Naltrexone Injection

Naltrexone injection is used along with counseling and social support to help people who have stopped drinking large amounts of alcohol to avoid drinking again. Naltrexone injection is also used along with counseling and social support to help people who have stopped abusing opiate medications or street drugs to avoid abusing the medications or street drugs again. Naltrexone injection should not be used to treat people who are still drinking alcohol, people who are still using opiates or street drugs, or people who have used opiates within the past 10 days. Naltrexone is in a class of medications called opiate antagonists. It works by blocking activity in the limbic system, a part of the brain that is involved in alcohol and opiate dependence.

Naltrexone injection comes as a solution (liquid) to be given by injection into the muscle of the buttocks by a healthcare provider once every 4 weeks.

Naltrexone injection will not prevent withdrawal symptoms that may occur when you stop drinking alcohol after drinking large amounts for a long time or when you stop using opiate medications or street drugs.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving naltrexone injection,

• tell your doctor and pharmacist if you are allergic to naltrexone, any other medications, carboxymethylcellulose (an ingredient in artificial tears and some medications), or polylactide-co-glycolide (PLG; an ingredient in some injected medications). Ask your doctor or pharmacist if you don't know if a medication you are allergic to contains carboxymethylcellulose or PLG.

• tell your doctor if you have taken any opiate medications including certain medications for diarrhea, cough, or pain; methadone (Dolophine); or buprenorphine (Buprenex, Subutex, in Suboxone) within the last 7 to 10 days. Ask your doctor if you are not sure if a medication you have taken is an opiate Also tell your doctor if you have used any opiate street drugs such as heroin within the last 7 to 10 days. Your doctor may order certain tests to see if you have recently taken any opiate medications or used street drugs. Your doctor will not give you naltrexone injection if you have recently taken an opiate medication or used street drug.

• do not take any opiate medications or use street drugs during your treatment with naltrexone injection. Naltrexone injection blocks the effects of opiate medications and street drugs. You may not feel the effects of these substances if you take or use them at low or normal doses at most times during your treatment. However, you may be more sensitive to the effects of these substances when it is almost time for you to receive a dose of naltrexone injection or if you miss a dose of naltrexone injection. You may experience an overdose if you take normal doses of opiate medications at these times, or if you take high doses of opiate medications or use street drugs at any time during your treatment with naltrexone. An opiate overdose may cause serious injury, coma (long-lasting unconscious state), or death. If you take or use opiate medications or street drugs during your treatment and you develop any of the following symptoms, call your doctor or seek emergency medical care immediately: difficulty breathing, slow, shallow breathing, faintness, dizziness, or confusion. Be sure that your family knows which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.

• you should know that you may be more sensitive to the effects of opiate medications or street drugs after you finish your treatment with naltrexone injection. After you finish your treatment, tell any doctor who may prescribe medication for you that you were previously treated with naltrexone injection.

• tell your doctor what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor if you have stopped taking opiates or using street drugs and are experiencing withdrawal symptoms such as anxiety, sleeplessness, yawning, fever, sweating, teary eyes, runny nose, goose bumps, shakiness, hot or cold flushes, muscle aches, muscle twitches, restlessness, nausea and vomiting, diarrhea, or stomach cramps, and if you have or have ever had bleeding problems such as hemophilia (a bleeding disorder in which the blood does not clot normally), a low number of platelets in your blood, depression, or kidney disease.

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving naltrexone injection, call your doctor.

• if you need medical treatment or surgery, including dental surgery, tell the doctor or dentist that you are receiving naltrexone injection. Wear or carry medical identification so that healthcare providers who treat you in an emergency will know that you are receiving naltrexone injection.

• you should know that naltrexone injection may make you feel dizzy or drowsy. Do not drive a car or operate machinery or do other dangerous activities until you know how this medication affects you.

• you should know that people who drink large amounts of alcohol or who use street drugs often become depressed and sometimes try to harm or kill themselves. Receiving naltrexone injection does not decrease the risk that you will try to harm yourself. You, your family, or your caregiver should call your doctor right away if you experience symptoms such as feelings of sadness, anxiousness, worthlessness, or helplessness, or thinking about harming or killing yourself or planning or trying to do so. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor right away if you are unable to seek treatment on your own.

