NDC 41250-0123-20 — Effervescent Orange Cold Relief Aspirin

🆔 Identity & classification

FDA NDC (as labeled) 41250-123-20

Product NDC 41250-123

11-digit billing NDC 41250012320

RxCUI 1536840

UNII 27O3Q5ML57, R16CO5Y76E, V1Q0O9OJ9Z

UPC 0719283792334

Application # M012

SPL Set ID 826b5c0d-7a75-bbf0-e053-2a91aa0aebd6

Established class (EPC) Nonsteroidal Anti-inflammatory Drug; Platelet Aggregation Inhibitor

Mechanism of action Cyclooxygenase Inhibitors

Physiologic effect Decreased Prostaglandin Production; Decreased Platelet Aggregation

Chemical class Anti-Inflammatory Agents, Non-Steroidal

DEA schedule Non-controlled

Marketing category OTC MONOGRAPH DRUG

Marketing status On market

FDA listing status Listed (active directory)

Marketing start 2013-05-26

Route ORAL

Dosage form TABLET, EFFERVESCENT

Substance PHENYLEPHRINE BITARTRATE; ASPIRIN; CHLORPHENIRAMINE MALEATE

Why two NDCs? The FDA registers this code as 41250-123-20 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 41250-0123-20. Same drug, same package — only the format differs.

Where does this data come from?

Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Platelet Aggregation Inhibitor class.

Pharmacologic class Platelet Aggregation Inhibitor, Nonsteroidal Anti-inflammatory Drug

Drug family (ATC) Other agents for local oral treatment, Platelet aggregation inhibitors excl. heparin, Salicylic acid and derivatives

How it works Cyclooxygenase Inhibitors

Where does this data come from?

Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerMeijer Distribution Inc.

FDA applicationM012 (OTC MONOGRAPH DRUG)

Labeler code41250

First marketedMay 2013

Product typeHuman Otc Drug

Portfolio36 products on file

🔎 All NDCs from Meijer Distribution Inc.

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).

Where does this data come from?

Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

🧪 What is this product?

This is an over-the-counter effervescent tablet that dissolves in water for oral use. It contains aspirin, which is typically used to relieve minor aches, pains, and fever, along with chlorpheniramine maleate, an antihistamine commonly used to reduce allergy and cold symptoms like sneezing and itching. The product also contains phenylephrine bitartrate, a decongestant typically used to help relieve nasal congestion. This combination is marketed as a cold relief product under the OTC monograph system.

Patient education

📘 MedlinePlus patient leaflet ↗

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →

Where does this data come from?

Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

UNII 23OV73Q5G9
Acesulfame potassium is an artificial sweetener that tastes about 200 times sweeter than sugar. It's added to medicines to improve taste without adding calories or affecting blood sugar.
UNII XF417D3PSL
Anhydrous citric acid is a sour, crystalline powder derived from citric acid with water removed. In medicines, it acts as a buffer to control pH, adds tartness to improve taste, and helps tablets disintegrate.
UNII Z0H242BBR1
Aspartame is an artificial sweetener made from amino acids. It's added to medicines to improve taste, making bitter or unpleasant-tasting drugs easier to take.
UNII F05Q2T2JA0
Docusate sodium is a stool softener compound that helps medicines dissolve and move through the digestive tract. It acts as a surfactant, reducing surface tension in the intestines, and also serves as a wetting agent in tablet formulations.
UNII WZB9127XOA
A synthetic red dye used to color medications and make them easier to identify. It serves as a colorant in tablets, capsules, and liquid formulations.
UNII H77VEI93A8
A synthetic yellow dye used to color medications. It helps identify the drug and make it visually distinctive, with no effect on how the medicine works.
UNII 3OWL53L36A
A natural sugar alcohol derived from seaweed or synthesized in the lab. It's used as a filler to add bulk, a sweetener in sugar-free formulas, and a disintegrant to help tablets break apart in the stomach.
UNII U725QWY32X
Povidone K30 is a synthetic polymer made from petroleum. It acts as a binder to hold tablet ingredients together and as a disintegrant to help the tablet break apart in the stomach so the medicine can be absorbed.
UNII OJ245FE5EU
Sodium benzoate is a salt derived from benzoic acid, a preservative. It's added to medicines to prevent growth of bacteria, fungi, and other microorganisms that could spoil the product.
UNII 8MDF5V39QO
A white powder form of baking soda that acts as a buffer and pH regulator in medicines. It helps maintain the right acid-base balance and may aid tablet disintegration.

10 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesacesulfame potassium, anhydrous citric acid, aspartame, docusate sodium, FD&C red #40, FD&C yellow #6, flavors, mannitol, povidone, sodium benzoate, sodium bicarbonate

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?

Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?

No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.

Why might an inactive ingredient be missing?

Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.

Can inactive ingredients matter?

Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price system	Per each	Per package
Retail pharmacies payNADAC · weekly	Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo	No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly	No Part D plan price is available for this NDC in our data.

ℹ️

No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.

Try another pack size: 2 tablets

Where does this data come from?

NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

Product	Labeler	Pack	NADAC/unit	TE	Status	Price vs. this
Alka-Seltzer Plus Severe Cold PowerFast Fizz Orange Zest 7 mg/1; 2 mg/1; 325 mg 00280-0020-01	Bayer	2 tablets	—	—	FDA listed	—
Alka-Seltzer Plus Cold Sparkling Original PowerFast Fizz 325 mg/1; 2 mg/1; 7.8 mg 00280-0060-01	Bayer	2 tablets	—	—	FDA listed	—
Alka-Seltzer Plus Cold Medicine Sparkling Original 325 mg/1; 2 mg/1; 7.8 mg 00280-1400-32	Bayer	2 tablets	—	—	FDA listed	—
Alka-Seltzer Plus Cold Orange Zest 325 mg/1; 2 mg/1; 7.8 mg 00280-1510-20	Bayer	2 tablets	—	—	FDA listed	—
Alka-Seltzer Plus Cold Sparkling Original 325 mg/1; 7.8 mg/1; 2 mg 00280-1520-04	Bayer	2 tablets	—	—	FDA listed	—
ALKA SELTZER COLD Cold and Headache Maximum Strength Fast Dissolve 325 mg/1; 2 mg/1; 7.8 mg 00280-8270-16	Bayer	2 tablets	—	—	FDA listed	—
Walgreens Effervescent Cold Relief Plus 325 mg/1; 2 mg/1; 7.8 mg 00363-0875-36	Walgreens	2 tablets	—	—	FDA listed	—
Kroger Effervescent Cold Relief 325 mg/1; 2 mg/1; 7.8 mg 30142-0875-36	Kroger	2 tablets	—	—	FDA listed	—
Effervescent Cold Relief 7.8 mg/1; 325 mg/1; 2 mg 36800-0768-20	Topco	2 tablets	—	—	FDA listed	—
Effervescent Orange Cold Relief 7.8 mg/1; 325 mg/1; 2 mg 37808-0768-20	H.	2 tablets	—	—	FDA listed	—
Equaline Effervescent Cold Relief 325 mg/1; 2 mg/1; 7.8 mg 41163-0768-20	United	2 tablets	—	—	FDA listed	—
Effervescent Orange Cold Relief 7.8 mg/1; 325 mg/1; 2 mgthis 41250-0123-20	Meijer	2 tablets	—	—	FDA listed	—
Meijer Effervescent Cold Relief 325 mg/1; 2 mg/1; 7.8 mg 41250-0768-36	Meijer	2 tablets	—	—	FDA listed	—
Equate Effervescent Cold Relief 325 mg/1; 2 mg/1; 7.8 mg 49035-0768-67	Walmart	2 tablets	—	—	FDA listed	—
Top Value Effervescent Cold Relief 325 mg/1; 7.8 mg/1; 2 mg 50201-7682-02	Tower	2 tablets	—	—	FDA listed	—
Top Value Effervescent Cold Relief - Orange 7.8 mg/1; 325 mg/1; 2 mg 50201-8752-00	Tower	2 tablets	—	—	FDA listed	—
Good Sense Effervescent Cold Relief 2 mg/1; 325 mg/1; 7.8 mg 50804-0873-20	Good	2 tablets	—	—	FDA listed	—
Effervescent Cold Relief 325 mg/1; 7.8 mg/1; 2 mg 53943-0873-20	Discount	2 tablets	—	—	FDA listed	—
Family Wellness Effervescent Cold Relief Orange 2 mg/1; 325 mg/1; 7.8 mg 55319-0875-20	Family	2 tablets	—	—	FDA listed	—
Effervescent Orange Cold Relief 7.8 mg/1; 325 mg/1; 2 mg 55910-0769-20	DOLGENCORP,	2 tablets	—	—	FDA listed	—
Dollar General Effervescent Cold Relief 325 mg/1; 2 mg/1; 7.8 mg 55910-0873-20	DOLGENCORP,	2 tablets	—	—	FDA listed	—
Quality Choice Effervescent Cold Relief Plus 325 mg/1; 2 mg/1; 7.8 mg 63868-0228-20	Chain	2 tablets	—	—	FDA listed	—
Quality Choice Effervescent Cold Relief - Orange 7.8 mg/1; 325 mg/1; 2 mg 63868-0568-20	Chain	2 tablets	—	—	FDA listed	—
Best Choice Effervescent Cold Relief 325 mg/1; 7.8 mg/1; 2 mg 63941-0873-20	Valu	2 tablets	—	—	FDA listed	—
WinCo Foods Effervescent Cold Relief 325 mg/1; 2 mg/1; 7.8 mg 67091-0109-20	WinCo	2 tablets	—	—	FDA listed	—
Effervescent Orange Cold Relief 7.8 mg/1; 325 mg/1; 2 mg 69842-0875-20	CVS	2 tablets	—	—	FDA listed	—

About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.

Where does this data come from?

Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️

2013

On the market since

May 2013

📍

2026

Currently FDA-listed

13 years listed

🔒

·

No generic listed yet

brand only

ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?

Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

🔬 Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate — the ingredient across all brands.

