Meperidine Injection

Generic name: Pronounced as (me per' i deen)
Brand names
  • Demerol®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2021

Meperidine injection may be habit forming, especially with prolonged use. Use meperidine injection exactly as directed. Do not use more of it, use it more often, or use it in a different way than directed by your doctor. While you are using meperidine injection, discuss with your health care provider your pain treatment goals, length of treatment, and other ways to manage your pain. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or has had an overdose, or if you have or have ever had depression or another mental illness. There is a greater risk that you will overuse meperidine if you have or have ever had any of these conditions. Talk to your health care provider immediately and ask for guidance if you think that you have an opioid addiction or call the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-HELP.

Meperidine injection may cause serious or life-threatening breathing problems, especially during the first 24 to 72 hours of your treatment and any time your dose is increased. Your doctor will monitor you carefully during your treatment. Tell your doctor if you have or have ever had slowed breathing or asthma. Your doctor will probably tell you not to use meperidine injection. Also tell your doctor if you have or have ever had lung disease such as chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways), a head injury, a brain tumor, or any condition that increases the amount of pressure in your brain. The risk that you will develop breathing problems may be higher if you are an older adult or are weak or malnourished due to disease. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: slowed breathing, long pauses between breaths, or shortness of breath.

Taking certain medications during your treatment with meperidine injection may increase the risk that you will experience breathing problems or other serious, life threatening breathing problems, sedation, or coma. Tell your doctor if you are taking or plan to take any of the following medications: benzodiazepines such as alprazolam (Xanax), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), and triazolam (Halcion); medications for anxiety, nausea, or pain; muscle relaxants; sedatives; sleeping pills; or tranquilizers. Your doctor may need to change the dosages of your medications and will monitor you carefully. If you use meperidine injection with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.

Drinking alcohol, taking prescription or nonprescription medications that contain alcohol, or using street drugs during your treatment with meperidine increases the risk that you will experience serious, life-threatening side effects. Do not drink alcohol, take prescription or nonprescription medications that contain alcohol, or use street drugs during your treatment.

Do not allow anyone else to use your medication. Meperidine injection may harm or cause death to other people who use your medication, especially children.

Tell your doctor if you are pregnant or plan to become pregnant. If you using meperidine injection regularly during your pregnancy, your baby may experience life-threatening withdrawal symptoms after birth. Tell your baby's doctor right away if your baby experiences any of the following symptoms: irritability, hyperactivity, abnormal sleep, high-pitched cry, uncontrollable shaking of a part of the body, vomiting, diarrhea, or failure to gain weight.

Talk to your doctor about the risks of using meperidine injection.

Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Meperidine injection is used to relieve moderate to severe pain. It may also be used before and during surgery or other medical procedures. Meperidine injection is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the body senses pain.

Meperidine injection comes as a solution (liquid) to inject subcutaneously (just under the skin), intramuscularly (into a muscle), or intravenously (into a vein). It is usually injected subcutaneously or intramuscularly once every 3 to 4 hours as needed. Use meperidine injection exactly as directed.

Your doctor may adjust your dose of meperidine injection during your treatment, depending on how well your pain is controlled and on the side effects that you experience. Talk to your doctor about how you are feeling during your treatment with meperidine injection.

If you have used meperidine injection for longer than a few days, do not stop using it suddenly. If you suddenly stop using meperidine injection, you may experience withdrawal symptoms including restlessness; teary eyes; runny nose; yawning; sweating; chills; muscle, back or joint pain; widening of the pupils; irritability; anxiety; weakness; stomach cramps; difficulty falling asleep or staying asleep; nausea; loss of appetite; vomiting; diarrhea; fast breathing; or fast heartbeat. Your doctor will probably decrease your dose gradually.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before using meperidine injection

  • tell your doctor and pharmacist if you are allergic to meperidine, any other medications, or ingredients in meperidine injection. Ask your pharmacist for a list of the ingredients.

  • do not use meperidine injection if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), procarbazine (Matulane), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) or if you have stopped taking any of these medications within the past 2 weeks. Your doctor will probably tell you not to use meperidine injection if you are taking one or more of these medications.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: cyclobenzaprine (Amrix); dextromethorphan (found in many cough medications; in Nuedexta); lithium (Lithobid, in Librax); medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, in Treximet), and zolmitriptan (Zomig); mirtazapine (Remeron); 5HT3 serotonin blockers such as alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), ondansetron (Zofran, Zuplenz), or palonosetron (Aloxi); selective serotonin-reuptake inhibitors such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Prozac, Pexeva), and sertraline (Zoloft); serotonin and norepinephrine reuptake inhibitors such as duloxetine (Cymbalta), desvenlafaxine (Khedezla, Pristiq), milnacipran (Savella), and venlafaxine (Effexor); tramadol (Conzip, Ultram); trazodone (Oleptro); or tricyclic antidepressants ('mood elevators') such as amitriptyline, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil). Many other medications may also interact with meperidine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Also tell your doctor or pharmacist if you are taking narcotic medications for pain or if you have recently taken these medications. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor what herbal products you are taking, especially St. John's wort and tryptophan.

  • tell your doctor if you have or have ever had problems urinating; Addison's disease (a condition in which the body does not produce certain important chemicals); prostatic hypertrophy (enlargement of a male reproductive gland called the prostate); urethral stricture (narrowing of the opening through which urine leaves the body); seizures; or thyroid, heart, kidney, or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using meperidine injection, call your doctor.

  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of using meperidine.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are using meperidine injection.

  • you should know that meperidine may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

  • you should know that meperidine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

Unless your doctor tells you otherwise, continue your normal diet.