• you should know that naltrexone injection is only helpful when it is used as part of an addiction treatment program. It is important that you attend all counseling sessions, support group meetings, education programs or other treatments recommended by your doctor.

• talk to your doctor about the risks and benefits of naltrexone injection before you receive your first dose. Naltrexone will remain in your body for about 1 month after you receive the injection and cannot be removed before this time.

Unless your doctor tells you otherwise, continue your normal diet.

If you miss an appointment to receive naltrexone injection, schedule another appointment as soon as possible.

• Naltrexone injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea

  • vomiting

  • diarrhea

  • stomach pain

  • decreased appetite

  • dry mouth

  • headache

  • difficulty falling asleep or staying asleep

  • dizziness

  • tiredness

  • anxiety

  • joint pain or stiffness

  • muscle cramps

  • weakness

  • tenderness, redness, bruising, or itching at the injection site

• Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

  • pain, hardness, swelling, lumps, blisters, open wounds, or a dark scab at the injection site

  • coughing

  • wheezing

  • shortness of breath

  • hives

  • rash

  • swelling of the eyes, face, mouth, lips, tongue, or throat

  • hoarseness

  • difficulty swallowing

  • chest pain

• Naltrexone injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• nausea

• stomach pain

• drowsiness

• dizziness

Keep all appointments with your doctor.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are receiving naltrexone injection.

