  • diarrhea

  • vomiting

  • sudden reddening of the face, neck, or upper chest

  • anxiety

  • restlessness

  • pounding or fast heartbeat

  • eye sensitivity to light

  • joint pain

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to isavuconazonium injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The serum concentration of Isavuconazonium can be increased when it is combined with Delavirdine.
Atorvastatin Atorvastatin The risk or severity of myopathy can be increased when Isavuconazonium is combined with Atorvastatin.
Aminophylline Aminophylline The metabolism of Aminophylline can be increased when combined with Isavuconazonium.
Calcium Carbonate Calcium Carbonate Calcium carbonate can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Isavuconazonium.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be increased when combined with Isavuconazonium.
Magnesium Hydroxide Magnesium Hydroxide Magnesium hydroxide can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium Oxide Magnesium Oxide Magnesium oxide can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mycophenolate Mycophenolate The serum concentration of Mycophenolic acid can be increased when it is combined with Isavuconazonium.
Paregoric Paregoric The serum concentration of Morphine can be increased when it is combined with Isavuconazonium.
Ranitidine Ranitidine Ranitidine can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Isavuconazonium.
Famotidine Injection Famotidine Injection Famotidine can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be decreased when combined with Isavuconazonium.
Morphine Injection Morphine Injection The serum concentration of Morphine can be increased when it is combined with Isavuconazonium.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Isavuconazonium.
Olanzapine Olanzapine Olanzapine can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Isavuconazonium.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Isavuconazonium.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Isavuconazonium.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Isavuconazonium.
Eplerenone Eplerenone The metabolism of Eplerenone can be decreased when combined with Isavuconazonium.
Zonisamide Zonisamide The therapeutic efficacy of Isavuconazonium can be increased when used in combination with Zonisamide.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Isavuconazonium.
Atazanavir Atazanavir The serum concentration of Isavuconazonium can be increased when it is combined with Atazanavir.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Isavuconazonium.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Isavuconazonium.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Isavuconazonium.
Tegaserod Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Isavuconazonium.
Progesterone Progesterone The metabolism of Progesterone can be increased when combined with Isavuconazonium.
Rifaximin Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Isavuconazonium.
Duloxetine Duloxetine The metabolism of Duloxetine can be increased when combined with Isavuconazonium.
Norethindrone Norethindrone The metabolism of Norethisterone can be increased when combined with Isavuconazonium.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Isavuconazonium.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Isavuconazonium.
Voriconazole Voriconazole The serum concentration of Isavuconazonium can be increased when it is combined with Voriconazole.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Isavuconazonium.
Tipranavir Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Isavuconazonium.
Ranolazine Ranolazine The metabolism of Ranolazine can be increased when combined with Isavuconazonium.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Isavuconazonium.
Paliperidone Paliperidone The serum concentration of Paliperidone can be increased when it is combined with Isavuconazonium.
Bortezomib Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Isavuconazonium.
Posaconazole Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Isavuconazonium.
Darunavir Darunavir The serum concentration of Isavuconazonium can be increased when it is combined with Darunavir.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Isavuconazonium.
Sorafenib Sorafenib The metabolism of Sorafenib can be increased when combined with Isavuconazonium.
Sunitinib Sunitinib The metabolism of Sunitinib can be increased when combined with Isavuconazonium.
Dasatinib Dasatinib The serum concentration of Dasatinib can be increased when it is combined with Isavuconazonium.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Isavuconazonium.
Nilotinib Nilotinib The serum concentration of Nilotinib can be increased when it is combined with Isavuconazonium.
Toremifene Toremifene The serum concentration of Toremifene can be increased when it is combined with Isavuconazonium.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Isavuconazonium.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Isavuconazonium.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Isavuconazonium.
Rufinamide Rufinamide The metabolism of Rufinamide can be increased when combined with Isavuconazonium.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Isavuconazonium.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Isavuconazonium.
Milnacipran Milnacipran The metabolism of Milnacipran can be increased when combined with Isavuconazonium.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Isavuconazonium.
Lacosamide Lacosamide The metabolism of Lacosamide can be increased when combined with Isavuconazonium.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Isavuconazonium.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Isavuconazonium.
Dronedarone Dronedarone The metabolism of Dronedarone can be increased when combined with Isavuconazonium.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Isavuconazonium.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Isavuconazonium.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Isavuconazonium.
Asenapine Asenapine Asenapine can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Albendazole Albendazole The metabolism of Albendazole can be increased when combined with Isavuconazonium.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Isavuconazonium.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Isavuconazonium.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Cabazitaxel can be increased when it is combined with Isavuconazonium.