  • Meperidine injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • lightheadedness

    • headache

    • agitation

    • constipation

    • uncontrollable shaking of a part of your body

    • blurred vision

    • dry mouth

    • pain or redness at injection site

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • slowed breathing

    • agitation, hallucinations (seeing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

    • nausea, vomiting, loss of appetite, weakness, or dizziness

    • inability to get or keep an erection

    • decreased sexual desire

    • irregular menstruation

    • intense happiness

    • sad mood

    • rash

    • itching

    • flushing

    • hives

    • seizures

    • hallucinations

  • Meperidine injection may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

While using meperidine injection, you should talk to your doctor about having a rescue medication called naloxone readily available (e.g., home, office). Naloxone is used to reverse the life-threatening effects of an overdose. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. Your doctor may also prescribe you naloxone if you are living in a household where there are small children or someone who has abused street or prescription drugs. You should make sure that you and your family members, caregivers, or the people who spend time with you know how to recognize an overdose, how to use naloxone, and what to do until emergency medical help arrives. Your doctor or pharmacist will show you and your family members how to use the medication. Ask your pharmacist for the instructions or visit the manufacturer's website to get the instructions. If symptoms of an overdose occur, a friend or family member should give the first dose of naloxone, call 911 immediately, and stay with you and watch you closely until emergency medical help arrives. Your symptoms may return within a few minutes after you receive naloxone. If your symptoms return, the person should give you another dose of naloxone. Additional doses may be given every 2 to 3 minutes, if symptoms return before medical help arrives.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • slow or shallow breathing

  • difficulty breathing

  • extreme sleepiness

  • unable to respond or wake up

  • loose, floppy muscles

  • cold, clammy skin

  • slow heartbeat

  • fainting

Keep all appointments with your doctor. Your doctor may order certain lab tests to check your body's response to meperidine.

Before having any laboratory test (especially those that involve methylene blue), tell your doctor and the laboratory personnel that you are using meperidine.

