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Leader Lubricant Eye Drops Carboxymethylcellulose sodium .5 g/100mL Solution/ Drops, 70 vials

by Cardinal Health · 70 VIAL, SINGLE-USE in 1 BOX (70000-0012-1) / .4 mL in 1 VIAL, SINGLE-USE
NDC 70000-0012-01
🏷️ FDA NDC (as labeled) 70000-0012-1 billing pads the package segment with a zero
This package
Contains70 vials Cost per ea$0.1628 NADAC Per package$11.40 / 70 vials Pack sizes2 compare ↓
Also priced by: Medicaid pays $0.2990/unit — full pricing hub ↓
Also comes in: 30 vials 70000-0012-02
OTC On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

⚠️
Other active recalls for Carboxymethylcellulose Sodium (different manufacturers) — 6 · tap to view
These affect other manufacturers’ products for the same ingredient — not necessarily the exact NDC on this page.
Class II · Apr 23, 2025 — cGMP deviations and lack of assurance of sterility. (BRS Analytical Services, LLC) · FDA recall D-0406-2025
Class III · Dec 18, 2024 — LABELING: LABEL MIX-UP (AvKARE) · FDA recall D-0175-2025
Class I · Nov 13, 2023 — Non-Sterility (Kilitch Healthcare India Limited) · FDA recall D-0291-2024
Class I · Nov 13, 2023 — Non-Sterility (Kilitch Healthcare India Limited) · FDA recall D-0299-2024
Class I · Oct 31, 2023 — Non-Sterility: FDA found insanitary conditions and positive bacterial test results from environmental sampling at the manufacturing facility. (Cardinal Health Inc.) · FDA recall D-0134-2024
Class I · Oct 31, 2023 — Non-Sterility: FDA found insanitary conditions and positive bacterial test results from environmental sampling at the manufacturing facility. (Cardinal Health Inc.) · FDA recall D-0132-2024
Each entry is an official FDA enforcement report — look up any recall number in the FDA recall database ↗

🆔 Identity & classification

FDA NDC (as labeled) 70000-0012-1
Product NDC 70000-0012
11-digit billing NDC 70000001201
NCPDP billing unit EA — each (per item)
RxCUI 1188426
UNII K679OBS311
UPC 0096295137651
Application # M018
SPL Set ID 8d9a4eec-bf0e-6c3b-e053-2995a90ae9aa
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2019-07-13
Route OPHTHALMIC
Dosage form SOLUTION/ DROPS
Substance CARBOXYMETHYLCELLULOSE SODIUM
GPI-14 86200010102021
GPI class Lubricant Eye Drops PF
GCN Seq No 030011
GCN 37384
HICL code 003843
Ingredient (HICL) Carboxymethylcellulose Sodium
HIC1 code Q
Therapeutic class — broad (HIC1) Ear/Eye/Nose/Rectum/Topical/Vagina/Other
HIC2 code Q6
Therapeutic class — intermediate (HIC2) Ophthalmic Preparations
HIC3 code Q6T
Therapeutic class — specific (HIC3) Artificial Tears
AHFS code 52:92.00.00
AHFS class Eent Drugs, Miscellaneous
FDB label name LUBRICANT 0.5% EYE DROPS
FDB brand name Lubricant Eye Drops
Legend status O — Over-the-counter (OTC) drug or device
Why two NDCs? The FDA registers this code as 70000-0012-1 — a 5-4-1 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the package segment → 70000-0012-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏭 Manufacturer & labeler

LabelerCardinal Health
FDA applicationM018 (OTC MONOGRAPH DRUG)
Labeler code70000
First marketedJul 2019
Product typeHuman Otc Drug
Portfolio84 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name LUBRICANT 0.5% EYE DROPS Ingredient Carboxymethylcellulose Sodium
🧪 What is this product?