Lurasidone Lurasidone The metabolism of Lurasidone can be decreased when combined with Isavuconazonium.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Isavuconazonium.
Roflumilast Roflumilast The metabolism of Roflumilast can be increased when combined with Isavuconazonium.
Linagliptin Linagliptin The serum concentration of Linagliptin can be increased when it is combined with Isavuconazonium.
Telaprevir Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Isavuconazonium.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Isavuconazonium.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Isavuconazonium.
Ticagrelor Ticagrelor The serum concentration of Ticagrelor can be increased when it is combined with Isavuconazonium.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Isavuconazonium.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Isavuconazonium.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Isavuconazonium.
Clobazam Clobazam The serum concentration of Clobazam can be increased when it is combined with Isavuconazonium.
Vemurafenib Vemurafenib The serum concentration of Vemurafenib can be increased when it is combined with Isavuconazonium.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Isavuconazonium.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Isavuconazonium.
Crizotinib Crizotinib The serum concentration of Crizotinib can be increased when it is combined with Isavuconazonium.
Cabergoline Cabergoline The metabolism of Cabergoline can be increased when combined with Isavuconazonium.
Naloxone Injection Naloxone Injection The serum concentration of Isavuconazonium can be increased when it is combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Isavuconazonium.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Isavuconazonium.
Mirabegron Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Isavuconazonium.
Regorafenib Regorafenib The serum concentration of Regorafenib can be increased when it is combined with Isavuconazonium.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Isavuconazonium.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Isavuconazonium.
Ponatinib Ponatinib The metabolism of Ponatinib can be increased when combined with Isavuconazonium.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Isavuconazonium.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Isavuconazonium.
Apixaban Apixaban The serum concentration of Apixaban can be increased when it is combined with Isavuconazonium.
Canagliflozin Canagliflozin The serum concentration of Canagliflozin can be increased when it is combined with Isavuconazonium.
Dabrafenib Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Isavuconazonium.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Isavuconazonium.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Isavuconazonium.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Isavuconazonium.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Isavuconazonium.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Isavuconazonium.
Lomitapide Lomitapide The metabolism of Lomitapide can be increased when combined with Isavuconazonium.
Avanafil Avanafil The metabolism of Avanafil can be decreased when combined with Isavuconazonium.
Simeprevir Simeprevir The serum concentration of Simeprevir can be increased when it is combined with Isavuconazonium.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Isavuconazonium.
Ceritinib Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Isavuconazonium.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Isavuconazonium.
Idelalisib Idelalisib The serum concentration of Isavuconazonium can be increased when it is combined with Idelalisib.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be increased when combined with Isavuconazonium.
Suvorexant Suvorexant The metabolism of Suvorexant can be increased when combined with Isavuconazonium.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Isavuconazonium.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Isavuconazonium.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be increased when combined with Isavuconazonium.
Nintedanib Nintedanib The serum concentration of Nintedanib can be increased when it is combined with Isavuconazonium.
Palbociclib Palbociclib The metabolism of Palbociclib can be increased when combined with Isavuconazonium.
Lenvatinib Lenvatinib The serum concentration of Lenvatinib can be increased when it is combined with Isavuconazonium.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Isavuconazonium.
Panobinostat Panobinostat The serum concentration of Panobinostat can be increased when it is combined with Isavuconazonium.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Isavuconazonium.
Ivabradine Ivabradine The metabolism of Ivabradine can be decreased when combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Isavuconazonium.
Flibanserin Flibanserin The metabolism of Flibanserin can be decreased when combined with Isavuconazonium.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Isavuconazonium.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Isavuconazonium.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Isavuconazonium.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Isavuconazonium.
Osimertinib Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Isavuconazonium.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Isavuconazonium.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Isavuconazonium.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The therapeutic efficacy of Amphotericin B can be decreased when used in combination with Isavuconazonium.
Venetoclax Venetoclax The serum concentration of Venetoclax can be increased when it is combined with Isavuconazonium.
Cobicistat Cobicistat The serum concentration of Isavuconazonium can be increased when it is combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Isavuconazonium.
Rucaparib Rucaparib The serum concentration of Rucaparib can be increased when it is combined with Isavuconazonium.
Ribociclib Ribociclib The serum concentration of Isavuconazonium can be increased when it is combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Isavuconazonium.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Deflazacort Deflazacort The serum concentration of Deflazacort can be increased when it is combined with Isavuconazonium.
Midostaurin Midostaurin The serum concentration of Midostaurin can be increased when it is combined with Isavuconazonium.