This prescription is not refillable. If you continue to have pain after you finish meperidine, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Leflunomide Leflunomide The metabolism of Leflunomide can be increased when combined with Meperidine.
Delavirdine Delavirdine The metabolism of Meperidine can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Meperidine can be increased when combined with Nevirapine.
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Meperidine is combined with Dolasetron.
Aminophylline Aminophylline The metabolism of Aminophylline can be increased when combined with Meperidine.
Anagrelide Anagrelide The metabolism of Anagrelide can be increased when combined with Meperidine.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Meperidine.
Cilostazol Cilostazol The metabolism of Cilostazol can be increased when combined with Meperidine.
Clopidogrel Clopidogrel Meperidine can cause a decrease in the absorption of Clopidogrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Meperidine is combined with Diphenoxylate.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Meperidine can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Conjugated estrogens can be increased when combined with Meperidine.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be increased when combined with Meperidine.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Meperidine is combined with Guanfacine.
Magnesium Hydroxide Magnesium Hydroxide The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Meperidine.
Magnesium Oxide Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Meperidine.
Methylergonovine Methylergonovine The metabolism of Meperidine can be decreased when combined with Methylergometrine.
Mycophenolate Mycophenolate Meperidine may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Meperidine is combined with Naratriptan.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Meperidine which could result in a higher serum level.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Meperidine.
Penbutolol Penbutolol The metabolism of Meperidine can be decreased when combined with Acebutolol.
Pentazocine Pentazocine The therapeutic efficacy of Pentazocine can be decreased when used in combination with Meperidine.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Meperidine.
Potassium Potassium Meperidine may increase the excretion rate of Potassium cation which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Meperidine may decrease the excretion rate of Prednisone which could result in a higher serum level.
Psyllium Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Meperidine.
Ranitidine Ranitidine The metabolism of Ranitidine can be increased when combined with Meperidine.
Reserpine Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Meperidine.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Meperidine is combined with Rizatriptan.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Meperidine is combined with Sumatriptan.
Tacrolimus Tacrolimus The metabolism of Meperidine can be increased when combined with Tacrolimus.
Tizanidine Tizanidine The metabolism of Tizanidine can be increased when combined with Meperidine.
Triamcinolone Triamcinolone The metabolism of Meperidine can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan The metabolism of Zolmitriptan can be increased when combined with Meperidine.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection The metabolism of Meperidine can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The metabolism of Meperidine can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Meperidine which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Meperidine.
Levofloxacin Injection Levofloxacin Injection Meperidine may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Meperidine can be increased when combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection The therapeutic efficacy of Metoclopramide can be decreased when used in combination with Meperidine.
Metronidazole Injection Metronidazole Injection The metabolism of Meperidine can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Meperidine.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Meperidine which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Meperidine may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine Altretamine The risk or severity of serotonin syndrome and opioid toxicity can be increased when Amphetamine is combined with Meperidine.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Meperidine which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Meperidine can be decreased when combined with Cyclosporine.
Ondansetron Ondansetron The risk or severity of adverse effects can be increased when Meperidine is combined with Ondansetron.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Meperidine is combined with Granisetron.
Torsemide Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Meperidine.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Meperidine is combined with Olanzapine.
Alosetron Alosetron The metabolism of Alosetron can be increased when combined with Meperidine.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Meperidine.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Meperidine is combined with Entacapone.
Hydroxychloroquine Hydroxychloroquine The metabolism of Meperidine can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Meperidine which could result in a higher serum level.
Orlistat Orlistat The metabolism of Meperidine can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The risk or severity of adverse effects can be increased when Meperidine is combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Meperidine which could result in a higher serum level.
Temozolomide Temozolomide Meperidine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Meperidine is combined with Zaleplon.
Anakinra Anakinra The metabolism of Meperidine can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Meperidine is combined with Desloratadine.
Linezolid Linezolid The risk or severity of serotonin syndrome and opioid toxicity can be increased when Linezolid is combined with Meperidine.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Meperidine.
Etanercept Injection Etanercept Injection The metabolism of Meperidine can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate The risk or severity of adverse effects can be increased when Meperidine is combined with Glycopyrronium.
Modafinil Modafinil The metabolism of Meperidine can be increased when combined with Modafinil.
Perindopril Perindopril Meperidine may decrease the excretion rate of Perindopril which could result in a higher serum level.
Tenofovir Tenofovir The metabolism of Tenofovir can be increased when combined with Meperidine.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Meperidine which could result in a higher serum level.
Sirolimus Sirolimus The metabolism of Sirolimus can be increased when combined with Meperidine.
Epinephrine Injection Epinephrine Injection The metabolism of Meperidine can be decreased when combined with Epinephrine.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Meperidine which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of serotonin syndrome can be increased when Escitalopram is combined with Meperidine.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Meperidine is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Meperidine can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Meperidine.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Meperidine.
Dexmethylphenidate Dexmethylphenidate The risk or severity of adverse effects can be increased when Meperidine is combined with Dexmethylphenidate.
Atazanavir Atazanavir The metabolism of Meperidine can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The risk or severity of adverse effects can be increased when Meperidine is combined with Almotriptan.
Eletriptan Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Meperidine.
Mefloquine Mefloquine The metabolism of Meperidine can be decreased when combined with Mefloquine.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Meperidine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Meperidine.
Aprepitant Aprepitant The metabolism of Meperidine can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Meperidine may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine The risk or severity of adverse effects can be increased when Meperidine is combined with Memantine.
Tegaserod Tegaserod The metabolism of Meperidine can be decreased when combined with Tegaserod.
Tadalafil Tadalafil Meperidine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be increased when combined with Meperidine.
Progesterone Progesterone The metabolism of Progesterone can be increased when combined with Meperidine.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Meperidine can be increased when combined with Infliximab.
Protriptyline Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Meperidine.
Rifaximin Rifaximin The metabolism of Meperidine can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Meperidine.
Norethindrone Norethindrone The metabolism of Norethisterone can be increased when combined with Meperidine.
Tinidazole Tinidazole Meperidine may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium Trospium The risk or severity of adverse effects can be increased when Trospium is combined with Meperidine.
Bosentan Bosentan The metabolism of Meperidine can be increased when combined with Bosentan.
Cefditoren Cefditoren Meperidine may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cinacalcet Cinacalcet The metabolism of Cinacalcet can be decreased when combined with Meperidine.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Meperidine.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Meperidine is combined with Eszopiclone.
Ganciclovir Ganciclovir Meperidine may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Meperidine may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin The risk or severity of adverse effects can be increased when Solifenacin is combined with Meperidine.
Valganciclovir Valganciclovir Meperidine may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Meperidine can be decreased when combined with Voriconazole.
Adefovir Adefovir Adefovir may decrease the excretion rate of Meperidine which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine The risk or severity of serotonin syndrome and opioid toxicity can be increased when Amphetamine is combined with Meperidine.