Leader Lubricant Eye Drops is an over-the-counter eye drop solution containing carboxymethylcellulose sodium, a lubricating agent. This product is marketed as an OTC monograph drug, meaning it follows established FDA guidelines for this category rather than undergoing individual application review. Carboxymethylcellulose sodium is typically used to coat and moisten the eye surface, and lubricant eye drops of this type are commonly used to help relieve dryness and irritation.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eaPer package
Retail pharmacies payNADAC · weekly $0.163 $11.40 / 70 vials
Medicaid paysCMS SDUD · 12 mo $0.2990 $20.93 / 70 vials
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per ea) — tap or hover for the price & month
Jul 2025 Jun 2026 Jul 2026 Sep 2026 $0.163 $0.138
▲ Up 18% over the last 5 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Leader Lubricant Eye Drops .5 g/100mLthis 70000-0012-01 Cardinal 70 vials $0.163 — Availability likely —
Rugby Lubricant Eye Drops .5 g/100mL 00536-1387-92 Rugby 30 vials $0.227 — Availability likely +39%
Good Neighbor Pharmacy Lubricant Eye Drops .5 g/100mL 46122-0756-56 Amerisource 30 vials $0.227 — Availability likely +39%
carboxymethylcellulose sodium 5 mg/mL 50268-0067-30 AvPAK 30 vials $0.227 — Availability likely +39%
Foster and Thrive Lubricant Eye Drops .5 g/100mL 70677-1190-01 Strategic 30 vials $0.227 — Availability likely +39%
Carboxymethylcellulose Sodium Eye Lubricant 5 mg/mL 42494-0448-05 Cameron 2 bottles $0.275 — Discontinued +69%
Rugby Carboxymethylcellulose Sodium 0.5% Eye Drops .5 g/100mL 00536-1386-35 Rugby 2 bottles $0.280 — Availability likely +72%
carboxymethylcellulose sodium 5 mg/mL 50268-0068-15 AvPAK 1 bottle $0.324 — Availability likely +99%
Leader Lubricant Eye Drops Soothing Relief .5 g/100mL 70000-0705-01 LEADER/Cardinal 1 bottle $0.324 — Availability likely +99%
Refresh Tears 5 mg/mL 00023-0798-01 Allergan, 2 bottles $0.412 — Availability likely +153%
Lubricant Drops 5 mg/mL 70000-0090-01 CARDINAL 1 bottle $0.498 — FDA listed +206%
Refresh Plus 5 mg/mL 00023-0403-05 Allergan, 5 vials — — FDA listed —
Refresh Tears 00023-0795-65 Allergan, 1 kit — — FDA listed —
Walgreens Lubricant Eye Drops Preservative Free .5 g/100mL 00363-8800-01 Walgreen 30 vials — — FDA listed —
Walgreens Lubricant Eye Drops 5 mg/mL 00363-8832-15 Walgreen 2 bottles — — FDA listed —
Walgreens Lubricant Eye Drops 5 mg/mL 00363-8833-15 Walgreen 1 bottle — — FDA listed —
Lubricant Eye 5 mg/mL 00536-1476-92 Rugby 30 ampules — — FDA listed —
Lubricant Eye Drops Preservative Free .5 g/100mL 11673-0150-01 Target 70 vials — — FDA listed —
Up and Up Dry Eye Relief Lubricant Eye Drops 5 mg/mL 11673-0771-01 Target 2 bottles — — FDA listed —
Up and Up Dry Eye Relief Lubricant Eye Drops 5 mg/mL 11716-0771-01 Hanlim 2 bottles — — FDA listed —
Auro-Cmc 5 mg/mL 16030-0401-10 Aurolab 10 ml — — FDA listed —
Carboxymethylcellulose Sodium Eye Drops 0.5% 5 mg/mL 16030-0501-05 Aurolab 5 ml — — FDA listed —