Ask your doctor or pharmacist any questions you have about naltrexone injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Montelukast	Montelukast The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Montelukast is combined with Naltrexone.
Leflunomide	Leflunomide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Leflunomide.
Atorvastatin	Atorvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Atorvastatin.
Dolasetron	Dolasetron The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Dolasetron.
Alendronate	Alendronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Alendronic acid is combined with Naltrexone.
Bisacodyl	Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Naltrexone.
Clopidogrel	Clopidogrel Naltrexone can cause a decrease in the absorption of Clopidogrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Diphenoxylate	Diphenoxylate The risk or severity of adverse effects can be increased when Naltrexone is combined with Diphenoxylate.
Fenofibrate	Fenofibrate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Fenofibrate.
Magnesium Hydroxide	Magnesium Hydroxide The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Naltrexone.
Magnesium Oxide	Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Naltrexone.
Nafarelin	Nafarelin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nafarelin is combined with Naltrexone.
Naratriptan	Naratriptan The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Naratriptan.
Pentazocine	Pentazocine The therapeutic efficacy of Naltrexone can be decreased when used in combination with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES)	Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Naltrexone.
Potassium	Potassium The therapeutic efficacy of Potassium can be decreased when used in combination with Naltrexone.
Psyllium	Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Naltrexone.
Ranitidine	Ranitidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Ranitidine.
Rizatriptan	Rizatriptan The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Rizatriptan.
Sumatriptan	Sumatriptan The risk or severity of serotonin syndrome can be increased when Sumatriptan is combined with Naltrexone.
Tacrolimus	Tacrolimus The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Tacrolimus.
Tizanidine	Tizanidine The risk or severity of respiratory depression can be increased when Naltrexone is combined with Tizanidine.
Triamcinolone	Triamcinolone The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Triamcinolone is combined with Naltrexone.
Zolmitriptan	Zolmitriptan The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Naltrexone.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Naltrexone.
Meperidine Injection	Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Naltrexone.
Metoclopramide Injection	Metoclopramide Injection The therapeutic efficacy of Naltrexone can be increased when used in combination with Metoclopramide.
Pamidronate Injection	Pamidronate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pamidronic acid is combined with Naltrexone.
Zidovudine Injection	Zidovudine Injection The metabolism of Naltrexone can be increased when combined with Zidovudine.
Altretamine	Altretamine Amphetamine may increase the analgesic activities of Naltrexone.
Cyclosporine	Cyclosporine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Cyclosporine is combined with Naltrexone.
Ondansetron	Ondansetron The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Ondansetron.
Granisetron	Granisetron The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Granisetron.
Torsemide	Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Naltrexone.
Olanzapine	Olanzapine The risk or severity of adverse effects can be increased when Naltrexone is combined with Olanzapine.
Eprosartan	Eprosartan The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Eprosartan.
Risedronate	Risedronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Risedronic acid.
Desloratadine	Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Naltrexone.
Linezolid	Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Naltrexone.
Trimipramine	Trimipramine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Trimipramine.
Glycopyrrolate	Glycopyrrolate The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Naltrexone.
Eplerenone	Eplerenone The therapeutic efficacy of Eplerenone can be decreased when used in combination with Naltrexone.
Escitalopram	Escitalopram The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Escitalopram.
Zonisamide	Zonisamide The therapeutic efficacy of Zonisamide can be decreased when used in combination with Naltrexone.
Aripiprazole	Aripiprazole The risk or severity of adverse effects can be increased when Naltrexone is combined with Aripiprazole.
Dexmethylphenidate	Dexmethylphenidate The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Dexmethylphenidate.
Atazanavir	Atazanavir The metabolism of Naltrexone can be decreased when combined with Atazanavir.
Almotriptan	Almotriptan The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Almotriptan.
Eletriptan	Eletriptan The risk or severity of serotonin syndrome can be increased when Eletriptan is combined with Naltrexone.
Mefloquine	Mefloquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Mefloquine is combined with Naltrexone.
Polyethylene Glycol 3350	Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Naltrexone.