Entecavir Entecavir The metabolism of Entecavir can be increased when combined with Meperidine.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Meperidine can be decreased when combined with Peginterferon alfa-2b.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Meperidine.
Isocarboxazid Isocarboxazid The risk or severity of serotonin syndrome and opioid toxicity can be increased when Isocarboxazid is combined with Meperidine.
Ramelteon Ramelteon The risk or severity of adverse effects can be increased when Meperidine is combined with Ramelteon.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Meperidine.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Meperidine is combined with Fentanyl.
Pregabalin Pregabalin The therapeutic efficacy of Meperidine can be increased when used in combination with Pregabalin.
Deferasirox Deferasirox The metabolism of Meperidine can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Meperidine can be decreased when combined with Tipranavir.
Felbamate Felbamate The risk or severity of adverse effects can be increased when Meperidine is combined with Felbamate.
Ranolazine Ranolazine The metabolism of Ranolazine can be increased when combined with Meperidine.
Abatacept Injection Abatacept Injection The metabolism of Meperidine can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of serotonin syndrome and opioid toxicity can be increased when Rasagiline is combined with Meperidine.
Imatinib Imatinib The metabolism of Meperidine can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Meperidine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Meperidine may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Meperidine can be decreased when combined with Gefitinib.
Albuterol Albuterol Meperidine may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Meperidine is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Bortezomib can be increased when combined with Meperidine.
Clofarabine Injection Clofarabine Injection Meperidine may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Lubiprostone Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Meperidine.
Posaconazole Posaconazole The metabolism of Meperidine can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Meperidine can be decreased when combined with Primaquine.
Darunavir Darunavir The metabolism of Meperidine can be decreased when combined with Darunavir.
Pemetrexed Injection Pemetrexed Injection Meperidine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Meperidine is combined with Dimenhydrinate.
Lisdexamfetamine Lisdexamfetamine The therapeutic efficacy of Meperidine can be increased when used in combination with Lisdexamfetamine.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Meperidine.
Retapamulin Retapamulin The metabolism of Retapamulin can be increased when combined with Meperidine.
Sorafenib Sorafenib The metabolism of Sorafenib can be increased when combined with Meperidine.
Sunitinib Sunitinib The metabolism of Meperidine can be increased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Meperidine.
Lapatinib Lapatinib The metabolism of Meperidine can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Meperidine is combined with Levocetirizine.
Pegaptanib Injection Pegaptanib Injection Meperidine may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Dasatinib can be increased when combined with Meperidine.
Mexiletine Mexiletine The metabolism of Mexiletine can be increased when combined with Meperidine.
Armodafinil Armodafinil The metabolism of Meperidine can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Meperidine may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Ivermectin Ivermectin The metabolism of Meperidine can be increased when combined with Ivermectin.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Meperidine.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be increased when combined with Meperidine.
Lenalidomide Lenalidomide Meperidine may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Meperidine can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Meperidine can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Budesonide can be increased when combined with Meperidine.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Meperidine can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin The risk or severity of hyponatremia can be increased when Meperidine is combined with Desmopressin.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Meperidine.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Meperidine.
Doripenem Injection Doripenem Injection Meperidine may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The metabolism of Meperidine can be increased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection Meperidine may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Meperidine can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Desvenlafaxine is combined with Meperidine.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Meperidine which could result in a higher serum level.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Meperidine.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Meperidine.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be increased when combined with Meperidine.
Pilocarpine Pilocarpine The metabolism of Meperidine can be decreased when combined with Pilocarpine.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Meperidine.
Certolizumab Injection Certolizumab Injection The metabolism of Meperidine can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Meperidine.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Meperidine.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Praziquantel Praziquantel The metabolism of Praziquantel can be increased when combined with Meperidine.
Mitotane Mitotane The metabolism of Meperidine can be increased when combined with Mitotane.
Alvimopan Alvimopan The risk or severity of adverse effects can be increased when Meperidine is combined with Alvimopan.
Methylnaltrexone Injection Methylnaltrexone Injection The therapeutic efficacy of Methylnaltrexone can be decreased when used in combination with Meperidine.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Meperidine.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Meperidine is combined with Midazolam.
Naltrexone Injection Naltrexone Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Naltrexone.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Meperidine which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be increased when combined with Meperidine.
Milnacipran Milnacipran The risk or severity of serotonin syndrome can be increased when Meperidine is combined with Milnacipran.
Plerixafor Injection Plerixafor Injection Meperidine may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Meperidine.
Fesoterodine Fesoterodine The risk or severity of adverse effects can be increased when Fesoterodine is combined with Meperidine.
Betaxolol Betaxolol The metabolism of Betaxolol can be increased when combined with Meperidine.
Iloperidone Iloperidone The risk or severity of adverse effects can be increased when Meperidine is combined with Iloperidone.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Meperidine.
Lacosamide Lacosamide The risk or severity of adverse effects can be increased when Meperidine is combined with Lacosamide.
Everolimus Everolimus The metabolism of Everolimus can be increased when combined with Meperidine.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Meperidine can be increased when combined with Tolvaptan.
Dronedarone Dronedarone The metabolism of Meperidine can be decreased when combined with Dronedarone.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Meperidine.
Pralatrexate Injection Pralatrexate Injection Meperidine may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Meperidine.
Saxagliptin Saxagliptin Meperidine may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Meperidine may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Meperidine.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Meperidine.
Topotecan Topotecan The metabolism of Topotecan can be increased when combined with Meperidine.
Golimumab Injection Golimumab Injection The metabolism of Meperidine can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be increased when combined with Meperidine.
Asenapine Asenapine The metabolism of Asenapine can be increased when combined with Meperidine.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Meperidine is combined with Vigabatrin.
Albendazole Albendazole The metabolism of Albendazole can be increased when combined with Meperidine.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Meperidine.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Meperidine.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Meperidine is combined with Oxymorphone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Meperidine can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine The risk or severity of seizure can be increased when Dalfampridine is combined with Meperidine.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Meperidine.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Meperidine.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Meperidine which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Meperidine is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Meperidine.
Vilazodone Vilazodone The metabolism of Meperidine can be decreased when combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Meperidine may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Meperidine can be decreased when combined with Aldesleukin.
Terbutaline Injection Terbutaline Injection Meperidine may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Meperidine.
Roflumilast Roflumilast The metabolism of Roflumilast can be increased when combined with Meperidine.
Linagliptin Linagliptin The metabolism of Meperidine can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Meperidine can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Meperidine can be decreased when combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Meperidine can be increased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Meperidine can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban Meperidine may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor Ticagrelor can cause a decrease in the absorption of Meperidine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Meperidine can be increased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Meperidine.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Meperidine.
