Can You Open Vyvanse Capsules?

In our latest question and answer, the pharmacist discusses whether or not Vyvanse capsules can safely be opened.


I have Vyvanse and sometimes I feel like they irritate my throat. I want to open them and take them that way. Is that safe?

Asked by Geoff On Oct 20, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Oct 20, 2022
Last updated Jul 18, 2024

Key points

  • Vyvanse (lisdexamfetamine) capsules are safe to open. You can mix the contents of the capsule with yogurt, water, or orange juice.


Yes, you can safely open Vyvanse capsules and mix the contents of the capsule with yogurt, water, or orange juice if you are having trouble swallowing the intact capsules.

The prescribing information for Vyvanse states the following regarding opening the capsules:

Open capsules, empty and mix the entire contents with yogurt, water, or orange juice. If the contents of the capsule include any compacted powder, a spoon may be used to break apart the powder. The contents should be mixed until completely dispersed. Consume the entire mixture immediately. It should not be stored. The active ingredient dissolves completely once dispersed; however, a film containing the inactive ingredients may remain in the glass or container once the mixture is consumed
Vyvanse Prescribing Information

It is important to take notice of the fact that some of the inactive ingredients in Vyvanse may not dissolve in a liquid. However, all of the active ingredient will dissolve, so it is important to consume all of the liquid you have mixed Vyvanse with.

Alternatives To Opening Vyvanse Capsules

If you don't want to open Vyvanse capsules, the drug is also available as a chewable tablet in the following strengths:

  • Vyvanse 10mg Chewable Tablet
  • Vyvanse 20mg Chewable Tablet
  • Vyvanse 30mg Chewable Tablet
  • Vyvanse 40mg Chewable Tablet
  • Vyvanse 50mg Chewable Tablet
  • Vyvanse 60mg Chewable Tablet

It is not unfortunately available in a 70mg strength like the capsules are.

Vyvanse Information

Vyvanse (Lisdexamfetamine) is used as part of a treatment program to control symptoms of attention deficit hyperactivity disorder (ADHD; more difficulty focusing, controlling actions, and remaining still or quiet than other people who are the same age) in adults and children 6 years of age and older. It is also used in adults to treat binge eating disorder (an eating disorder characterized by periods of uncontrolled overeating).

Vyvanse is in a class of medications called central nervous system stimulants and works by changing the amounts of certain natural substances in the brain.

Final Words

Thanks for your question and I hope you found this helpful!


  • Vyvanse Prescribing Information, Shire
  • Vyvanse Monograph, PubChem

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

Recent Questions