Gentle Eyes Lubricant Eye Drops 5 mg/mL 17312-0430-15 TRP 1 bottle — — FDA listed —
Signature Care Lubricant Eye Drops .5 g/100mL 21130-0705-01 Better 30 vials — — FDA listed —
Kroger Lubricant Eye .5 g/100mL 30142-0373-33 The 30 vials — — FDA listed —
HEB Lubricant Eye Drops .5 g/100mL 37808-0100-01 HEB 30 vials — — FDA listed —
Medi-First Lubricant Eye Drops .5 g/100mL 47682-0193-83 Unifirst 30 ampules — — FDA listed —
Green Guard Lubricant Eye Drops .5 g/100mL 47682-0194-83 UniFirst 30 ampules — — FDA listed —
Equate Lubricant Eye Drops Preservative-Free .5 g/100mL 49035-0245-01 Wal-Mart 25 vials — — FDA listed —
Equate Restore Plus Lubricant Eye Drops .5 g/100mL 49035-0389-01 Walmart, 70 vials — — FDA listed —
Good Sense Lubricating Plus Lubricant Eye Drops .5 g/100mL 50804-0700-01 GoodSense 30 bottles — — FDA listed —
Carboxymethylcellulose Sodium 0.5% 5 mg/mL 51407-0945-30 Golden 3 pouches — — Discontinued —
Discount Drug Mart Lubricant Eye Drops 5 mg/mL 53943-0510-01 Discount 5 bottles — — FDA listed —
Retaine CMC 5 mg/mL 54799-0460-30 OCuSOFT 30 vials — — FDA listed —
Medics Choice Lubricant Eye Drops .5 g/100mL 55651-0030-01 K.C. 5 ampules — — FDA listed —
Lubricant Eye Drops 5 mg/mL 55651-0105-05 KC 5 bottles — — FDA listed —
Lubricant Eye Drops 5 mg/mL 55651-0510-01 KC 5 bottles — — FDA listed —
Publix Moisturizing Relief Eye Drops .5 g/100mL 56062-0789-01 Publix 30 vials — — FDA listed —
TheraTears Dry and Tired 5 mg/mL 58790-0013-30 MEDTECH 6 pouches — — FDA listed —
Family Care Single Use Lubricant Eye Drop 0.4mL 5ct 5 mg/mL 65923-0575-05 United 1 vial — — FDA listed —
Family Care Single Use Lubricant Eye Drop 0.4mL 30ct 5 mg/mL 65923-0576-30 United 30 vials — — FDA listed —
Refresh Tears 5 mg/mL 66715-1073-00 Lil' 1 bottle — — Discontinued —
Refresh Tears Lubricant 5 mg/mL 67751-0130-01 Navajo 3 ml — — Discontinued —
Lubricating Tears 5 mg/mL 69618-0076-55 Reliable 1 bottle — — FDA listed —
CVS Lubricant Eye Drops .5 g/100mL 69842-0804-01 CVS 70 vials — — FDA listed —
CVS Lubricant Eye Drops 30 ct .5 g/100mL 69842-0993-01 CVS 30 vials — — FDA listed —
Lubricant Eye 5 mg/mL 70000-0751-01 CARDINAL 30 ampules — — FDA listed —
Lubricant Eye Drops 5 mg/mL 71105-0105-05 Redicare 5 bottles — — FDA listed —
TopCare Health Lubricant Eye Drops .5 g/100mL 76162-0089-30 Topcare 30 vials — — FDA listed —
Meijer Lubricant Eye Drops .5 g/100mL 79481-0066-01 Meijer 30 vials — — FDA listed —
Rain Renewal Eye Drops .5 g/100mL 79662-0001-30 Rain 30 bottles — — FDA listed —
Equate Moisturizing Comfort Lubricant Eye Drops .5 g/100mL 79903-0264-05 Walmart 1 bottle — — FDA listed —
Focus Tears PF 5 mg/mL 82724-0009-20 Covalent 30 vials — — FDA listed —
Eyes Alive Lubricating 5 mg/mL 83291-0200-00 RIVIERA 100 ampules — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2019
On the market since
Jul 2019
📍
2026
Currently FDA-listed
7 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

