Naltrexone Injection

Generic name: Pronounced as (nal trex' one)
Brand names
  • Vivitrol®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 11/01/2010

Naltrexone injection may cause liver damage when given in large doses. It is not likely that naltrexone injection will cause liver damage when given in recommended doses. Tell your doctor if you have or have ever had hepatitis or another liver disease. If you experience any of the following symptoms, call your doctor immediately: excessive tiredness, unusual bleeding or bruising, pain in the upper right part of your stomach that lasts more than a few days, light-colored bowel movements, dark urine, or yellowing of the skin or eyes. Your doctor will probably not give you naltrexone injection if you have liver disease or if you develop symptoms of liver disease during your treatment.

Talk to your doctor about the risks of receiving naltrexone injection.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with naltrexone injection and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website http://www.vivitrol.com to obtain the Medication Guide.

Naltrexone injection is used along with counseling and social support to help people who have stopped drinking large amounts of alcohol to avoid drinking again. Naltrexone injection is also used along with counseling and social support to help people who have stopped abusing opiate medications or street drugs to avoid abusing the medications or street drugs again. Naltrexone injection should not be used to treat people who are still drinking alcohol, people who are still using opiates or street drugs, or people who have used opiates within the past 10 days. Naltrexone is in a class of medications called opiate antagonists. It works by blocking activity in the limbic system, a part of the brain that is involved in alcohol and opiate dependence.

Naltrexone injection comes as a solution (liquid) to be given by injection into the muscle of the buttocks by a healthcare provider once every 4 weeks.

Naltrexone injection will not prevent withdrawal symptoms that may occur when you stop drinking alcohol after drinking large amounts for a long time or when you stop using opiate medications or street drugs.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving naltrexone injection,

  • tell your doctor and pharmacist if you are allergic to naltrexone, any other medications, carboxymethylcellulose (an ingredient in artificial tears and some medications), or polylactide-co-glycolide (PLG; an ingredient in some injected medications). Ask your doctor or pharmacist if you don't know if a medication you are allergic to contains carboxymethylcellulose or PLG.

  • tell your doctor if you have taken any opiate medications including certain medications for diarrhea, cough, or pain; methadone (Dolophine); or buprenorphine (Buprenex, Subutex, in Suboxone) within the last 7 to 10 days. Ask your doctor if you are not sure if a medication you have taken is an opiate Also tell your doctor if you have used any opiate street drugs such as heroin within the last 7 to 10 days. Your doctor may order certain tests to see if you have recently taken any opiate medications or used street drugs. Your doctor will not give you naltrexone injection if you have recently taken an opiate medication or used street drug.

  • do not take any opiate medications or use street drugs during your treatment with naltrexone injection. Naltrexone injection blocks the effects of opiate medications and street drugs. You may not feel the effects of these substances if you take or use them at low or normal doses at most times during your treatment. However, you may be more sensitive to the effects of these substances when it is almost time for you to receive a dose of naltrexone injection or if you miss a dose of naltrexone injection. You may experience an overdose if you take normal doses of opiate medications at these times, or if you take high doses of opiate medications or use street drugs at any time during your treatment with naltrexone. An opiate overdose may cause serious injury, coma (long-lasting unconscious state), or death. If you take or use opiate medications or street drugs during your treatment and you develop any of the following symptoms, call your doctor or seek emergency medical care immediately: difficulty breathing, slow, shallow breathing, faintness, dizziness, or confusion. Be sure that your family knows which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.

  • you should know that you may be more sensitive to the effects of opiate medications or street drugs after you finish your treatment with naltrexone injection. After you finish your treatment, tell any doctor who may prescribe medication for you that you were previously treated with naltrexone injection.

  • tell your doctor what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have stopped taking opiates or using street drugs and are experiencing withdrawal symptoms such as anxiety, sleeplessness, yawning, fever, sweating, teary eyes, runny nose, goose bumps, shakiness, hot or cold flushes, muscle aches, muscle twitches, restlessness, nausea and vomiting, diarrhea, or stomach cramps, and if you have or have ever had bleeding problems such as hemophilia (a bleeding disorder in which the blood does not clot normally), a low number of platelets in your blood, depression, or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving naltrexone injection, call your doctor.