Clobazam Clobazam The risk or severity of adverse effects can be increased when Meperidine is combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Meperidine can be increased when combined with Vemurafenib.
Ivacaftor Ivacaftor The metabolism of Meperidine can be decreased when combined with Ivacaftor.
Deferiprone Deferiprone Meperidine may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Meperidine can be increased when combined with Axitinib.
Crizotinib Crizotinib The metabolism of Meperidine can be increased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Meperidine can be increased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Meperidine can be decreased when combined with Naloxone.
Fondaparinux Injection Fondaparinux Injection Meperidine may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Meperidine is combined with Tiagabine.
Enzalutamide Enzalutamide The metabolism of Meperidine can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The metabolism of Meperidine can be decreased when combined with Mirabegron.
Regorafenib Regorafenib The metabolism of Meperidine can be increased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Meperidine can be increased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Meperidine can be increased when combined with Corticotropin.
Linaclotide Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Meperidine.
Teduglutide Injection Teduglutide Injection Meperidine may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin Meperidine may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Ponatinib can be increased when combined with Meperidine.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be increased when combined with Meperidine.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Meperidine can be increased when combined with Trastuzumab emtansine.
Canagliflozin Canagliflozin Meperidine may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide The therapeutic efficacy of Methazolamide can be decreased when used in combination with Meperidine.
Dabrafenib Dabrafenib The metabolism of Meperidine can be increased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Meperidine.
Trametinib Trametinib The metabolism of Trametinib can be increased when combined with Meperidine.
Levomilnacipran Levomilnacipran The risk or severity of serotonin syndrome can be increased when Meperidine is combined with Levomilnacipran.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Meperidine which could result in a higher serum level.
Vortioxetine Vortioxetine The risk or severity of adverse effects can be increased when Meperidine is combined with Vortioxetine.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Meperidine.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Meperidine.
Lomitapide Lomitapide The metabolism of Lomitapide can be increased when combined with Meperidine.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Meperidine which could result in a higher serum level.
Simeprevir Simeprevir The metabolism of Meperidine can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Meperidine may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be increased when combined with Meperidine.
Apremilast Apremilast The metabolism of Meperidine can be increased when combined with Apremilast.
Droxidopa Droxidopa Meperidine may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Ceritinib can be increased when combined with Meperidine.
Siltuximab Injection Siltuximab Injection The metabolism of Meperidine can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Meperidine is combined with Eslicarbazepine.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Meperidine.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be increased when combined with Meperidine.
Oritavancin Injection Oritavancin Injection The metabolism of Meperidine can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be increased when combined with Meperidine.
Hydrocodone Hydrocodone Meperidine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant Suvorexant Meperidine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban Edoxaban Meperidine may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Olaparib Olaparib The metabolism of Meperidine can be increased when combined with Olaparib.
Methamphetamine Methamphetamine The therapeutic efficacy of Meperidine can be increased when used in combination with Metamfetamine.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Meperidine is combined with Tasimelteon.
Lanreotide Injection Lanreotide Injection The metabolism of Meperidine can be decreased when combined with Lanreotide.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be increased when combined with Meperidine.
Nintedanib Nintedanib The metabolism of Nintedanib can be increased when combined with Meperidine.
Secukinumab Injection Secukinumab Injection The metabolism of Meperidine can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Risperidone.
Palbociclib Palbociclib The metabolism of Meperidine can be increased when combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Meperidine can be increased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Meperidine can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Meperidine can be decreased when combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Meperidine.
Amiloride Amiloride Amiloride may increase the excretion rate of Meperidine which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Meperidine can be decreased when combined with Isavuconazonium.
Macitentan Macitentan Meperidine may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Meperidine.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Meperidine is combined with Flibanserin.
Rolapitant Rolapitant The metabolism of Meperidine can be decreased when combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Meperidine can be increased when combined with Prednisolone.
Brexpiprazole Brexpiprazole The risk or severity of adverse effects can be increased when Meperidine is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Meperidine.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Meperidine is combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Meperidine may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The risk or severity of constipation can be increased when Meperidine is combined with Eluxadoline.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be increased when combined with Meperidine.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Meperidine.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Meperidine.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Meperidine.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Meperidine.
Rifapentine Rifapentine The metabolism of Meperidine can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be increased when combined with Meperidine.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Meperidine which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The metabolism of Meperidine can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Brivaracetam.
Venetoclax Venetoclax The metabolism of Meperidine can be increased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Meperidine can be decreased when combined with Cobicistat.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Meperidine is combined with Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Meperidine.
Furosemide Injection Furosemide Injection Furosemide may decrease the excretion rate of Meperidine which could result in a higher serum level.
Rucaparib Rucaparib The metabolism of Meperidine can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Meperidine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib Ribociclib The metabolism of Meperidine can be decreased when combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Meperidine can be increased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The risk or severity of adverse effects can be increased when Meperidine is combined with Doxepin.
Plecanatide Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Meperidine.
Deutetrabenazine Deutetrabenazine Meperidine may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Meperidine may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The metabolism of Meperidine can be increased when combined with Deflazacort.
Safinamide Safinamide The risk or severity of serotonin syndrome and opioid toxicity can be increased when Safinamide is combined with Meperidine.
Naldemedine Naldemedine The therapeutic efficacy of Naldemedine can be decreased when used in combination with Meperidine.
Sarilumab Injection Sarilumab Injection The metabolism of Meperidine can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Meperidine can be increased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be increased when combined with Meperidine.
Enasidenib Enasidenib The metabolism of Enasidenib can be increased when combined with Meperidine.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Meperidine.
Benznidazole Benznidazole Meperidine may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Meperidine.
Delafloxacin Delafloxacin Meperidine may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be increased when combined with Meperidine.
Acalabrutinib Acalabrutinib The metabolism of Meperidine can be increased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Meperidine can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Meperidine.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Meperidine which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection Meperidine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide The metabolism of Meperidine can be increased when combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Meperidine can be decreased when combined with Fostamatinib.
Baricitinib Baricitinib The metabolism of Baricitinib can be increased when combined with Meperidine.
Lofexidine Lofexidine The therapeutic efficacy of Meperidine can be increased when used in combination with Lofexidine.
Plazomicin Injection Plazomicin Injection Meperidine may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat Eliglustat The metabolism of Meperidine can be decreased when combined with Eliglustat.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Meperidine.
