Home › NDC Lookup › Ingredients › Acetaminophen, Dextromethorphan Hydrobro... › 63824-0223-66
Delsym Nighttime Cough ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, and TRIPROLIDINE HYDROCHLORIDE 650 mg/20mL; 2.5 mg/20mL; 20 mg/20mL Solution, 180 mL — NDC 63824-0223-66 package photo

Delsym Nighttime Cough ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, and TRIPROLIDINE HYDROCHLORIDE 650 mg/20mL; 2.5 mg/20mL; 20 mg/20mL Solution, 180 mL

by Reckitt Benckiser LLC · 180 mL in 1 BOTTLE (63824-223-66)
NDC 63824-0223-66
🏷️ FDA NDC (as labeled) 63824-223-66 billing pads the product segment with a zero
OTC On market Non-controlled
🗂️ Data synced Aug 27, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 63824-223-66
Product NDC 63824-223
11-digit billing NDC 63824022366
NCPDP billing unit ML — per mL (volume)
RxCUI 2173667
UNII 362O9ITL9D, YAN7R5L890, 9D2RTI9KYH
UPC 0363824213675
Application # M012
SPL Set ID 27f9d2db-38ce-41d2-8f1a-0eb171600274
Established class (EPC) Sigma-1 Agonist; Uncompetitive N-methyl-D-aspartate Receptor Antagonist
Mechanism of action Sigma-1 Receptor Agonists; Uncompetitive NMDA Receptor Antagonists
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2020-06-30
Route ORAL
Dosage form SOLUTION
Substance ACETAMINOPHEN; TRIPROLIDINE HYDROCHLORIDE; DEXTROMETHORPHAN HYDROBROMIDE
GPI-14 43998903302020
GPI class Delsym Nighttime Cough Max Str
GCN Seq No 080838
GCN 47819
HICL code 046405
Ingredient (HICL) Triprolidine/Dm/Acetaminophen
HIC1 code B
Therapeutic class — broad (HIC1) Respiratory System
HIC2 code B4
Therapeutic class — intermediate (HIC2) Drugs Affecting The Trachea And Bronchi (Contin.1)
HIC3 code B4G
Therapeutic class — specific (HIC3) Non-Opioid Antitus-1St Gen Antihist-Analgesic Comb
AHFS code 04:04.20.00
AHFS class Propylamine Derivatives
FDB label name DELSYM NIGHTTIME COUGH LIQUID
FDB brand name Delsym Nighttime Cough
Legend status O — Over-the-counter (OTC) drug or device
Why two NDCs? The FDA registers this code as 63824-223-66 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 63824-0223-66. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Other antihistamines for systemic use class.

Drug family (ATC) Other antihistamines for systemic use
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerReckitt Benckiser LLC
FDA applicationM012 (OTC MONOGRAPH DRUG)
Labeler code63824
First marketedJun 2020
Product typeHuman Otc Drug
Portfolio174 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name DELSYM NIGHTTIME COUGH LIQUID Ingredient Triprolidine/Dm/Acetaminophen
🧪 What is this product?

Delsym Nighttime Cough is an oral solution that combines three active ingredients commonly used in over-the-counter cold and cough products. Acetaminophen is typically used to reduce fever and relieve pain or aches. Dextromethorphan is a cough suppressant commonly found in nighttime cold medicines. Triprolidine is an antihistamine that is frequently used to help dry up nasal secretions and reduce sneezing or runny nose symptoms associated with colds.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