🗺️ Medicaid utilization & spend

📍 This exact package only: Medicaid data is reported per full 11-digit NDC — labeler, product and pack size — so every number here is for 70000-0012-01, not the drug overall. Other pack sizes report separately.
💊 Pharmacy benefit only: These are Medicaid outpatient pharmacy claims, billed by NDC. They exclude the medical benefit — clinic- or hospital-administered drugs billed under HCPCS J-codes — so drugs used mostly that way (e.g. Avastin, Lucentis, Keytruda) can look low or missing here. That’s expected, not an error.
📅 Q1 2025 – Q1 2026 · 5 quarters of data
ⓘ The newest quarter is usually incomplete when first published; states restate recent quarters in later CMS releases, so the latest figures typically revise upward. State coverage-policy changes can also shift quarter-to-quarter totals.
Prescriptions last 4 qtrs
3.9K
Units reimbursed last 4 qtrs
262.5K
Gross reimbursed last 4 qtrs
$78.5K
Avg / prescription
$19.92
Avg / unit
$0.2990
Latest quarter Q1 2026
563Rx
Medicaid pays / ea
$0.2990
gross reimbursed
vs
NADAC / ea
$0.1628
acquisition cost
=
Spread
+$0.1362
+84% vs cost
What Medicaid paid per ea (before rebates; includes the pharmacy’s dispensing fee) compared with NADAC — the average price pharmacies pay to buy the drug. A positive spread means Medicaid reimbursed more than the purchase price, before manufacturer rebates.
Fee-for-service vs managed care ⓘ
81% FFS 19% MCO
Fee-for-service · 3,193 Rx Managed care · 748 Rx
State Medicaid map
Alaska: no data reported AK Maine: no data reported ME Washington: 106,640 units · 1,365 per 100k residents WA Idaho: no data reported ID Montana: no data reported MT North Dakota: no data reported ND Minnesota: 5,798 units · 101 per 100k residents MN Wisconsin: 1,610 units · 27.2 per 100k residents WI Michigan: 21,725 units · 216 per 100k residents MI New York: 124,290 units · 635 per 100k residents NY Vermont: no data reported VT New Hampshire: no data reported NH Oregon: no data reported OR Nevada: no data reported NV Wyoming: no data reported WY South Dakota: no data reported SD Iowa: no data reported IA Illinois: no data reported IL Indiana: no data reported IN Ohio: no data reported OH Pennsylvania: no data reported PA New Jersey: no data reported NJ Massachusetts: no data reported MA California: no data reported CA Utah: no data reported UT Colorado: no data reported CO Nebraska: 126 units · 6.4 per 100k residents NE Missouri: no data reported MO Kentucky: no data reported KY West Virginia: no data reported WV Virginia: no data reported VA Maryland: no data reported MD Connecticut: no data reported CT Rhode Island: no data reported RI Arizona: no data reported AZ New Mexico: no data reported NM Kansas: no data reported KS Arkansas: no data reported AR Tennessee: no data reported TN North Carolina: no data reported NC South Carolina: no data reported SC Delaware: no data reported DE Oklahoma: no data reported OK Louisiana: no data reported LA Mississippi: no data reported MS Alabama: no data reported AL Georgia: no data reported GA D.C.: no data reported DC Hawaii: no data reported HI Texas: 2,266 units · 7.4 per 100k residents TX Florida: no data reported FL
Units reimbursed · per 100k residents
6.41,365
gray = no data reported ⓘ
Colors are per 100,000 residents, so big states don’t automatically dominate. Tap or hover a state for its actual totals.
Tap or hover a state
…for its Medicaid breakdown
🏆 Top states by units · per 100k residents
1 Washington 1,365 /100k
2 New York 635 /100k
3 Michigan 216 /100k
4 Minnesota 101 /100k
5 Wisconsin 27.2 /100k
6 Texas 7.4 /100k
7 Nebraska 6.4 /100k
National units — by quarter
💵 About the dollar figures: “reimbursed” is what Medicaid paid pharmacies before confidential manufacturer rebates, so the program’s real net cost is lower than these numbers. Fee-for-service and managed-care claims are combined unless split above. Source: CMS State Drug Utilization Data; per-100k rates use 2023 Census population estimates.