Binimetinib Binimetinib The metabolism of Binimetinib can be increased when combined with Meperidine.
Ivosidenib Ivosidenib The metabolism of Meperidine can be increased when combined with Ivosidenib.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Meperidine.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Meperidine.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Meperidine.
Dacomitinib Dacomitinib The metabolism of Meperidine can be increased when combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be increased when combined with Meperidine.
Stiripentol Stiripentol The metabolism of Stiripentol can be decreased when combined with Meperidine.
Gilteritinib Gilteritinib The therapeutic efficacy of Meperidine can be decreased when used in combination with Gilteritinib.
Lorlatinib Lorlatinib The metabolism of Meperidine can be increased when combined with Lorlatinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Meperidine.
Rifamycin Rifamycin The metabolism of Meperidine can be increased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be increased when combined with Meperidine.
Magnesium Citrate Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Meperidine.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Meperidine can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be increased when combined with Meperidine.
Acyclovir Ophthalmic Acyclovir Ophthalmic The metabolism of Acyclovir can be increased when combined with Meperidine.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be increased when combined with Meperidine.
Alpelisib Alpelisib The metabolism of Meperidine can be increased when combined with Alpelisib.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Brexanolone.
Solriamfetol Solriamfetol The risk or severity of adverse effects can be increased when Meperidine is combined with Solriamfetol.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be increased when combined with Meperidine.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Meperidine.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Meperidine.
Istradefylline Istradefylline The metabolism of Istradefylline can be increased when combined with Meperidine.
Pitolisant Pitolisant The serum concentration of Meperidine can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Meperidine can be decreased when combined with Fedratinib.
Lefamulin Lefamulin The metabolism of Lefamulin can be increased when combined with Meperidine.
Phenytoin Injection Phenytoin Injection The serum concentration of Meperidine can be decreased when it is combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Meperidine can be decreased when it is combined with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Meperidine.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Meperidine.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Meperidine.
Lasmiditan Lasmiditan The risk or severity of serotonin syndrome can be increased when Meperidine is combined with Lasmiditan.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be increased when combined with Meperidine.
Cenobamate Cenobamate The serum concentration of Meperidine can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The metabolism of Selumetinib can be increased when combined with Meperidine.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Meperidine.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Meperidine.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Meperidine.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Meperidine.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Meperidine.
Fenfluramine Fenfluramine The risk or severity of serotonin syndrome can be increased when Meperidine is combined with Fenfluramine.
Octreotide Octreotide The metabolism of Meperidine can be decreased when combined with Octreotide.
Pralsetinib Pralsetinib The metabolism of Meperidine can be increased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Meperidine can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Meperidine which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Meperidine is combined with Viloxazine.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Meperidine can be increased when combined with Vitamin E.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Meperidine.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Meperidine which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Meperidine which could result in a higher serum level.
Naproxen Naproxen The metabolism of Naproxen can be increased when combined with Meperidine.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Meperidine which could result in a higher serum level.
Trazodone Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Meperidine.
Isotretinoin Isotretinoin Meperidine may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Meperidine which could result in a higher serum level.
Hydroxyurea Hydroxyurea The metabolism of Meperidine can be decreased when combined with Hydroxyurea.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Meperidine which could result in a higher serum level.
Phenobarbital Phenobarbital Phenobarbital may increase the hypotensive and central nervous system depressant (CNS depressant) activities of Meperidine.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Meperidine is combined with Metaxalone.
Methotrexate Injection Methotrexate Injection The metabolism of Meperidine can be increased when combined with Methotrexate.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Meperidine is combined with Levorphanol.
Primidone Primidone Primidone may increase the hypotensive and central nervous system depressant (CNS depressant) activities of Meperidine.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Meperidine is combined with Methsuximide.
Diethylpropion Diethylpropion The therapeutic efficacy of Meperidine can be increased when used in combination with Diethylpropion.
Chlorpromazine Chlorpromazine The metabolism of Meperidine can be decreased when combined with Chlorpromazine.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Meperidine is combined with Diazepam.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Meperidine is combined with Oxazepam.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Meperidine is combined with Flurazepam.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Meperidine is combined with Clorazepic acid.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Meperidine is combined with Lorazepam.
Carmustine Carmustine The metabolism of Carmustine can be increased when combined with Meperidine.
Amantadine Amantadine The risk or severity of adverse effects can be increased when Amantadine is combined with Meperidine.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Meperidine.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Meperidine.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Meperidine is combined with Chlordiazepoxide.
Bromocriptine Bromocriptine The metabolism of Meperidine can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The risk or severity of serotonin syndrome and opioid toxicity can be increased when Tranylcypromine is combined with Meperidine.
Phenelzine Phenelzine The risk or severity of serotonin syndrome and opioid toxicity can be increased when Phenelzine is combined with Meperidine.
Procarbazine Procarbazine The risk or severity of serotonin syndrome and opioid toxicity can be increased when Procarbazine is combined with Meperidine.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Meperidine is combined with Ergoloid mesylate.
Tetracycline Tetracycline The metabolism of Tetracycline can be decreased when combined with Meperidine.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Meperidine.
Prochlorperazine Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Meperidine.
Thioridazine Thioridazine The metabolism of Thioridazine can be decreased when combined with Meperidine.
Trifluoperazine Trifluoperazine The risk or severity of hypotension and CNS depression can be increased when Trifluoperazine is combined with Meperidine.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Meperidine which could result in a higher serum level.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Meperidine is combined with Oxycodone.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Meperidine.
Oxybutynin Oxybutynin The risk or severity of adverse effects can be increased when Oxybutynin is combined with Meperidine.
Benztropine Benztropine The risk or severity of adverse effects can be increased when Benzatropine is combined with Meperidine.
Maprotiline Maprotiline The risk or severity of adverse effects can be increased when Maprotiline is combined with Meperidine.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Meperidine which could result in a higher serum level.
Trihexyphenidyl Trihexyphenidyl The risk or severity of adverse effects can be increased when Meperidine is combined with Trihexyphenidyl.
Orphenadrine Orphenadrine Meperidine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The risk or severity of adverse effects can be increased when Meperidine is combined with Perphenazine.
Azathioprine Azathioprine The metabolism of Azathioprine can be increased when combined with Meperidine.
Fluphenazine Fluphenazine The risk or severity of adverse effects can be increased when Meperidine is combined with Fluphenazine.
Phentermine Phentermine The therapeutic efficacy of Meperidine can be increased when used in combination with Phentermine.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Meperidine which could result in a higher serum level.
Amoxapine Amoxapine The risk or severity of adverse effects can be increased when Meperidine is combined with Amoxapine.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Meperidine which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Meperidine can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Meperidine can be increased when combined with Doxorubicin.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Meperidine which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Meperidine.
Molindone Molindone The risk or severity of adverse effects can be increased when Meperidine is combined with Molindone.
Methyldopa Methyldopa Meperidine may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Meperidine.
Hydralazine Hydralazine The metabolism of Hydralazine can be decreased when combined with Meperidine.
