Can You Take Vraylar And Sudafed Together?

In our latest question and answer, the pharmacist discusses the safety of taking Vraylar with pseudoephedrine.

2 min read Updated Jun 2026 1,489 views
Can You Take Vraylar And Sudafed Together?
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Lisa asked

Can you take Vraylar and pseudoephedrine? I have a horrible stuffy nose and have been on Vraylar for about 3 years. If I can't take that, what can I take? It's just a cold.

Jan 20, 2023
The quick answer
  • Vraylar and Sudafed are safe to take together with no known interactions between them. Other options for treating congestion like nasal steroids and antihistamines also don't interact with Vraylar. Common over-the-counter cold medications including acetaminophen, ibuprofen, and cough suppressants are safe to use with Vraylar.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.

Answer

Thanks for your question! You're certainly right to ask about potential interactions between Vraylar and over-the-counter medications to ensure you are taking a safe combination of drugs, especially when it involves drugs that are used for mental health indications as they often affect brain chemistry.

The good news here is that it is generally safe to take Vraylar (cariprazine) and Sudafed (pseudoephedrine) together, as there are no known interactions between the two medications.

While Sudafed doesn't interact with Vraylar and is an option you should, if nasal congestion is something that has consistently been a problem, I might suggest trying something that can help prevent congestion from happening in the first place. This would include options like:

  • Antihistamines
  • Nasal steroids

Antihistamines, like Claritin, Allegra and Zyrtec are considered safe to take with Vraylar and can help prevent nasal congestion if it is due to allergies. It is important to note that some 'drug-interaction checkers' will report an interaction between Vraylar and antihistamines, but this is only due to the fact that Vraylar can be sedating, as some antihistamines can be as well.

Nasal steroids are also a good option for preventing congestion. Over-the-counter nasal steroids include:

  • Flonase
  • Flonase Sensimist
  • Rhinocort
  • Nasonex

These drugs don't interact with Vraylar either.

Are There Any Cold Medications To Be Concerned About?

It is safe to take Vraylar in conjunction with a variety of over-the-counter cold medications, including antihistamines, nasal steroids, pseudoephedrine, the expectorant Mucinex (guaifenesin), and analgesics such as acetaminophen and ibuprofen. There are no reported interactions here.

Furthermore, even the cough suppressant dextromethorphan, which must be used cautiously with some antidepressants (e.g., SSRIs) due to its potential effects on serotonin, doesn't have documented evidence of an interaction with Vraylar.

Like antihistamines, you may see interactions reported with dextromethorphan, but it's simply due to its potential sedative effects. It is not known to affect how our bodies metabolize Vraylar or alter its effects.

If you have any questions about a specific over-the-counter cold medication I didn't touch on here, feel free to reach back out and I'll be sure to go over it in detail.

Final Words

In summary, Vraylar and pseudoephedrine can be taken together as there are no reported interactions.

You have other options to help treat your congestion as well, such as nasal steroids.

I really appreciate you contacting us to help answer your question. We're always available to help!

References & sources
  1. Vraylar Prescribing Information — AccessFDA
  2. Cariprazine Monograph — PubChem
Glossary — Terms in This Answer
Cariprazine
The active ingredient in the medication Vraylar, used to treat mental health conditions.
Pseudoephedrine
A decongestant medication found in Sudafed that helps relieve nasal congestion.
Antihistamines
Medications that reduce allergy symptoms by blocking the body's histamine response.
Nasal steroids
Anti-inflammatory medications sprayed into the nose to reduce congestion and swelling.
Guaifenesin
An expectorant medication that helps thin mucus and makes coughing easier.
Dextromethorphan
A cough suppressant ingredient used in over-the-counter cold medications.
SSRIs
A class of antidepressant medications that affect serotonin levels in the brain.
Metabolize
The process by which the body breaks down and processes medications.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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