Top reported reactions

Cerebrovascular Accident9

Drug Dependence5

Malaise5

Rectal Haemorrhage5

Choking4

Dizziness4

Nausea4

Reporter sex

Male · 33%

Female · 64%

Unknown · 3%

Reports over time (by year) — tap or hover for the count & year

Most recent year is provisional (FAERS lags ~3 months).

Where does this data come from?

Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

📦 Packaging — all sizes for this product

Package NDC	Description	Marketing start	Status
41250-0123-20 You're viewing this	10 POUCH in 1 CARTON (41250-123-20) / 2 TABLET, EFFERVESCENT in 1 POUCH	2013-05-26	Active
41250-0123-24	12 POUCH in 1 CARTON (41250-123-24) / 2 TABLET, EFFERVESCENT in 1 POUCH	2024-06-06	Active

Pack size FAQ

What quantity is in NDC 41250-0123-20?

NDC 41250-0123-20 is listed by the FDA — 10 pouch in 1 carton / 2 tablet, effervescent in 1 pouch.

What NDC number is used to bill for this package of Effervescent Orange Cold Relief Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate 7.8 mg; 325 mg; 2 mg Tablet, Effervescent?

Bill NDC 41250-0123-20 — the 11-digit billing format is 41250012320. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product

What data is (and isn’t) available for this NDC — tap to expand

NDC identity (package / product / labeler codes)	✓ Available
Labeler	✓ Available
Product & package description	✓ Available
Marketing category & status	✓ Available
Active ingredient / dosage form / route	✓ Available
FDA label (SPL via DailyMed)	✓ Available
Package photos	✓ Available
Inactive ingredients (structured)	✓ Available
NADAC pharmacy acquisition price (CMS)	— Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data	— Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk	— Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD)	— Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.

“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?

An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.

Why is there no price listed?

The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.

Is the NDC printed on the package the same as the 11-digit billing NDC?

Yes, they identify this exact package in different formats. The FDA registers it as 41250-123-20, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 41250-0123-20, written without dashes as 41250012320. The Identity section at the top of this page lists every form of this code.

What do the three segments of this NDC mean?

In 41250-0123-20, the first segment (41250) is the labeler code FDA assigned to Meijer Distribution Inc.; the middle segment (0123) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (20) identifies this exact package size and type. Together they name one specific package of one specific product.

Is this package still being marketed?

Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Meijer Distribution Inc.. Listing status can change — the directory data on this page refreshes weekly.

Does this product come in other package sizes?

Yes — the FDA directory lists 1 other package presentation of this same product, including 2 tablets (41250-0123-24). Each has its own NDC and its own page — see the package list near the top of this page.

Who lists this product with the FDA?

Meijer Distribution Inc. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.

Do I need a prescription for this product?

This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.

This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.

Where does this data come from?

Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.

🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🆘 Overdosage 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose

🎯 Indications and Usage 38 words ▾

Uses ■ temporarily relieves these symptoms due to the common cold: ■ sneezing ■ nasal congestion ■ sore throat ■ headache ■ minor aches and pains ■ runny nose ■ sinus congestion and pressure ■ temporarily reduces fever

⏱️ Dosage and Administration 51 words ▾

Directions ■ do not use more than directed (see overdose warning) ■ adults and children 12 years and over: take 2 tablets completely dissolved in 4 oz of water every 4 hours ■ do not take more than 8 tablets in 24 hours ■ children under 12 years: ask a doctor

⚠️ Warnings 185 words ▾

Warnings Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert: Aspirin may cause a severe allergic reaction which may include: ■ hives ■ facial swelling ■ asthma (wheezing) ■ shock Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding.

The chance is higher if you ■ are age 60 or older ■ have had stomach ulcers or bleeding problems ■ take a blood thinning (anticoagulant) or steroid drug ■ take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) ■ have 3 or more alcoholic drinks every day while using this product ■ take more or for a longer time than directed Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.

🆘 Overdosage 19 words ▾

In case of overdose In case of overdose, get medical help or contact a Poison Control Center right away.

🧪 Active Ingredient 21 words ▾

Active Ingredients (in each effervescent tablet) Aspirin 325 mg (NSAID)* Chlorpheniramine maleate 2 mg Phenylephrine bitartrate 7.8 mg *Nonsteroidal anti-inflammatory drug

🧪 Inactive Ingredients 23 words ▾

Inactive ingredients acesulfame potassium, anhydrous citric acid, aspartame, docusate sodium, FD&C red #40, FD&C yellow #6, flavors, mannitol, povidone, sodium benzoate, sodium bicarbonate

🎯 Purpose 64 words ▾

Purpose Aspirin 325 mg (NSAID)* . . . . . . . . . . . . . . . . . . .Pain reliever/fever reducer Chlorpheniramine maleate 2 mg . . . . . . . . . . . . .Antihistamine Phenylephrine bitartrate 7.8 mg . . . . . . . . . . . . .Nasal decongestant *Nonsteroidal anti-inflammatory drug

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

🔗 Related NDC lookups

🧪 All Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate NDCsSame ingredient 🏭 All Meijer labeler NDCsLabeler code 41250