Can You Take Allegra Twice A Day?

In our latest question and answer, the pharmacist discusses whether or not the antihistamine Allegra (fexofenadine) can be taken twice a day.

Question

I take Allegra for my allergies and it works great but doesn't last 24 hours. Is it ok to take another 24-hour tablet in the evening? Or maybe a 12-hour tablet in the evening for full coverage? Thank you.

Asked by Karen On Sep 19, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Sep 19, 2022
Last updated Apr 30, 2024

Key points

  • Some Allegra products can be taken twice daily, such as the 60mg formulation.
  • Allegra 180mg, which is labeled as a '24-hour' product, should only be taken once daily.
  • If Allegra has started to lose effectiveness over time, you should consider switching to a lower dose and taking that dose twice daily, an alternative antihistamine, such as Claritin or Zyrtec, or a nasal steroid, such as Flonase and Nasacort.

Answer

Allegra (fexofenadine) is a non-sedating antihistamine approved for the treatment of seasonal allergic rhinitis as well as chronic urticaria (a type of skin rash). Allegra is available over the counter in a variety of forms including:

  • 12-hour tablet
  • 24 hour tablet/gelcap
  • Orally disintegrating tablet
  • Oral liquid

Allegra is also available in combination with pseudoephedrine (decongestant) in both 12 and 24-hour formulations. So, some Allegra products can be taken twice a day, but not all of them.

Taking Allegra More Than Once A Day

You should not take more than 180 mg of Allegra a day, which is what is contained in one 24-hour tablet/gelcap.

If a 24-hour formulation of Allegra is not providing the desired effects, there are other options to consider for treating your seasonal allergies:

  • Switch to the 12-hour formulation of Allegra and take it twice daily. Some individuals have experienced more consistent allergy symptom relief by switching to the 12-hour formulation if the 24-hour formulation seems to be lacking. The disadvantage to this is adherence as you are less likely to be adherent with dosing if you have to remember to take it twice daily rather than once daily.
  • Try a different non-sedating antihistamine. These other options include loratadine (Claritin, Alavert), cetirizine (Zyrtec), or levocetirizine (Xyzal). Every individual responds to medication differently and you can experience better or more consistent results with one non-sedating antihistamine over another. Switching and trying a new medication in this class may also work well when you have been on one for a long time and have noticed that it is no longer as effective as it used to be. 
  • Adding on another type of treatment for allergy symptoms.  The most common over-the-counter options for this are nasal steroid sprays such as Nasonex and Flonase. Sometimes adding on another type of treatment is enough to put your symptoms at ease. 

Additional Information

Allegra can be taken without regard to meals but should be taken with water. You should separate Allegra from any grapefruit juice, orange juice, or apple juice for about four hours as they can hinder the absorption of Allegra.

Lastly, you should consider taking a nasal steroid as well. These include:

  • Flonase
  • Rhinocort
  • Nasacort

Nasal steroids are very effective in treating allergy symptoms, and some studies suggest they are more effective than antihistamines.  It's not uncommon for antihistamines to lose their effect if taken consistently for a long period of time, so a switch to a nasal steroid could be beneficial for you.

Final Words

Thanks again for reaching out to us and please do so again anytime!

References

  • Fexofenadine Monograph, PubChem
  • Intranasal corticosteroids compared with oral antihistamines in allergic rhinitis: A systematic review and meta-analysis, PubMed
  • Allegra Manufacturer Website, Allegra

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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