Can You Take Turmeric With Hydroxyzine?

Quick Answer

There is a theoretical possibility of an interaction between turmeric and hydroxyzine. Turmeric has been found in some small studies to inhibit the activity of CYP3A4, an enzyme responsible for metabolizing hydroxyzine in the liver. This inhibition could potentially lead to increased levels of hydroxyzine in the body, although there are no specific studies evaluating this interaction.

Detailed Answer

As mentioned, there is a theoretical interaction between turmeric (which contains curcumin) and hydroxyzine based on some small studies, mostly lab and animal studies, that indicate turmeric may inhibit a liver enzyme known as CYP3A4, which is at least partially responsible for breaking down hydroxyzine.

This inhibitory effect of turmeric curcumin on CYP3A4 could potentially impact the metabolism of drugs metabolized by CYP3A4, which includes hydroxyzine. If hydroxyzine is metabolized more slowly due to the inhibition of CYP3A4, its levels in the body may increase, possibly leading to an increased risk of side effects, such as:

• Dizziness
• Drowsiness
• Dry eyes
• Dry mouth
• Constipation
• Sedation

However, it's worth noting that while in vitro and animal studies can provide valuable initial data, they cannot precisely predict the actual effects of this interaction in humans. Further research, such as human clinical trials, is necessary to fully understand the significance and clinical relevance of this interaction.

Nevertheless, there is a case report in humans I found that documented a patient who experienced elevated levels of the immunosuppressant drug tacrolimus, which is also metabolized by CYP3A4, after consuming high doses of turmeric powder. However, there certainly may have been other factors at play here too. This specific case study is documented on our interaction detail page.

Overall, it is reasonable to assume that there is the potential for turmeric to interact with hydroxyzine, but whether or not this will be to a clinically significant degree is unknown.

Additionally, individual factors such as dosage, medical history, and other medications being taken can influence the likelihood and severity of any potential interaction, so it is crucial to consult with your doctor before making any changes to your medication regimen. They can evaluate the risks, benefits, and overall impact of the potential interaction for your specific situation.

Final Words

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