Neratinib Neratinib The metabolism of Neratinib can be increased when combined with Isavuconazonium.
Enasidenib Enasidenib The metabolism of Enasidenib can be increased when combined with Isavuconazonium.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Isavuconazonium.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Isavuconazonium.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Isavuconazonium.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be increased when combined with Isavuconazonium.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Isavuconazonium.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Isavuconazonium.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Isavuconazonium.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Isavuconazonium.
Baricitinib Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Isavuconazonium.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Isavuconazonium.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Isavuconazonium.
Ivosidenib Ivosidenib The serum concentration of Ivosidenib can be increased when it is combined with Isavuconazonium.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Isavuconazonium.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Isavuconazonium.
Dacomitinib Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Isavuconazonium.
Duvelisib Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Isavuconazonium.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Isavuconazonium.
Stiripentol Stiripentol The serum concentration of Isavuconazonium can be increased when it is combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Isavuconazonium.
Gilteritinib Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Isavuconazonium.
Glasdegib Glasdegib The serum concentration of Glasdegib can be increased when it is combined with Isavuconazonium.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Isavuconazonium.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Isavuconazonium.
Rifamycin Rifamycin The serum concentration of Rifamycin can be increased when it is combined with Isavuconazonium.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Isavuconazonium.
Siponimod Siponimod The risk or severity of adverse effects can be increased when Isavuconazonium is combined with Siponimod.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be increased when combined with Isavuconazonium.
Alpelisib Alpelisib The metabolism of Alpelisib can be increased when combined with Isavuconazonium.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Isavuconazonium.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Isavuconazonium.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Isavuconazonium.
Pitolisant Pitolisant The serum concentration of Isavuconazonium can be decreased when it is combined with Pitolisant.
Pretomanid Pretomanid The serum concentration of Pretomanid can be increased when it is combined with Isavuconazonium.
Fedratinib Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Isavuconazonium.
Lefamulin Lefamulin Isavuconazonium may decrease the excretion rate of Lefamulin which could result in a higher serum level.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be increased when combined with Isavuconazonium.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Isavuconazonium.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Isavuconazonium.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Isavuconazonium.
Lumateperone Lumateperone The serum concentration of Lumateperone can be increased when it is combined with Isavuconazonium.
Lasmiditan Lasmiditan The serum concentration of Lasmiditan can be increased when it is combined with Isavuconazonium.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Isavuconazonium.
Tazemetostat Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Isavuconazonium.
Cenobamate Cenobamate The serum concentration of Isavuconazonium can be decreased when it is combined with Cenobamate.
Pemigatinib Pemigatinib The metabolism of Pemigatinib can be decreased when combined with Isavuconazonium.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Isavuconazonium.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Isavuconazonium.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Isavuconazonium.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Isavuconazonium.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Isavuconazonium.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Isavuconazonium.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Isavuconazonium.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Isavuconazonium.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Isavuconazonium.
Lurbinectedin Injection Lurbinectedin Injection The serum concentration of Lurbinectedin can be increased when it is combined with Isavuconazonium.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Isavuconazonium.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Isavuconazonium.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Isavuconazonium can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Isavuconazonium.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Isavuconazonium.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Isavuconazonium.
Sucralfate Sucralfate Sucralfate can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sodium Bicarbonate Sodium Bicarbonate Sodium bicarbonate can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be increased when combined with Isavuconazonium.
Methsuximide Methsuximide The therapeutic efficacy of Isavuconazonium can be increased when used in combination with Methsuximide.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Isavuconazonium.
Lorazepam Lorazepam The metabolism of Lorazepam can be increased when combined with Isavuconazonium.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Isavuconazonium.
Phentermine Phentermine The metabolism of Phentermine can be increased when combined with Isavuconazonium.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Isavuconazonium.
Dactinomycin Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Isavuconazonium.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Isavuconazonium.
Clonidine Clonidine The metabolism of Clonidine can be increased when combined with Isavuconazonium.
Cimetidine Cimetidine Cimetidine can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Isavuconazonium.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Isavuconazonium.