  • if you need medical treatment or surgery, including dental surgery, tell the doctor or dentist that you are receiving naltrexone injection. Wear or carry medical identification so that healthcare providers who treat you in an emergency will know that you are receiving naltrexone injection.

  • you should know that naltrexone injection may make you feel dizzy or drowsy. Do not drive a car or operate machinery or do other dangerous activities until you know how this medication affects you.

  • you should know that people who drink large amounts of alcohol or who use street drugs often become depressed and sometimes try to harm or kill themselves. Receiving naltrexone injection does not decrease the risk that you will try to harm yourself. You, your family, or your caregiver should call your doctor right away if you experience symptoms such as feelings of sadness, anxiousness, worthlessness, or helplessness, or thinking about harming or killing yourself or planning or trying to do so. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor right away if you are unable to seek treatment on your own.

  • you should know that naltrexone injection is only helpful when it is used as part of an addiction treatment program. It is important that you attend all counseling sessions, support group meetings, education programs or other treatments recommended by your doctor.

  • talk to your doctor about the risks and benefits of naltrexone injection before you receive your first dose. Naltrexone will remain in your body for about 1 month after you receive the injection and cannot be removed before this time.

Unless your doctor tells you otherwise, continue your normal diet.

If you miss an appointment to receive naltrexone injection, schedule another appointment as soon as possible.

  • Naltrexone injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • diarrhea

    • stomach pain

    • decreased appetite

    • dry mouth

    • headache

    • difficulty falling asleep or staying asleep

    • dizziness

    • tiredness

    • anxiety

    • joint pain or stiffness

    • muscle cramps

    • weakness

    • tenderness, redness, bruising, or itching at the injection site

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

    • pain, hardness, swelling, lumps, blisters, open wounds, or a dark scab at the injection site

    • coughing

    • wheezing

    • shortness of breath

    • hives

    • rash

    • swelling of the eyes, face, mouth, lips, tongue, or throat

    • hoarseness

    • difficulty swallowing

    • chest pain

  • Naltrexone injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • nausea

  • stomach pain

  • drowsiness

  • dizziness

Keep all appointments with your doctor.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are receiving naltrexone injection.