💊 What it looks like

Color blue
FlavorFruit
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 3VRD35U26C
    A natural extract from licorice root, ammonium glycyrrhizate is used as a flavoring agent and sweetener in medicines. It may also help soothe irritated tissues in the mouth or throat.
  • UNII XF417D3PSL
    Anhydrous citric acid is a sour, crystalline powder derived from citric acid with water removed. In medicines, it acts as a buffer to control pH, adds tartness to improve taste, and helps tablets disintegrate.
  • UNII 7FLD91C86K
    Edetate disodium is a chemical compound that binds and removes certain metal ions. In medicines, it acts as a preservative and stabilizer by preventing metals like calcium from interfering with the product's shelf life and consistency.
  • UNII H3R47K3TBD
    FD&C Blue No. 1 is a synthetic blue dye approved for use in foods and medicines. It serves as a colorant to give the medication its distinctive appearance and help with product identification.
  • UNII WZB9127XOA
    A synthetic red dye used to color medications and make them easier to identify. It serves as a colorant in tablets, capsules, and liquid formulations.
  • UNII PDC6A3C0OX
    Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
  • UNII 6DC9Q167V3
    Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
  • UNII OJ245FE5EU
    Sodium benzoate is a salt derived from benzoic acid, a preservative. It's added to medicines to prevent growth of bacteria, fungi, and other microorganisms that could spoil the product.
  • UNII 451W47IQ8X
    Sodium chloride is common table salt. It's used in medicines as a buffer to maintain proper pH, as a filler to add bulk, or to adjust the osmotic balance in liquid formulations.
  • UNII 36KCS0R750
    Sodium sulfate anhydrous is a salt derived from sodium and sulfuric acid. It acts as a filler and diluent in tablets and capsules to add bulk and help achieve proper tablet size and weight.
  • UNII 506T60A25R
    Sorbitol is a natural sugar alcohol derived from glucose. It serves as a sweetener, humectant, and bulking agent in medications to improve taste and help maintain moisture in the product.
  • UNII 96K6UQ3ZD4
    Sucralose is a synthetic sweetener made from sugar. It's added to medicines to improve taste without adding calories, helping make bitter or unpleasant-tasting drugs easier to take.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
  • UNII TTV12P4NEE
    Xanthan gum is a thickening and stabilizing ingredient made from fermented corn or other sugars. It's added to medicines to improve texture, prevent separation of liquids and solids, and help the product stay consistent.

14 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesammonium glycyrrhizate, anhydrous citric acid, edetate disodium, FD&C blue no. 1, FD&C red no. 40, flavor, glycerin (soy), propylene glycol, purified water, sodium benzoate, sodium chloride, sodium sulfate anhydrous, sorbitol, sucralose, xanthan gum

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly $0.057 $10.21 / 180 ml
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per mL) — tap or hover for the price & month
Feb 2021 Jan 2022 Apr 2022 $0.059 $0.051
▲ Up 11% over the last 3 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Delsym Nighttime Cough 650 mg/20mL; 2.5 mg/20mL; 20 mg/20mLthis 63824-0223-66 Reckitt 180 ml $0.057 — FDA listed —
Overnight Cold and Flu 650 mg/20mL; 20 mg/20mL; 2.5 mg/20mL 00363-6980-06 WALGREENS 180 ml — — FDA listed —
Cold and Flu Nighttime 650 mg/20mL; 20 mg/20mL; 2.5 mg/20mL 00363-8063-45 Walgreen 177 ml — — FDA listed —
Target Overnight Cold and Flu 650 mg/20mL; 20 mg/20mL; 2.5 mg/20mL 11673-0698-06 TARGET 180 ml — — FDA listed —
Meijer Nighttime Cold and Flu 650 mg/20mL; 20 mg/20mL; 2.5 mg/20mL 41250-0869-06 MEIJER 180 ml — — FDA listed —
Cold and Flu Nighttime 650 mg/20mL; 20 mg/20mL; 2.5 mg/20mL 51316-0963-45 CVS 177 ml — — FDA listed —
Mucinex Nightshift Cold and Flu 650 mg/20mL; 20 mg/20mL; 2.5 mg/20mL 63824-0503-64 Reckitt 1 bottle — — Discontinued —
Overnight Cold and Flu 650 mg/20mL; 20 mg/20mL; 2.5 mg/20mL 68163-0698-06 RARITAN 180 ml — — FDA listed —
CVS Nighttime Cold and Flu 650 mg/20mL; 20 mg/20mL; 2.5 mg/20mL 69842-0886-06 CVS 180 ml — — FDA listed —
Mucinex Childrens Night Time Multi-Symptom Cold and Flu 1.25 mg/10mL; 10 mg/10mL; 325 mg/10mL 72854-0063-04 Reckitt 1 bottle — — FDA listed —
Mucinex Fast-Max Nighttime Cold And Flu 650 mg/20mL; 20 mg/20mL; 2.5 mg/20mL 72854-0143-66 Reckitt 180 ml — — FDA listed —
Mucinex Fast-Max Recharge Nighttime Cold and Flu 650 mg/20mL; 20 mg/20mL; 2.5 mg/20mL 72854-0167-66 Reckitt 180 ml — — FDA listed —
Cold and Flu Nighttime 650 mg/20mL; 20 mg/20mL; 2.5 mg/20mL 79903-0119-45 WALMART 177 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2020
On the market since
Jun 2020
📍
2026
Currently FDA-listed
6 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