Loperamide Loperamide The serum concentration of Loperamide can be increased when it is combined with Isavuconazonium.
Promethazine Promethazine Promethazine can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Isavuconazonium.
Quinine Quinine The serum concentration of Quinine can be increased when it is combined with Isavuconazonium.
Ethosuximide Ethosuximide The therapeutic efficacy of Isavuconazonium can be increased when used in combination with Ethosuximide.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Isavuconazonium.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Isavuconazonium.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Isavuconazonium.
Quinidine Quinidine The serum concentration of Quinidine can be increased when it is combined with Isavuconazonium.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be increased when combined with Isavuconazonium.
Methimazole Methimazole The serum concentration of Isavuconazonium can be increased when it is combined with Methimazole.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Isavuconazonium.
Amphotericin B Injection Amphotericin B Injection The therapeutic efficacy of Amphotericin B can be decreased when used in combination with Isavuconazonium.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Isavuconazonium.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Isavuconazonium.
Cephalexin Cephalexin The metabolism of Cephalexin can be increased when combined with Isavuconazonium.
Ketoconazole Ketoconazole The serum concentration of Isavuconazonium can be increased when it is combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Isavuconazonium.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Isavuconazonium.
Vinblastine Vinblastine The serum concentration of Vinblastine can be increased when it is combined with Isavuconazonium.
Metoprolol Metoprolol The metabolism of Metoprolol can be increased when combined with Isavuconazonium.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Isavuconazonium.
Diltiazem Diltiazem The therapeutic efficacy of Isavuconazonium can be increased when used in combination with Diltiazem.
Nifedipine Nifedipine The therapeutic efficacy of Isavuconazonium can be increased when used in combination with Nifedipine.
Verapamil Verapamil The therapeutic efficacy of Isavuconazonium can be increased when used in combination with Verapamil.
Etoposide Etoposide The serum concentration of Etoposide can be increased when it is combined with Isavuconazonium.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Isavuconazonium.
Amiodarone Amiodarone The metabolism of Amiodarone can be increased when combined with Isavuconazonium.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Isavuconazonium.
Nimodipine Nimodipine The therapeutic efficacy of Isavuconazonium can be increased when used in combination with Nimodipine.
Clarithromycin Clarithromycin The serum concentration of Isavuconazonium can be increased when it is combined with Clarithromycin.
Felodipine Felodipine The therapeutic efficacy of Isavuconazonium can be increased when used in combination with Felodipine.
Pravastatin Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Isavuconazonium.
Simvastatin Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Isavuconazonium.
Amlodipine Amlodipine The metabolism of Amlodipine can be increased when combined with Isavuconazonium.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be increased when combined with Isavuconazonium.
Itraconazole Itraconazole The serum concentration of Isavuconazonium can be increased when it is combined with Itraconazole.
Bisoprolol Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Isavuconazonium.
Zolpidem Zolpidem The metabolism of Zolpidem can be increased when combined with Isavuconazonium.
Doxazosin Doxazosin The metabolism of Doxazosin can be increased when combined with Isavuconazonium.
Isradipine Isradipine The therapeutic efficacy of Isavuconazonium can be increased when used in combination with Isradipine.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Isavuconazonium.
Nizatidine Nizatidine Nizatidine can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Famciclovir Famciclovir The metabolism of Famciclovir can be increased when combined with Isavuconazonium.
Nefazodone Nefazodone The serum concentration of Isavuconazonium can be increased when it is combined with Nefazodone.
Lamotrigine Lamotrigine The therapeutic efficacy of Isavuconazonium can be increased when used in combination with Lamotrigine.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Isavuconazonium.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be increased when combined with Isavuconazonium.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Isavuconazonium.
Nicardipine Nicardipine The therapeutic efficacy of Isavuconazonium can be increased when used in combination with Nicardipine.
Bupropion Bupropion The serum concentration of Bupropion can be decreased when it is combined with Isavuconazonium.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be increased when combined with Isavuconazonium.
Saquinavir Saquinavir The serum concentration of Saquinavir can be increased when it is combined with Isavuconazonium.
Nisoldipine Nisoldipine The therapeutic efficacy of Isavuconazonium can be increased when used in combination with Nisoldipine.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Isavuconazonium.
Ritonavir Ritonavir The serum concentration of Isavuconazonium can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Isavuconazonium.
Clomipramine Clomipramine The metabolism of Clomipramine can be increased when combined with Isavuconazonium.
Zafirlukast Zafirlukast The metabolism of Isavuconazonium can be increased when combined with Zafirlukast.
Fexofenadine Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Isavuconazonium.
Azithromycin Azithromycin The metabolism of Azithromycin can be increased when combined with Isavuconazonium.
Carvedilol Carvedilol The therapeutic efficacy of Isavuconazonium can be increased when used in combination with Carvedilol.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be increased when combined with Isavuconazonium.
Efavirenz Efavirenz The serum concentration of Isavuconazonium can be increased when it is combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Isavuconazonium.
Aluminum Hydroxide Aluminum Hydroxide Aluminum hydroxide can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.

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