Can Arginine Supplements Be Taken With Losartan?

In our latest question and answer, the pharmacist discusses the interaction between arginine supplements and losartan.


Can I take total arginine with losartan 100mg?

Asked by Ginny On Jun 27, 2024

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Jun 28, 2024
Last updated Jul 18, 2024


Hello and thanks for reaching out to us!

Our herbal-drug interaction checker does list an interaction between arginine and losartan, which can be found on our website (L-arginine - Losartan Potassium Interaction Details | HelloPharmacist).

The interaction is as follows:

  • L-arginine boosts nitric oxide, which helps widen blood vessels and can lower blood pressure.
  • When combined with certain blood pressure medications, the effects of widening blood vessels and lowering blood pressure can be stronger, increasing the risk of blood pressure dropping too low.

When your blood pressure drops too low, you may experience symptoms such as dizziness and drowsiness, and it also increases your risk of falling.

This interaction is simply a precaution to make you aware of the combined effects of losartan and arginine. If your blood pressure already runs low, it may be more of a concern compared to if you have normal blood pressure.

Arginine also tends to have only intermittent effects and doesn't appear to be long-lasting. So if you only take it as a workout supplement, the long-term risk might not be significant.

I highly recommend speaking with your doctor about whether or not combining losartan and arginine is safe for your medical situation.

Final Words

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  • Blood pressure and metabolic changes during dietary L-arginine supplementation in humans, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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