Can You Cut Or Split Sertraline Tablets?
In our latest question and answer, the pharmacist discusses whether or not Zoloft (sertraline) tablets can safely be cut.

Question
I take 50mg sertraline. Can I split the pill in half and take them together for easier swallowing?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 11, 2025
Key points
- Zoloft (sertraline) tablets can safely be cut in half.
Answer
Zoloft (sertraline) is an antidepressant used in the treatment of depression, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, and social anxiety disorder. Sertraline 50mg is a scored tablet that can be split. All other strengths of sertraline (25mg, 100mg) are safe to split as well.
It is perfectly fine, and safe, split your sertraline tablet and then swallow both halves. Remember that it is always a good idea to check with your pharmacist before splitting a medication since not all tablets can be split. Some general information on tablet splitting can be found below.
Tablet Splitting: General Information
There are several considerations to take into account before splitting a tablet. In general, tablets that have the following characteristics should not be split:
- Time released tablets
- Film-coated tablets
- Combination products
- Odd shaped tablets
- Tablets that crumble when cut
- Capsules
Tablets that are scored, in general, can be split. The FDA lists some things to keep in mind when splitting a tablet include:
- Tablet splitters are a good tool to use but will not work well for all tablets, especially small tablets.
- Tablets should only be split at the time they are needed. Splitting the tablet before it is needed will possibly expose tablets to unnecessary moisture, heat and other conditions.
- If the manufacturer of the tablet changes, check with your pharmacist to see if splitting the tablet is still advisable.
Tablet splitting can be a good way to help patients that have difficulty swallowing. If a tablet cannot be split, talk to your pharmacist about other options like liquids or alternative drugs that may be easier to swallow.
As stated at the beginning of this answer, Zoloft (sertraline) tablets are safe to split.
Final Words
Thanks for reaching out to us! I hope this answer helped.
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Dr. Brian Staiger, PharmD
- 13318 views