Rosuvastatin	Rosuvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Rosuvastatin.
Tegaserod	Tegaserod The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Tegaserod.
Frovatriptan	Frovatriptan The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Frovatriptan.
Apomorphine Injection	Apomorphine Injection The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Apomorphine.
Infliximab Injection	Infliximab Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Infliximab is combined with Naltrexone.
Protriptyline	Protriptyline The risk or severity of serotonin syndrome can be increased when Protriptyline is combined with Naltrexone.
Duloxetine	Duloxetine The risk or severity of serotonin syndrome can be increased when Duloxetine is combined with Naltrexone.
Trospium	Trospium The risk or severity of adverse effects can be increased when Trospium is combined with Naltrexone.
Erlotinib	Erlotinib The metabolism of Naltrexone can be decreased when combined with Erlotinib.
Eszopiclone	Eszopiclone The risk or severity of respiratory depression can be increased when Naltrexone is combined with Eszopiclone.
Ganciclovir	Ganciclovir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Ganciclovir.
Solifenacin	Solifenacin The risk or severity of adverse effects can be increased when Solifenacin is combined with Naltrexone.
Dextroamphetamine	Dextroamphetamine Amphetamine may increase the analgesic activities of Naltrexone.
Ibandronate	Ibandronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Ibandronate.
Isocarboxazid	Isocarboxazid The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Isocarboxazid.
Darifenacin	Darifenacin The risk or severity of adverse effects can be increased when Darifenacin is combined with Naltrexone.
Fentanyl	Fentanyl The risk or severity of adverse effects can be increased when Naltrexone is combined with Fentanyl.
Pregabalin	Pregabalin The risk or severity of respiratory depression can be increased when Naltrexone is combined with Pregabalin.
Deferasirox	Deferasirox The metabolism of Naltrexone can be decreased when combined with Deferasirox.
Tipranavir	Tipranavir The metabolism of Naltrexone can be increased when combined with Tipranavir.
Rasagiline	Rasagiline The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Rasagiline.
Paliperidone	Paliperidone The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Paliperidone.
Lubiprostone	Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Naltrexone.
Lisdexamfetamine	Lisdexamfetamine Lisdexamfetamine may increase the analgesic activities of Naltrexone.
Sorafenib	Sorafenib The metabolism of Naltrexone can be decreased when combined with Sorafenib.
Ivermectin	Ivermectin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ivermectin is combined with Naltrexone.
Paclitaxel (with polyoxyethylated castor oil) Injection	Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Naltrexone.
Nilotinib	Nilotinib The metabolism of Naltrexone can be decreased when combined with Nilotinib.
Raltegravir	Raltegravir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Raltegravir.
Desmopressin	Desmopressin The risk or severity of hyponatremia can be increased when Naltrexone is combined with Desmopressin.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of respiratory depression can be increased when Naltrexone is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of respiratory depression can be increased when Naltrexone is combined with Botulinum Toxin Type B.
Desvenlafaxine	Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Desvenlafaxine.
Daptomycin Injection	Daptomycin Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Naltrexone.
Alvimopan	Alvimopan The risk or severity of adverse effects can be increased when Naltrexone is combined with Alvimopan.
Methylnaltrexone Injection	Methylnaltrexone Injection Naltrexone may increase the opioid antagonism activities of Methylnaltrexone.
Midazolam	Midazolam The risk or severity of adverse effects can be increased when Naltrexone is combined with Midazolam.
Eltrombopag	Eltrombopag The metabolism of Naltrexone can be decreased when combined with Eltrombopag.
Milnacipran	Milnacipran The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Milnacipran.
Sodium Phosphate	Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Naltrexone.
Fesoterodine	Fesoterodine The risk or severity of adverse effects can be increased when Fesoterodine is combined with Naltrexone.
Iloperidone	Iloperidone The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Iloperidone.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Naltrexone.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of respiratory depression can be increased when Naltrexone is combined with Botulinum toxin type A.
Palonosetron Injection	Palonosetron Injection The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Naltrexone.
Tapentadol	Tapentadol The risk or severity of adverse effects can be increased when Naltrexone is combined with Tapentadol.
Pazopanib	Pazopanib The metabolism of Naltrexone can be decreased when combined with Pazopanib.
Asenapine	Asenapine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Asenapine.
Pitavastatin	Pitavastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Pitavastatin.
Oxymorphone	Oxymorphone The risk or severity of adverse effects can be increased when Naltrexone is combined with Oxymorphone.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of respiratory depression can be increased when Naltrexone is combined with Botulinum toxin type A.