Cimetidine Cimetidine The serum concentration of Meperidine can be increased when it is combined with Cimetidine.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Meperidine.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Meperidine.
Loperamide Loperamide The metabolism of Meperidine can be decreased when combined with Loperamide.
Promethazine Promethazine The risk or severity of adverse effects can be increased when Promethazine is combined with Meperidine.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Meperidine which could result in a higher serum level.
Daunorubicin Daunorubicin The metabolism of Meperidine can be decreased when combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Meperidine may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Meperidine can be increased when combined with Griseofulvin.
Digoxin Digoxin Digoxin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Meperidine.
Chloroquine Chloroquine The metabolism of Meperidine can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Meperidine can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Meperidine is combined with Ethosuximide.
Calcitriol Calcitriol The metabolism of Meperidine can be increased when combined with Calcitriol.
Triamterene Triamterene The metabolism of Triamterene can be increased when combined with Meperidine.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Meperidine.
Sulfinpyrazone Sulfinpyrazone The metabolism of Meperidine can be increased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Meperidine.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Meperidine.
Metolazone Metolazone Meperidine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Meperidine.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Meperidine.
Secobarbital Secobarbital Secobarbital may increase the hypotensive and central nervous system depressant (CNS depressant) activities of Meperidine.
Desipramine Desipramine The metabolism of Meperidine can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The risk or severity of adverse effects can be increased when Meperidine is combined with Amitriptyline.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Meperidine.
Probenecid Probenecid The metabolism of Probenecid can be increased when combined with Meperidine.
Quinidine Quinidine The risk or severity of adverse effects can be increased when Meperidine is combined with Quinidine.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Meperidine.
Isoniazid Isoniazid The metabolism of Meperidine can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Meperidine which could result in a higher serum level.
Rifampin Rifampin The metabolism of Meperidine can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of adverse effects can be increased when Meperidine is combined with Disopyramide.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Meperidine.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be increased when combined with Meperidine.
Butabarbital Butabarbital Butabarbital may increase the hypotensive and central nervous system depressant (CNS depressant) activities of Meperidine.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Meperidine which could result in a higher serum level.
Methimazole Methimazole The metabolism of Meperidine can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide Meperidine may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Tolbutamide Tolbutamide Meperidine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Meperidine may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Meperidine.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Meperidine is combined with Cyclobenzaprine.
Niacin Niacin The metabolism of Meperidine can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Meperidine.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Meperidine.
Cyproheptadine Cyproheptadine The risk or severity of adverse effects can be increased when Cyproheptadine is combined with Meperidine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Meperidine.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Meperidine is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Meperidine.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Meperidine is combined with Meclizine.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Meperidine which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Meperidine.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Meperidine which could result in a higher serum level.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Meperidine is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Meperidine.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Meperidine.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Meperidine.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Meperidine which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Meperidine which could result in a higher serum level.
Danazol Danazol The metabolism of Meperidine can be decreased when combined with Danazol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Propranolol can be increased when combined with Meperidine.
Pseudoephedrine Pseudoephedrine The therapeutic efficacy of Meperidine can be increased when used in combination with Pseudoephedrine.
Nortriptyline Nortriptyline The risk or severity of adverse effects can be increased when Meperidine is combined with Nortriptyline.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Meperidine which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Meperidine which could result in a higher serum level.
Phytonadione Phytonadione Meperidine may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Nadolol Nadolol Meperidine may decrease the excretion rate of Nadolol which could result in a higher serum level.
Butorphanol Injection Butorphanol Injection The therapeutic efficacy of Butorphanol can be decreased when used in combination with Meperidine.
Nalbuphine Injection Nalbuphine Injection The therapeutic efficacy of Nalbuphine can be decreased when used in combination with Meperidine.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Meperidine which could result in a higher serum level.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Meperidine is combined with Trimethobenzamide.
Flavoxate Flavoxate The risk or severity of adverse effects can be increased when Flavoxate is combined with Meperidine.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be increased when combined with Meperidine.
Colchicine Colchicine The metabolism of Colchicine can be increased when combined with Meperidine.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Meperidine which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Meperidine which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Cephalexin Cephalexin The metabolism of Cephalexin can be increased when combined with Meperidine.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Dacarbazine Dacarbazine The metabolism of Dacarbazine can be increased when combined with Meperidine.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Meperidine is combined with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Meperidine which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Ketoconazole Ketoconazole The metabolism of Meperidine can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Meperidine is combined with Pyrantel.
Thiotepa Injection Thiotepa Injection The metabolism of Meperidine can be increased when combined with Thiotepa.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be increased when combined with Meperidine.
Vinblastine Vinblastine The metabolism of Meperidine can be increased when combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Meperidine which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Meperidine which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Meperidine can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Meperidine.
Thiothixene Thiothixene The metabolism of Thiothixene can be increased when combined with Meperidine.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Meperidine which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Meperidine which could result in a higher serum level.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Meperidine is combined with Alprazolam.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Meperidine is combined with Temazepam.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Meperidine is combined with Triazolam.
Dicyclomine Dicyclomine The risk or severity of adverse effects can be increased when Dicyclomine is combined with Meperidine.
Hyoscyamine Hyoscyamine The risk or severity of adverse effects can be increased when Meperidine is combined with Hyoscyamine.
Propantheline Propantheline The risk or severity of adverse effects can be increased when Propantheline is combined with Meperidine.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Meperidine which could result in a higher serum level.
Diltiazem Diltiazem The metabolism of Meperidine can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Nifedipine can be increased when combined with Meperidine.
Timolol Timolol Timolol may decrease the excretion rate of Meperidine which could result in a higher serum level.
Verapamil Verapamil The metabolism of Verapamil can be increased when combined with Meperidine.
Atenolol Atenolol The metabolism of Meperidine can be decreased when combined with Atenolol.
Pindolol Pindolol The risk or severity of adverse effects can be increased when Meperidine is combined with Pindolol.
Cisplatin Injection Cisplatin Injection Cisplatin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Meperidine which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Meperidine which could result in a higher serum level.
Bumetanide Bumetanide Bumetanide may decrease the excretion rate of Meperidine which could result in a higher serum level.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Meperidine.
Glyburide Glyburide The metabolism of Meperidine can be decreased when combined with Glyburide.
Glipizide Glipizide Meperidine may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide Indapamide Meperidine may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Meperidine may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Dicloxacillin Dicloxacillin The metabolism of Meperidine can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Meperidine can be increased when combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Meperidine may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline The metabolism of Pentoxifylline can be increased when combined with Meperidine.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Meperidine which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Meperidine which could result in a higher serum level.