Ask your doctor or pharmacist any questions you have about naltrexone injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Montelukast Montelukast The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Naltrexone.
Leflunomide Leflunomide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Leflunomide.
Atorvastatin Atorvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Atorvastatin.
Dolasetron Dolasetron The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Dolasetron.
Alendronate Alendronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Alendronic acid is combined with Naltrexone.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Naltrexone.
Clopidogrel Clopidogrel Naltrexone can cause a decrease in the absorption of Clopidogrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Naltrexone is combined with Diphenoxylate.
Fenofibrate Fenofibrate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Fenofibrate.
Magnesium Hydroxide Magnesium Hydroxide The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Naltrexone.
Magnesium Oxide Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Naltrexone.
Nafarelin Nafarelin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nafarelin is combined with Naltrexone.
Naratriptan Naratriptan The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Naratriptan.
Pentazocine Pentazocine The therapeutic efficacy of Naltrexone can be decreased when used in combination with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Naltrexone.
Potassium Potassium The therapeutic efficacy of Potassium can be decreased when used in combination with Naltrexone.
Psyllium Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Naltrexone.
Ranitidine Ranitidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Ranitidine.
Rizatriptan Rizatriptan The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Rizatriptan.
Sumatriptan Sumatriptan The risk or severity of serotonin syndrome can be increased when Sumatriptan is combined with Naltrexone.
Tacrolimus Tacrolimus The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Tacrolimus.
Tizanidine Tizanidine The risk or severity of respiratory depression can be increased when Naltrexone is combined with Tizanidine.
Triamcinolone Triamcinolone The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Triamcinolone is combined with Naltrexone.
Zolmitriptan Zolmitriptan The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Naltrexone.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Naltrexone.
Meperidine Injection Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Naltrexone.
Metoclopramide Injection Metoclopramide Injection The therapeutic efficacy of Naltrexone can be increased when used in combination with Metoclopramide.
Pamidronate Injection Pamidronate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pamidronic acid is combined with Naltrexone.
Zidovudine Injection Zidovudine Injection The metabolism of Naltrexone can be increased when combined with Zidovudine.
Altretamine Altretamine Amphetamine may increase the analgesic activities of Naltrexone.
Cyclosporine Cyclosporine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Cyclosporine is combined with Naltrexone.
Ondansetron Ondansetron The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Ondansetron.
Granisetron Granisetron The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Granisetron.
Torsemide Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Naltrexone.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Naltrexone is combined with Olanzapine.
Eprosartan Eprosartan The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Eprosartan.
Risedronate Risedronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Risedronic acid.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Naltrexone.
Linezolid Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Naltrexone.
Trimipramine Trimipramine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Trimipramine.
Glycopyrrolate Glycopyrrolate The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Naltrexone.
Eplerenone Eplerenone The therapeutic efficacy of Eplerenone can be decreased when used in combination with Naltrexone.
Escitalopram Escitalopram The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Escitalopram.
Zonisamide Zonisamide The therapeutic efficacy of Zonisamide can be decreased when used in combination with Naltrexone.
Aripiprazole Aripiprazole The risk or severity of adverse effects can be increased when Naltrexone is combined with Aripiprazole.
Dexmethylphenidate Dexmethylphenidate The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Dexmethylphenidate.
Atazanavir Atazanavir The metabolism of Naltrexone can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Almotriptan.
Eletriptan Eletriptan The risk or severity of serotonin syndrome can be increased when Eletriptan is combined with Naltrexone.
Mefloquine Mefloquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Mefloquine is combined with Naltrexone.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Naltrexone.
Rosuvastatin Rosuvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Rosuvastatin.
Tegaserod Tegaserod The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Tegaserod.
Frovatriptan Frovatriptan The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Frovatriptan.
Apomorphine Injection Apomorphine Injection The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Apomorphine.
Infliximab Injection Infliximab Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Infliximab is combined with Naltrexone.
Protriptyline Protriptyline The risk or severity of serotonin syndrome can be increased when Protriptyline is combined with Naltrexone.
Duloxetine Duloxetine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Naltrexone.
Trospium Trospium The risk or severity of adverse effects can be increased when Trospium is combined with Naltrexone.
Erlotinib Erlotinib The metabolism of Naltrexone can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The risk or severity of respiratory depression can be increased when Naltrexone is combined with Eszopiclone.
