Can You Take Pepto-Bismol With Tylenol?
In our latest question and answer, the pharmacist discusses whether or not there is an interaction between Tylenol and Pepto-Bismol.

Question
Is it okay to use Pepto-Bismol and Tylenol together? Thanks!

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 03, 2025
Key points
- There is no drug interaction between Tylenol (acetaminophen) and Pepto-Bismol. They are considered safe to take together.
Answer
Thanks for reaching out to us! We're always more than happy to answer drug interaction questions.
Tylenol (acetaminophen) and Pepto-Bismol are considered safe to take with each other. There is no drug interaction between them.
Now, even those these two drugs are available over the counter, that doesn't mean they don't have their fair share of interactions with other drugs.
Pepto-Bismol for example contains a derivative of aspirin (bismuth subsalicylate), and shouldn't be taken with blood thinners. Tylenol is well known to be toxic to the liver at higher than recommended doses, and shouldn't be taken with drugs that can affect the liver as well.
Nevertheless, as mentioned, these two drugs are safe to combine.
About Tylenol
Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. It may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints).
Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.
About Pepto Bismol
Bismuth subsalicylate is used to treat diarrhea, heartburn, and upset stomach in adults and children 12 years of age and older. It is in a class of medications called antidiarrheal agents. It works by decreasing the flow of fluids and electrolytes into the bowel, reduces inflammation within the intestine, and may kill the organisms that can cause diarrhea.
Final Words
Thanks again for reaching out and we hope to hear from you again soon!
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Dr. Brian Staiger, PharmD
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