Lurasidone	Lurasidone The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Lurasidone.
Vilazodone	Vilazodone The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Vilazodone.
Telaprevir	Telaprevir The metabolism of Naltrexone can be decreased when combined with Glecaprevir.
Ticagrelor	Ticagrelor Naltrexone can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Clobazam	Clobazam The risk or severity of adverse effects can be increased when Naltrexone is combined with Clobazam.
Cabergoline	Cabergoline The risk or severity of serotonin syndrome can be increased when Cabergoline is combined with Naltrexone.
Naloxone Injection	Naloxone Injection The therapeutic efficacy of Naltrexone can be decreased when used in combination with Naloxone.
Iloprost	Iloprost The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Iloprost.
Regorafenib	Regorafenib The metabolism of Naltrexone can be decreased when combined with Regorafenib.
Linaclotide	Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Naltrexone.
Canagliflozin	Canagliflozin The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Naltrexone.
Methazolamide	Methazolamide The therapeutic efficacy of Methazolamide can be decreased when used in combination with Naltrexone.
Levomilnacipran	Levomilnacipran The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Levomilnacipran.
Vortioxetine	Vortioxetine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Vortioxetine.
Dapagliflozin	Dapagliflozin The therapeutic efficacy of Dapagliflozin can be decreased when used in combination with Naltrexone.
Hydrocodone	Hydrocodone The risk or severity of serotonin syndrome can be increased when Hydrocodone is combined with Naltrexone.
Methamphetamine	Methamphetamine Metamfetamine may increase the analgesic activities of Naltrexone.
Risperidone Injection	Risperidone Injection The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Risperidone.
Naloxegol	Naloxegol Naltrexone may increase the opioid antagonism activities of Naloxegol.
Amiloride	Amiloride The therapeutic efficacy of Amiloride can be decreased when used in combination with Naltrexone.
Flibanserin	Flibanserin The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Flibanserin.
Brexpiprazole	Brexpiprazole The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Brexpiprazole.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Naltrexone.
Cariprazine	Cariprazine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Cariprazine.
Eluxadoline	Eluxadoline The risk or severity of constipation can be increased when Naltrexone is combined with Eluxadoline.
Trabectedin Injection	Trabectedin Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Trabectedin.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Amphotericin B is combined with Naltrexone.
Dexamethasone Injection	Dexamethasone Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Dexamethasone.
Pimavanserin	Pimavanserin The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Pimavanserin.
Diphenhydramine Injection	Diphenhydramine Injection The risk or severity of adverse effects can be increased when Naltrexone is combined with Diphenhydramine.
Furosemide Injection	Furosemide Injection The therapeutic efficacy of Furosemide can be decreased when used in combination with Naltrexone.
Rucaparib	Rucaparib The metabolism of Naltrexone can be decreased when combined with Rucaparib.
Doxepin (Insomnia)	Doxepin (Insomnia) The risk or severity of adverse effects can be increased when Naltrexone is combined with Doxepin.
Plecanatide	Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Naltrexone.
Safinamide	Safinamide The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Safinamide.
Naldemedine	Naldemedine The therapeutic efficacy of Naltrexone can be decreased when used in combination with Naldemedine.
Enasidenib	Enasidenib The metabolism of Naltrexone can be decreased when combined with Enasidenib.
Ertugliflozin	Ertugliflozin The metabolism of Naltrexone can be decreased when combined with Ertugliflozin.
Buprenorphine Injection	Buprenorphine Injection The therapeutic efficacy of Buprenorphine can be decreased when used in combination with Naltrexone.
Penicillamine	Penicillamine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Penicillamine.
Fostamatinib	Fostamatinib The metabolism of Naltrexone can be decreased when combined with Fostamatinib.
Lofexidine	Lofexidine The bioavailability of Naltrexone can be decreased when combined with Lofexidine.
Cannabidiol	Cannabidiol The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Cannabidiol.
Dacomitinib	Dacomitinib The metabolism of Naltrexone can be decreased when combined with Dacomitinib.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Paclitaxel.
Prucalopride	Prucalopride The therapeutic efficacy of Prucalopride can be decreased when used in combination with Naltrexone.
Magnesium Citrate	Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Naltrexone.
Cladribine	Cladribine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Cladribine is combined with Naltrexone.
Pexidartinib	Pexidartinib The metabolism of Naltrexone can be decreased when combined with Pexidartinib.
Bremelanotide Injection	Bremelanotide Injection The serum concentration of Naltrexone can be decreased when it is combined with Bremelanotide.
Phenytoin Injection	Phenytoin Injection The metabolism of Naltrexone can be increased when combined with Phenytoin.
Lasmiditan	Lasmiditan The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Lasmiditan.
Fenfluramine	Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Naltrexone.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Drospirenone can be decreased when used in combination with Naltrexone.
Indomethacin	Indomethacin The metabolism of Naltrexone can be decreased when combined with Indomethacin.
Trazodone	Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Naltrexone.
Isotretinoin	Isotretinoin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Isotretinoin.
Phenobarbital	Phenobarbital The risk or severity of adverse effects can be increased when Phenobarbital is combined with Naltrexone.
Metaxalone	Metaxalone The risk or severity of respiratory depression can be increased when Naltrexone is combined with Metaxalone.
Methotrexate Injection	Methotrexate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Methotrexate is combined with Naltrexone.
Levorphanol	Levorphanol The risk or severity of adverse effects can be increased when Naltrexone is combined with Levorphanol.
Primidone	Primidone The risk or severity of adverse effects can be increased when Primidone is combined with Naltrexone.
Diethylpropion	Diethylpropion Diethylpropion may increase the analgesic activities of Naltrexone.
Chlorpromazine	Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Naltrexone.
Diazepam	Diazepam The risk or severity of adverse effects can be increased when Naltrexone is combined with Diazepam.
Oxazepam	Oxazepam The risk or severity of adverse effects can be increased when Naltrexone is combined with Oxazepam.
Flurazepam	Flurazepam The risk or severity of adverse effects can be increased when Naltrexone is combined with Flurazepam.
Clorazepate	Clorazepate The risk or severity of adverse effects can be increased when Naltrexone is combined with Clorazepic acid.
Lorazepam	Lorazepam The risk or severity of adverse effects can be increased when Naltrexone is combined with Lorazepam.
Amantadine	Amantadine The risk or severity of adverse effects can be increased when Naltrexone is combined with Amantadine.
Codeine	Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Naltrexone.
Meprobamate	Meprobamate The risk or severity of respiratory depression can be increased when Naltrexone is combined with Meprobamate.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Naltrexone is combined with Chlordiazepoxide.
Tranylcypromine	Tranylcypromine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Tranylcypromine.
Phenelzine	Phenelzine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Phenelzine.
Procarbazine	Procarbazine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Procarbazine.
Ergoloid Mesylates	Ergoloid Mesylates The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Ergoloid mesylate.
Minocycline	Minocycline The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Minocycline.
Prochlorperazine	Prochlorperazine The risk or severity of hypotension and CNS depression can be increased when Prochlorperazine is combined with Naltrexone.
Thioridazine	Thioridazine The risk or severity of hypotension and CNS depression can be increased when Thioridazine is combined with Naltrexone.
Trifluoperazine	Trifluoperazine The risk or severity of hypotension and CNS depression can be increased when Trifluoperazine is combined with Naltrexone.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Naltrexone.
Oxybutynin	Oxybutynin The risk or severity of adverse effects can be increased when Oxybutynin is combined with Naltrexone.
Benztropine	Benztropine The risk or severity of adverse effects can be increased when Benzatropine is combined with Naltrexone.
Maprotiline	Maprotiline The risk or severity of adverse effects can be increased when Naltrexone is combined with Maprotiline.
Trihexyphenidyl	Trihexyphenidyl The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Naltrexone.
Orphenadrine	Orphenadrine The risk or severity of adverse effects can be increased when Naltrexone is combined with Orphenadrine.
Perphenazine	Perphenazine The risk or severity of hypotension and CNS depression can be increased when Perphenazine is combined with Naltrexone.
Fluphenazine	Fluphenazine The risk or severity of hypotension and CNS depression can be increased when Fluphenazine is combined with Naltrexone.
Phentermine	Phentermine Phentermine may increase the analgesic activities of Naltrexone.
Amoxapine	Amoxapine The risk or severity of adverse effects can be increased when Amoxapine is combined with Naltrexone.
Cytarabine	Cytarabine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Cytarabine.
Carbamazepine	Carbamazepine The metabolism of Naltrexone can be increased when combined with Carbamazepine.
Methyldopa	Methyldopa The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Methyldopa.
Clonidine	Clonidine The risk or severity of hypotension can be increased when Naltrexone is combined with Clonidine.
Cimetidine	Cimetidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Cimetidine is combined with Naltrexone.
Clonazepam	Clonazepam The risk or severity of adverse effects can be increased when Naltrexone is combined with Clonazepam.
Promethazine	Promethazine The risk or severity of adverse effects can be increased when Promethazine is combined with Naltrexone.
Loxapine	Loxapine The risk or severity of serotonin syndrome can be increased when Loxapine is combined with Naltrexone.
Chloroquine	Chloroquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Chloroquine is combined with Naltrexone.
Quinine	Quinine The risk or severity of respiratory depression can be increased when Naltrexone is combined with Quinine.
Triamterene	Triamterene The therapeutic efficacy of Triamterene can be decreased when used in combination with Naltrexone.
Lactulose	Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Naltrexone.
Chlorothiazide	Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Naltrexone.
Chlorthalidone	Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Naltrexone.
Metolazone	Metolazone The therapeutic efficacy of Metolazone can be decreased when used in combination with Naltrexone.
Isosorbide	Isosorbide The therapeutic efficacy of Isosorbide can be decreased when used in combination with Naltrexone.
Secobarbital	Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Naltrexone.
Desipramine	Desipramine The risk or severity of adverse effects can be increased when Naltrexone is combined with Desipramine.
Amitriptyline	Amitriptyline The risk or severity of adverse effects can be increased when Amitriptyline is combined with Naltrexone.
Imipramine	Imipramine The risk or severity of adverse effects can be increased when Imipramine is combined with Naltrexone.
Probenecid	Probenecid The metabolism of Naltrexone can be decreased when combined with Probenecid.
Quinidine	Quinidine The risk or severity of adverse effects can be increased when Quinidine is combined with Naltrexone.
Procainamide	Procainamide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Procainamide.
Isoniazid	Isoniazid The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Isoniazid.
Rifampin	Rifampin The metabolism of Naltrexone can be increased when combined with Rifampicin.
Disopyramide	Disopyramide The risk or severity of adverse effects can be increased when Disopyramide is combined with Naltrexone.
Valproic Acid	Valproic Acid The metabolism of Naltrexone can be decreased when combined with Valproic acid.
Butabarbital	Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Naltrexone.
Propylthiouracil	Propylthiouracil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Propylthiouracil is combined with Naltrexone.
Dextromethorphan	Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Naltrexone.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of respiratory depression can be increased when Naltrexone is combined with Cyclobenzaprine.
Niacin	Niacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Niacin is combined with Naltrexone.
Baclofen	Baclofen The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Baclofen is combined with Naltrexone.
Doxylamine	Doxylamine The risk or severity of adverse effects can be increased when Doxylamine is combined with Naltrexone.
Cyproheptadine	Cyproheptadine The risk or severity of adverse effects can be increased when Cyproheptadine is combined with Naltrexone.
Chlorpheniramine	Chlorpheniramine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Chlorpheniramine.
Brompheniramine	Brompheniramine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Naltrexone.
Methyclothiazide	Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Naltrexone.
Hydrochlorothiazide	Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Naltrexone.
Dantrolene	Dantrolene The risk or severity of respiratory depression can be increased when Naltrexone is combined with Dantrolene.
Chlorzoxazone	Chlorzoxazone The risk or severity of respiratory depression can be increased when Naltrexone is combined with Chlorzoxazone.
Carisoprodol	Carisoprodol The risk or severity of respiratory depression can be increased when Naltrexone is combined with Carisoprodol.
Methocarbamol	Methocarbamol The risk or severity of respiratory depression can be increased when Naltrexone is combined with Methocarbamol.
Pseudoephedrine	Pseudoephedrine Pseudoephedrine may increase the analgesic activities of Naltrexone.
Nortriptyline	Nortriptyline The risk or severity of adverse effects can be increased when Nortriptyline is combined with Naltrexone.
Spironolactone	Spironolactone The therapeutic efficacy of Spironolactone can be decreased when used in combination with Naltrexone.
Amphotericin B Injection	Amphotericin B Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Amphotericin B is combined with Naltrexone.
Butorphanol Injection	Butorphanol Injection The therapeutic efficacy of Naltrexone can be decreased when used in combination with Butorphanol.
Nalbuphine Injection	Nalbuphine Injection The therapeutic efficacy of Nalbuphine can be decreased when used in combination with Naltrexone.
Flavoxate	Flavoxate The risk or severity of adverse effects can be increased when Flavoxate is combined with Naltrexone.
Colchicine	Colchicine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Colchicine.
Acetazolamide	Acetazolamide The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Naltrexone.
Ketoconazole	Ketoconazole The metabolism of Naltrexone can be decreased when combined with Ketoconazole.
Vincristine Injection	Vincristine Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Vincristine is combined with Naltrexone.
Captopril	Captopril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Captopril.
Ethacrynic Acid	Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Naltrexone.
Alprazolam	Alprazolam The risk or severity of adverse effects can be increased when Naltrexone is combined with Alprazolam.