Ganciclovir Ganciclovir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Ganciclovir.
Solifenacin Solifenacin The risk or severity of adverse effects can be increased when Solifenacin is combined with Naltrexone.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the analgesic activities of Naltrexone.
Ibandronate Ibandronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Ibandronate.
Isocarboxazid Isocarboxazid The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Isocarboxazid.
Darifenacin Darifenacin The risk or severity of adverse effects can be increased when Darifenacin is combined with Naltrexone.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Naltrexone is combined with Fentanyl.
Pregabalin Pregabalin The risk or severity of respiratory depression can be increased when Naltrexone is combined with Pregabalin.
Deferasirox Deferasirox The metabolism of Naltrexone can be decreased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Naltrexone can be increased when combined with Tipranavir.
Rasagiline Rasagiline The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Rasagiline.
Paliperidone Paliperidone The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Paliperidone.
Lubiprostone Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Naltrexone.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may increase the analgesic activities of Naltrexone.
Sorafenib Sorafenib The metabolism of Naltrexone can be decreased when combined with Sorafenib.
Ivermectin Ivermectin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ivermectin is combined with Naltrexone.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Naltrexone.
Nilotinib Nilotinib The metabolism of Naltrexone can be decreased when combined with Nilotinib.
Raltegravir Raltegravir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Raltegravir.
Desmopressin Desmopressin The risk or severity of hyponatremia can be increased when Naltrexone is combined with Desmopressin.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of respiratory depression can be increased when Naltrexone is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of respiratory depression can be increased when Naltrexone is combined with Botulinum Toxin Type B.
Desvenlafaxine Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Desvenlafaxine.
Daptomycin Injection Daptomycin Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Naltrexone.
Alvimopan Alvimopan The risk or severity of adverse effects can be increased when Naltrexone is combined with Alvimopan.
Methylnaltrexone Injection Methylnaltrexone Injection Naltrexone may increase the opioid antagonism activities of Methylnaltrexone.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Naltrexone is combined with Midazolam.
Eltrombopag Eltrombopag The metabolism of Naltrexone can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Milnacipran.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Naltrexone.
Fesoterodine Fesoterodine The risk or severity of adverse effects can be increased when Fesoterodine is combined with Naltrexone.
Iloperidone Iloperidone The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Iloperidone.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Naltrexone.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of respiratory depression can be increased when Naltrexone is combined with Botulinum toxin type A.
Palonosetron Injection Palonosetron Injection The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Naltrexone.
Tapentadol Tapentadol The risk or severity of adverse effects can be increased when Naltrexone is combined with Tapentadol.
Pazopanib Pazopanib The metabolism of Naltrexone can be decreased when combined with Pazopanib.
Asenapine Asenapine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Asenapine.
Pitavastatin Pitavastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Pitavastatin.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Naltrexone is combined with Oxymorphone.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of respiratory depression can be increased when Naltrexone is combined with Botulinum toxin type A.
Lurasidone Lurasidone The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Lurasidone.
Vilazodone Vilazodone The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Vilazodone.
Telaprevir Telaprevir The metabolism of Naltrexone can be decreased when combined with Glecaprevir.
Ticagrelor Ticagrelor Naltrexone can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Clobazam Clobazam The risk or severity of adverse effects can be increased when Naltrexone is combined with Clobazam.
Cabergoline Cabergoline The risk or severity of serotonin syndrome can be increased when Cabergoline is combined with Naltrexone.
Naloxone Injection Naloxone Injection The therapeutic efficacy of Naltrexone can be decreased when used in combination with Naloxone.
Iloprost Iloprost The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Iloprost.
Regorafenib Regorafenib The metabolism of Naltrexone can be decreased when combined with Regorafenib.
Linaclotide Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Naltrexone.
Canagliflozin Canagliflozin The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Naltrexone.
Methazolamide Methazolamide The therapeutic efficacy of Methazolamide can be decreased when used in combination with Naltrexone.
Levomilnacipran Levomilnacipran The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Levomilnacipran.
Vortioxetine Vortioxetine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Vortioxetine.
Dapagliflozin Dapagliflozin The therapeutic efficacy of Dapagliflozin can be decreased when used in combination with Naltrexone.
Hydrocodone Hydrocodone The risk or severity of serotonin syndrome can be increased when Hydrocodone is combined with Naltrexone.
Methamphetamine Methamphetamine Metamfetamine may increase the analgesic activities of Naltrexone.
Risperidone Injection Risperidone Injection The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Risperidone.
Naloxegol Naloxegol Naltrexone may increase the opioid antagonism activities of Naloxegol.