Labetalol Labetalol The metabolism of Labetalol can be decreased when combined with Meperidine.
Auranofin Auranofin Meperidine may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Meperidine which could result in a higher serum level.
Gemfibrozil Gemfibrozil Meperidine may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Guanabenz Guanabenz The metabolism of Guanabenz can be increased when combined with Meperidine.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Meperidine which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Meperidine which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Meperidine which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Meperidine which could result in a higher serum level.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Meperidine.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Meperidine which could result in a higher serum level.
Amiodarone Amiodarone The metabolism of Amiodarone can be increased when combined with Meperidine.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Meperidine which could result in a higher serum level.
Buspirone Buspirone The risk or severity of serotonin syndrome can be increased when Meperidine is combined with Buspirone.
Lovastatin Lovastatin The metabolism of Meperidine can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Meperidine can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Meperidine which could result in a higher serum level.
Diclofenac Diclofenac The metabolism of Diclofenac can be increased when combined with Meperidine.
Fluoxetine Fluoxetine The serum concentration of Meperidine can be increased when it is combined with Fluoxetine.
Clozapine Clozapine The metabolism of Meperidine can be decreased when combined with Clozapine.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Meperidine is combined with Estazolam.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Meperidine.
Didanosine Didanosine Meperidine may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Meperidine may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Clarithromycin Clarithromycin The metabolism of Meperidine can be decreased when combined with Clarithromycin.
Etodolac Etodolac Etodolac may decrease the excretion rate of Meperidine which could result in a higher serum level.
Felodipine Felodipine The metabolism of Meperidine can be decreased when combined with Felodipine.
Fosinopril Fosinopril Meperidine may decrease the excretion rate of Fosinopril which could result in a higher serum level.
Nabumetone Nabumetone The metabolism of Nabumetone can be increased when combined with Meperidine.
Simvastatin Simvastatin The metabolism of Meperidine can be increased when combined with Simvastatin.
Amlodipine Amlodipine The metabolism of Amlodipine can be increased when combined with Meperidine.
Teniposide Injection Teniposide Injection The metabolism of Meperidine can be increased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Meperidine can be decreased when combined with Itraconazole.
Lisinopril Lisinopril Meperidine may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Rifabutin Rifabutin The metabolism of Meperidine can be increased when combined with Rifabutin.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Meperidine.
Bisoprolol Bisoprolol Meperidine may decrease the excretion rate of Bisoprolol which could result in a higher serum level.
Zolpidem Zolpidem The metabolism of Zolpidem can be increased when combined with Meperidine.
Doxazosin Doxazosin The metabolism of Doxazosin can be increased when combined with Meperidine.
Isradipine Isradipine The metabolism of Meperidine can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Meperidine can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Meperidine can be decreased when combined with Cisapride.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Meperidine is combined with Gabapentin.
Fluvastatin Fluvastatin The metabolism of Meperidine can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The metabolism of Meperidine can be decreased when combined with Venlafaxine.
Famciclovir Famciclovir The metabolism of Famciclovir can be increased when combined with Meperidine.
Fluvoxamine Fluvoxamine The risk or severity of serotonin syndrome can be increased when Fluvoxamine is combined with Meperidine.
Nefazodone Nefazodone The risk or severity of serotonin syndrome can be increased when Nefazodone is combined with Meperidine.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Meperidine.
Losartan Losartan The metabolism of Meperidine can be decreased when combined with Losartan.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Meperidine which could result in a higher serum level.
Tramadol Tramadol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Meperidine.
Vinorelbine Injection Vinorelbine Injection The metabolism of Meperidine can be increased when combined with Vinorelbine.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Lansoprazole Lansoprazole The metabolism of Meperidine can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Meperidine.
Nicardipine Nicardipine The metabolism of Meperidine can be decreased when combined with Nicardipine.
Bupropion Bupropion The risk or severity of seizure can be increased when Bupropion is combined with Meperidine.
Ticlopidine Ticlopidine The metabolism of Meperidine can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Meperidine can be decreased when combined with Saquinavir.
Metformin Metformin Metformin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Meperidine which could result in a higher serum level.
Lamivudine Lamivudine Meperidine may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole The metabolism of Riluzole can be increased when combined with Meperidine.
Acarbose Acarbose Acarbose may decrease the excretion rate of Meperidine which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Meperidine which could result in a higher serum level.
Ritonavir Ritonavir The serum concentration of normeperidine, an active metabolite of Meperidine, can be increased when used in combination with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Meperidine can be increased when combined with Docetaxel.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Meperidine which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meperidine may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine The metabolism of Clomipramine can be increased when combined with Meperidine.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be increased when combined with Meperidine.
Fosfomycin Fosfomycin Meperidine may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine Meperidine may increase the serotonergic activities of Mirtazapine.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Meperidine.
Zileuton Zileuton The metabolism of Zileuton can be increased when combined with Meperidine.
Pramipexole Pramipexole Meperidine may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of adverse effects can be increased when Meperidine is combined with Donepezil.
Nelfinavir Nelfinavir The metabolism of Meperidine can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Azithromycin can be increased when combined with Meperidine.
Carvedilol Carvedilol The metabolism of Carvedilol can be increased when combined with Meperidine.
Nilutamide Nilutamide Meperidine may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide The metabolism of Flutamide can be increased when combined with Meperidine.
Selegiline Selegiline The risk or severity of serotonin syndrome and opioid toxicity can be increased when Selegiline is combined with Meperidine.
Bicalutamide Bicalutamide The metabolism of Meperidine can be increased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Meperidine.
Propafenone Propafenone The metabolism of Propafenone can be decreased when combined with Meperidine.
Raloxifene Raloxifene The metabolism of Meperidine can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Meperidine can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin Meperidine may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Ropinirole Ropinirole The metabolism of Ropinirole can be increased when combined with Meperidine.
Quetiapine Quetiapine The risk or severity of adverse effects can be increased when Meperidine is combined with Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Meperidine which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Meperidine which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Meperidine which could result in a higher serum level.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Meperidine.
Paroxetine Paroxetine The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Meperidine.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Meperidine.
Citalopram Citalopram The risk or severity of serotonin syndrome can be increased when Citalopram is combined with Meperidine.
Capecitabine Capecitabine Meperidine may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Efavirenz Efavirenz The metabolism of Efavirenz can be decreased when combined with Meperidine.
Abacavir Abacavir Meperidine may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Meperidine can be decreased when combined with Sildenafil.
Celecoxib Celecoxib The metabolism of Meperidine can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Meperidine can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The risk or severity of adverse effects can be increased when Tolterodine is combined with Meperidine.
Thalidomide Thalidomide Meperidine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Meperidine which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Meperidine which could result in a higher serum level.
Nateglinide Nateglinide Meperidine may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Galantamine Galantamine The metabolism of Galantamine can be decreased when combined with Meperidine.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Meperidine is combined with Levetiracetam.
Rabeprazole Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Meperidine.
Terbinafine Terbinafine The metabolism of Meperidine can be decreased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists