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GUNA LIVER PLUS SODIUM PYRUVATE - SILYBUM MARIANUM SEED - CHELIDONIUM MAJUS - FUMARIC ACID - PORK LIVER - TARAXACUM OFFICINALE - LYCOPODIUM CLAVATUM SPORE - SODIUM SULFATE - PHOSPHORUS - BERBERIS VULGARIS ROOT BARK 2 [hp_X]/4g; 4 [hp_X]/4g; 6 [hp_X]/4g; 6 [hp_X]/4g; 3 [hp_X]/4g; 6 [hp_X]/4g; 6 [hp_X]/4g; 8 [hp_X]/4g Pellet — NDC 17089-0478-21 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

GUNA LIVER PLUS SODIUM PYRUVATE - SILYBUM MARIANUM SEED - CHELIDONIUM MAJUS - FUMARIC ACID - PORK LIVER - TARAXACUM OFFICINALE - LYCOPODIUM CLAVATUM SPORE - SODIUM SULFATE - PHOSPHORUS - BERBERIS VULGARIS ROOT BARK 2 [hp_X]/4g; 4 [hp_X]/4g; 6 [hp_X]/4g; 6 [hp_X]/4g; 3 [hp_X]/4g; 6 [hp_X]/4g; 6 [hp_X]/4g; 8 [hp_X]/4g Pellet — NDC 17089-478-21 (Billing 17089-0478-21)

by Guna spa · 1 TUBE in 1 BOX / 4 g in 1 TUBE

This is a package of GUNA LIVER PLUS SODIUM PYRUVATE - SILYBUM MARIANUM SEED - CHELIDONIUM MAJUS - FUMARIC ACID - PORK LIVER - TARAXACUM OFFICINALE - LYCOPODIUM CLAVATUM SPORE - SODIUM SULFATE - PHOSPHORUS - BERBERIS VULGARIS ROOT BARK 2 [hp_X]/4g; 4 [hp_X]/4g; 6 [hp_X]/4g; 6 [hp_X]/4g; 3 [hp_X]/4g; 6 [hp_X]/4g; 6 [hp_X]/4g; 8 [hp_X]/4g Pellet from Guna spa, marketed since Feb 2021 and currently FDA-listed.

NDC 17089-0478-21
🏷️ FDA NDC (as labeled) 17089-478-21 billing pads the product segment with a zero
This package
Contains4 g in 1 tube Pack sizes2 compare ↓
Product page 17089-0478-20 Also comes in: 2 tubes 17089-478-20
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Oct 1, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 17089-478-21 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
17089 labeler · 478 product · 21 package
Package marketed since
Dec 15, 2021
Sample package
No — commercial package
Listing certified through
Dec 31, 2026
Barcode (UPC)
0317089478201
FDA record last changed
Oct 1, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 17089-478-21
Product NDC 17089-478
11-digit billing NDC 17089047821
UNII U946SH95EE, 7E889U5RNN, 88XHZ13131, 6EC706HI7F, POD38AIF08, C88X29Y479 +4 more
UPC 0317089478201
SPL Set ID ba44c46e-4509-2e4d-e053-2a95a90a9c95
Established class (EPC) Osmotic Laxative
Mechanism of action Osmotic Activity
Physiologic effect Increased Large Intestinal Motility; Inhibition Large Intestine Fluid/Electrolyte Absorption
DEA schedule Non-controlled
Marketing category UNAPPROVED HOMEOPATHIC
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2021-02-17
Route ORAL
Dosage form PELLET
Substance SILYBUM MARIANUM SEED; CHELIDONIUM MAJUS; FUMARIC ACID; PORK LIVER; SODIUM PYRUVATE; LYCOPODIUM CLAVATUM SPORE; SODIUM SULFATE; PHOSPHORUS; BERBERIS VULGARIS ROOT BARK; TARAXACUM OFFICINALE
Why two NDCs? The FDA registers this code as 17089-478-21 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 17089-0478-21. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

Clinical

🧪 What is this product?

Guna Liver Plus is a homeopathic oral pellet product containing multiple plant and mineral substances. In homeopathic practice, ingredients like milk thistle seed, celandine, and dandelion are traditionally used for liver and digestive support, while berberis root bark and phosphorus are used in homeopathic formulations for various organ functions. Homeopathic products are marketed based on traditional use; the FDA has not evaluated this product for effectiveness.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 2 tubes
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
17089-0478-20 17089-478-20 Main listing 2 TUBE in 1 BOX / 4 g in 1 TUBE 2021-02-17 — Active
17089-0478-21 You're viewing this 1 TUBE in 1 BOX / 4 g in 1 TUBE 2021-12-15 — Active

Pack size FAQ

What quantity is in this package?
This package is listed by the FDA — 1 tube in 1 box / 4 g in 1 tube.
What NDC number is used to bill for this package of GUNA LIVER PLUS SODIUM PYRUVATE - SILYBUM MARIANUM SEED - CHELIDONIUM MAJUS - FUMARIC ACID - PORK LIVER - TARAXACUM OFFICINALE - LYCOPODIUM CLAVATUM SPORE - SODIUM SULFATE - PHOSPHORUS - BERBERIS VULGARIS ROOT BARK 2 [hp_X]/4g; 4 [hp_X]/4g; 6 [hp_X]/4g; 6 [hp_X]/4g; 3 [hp_X]/4g; 6 [hp_X]/4g; 6 [hp_X]/4g; 8 [hp_X]/4g Pellet?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Guna Liver Plus 2 [hp_X]/4g; 4 [hp_X]/4g; 6 [hp_X]/4g; 6 [hp_X]/4g; 3 [hp_X]/4g; 6 [hp_X]/4g; 6 [hp_X]/4g; 8 [hp_X]/4gthis 17089-0478-21 Guna 1 tube — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2021
On the market since
Feb 2021
📍
2026
Currently FDA-listed
5 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

What it looks like

Color white
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII C151H8M554
    A natural sugar derived from sugar cane or sugar beets. It's used as a sweetener, filler, and binder to improve taste, add bulk, and help hold tablet or capsule ingredients together.

1 inactive ingredient listed in the exact product block matched to this NDC.

The official label also statesInactive ingredient: Sucrose.

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerGuna spa
Labeler code17089
First marketedFeb 2021
Product typeHuman Otc Drug
Portfolio83 products on file

More NDCs from Guna spa labeler code 17089

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 🤰 If Pregnant or Breast-Feeding 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 34 words ▾

Turn tube upside down and rotate cap to release pellets into cap. Unscrew cap and without touching pellets tip them into the mouth under the tongue. Allow to dissolve Take 15 minutes before meals.

⏱️ Dosage and Administration 22 words ▾

Adults and children 12 years and older 5 pellets 3 times per day Children under 12 years of age consult a physician

⚠️ Warnings 73 words ▾

Stop use and ask doctor if symptoms persist more than 5 days or worsen. If pregnant or breast-feeding ask a health care professional before use. Keep out of reach of children. Gallstones, occlusion of the bile ducts, jaundice and any other unclear or persistent discomfort in the upper abdomen may be serious. Consult a doctor promptly if any of these symptoms occur If you suffer from liver diseases, you should consult a doctor

🧪 Active Ingredient 65 words ▾

Berberis vulgaris 3X Supports liver and kidney drainage Carduus marianus 2X Supports liver function Chelidonium majus 4X Supports liver and gall bladder function Fumaricum acidum 6X Supports detoxification Hepar suis 6X Supports detoxification Lycopodium clavatum 6X Supports liver function and drainage Natrum pyruvicum 3X Supports detoxification, relieves skin rashes Natrum sulphuricum 6X Supports detoxification Phosphorus 8X Supports liver function Taraxacum officinale 3X Supports liver function

🧪 Inactive Ingredients 4 words ▾

Inactive ingredient : Sucrose.

🎯 Purpose 17 words ▾

Supports liver function, relieves minor symptoms of liver intoxication, such as: abdominal pain and bloating skin rashes

🤰 If Pregnant or Breast-Feeding 11 words ▾

If pregnant or breast-feeding ask a health care professional before use.

📄 Keep Out of Reach of Children 6 words ▾

Keep out of reach of children

📄 Questions or Comments 5 words ▾

Questions?: [email protected] tel. (484) 223-3500

📄 Package Label / Principal Display Panel 2 words ▾

5USLP1 5USLIP-5

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Over-the-counter (OTC) product Homeopathic listing

About homeopathic listings

GUNA LIVER PLUS SODIUM PYRUVATE - SILYBUM MARIANUM SEED - CHELIDONIUM MAJUS - FUMARIC ACID - PORK LIVER - TARAXACUM OFFICINALE - LYCOPODIUM CLAVATUM SPORE - SODIUM SULFATE - PHOSPHORUS - BERBERIS VULGARIS ROOT BARK 2 [hp_X]/4g; 4 [hp_X]/4g; 6 [hp_X]/4g; 6 [hp_X]/4g; 3 [hp_X]/4g; 6 [hp_X]/4g; 6 [hp_X]/4g; 8 [hp_X]/4g PELLET is listed under the homeopathic marketing category. An NDC listing in this category does not by itself establish FDA approval, and FDA does not evaluate homeopathic products for effectiveness. This page reports the listing data as published.

What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Unapproved Homeopathic". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Guna spa. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 1 other package presentation of this same product, including 2 tubes (17089-0478-20). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Guna spa is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 17089-0477-20 · Guna 17089-0479-27 · Guna →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.