Amiloride Amiloride The therapeutic efficacy of Amiloride can be decreased when used in combination with Naltrexone.
Flibanserin Flibanserin The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Flibanserin.
Brexpiprazole Brexpiprazole The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Naltrexone.
Cariprazine Cariprazine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Cariprazine.
Eluxadoline Eluxadoline The risk or severity of constipation can be increased when Naltrexone is combined with Eluxadoline.
Trabectedin Injection Trabectedin Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Trabectedin.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Amphotericin B is combined with Naltrexone.
Dexamethasone Injection Dexamethasone Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Dexamethasone.
Pimavanserin Pimavanserin The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of adverse effects can be increased when Naltrexone is combined with Diphenhydramine.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Furosemide can be decreased when used in combination with Naltrexone.
Rucaparib Rucaparib The metabolism of Naltrexone can be decreased when combined with Rucaparib.
Doxepin (Insomnia) Doxepin (Insomnia) The risk or severity of adverse effects can be increased when Naltrexone is combined with Doxepin.
Plecanatide Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Naltrexone.
Safinamide Safinamide The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Safinamide.
Naldemedine Naldemedine The therapeutic efficacy of Naltrexone can be decreased when used in combination with Naldemedine.
Enasidenib Enasidenib The metabolism of Naltrexone can be decreased when combined with Enasidenib.
Ertugliflozin Ertugliflozin The metabolism of Naltrexone can be decreased when combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection The therapeutic efficacy of Buprenorphine can be decreased when used in combination with Naltrexone.
Penicillamine Penicillamine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Penicillamine.
Fostamatinib Fostamatinib The metabolism of Naltrexone can be decreased when combined with Fostamatinib.
Lofexidine Lofexidine The bioavailability of Naltrexone can be decreased when combined with Lofexidine.
Cannabidiol Cannabidiol The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Cannabidiol.
Dacomitinib Dacomitinib The metabolism of Naltrexone can be decreased when combined with Dacomitinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Paclitaxel.
Prucalopride Prucalopride The therapeutic efficacy of Prucalopride can be decreased when used in combination with Naltrexone.
Magnesium Citrate Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Naltrexone.
Cladribine Cladribine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Cladribine is combined with Naltrexone.
Pexidartinib Pexidartinib The metabolism of Naltrexone can be decreased when combined with Pexidartinib.
Bremelanotide Injection Bremelanotide Injection The serum concentration of Naltrexone can be decreased when it is combined with Bremelanotide.
Phenytoin Injection Phenytoin Injection The metabolism of Naltrexone can be increased when combined with Phenytoin.
Lasmiditan Lasmiditan The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Lasmiditan.
Fenfluramine Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Naltrexone.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Drospirenone can be decreased when used in combination with Naltrexone.
Indomethacin Indomethacin The metabolism of Naltrexone can be decreased when combined with Indomethacin.
Trazodone Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Naltrexone.
Isotretinoin Isotretinoin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Isotretinoin.
Phenobarbital Phenobarbital The risk or severity of adverse effects can be increased when Phenobarbital is combined with Naltrexone.
Metaxalone Metaxalone The risk or severity of respiratory depression can be increased when Naltrexone is combined with Metaxalone.
Methotrexate Injection Methotrexate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Methotrexate is combined with Naltrexone.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Naltrexone is combined with Levorphanol.
Primidone Primidone The risk or severity of adverse effects can be increased when Primidone is combined with Naltrexone.
Diethylpropion Diethylpropion Diethylpropion may increase the analgesic activities of Naltrexone.
Chlorpromazine Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Naltrexone.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Naltrexone is combined with Diazepam.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Naltrexone is combined with Oxazepam.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Naltrexone is combined with Flurazepam.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Naltrexone is combined with Clorazepic acid.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Naltrexone is combined with Lorazepam.
Amantadine Amantadine The risk or severity of adverse effects can be increased when Naltrexone is combined with Amantadine.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Naltrexone.
Meprobamate Meprobamate The risk or severity of respiratory depression can be increased when Naltrexone is combined with Meprobamate.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Naltrexone is combined with Chlordiazepoxide.
Tranylcypromine Tranylcypromine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Tranylcypromine.
Phenelzine Phenelzine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Procarbazine.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Ergoloid mesylate.
Minocycline Minocycline The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Minocycline.
Prochlorperazine Prochlorperazine The risk or severity of hypotension and CNS depression can be increased when Prochlorperazine is combined with Naltrexone.
Thioridazine Thioridazine The risk or severity of hypotension and CNS depression can be increased when Thioridazine is combined with Naltrexone.
