Can You Take Sudafed With Benzonatate?
In our latest question and answer, our pharmacist discusses the safety of taking benzonatate with Sudafed.

Question
I have a sinus infection and my doctor prescribed me with benzonatate. I am also congested. Is it okay to take it with Sudafed?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 02, 2025
Key points
- Benzonatate (Tessalon) is a non-narcotic cough medication that is not known to have many drug interactions. It is considered safe to take with Sudafed (pseudoephedrine).
Answer
Benzonatate (generic for Tessalon), a medication used to relieve cough, is not known to have many clinically significant drug interactions. In fact, the prescribing information for the drug does not list any. In regard to taking benzonatate with Sudafed, a nasal decongestant, they are not known to have any interaction and are generally considered safe to take together.
Additionally, they don't share similar side effects so there are no precautions in that regard either.
What Is Benzonatate?
Benzonatate is a non-narcotic cough medication that works by numbing the cough reflex in the lungs and throat. It is commonly prescribed to alleviate coughing associated with respiratory conditions such as sinus infections, bronchitis, or the common cold.
As mentioned in the above section, benzonatate is not known to have many significant drug interactions. It does not interact with common over-the-counter medications such as Sudafed or other decongestants, antihistamines, or pain relievers. This makes benzonatate a suitable choice for individuals who require cough relief while taking other medications.
Full information on benzonatate can be found here: Benzonatate Drug Information
What Is Sudafed?
Sudafed is a brand name for the active ingredient pseudoephedrine, which is a decongestant. It works by narrowing the blood vessels in the nasal passages, thereby reducing swelling and congestion.
Sudafed provides temporary relief from symptoms related to nasal congestion caused by allergies, colds, or sinus infections. It is available in various formulations, including tablets, capsules, and as a liquid.
Full information on pseudoephedrine can be found here: Pseudoephedrine Drug Information
Safe to Combine?
Combining benzonatate with Sudafed is generally safe for most people. Since benzonatate does not interact significantly with other medications, including Sudafed, there is no specific concern about combining these two drugs. Both medications target different symptoms: benzonatate for cough relief and Sudafed for nasal congestion relief. By taking them together, you can address both the cough and congestion symptoms commonly associated with sinus infections.
However, as with any medication, it is important to consult with your pharmacist or healthcare provider to ensure that there are no individual factors or specific concerns that need to be taken into account.
For example, Sudafed must be used cautiously in those with high blood pressure. It is therefore important to discuss its use with a healthcare professional so they can give guidance on your specific medical situation.
Final Words
Thanks so much for reaching out to us and please feel free to contact us again in the future!
References
- Tessalon Prescribing Information, AccessFDA
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Dr. Brian Staiger, PharmD
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