💊 Medicaid utilization by pack size

Medicaid (SDUD) totals over the four most recent reported quarters for every package size of this drug — handy when a specific package (e.g. a starter/titration pack) carries little or no Medicaid volume on its own.
30 vials70000-0012-02 30,523 Rx · $502,150
70 vials this page70000-0012-01 3,941 Rx · $78,486
Drug total (last 4 qtrs): 34,464 Rx · 1,433,448 units · $580,636 gross reimbursed
Tap a pack size to open its page. Source: CMS State Drug Utilization Data, last 4 quarters.

📦 Packaging — all sizes for this product

Package NDCDescription Per unit Per pack Marketing startStatus
70000-0012-01 You're viewing this 70 VIAL, SINGLE-USE in 1 BOX (70000-0012-1) / .4 mL in 1 VIAL, SINGLE-USE $0.1628 / ea $11.39 2019-07-13 Active
70000-0012-02 30 VIAL, SINGLE-USE in 1 BOX (70000-0012-2) / .4 mL in 1 VIAL, SINGLE-USE $0.2268 / ea $6.80 2019-07-13 Active

This pack has the lowest per-ea cost of the 2 priced pack sizes ($0.1628 NADAC).

This pack accounts for about 11% of this product's recent Medicaid fills; most go to a different pack size. See all packs ↓

Pack size FAQ

What quantity is in NDC 70000-0012-01?
NDC 70000-0012-01 contains 70 vials — 70 vial, single-use in 1 box / .4 ml in 1 vial, single-use.
What is the difference between NDC 70000-0012-01 and NDC 70000-0012-02?
Both are Leader Lubricant Eye Drops Carboxymethylcellulose sodium .5 g/100mL Solution/ Drops — the drug itself is identical. NDC 70000-0012-01 is the 70 vials package, while NDC 70000-0012-02 is the 30 vials package. Per-ea NADAC also differs: $0.1628 here vs $0.2268 for the 30 vials pack.
What NDC number is used to bill for this package of Leader Lubricant Eye Drops Carboxymethylcellulose sodium .5 g/100mL Solution/ Drops?
Bill NDC 70000-0012-01 — the 11-digit billing format is 70000001201. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 31 words ▾

Uses for the temoprary relief of burning, irritation, and discomfort due to dryness of the eyes or exposure to wind or sun may be used as a protectant against further irritation

⏱️ Dosage and Administration 37 words ▾

Directions to open, twist and pull tab to remove instill 1 or 2 drops in the affected eye(s) as needed and discard container if used for post-operative (e.g. LASIK) dryness and discomfort, follow your eye doctor's instructions

⚠️ Warnings 103 words ▾

Warnings For external use only Do not use this product if solution changes color or becomes cloudy When using this product do not reuse once opened, discard to avoid contamination, do not touch tip of container to any surface do not touch unit-dose tip to eye Stop use and ask a doctor if you experience eye pain changes in vision occur redness or irritation of the eye continues redness or irritation of the eye worsens or persists for more than 72 hours Keep out of the reach of children. If accidentally swallowed, get medical help or contact a Poison Control Center (1800-222-1222) immediately.

🧪 Active Ingredient 5 words ▾

Active ingredients Carboxymethylcellulose sodium 0.5%

🧪 Inactive Ingredients 25 words ▾

Inactive ingredients calcium chloride, magnesium chloride, potassium chloride, purified water, sodium chloride and sodium lactate. May contain sodium hydroxide and/or hydrochloric acid to adjust pH.

🎯 Purpose 2 words ▾

Purpose Lubricant

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 70000-0011-01 · Cardinal 70000-0013-01 · Cardinal →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.