Trifluoperazine Trifluoperazine The risk or severity of hypotension and CNS depression can be increased when Trifluoperazine is combined with Naltrexone.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Naltrexone.
Oxybutynin Oxybutynin The risk or severity of adverse effects can be increased when Oxybutynin is combined with Naltrexone.
Benztropine Benztropine The risk or severity of adverse effects can be increased when Benzatropine is combined with Naltrexone.
Maprotiline Maprotiline The risk or severity of adverse effects can be increased when Naltrexone is combined with Maprotiline.
Trihexyphenidyl Trihexyphenidyl The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Naltrexone.
Orphenadrine Orphenadrine The risk or severity of adverse effects can be increased when Naltrexone is combined with Orphenadrine.
Perphenazine Perphenazine The risk or severity of hypotension and CNS depression can be increased when Perphenazine is combined with Naltrexone.
Fluphenazine Fluphenazine The risk or severity of hypotension and CNS depression can be increased when Fluphenazine is combined with Naltrexone.
Phentermine Phentermine Phentermine may increase the analgesic activities of Naltrexone.
Amoxapine Amoxapine The risk or severity of adverse effects can be increased when Amoxapine is combined with Naltrexone.
Cytarabine Cytarabine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Cytarabine.
Carbamazepine Carbamazepine The metabolism of Naltrexone can be increased when combined with Carbamazepine.
Methyldopa Methyldopa The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Methyldopa.
Clonidine Clonidine The risk or severity of hypotension can be increased when Naltrexone is combined with Clonidine.
Cimetidine Cimetidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Cimetidine is combined with Naltrexone.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Naltrexone is combined with Clonazepam.
Promethazine Promethazine The risk or severity of adverse effects can be increased when Promethazine is combined with Naltrexone.
Loxapine Loxapine The risk or severity of serotonin syndrome can be increased when Loxapine is combined with Naltrexone.
Chloroquine Chloroquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Chloroquine is combined with Naltrexone.
Quinine Quinine The risk or severity of respiratory depression can be increased when Naltrexone is combined with Quinine.
Triamterene Triamterene The therapeutic efficacy of Triamterene can be decreased when used in combination with Naltrexone.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Naltrexone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Naltrexone.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Naltrexone.
Metolazone Metolazone The therapeutic efficacy of Metolazone can be decreased when used in combination with Naltrexone.
Isosorbide Isosorbide The therapeutic efficacy of Isosorbide can be decreased when used in combination with Naltrexone.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Naltrexone.
Desipramine Desipramine The risk or severity of adverse effects can be increased when Naltrexone is combined with Desipramine.
Amitriptyline Amitriptyline The risk or severity of adverse effects can be increased when Amitriptyline is combined with Naltrexone.
Imipramine Imipramine The risk or severity of adverse effects can be increased when Imipramine is combined with Naltrexone.
Probenecid Probenecid The metabolism of Naltrexone can be decreased when combined with Probenecid.
Quinidine Quinidine The risk or severity of adverse effects can be increased when Quinidine is combined with Naltrexone.
Procainamide Procainamide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Procainamide.
Isoniazid Isoniazid The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Isoniazid.
Rifampin Rifampin The metabolism of Naltrexone can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of adverse effects can be increased when Disopyramide is combined with Naltrexone.
Valproic Acid Valproic Acid The metabolism of Naltrexone can be decreased when combined with Valproic acid.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Naltrexone.
Propylthiouracil Propylthiouracil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Propylthiouracil is combined with Naltrexone.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Naltrexone.
Cyclobenzaprine Cyclobenzaprine The risk or severity of respiratory depression can be increased when Naltrexone is combined with Cyclobenzaprine.
Niacin Niacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Niacin is combined with Naltrexone.
Baclofen Baclofen The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Baclofen is combined with Naltrexone.
Doxylamine Doxylamine The risk or severity of adverse effects can be increased when Doxylamine is combined with Naltrexone.
Cyproheptadine Cyproheptadine The risk or severity of adverse effects can be increased when Cyproheptadine is combined with Naltrexone.
Chlorpheniramine Chlorpheniramine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Naltrexone.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Naltrexone.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Naltrexone.
Dantrolene Dantrolene The risk or severity of respiratory depression can be increased when Naltrexone is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The risk or severity of respiratory depression can be increased when Naltrexone is combined with Chlorzoxazone.
Carisoprodol Carisoprodol The risk or severity of respiratory depression can be increased when Naltrexone is combined with Carisoprodol.
Methocarbamol Methocarbamol The risk or severity of respiratory depression can be increased when Naltrexone is combined with Methocarbamol.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may increase the analgesic activities of Naltrexone.
Nortriptyline Nortriptyline The risk or severity of adverse effects can be increased when Nortriptyline is combined with Naltrexone.
Spironolactone Spironolactone The therapeutic efficacy of Spironolactone can be decreased when used in combination with Naltrexone.
Amphotericin B Injection Amphotericin B Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Amphotericin B is combined with Naltrexone.
