Can You Take L-Theanine With Levothyroxine?

In our latest question and answer, the pharmacist discusses whether or not there is an interaction between L-Theanine and levothyroxine.

2 min read Updated Jun 2026 Read by 6,044 people
Can You Take L-Theanine With Levothyroxine?
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Amy asked

Hello, I take 100 mcg of levothyroxine per day for hypothyroidism. Am I able to also take L-Theanine for anxiety without it causing any problems with my thyroid? Thank you!

Aug 29, 2023
The quick answer
  • L-Theanine and levothyroxine have no known interactions and are considered safe to take together.
  • Levothyroxine should be taken on an empty stomach at least 30 minutes before food and other medications to ensure it absorbs properly.
  • It's best to take L-Theanine separately from your levothyroxine dose and discuss any new supplements with your doctor or pharmacist.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
Medications in this answer — tap to explore

Quick Answer

In general, it is considered safe to take L-Theanine along with levothyroxine, as there are currently no known interactions between the two. However, it's important to note that levothyroxine has specific administration instructions to ensure maximum absorption. It is generally recommended to take it on an empty stomach, at least 30 minutes before food and other medications.

Detailed Answer

L-Theanine is an amino acid naturally found in green and black teas, as well as in certain types of mushrooms. It is often utilized as a dietary supplement due to its potential to reduce anxiety and induce calming effects.

Its mechanism is thought to involve the promotion of brain chemicals like serotonin and dopamine, which elevate mood and create a sense of calmness. As far as we know, it does not impact thyroid hormone levels or interfere with thyroid medication.

Levothyroxine is a medication used to treat hypothyroidism. It is a synthetic version of thyroxine (T4), a hormone that the thyroid gland fails to produce adequately in cases of hypothyroidism.

While there is no known interaction between L-Theanine and levothyroxine, it's important to understand that levothyroxine comes with specific administration requirements. Adhering to these instructions is crucial for optimal drug absorption. Generally, unless instructed otherwise by your doctor, levothyroxine should be taken on an empty stomach, at least 30 minutes before consuming food, other supplements, or medications.

Therefore, even though no specific interaction exists, it's advisable to take supplements like L-Theanine separately from levothyroxine.

Final Words

As always, it's best to consult your doctor or pharmacist before initiating any new medication or supplement, especially if you have existing health conditions or are taking other medications. This ensures that you can be appropriately monitored.

References & sources
  1. Synthroid Prescribing Information — AccessFDA
  2. L-theanine, a natural constituent in tea, and its effect on mental state — PubMed
Glossary — Terms in This Answer
L-Theanine
An amino acid found naturally in tea and mushrooms that is taken as a dietary supplement to reduce anxiety and promote calmness.
Levothyroxine
A synthetic thyroid hormone medication used to treat hypothyroidism by replacing the hormone the thyroid gland cannot produce adequately.
Hypothyroidism
A condition in which the thyroid gland does not produce enough thyroid hormone.
Thyroxine (T4)
A natural hormone produced by the thyroid gland that regulates metabolism and body functions.
Serotonin
A brain chemical that helps regulate mood and is associated with feelings of well-being.
Dopamine
A brain chemical that plays a role in mood regulation and the sense of pleasure and motivation.
Absorption
The process by which a medication passes from the digestive system into the bloodstream to be used by the body.
Dietary supplement
A product taken by mouth containing vitamins, minerals, amino acids, or other substances intended to supplement the diet.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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