🔬 Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Delsym Nighttime Cough (this brand).

Top reported reactions

Expired Product Administered2
Product Complaint2
Somnolence2
Disorientation1
Dizziness1
Drug Effective For Unapproved Indication1
Dysarthria1

Reporter sex

0 reports
Reports over time (by year) — tap or hover for the count & year
2021 2022 2024 2026 10 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
63824-0223-66 You're viewing this 180 mL in 1 BOTTLE (63824-223-66) 2020-06-30 Active

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 44 words ▾

Uses temporarily relieves these common cold and flu symptoms: cough minor aches and pains sore throat headache runny nose sneezing itching of the nose or throat itchy, watery eyes due to hay fever temporarily reduces fever controls cough to help you get to sleep

⏱️ Dosage and Administration 72 words ▾

Directions do not take more than directed (see Overdose warning ) do not take more than 4 doses in any 24-hour period measure only with dosing cup provided do not use dosing cup with other products dose as follows or as directed by a doctor adults and children 12 years of age and over: 20 mL in dosing cup provided every 4 hours children under 12 years of age: do not use

⚠️ Warnings ~2 min read ▾

Warnings Liver warning This product contains acetaminophen. Severe liver damage may occur if you take: more than 4 doses (80 mL) in 24 hours, which is the maximum daily amount for this product with other drugs containing acetaminophen 3 or more alcoholic drinks daily while using this product Allergy alert Acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If a skin reaction occurs, stop use and seek medical help right away.

Sore throat warning If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug.

If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. Ask a doctor before use if you have liver disease glaucoma trouble urinating due to an enlarged prostate gland a breathing problem such as emphysema or chronic bronchitis persistent or chronic cough such as occurs with smoking, asthma, or emphysema cough that occurs with too much phlegm (mucus) Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin taking sedatives or tranquilizers When using this product do not use more than directed excitability may occur, especially in children marked drowsiness may occur alcohol, sedatives, and tranquilizers may increase drowsiness avoid alcoholic drinks use caution when driving a motor vehicle or operating machinery Stop use and ask a doctor if pain or cough gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur cough comes back, or occurs with fever, rash, or headache that lasts.

These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children.

📦 Storage and Handling 16 words ▾

Other information each 20 mL contains: sodium 16 mg store at 20-25°C (68-77°F) do not refrigerate

🧪 Active Ingredient 24 words ▾

Active ingredients (in each 20 mL) Purposes Acetaminophen 650 mg Pain reliever/fever reducer Dextromethorphan HBr 20 mg Cough suppressant Triprolidine HCl 2.5 mg Antihistamine

🧪 Inactive Ingredients 35 words ▾

Inactive ingredients ammonium glycyrrhizate, anhydrous citric acid, edetate disodium, FD&C blue no. 1, FD&C red no. 40, flavor, glycerin (soy), propylene glycol, purified water, sodium benzoate, sodium chloride, sodium sulfate anhydrous, sorbitol, sucralose, xanthan gum

🎯 Purpose 24 words ▾

Active ingredients (in each 20 mL) Purposes Acetaminophen 650 mg Pain reliever/fever reducer Dextromethorphan HBr 20 mg Cough suppressant Triprolidine HCl 2.5 mg Antihistamine

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 63824-0221-66 · Reckitt 63824-0237-20 · Reckitt →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.