Butorphanol Injection Butorphanol Injection The therapeutic efficacy of Naltrexone can be decreased when used in combination with Butorphanol.
Nalbuphine Injection Nalbuphine Injection The therapeutic efficacy of Nalbuphine can be decreased when used in combination with Naltrexone.
Flavoxate Flavoxate The risk or severity of adverse effects can be increased when Flavoxate is combined with Naltrexone.
Colchicine Colchicine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Colchicine.
Acetazolamide Acetazolamide The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Naltrexone.
Ketoconazole Ketoconazole The metabolism of Naltrexone can be decreased when combined with Ketoconazole.
Vincristine Injection Vincristine Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Vincristine is combined with Naltrexone.
Captopril Captopril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Captopril.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Naltrexone.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Naltrexone is combined with Alprazolam.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Naltrexone is combined with Temazepam.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Naltrexone is combined with Triazolam.
Dicyclomine Dicyclomine The risk or severity of adverse effects can be increased when Dicyclomine is combined with Naltrexone.
Hyoscyamine Hyoscyamine The risk or severity of adverse effects can be increased when Hyoscyamine is combined with Naltrexone.
Propantheline Propantheline The risk or severity of adverse effects can be increased when Propantheline is combined with Naltrexone.
Trimethoprim Trimethoprim The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Naltrexone.
Pindolol Pindolol The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Pindolol.
Bumetanide Bumetanide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Bumetanide.
Indapamide Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Naltrexone.
Leuprolide Injection Leuprolide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leuprolide is combined with Naltrexone.
Gemfibrozil Gemfibrozil The metabolism of Naltrexone can be decreased when combined with Gemfibrozil.
Enalapril Enalapril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Enalapril is combined with Naltrexone.
Flurbiprofen Flurbiprofen The metabolism of Naltrexone can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Amiodarone.
Buspirone Buspirone The risk or severity of serotonin syndrome can be increased when Buspirone is combined with Naltrexone.
Lovastatin Lovastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Naltrexone.
Ciprofloxacin Ciprofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ciprofloxacin is combined with Naltrexone.
Fluoxetine Fluoxetine The risk or severity of serotonin syndrome can be increased when Fluoxetine is combined with Naltrexone.
Clozapine Clozapine The risk or severity of adverse effects can be increased when Clozapine is combined with Naltrexone.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Naltrexone is combined with Estazolam.
Ofloxacin Ofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Ofloxacin.
Pravastatin Pravastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Naltrexone.
Simvastatin Simvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Naltrexone.
Cisapride Cisapride The risk or severity of serotonin syndrome can be increased when Cisapride is combined with Naltrexone.
Fluvastatin Fluvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of serotonin syndrome can be increased when Venlafaxine is combined with Naltrexone.
Nizatidine Nizatidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nizatidine is combined with Naltrexone.
Stavudine Stavudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Stavudine is combined with Naltrexone.
Fluvoxamine Fluvoxamine The risk or severity of serotonin syndrome can be increased when Fluvoxamine is combined with Naltrexone.
Nefazodone Nefazodone The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Naltrexone.
Tramadol Tramadol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Naltrexone.
Nicardipine Nicardipine The risk or severity of adverse effects can be increased when Nicardipine is combined with Naltrexone.
Saquinavir Saquinavir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Saquinavir.
Lamivudine Lamivudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Lamivudine.
Indinavir Indinavir The metabolism of Naltrexone can be decreased when combined with Indinavir.
Ritonavir Ritonavir The metabolism of Naltrexone can be increased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Docetaxel.
Clomipramine Clomipramine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Clomipramine.
Mirtazapine Mirtazapine Naltrexone may increase the serotonergic activities of Mirtazapine.
Donepezil Donepezil The risk or severity of respiratory depression can be increased when Naltrexone is combined with Donepezil.
Nelfinavir Nelfinavir The metabolism of Naltrexone can be increased when combined with Nelfinavir.
Selegiline Selegiline The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Selegiline.
Sertraline Sertraline The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Sertraline.
Letrozole Letrozole The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Letrozole.
Quetiapine Quetiapine The risk or severity of adverse effects can be increased when Naltrexone is combined with Quetiapine.
Paroxetine Paroxetine The risk or severity of adverse effects can be increased when Naltrexone is combined with Paroxetine.
Citalopram Citalopram The risk or severity of serotonin syndrome can be increased when Citalopram is combined with Naltrexone.
Efavirenz Efavirenz The metabolism of Naltrexone can be increased when combined with Efavirenz.
Sildenafil Sildenafil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Naltrexone.
Tolterodine Tolterodine The risk or severity of adverse effects can be increased when Tolterodine is combined with Naltrexone.
Terbinafine Terbinafine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Terbinafine.

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