Temazepam	Temazepam The risk or severity of adverse effects can be increased when Naltrexone is combined with Temazepam.
Triazolam	Triazolam The risk or severity of adverse effects can be increased when Naltrexone is combined with Triazolam.
Dicyclomine	Dicyclomine The risk or severity of adverse effects can be increased when Dicyclomine is combined with Naltrexone.
Hyoscyamine	Hyoscyamine The risk or severity of adverse effects can be increased when Hyoscyamine is combined with Naltrexone.
Propantheline	Propantheline The risk or severity of adverse effects can be increased when Propantheline is combined with Naltrexone.
Trimethoprim	Trimethoprim The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Naltrexone.
Pindolol	Pindolol The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Pindolol.
Bumetanide	Bumetanide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Bumetanide.
Indapamide	Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Naltrexone.
Leuprolide Injection	Leuprolide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leuprolide is combined with Naltrexone.
Gemfibrozil	Gemfibrozil The metabolism of Naltrexone can be decreased when combined with Gemfibrozil.
Enalapril	Enalapril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Enalapril is combined with Naltrexone.
Flurbiprofen	Flurbiprofen The metabolism of Naltrexone can be decreased when combined with Flurbiprofen.
Amiodarone	Amiodarone The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Amiodarone.
Buspirone	Buspirone The risk or severity of serotonin syndrome can be increased when Buspirone is combined with Naltrexone.
Lovastatin	Lovastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Naltrexone.
Ciprofloxacin	Ciprofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ciprofloxacin is combined with Naltrexone.
Fluoxetine	Fluoxetine The risk or severity of serotonin syndrome can be increased when Fluoxetine is combined with Naltrexone.
Clozapine	Clozapine The risk or severity of adverse effects can be increased when Clozapine is combined with Naltrexone.
Estazolam	Estazolam The risk or severity of adverse effects can be increased when Naltrexone is combined with Estazolam.
Ofloxacin	Ofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Ofloxacin.
Pravastatin	Pravastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Naltrexone.
Simvastatin	Simvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Simvastatin is combined with Naltrexone.
Cisapride	Cisapride The risk or severity of serotonin syndrome can be increased when Cisapride is combined with Naltrexone.
Fluvastatin	Fluvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Fluvastatin.
Venlafaxine	Venlafaxine The risk or severity of serotonin syndrome can be increased when Venlafaxine is combined with Naltrexone.
Nizatidine	Nizatidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nizatidine is combined with Naltrexone.
Stavudine	Stavudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Stavudine is combined with Naltrexone.
Fluvoxamine	Fluvoxamine The risk or severity of serotonin syndrome can be increased when Fluvoxamine is combined with Naltrexone.
Nefazodone	Nefazodone The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Nefazodone.
Lamotrigine	Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Naltrexone.
Tramadol	Tramadol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Naltrexone.
Nicardipine	Nicardipine The risk or severity of adverse effects can be increased when Nicardipine is combined with Naltrexone.
Saquinavir	Saquinavir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Saquinavir.
Lamivudine	Lamivudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Lamivudine.
Indinavir	Indinavir The metabolism of Naltrexone can be decreased when combined with Indinavir.
Ritonavir	Ritonavir The metabolism of Naltrexone can be increased when combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Docetaxel.
Clomipramine	Clomipramine The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Clomipramine.
Mirtazapine	Mirtazapine Naltrexone may increase the serotonergic activities of Mirtazapine.
Donepezil	Donepezil The risk or severity of respiratory depression can be increased when Naltrexone is combined with Donepezil.
Nelfinavir	Nelfinavir The metabolism of Naltrexone can be increased when combined with Nelfinavir.
Selegiline	Selegiline The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Selegiline.
Sertraline	Sertraline The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Sertraline.
Letrozole	Letrozole The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Letrozole.
Quetiapine	Quetiapine The risk or severity of adverse effects can be increased when Naltrexone is combined with Quetiapine.
Paroxetine	Paroxetine The risk or severity of adverse effects can be increased when Naltrexone is combined with Paroxetine.
Citalopram	Citalopram The risk or severity of serotonin syndrome can be increased when Citalopram is combined with Naltrexone.
Efavirenz	Efavirenz The metabolism of Naltrexone can be increased when combined with Efavirenz.
Sildenafil	Sildenafil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Naltrexone.
Tolterodine	Tolterodine The risk or severity of adverse effects can be increased when Tolterodine is combined with Naltrexone.
Terbinafine	Terbinafine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Naltrexone is combined with Terbinafine.