Combining DayQuil With Zarbee's Cough Syrup
In our latest question and answer, our pharmacist discusses the safety of combining DayQuil with Zarbee's Cough syrup for kids.

Question
Is it safe to take DayQuil Kids Daytime Plus Honey with Zarbee's cough syrup?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 16, 2025
Key points
- Kids DayQuil contains Guaifenesin, Dextromethorphan HBr, and Phenylephrine HCl while Zarbee's Cough contains natural remedies like Dark honey, English Ivy Leaf Extract, Elderberry, and Zinc. There is no known clinically significant interaction between the products.
Quick Answer
There is no known interaction between Kids DayQuil and Zarbee's Cough Syrup. They are considered safe to use together.
Detailed Answer
Thanks so much for reaching out to us!
As mentioned in the 'quick answer' section above, there is no known interaction between DayQuil (you mentioned the kids' version) and Zarbee's Cough. I'll break down each product in the sections below and discuss their ingredients.
What Is In Kids DayQuil?
Kids DayQuil contains the following medications:
- Guaifenesin
- Dextromethorphan HBr
- Phenylephrine HCl
Guaifenesin is the active ingredient in the brand-name product Mucinex. It is an expectorant that works by thinning and loosening mucus in the respiratory tract, making it easier to cough up.
Dextromethorphan HBr is a commonly used cough suppressant that works by blocking the cough reflex in the brain. It is commonly used to relieve dry, hacking coughs associated with colds and other respiratory illnesses.
Phenylephrine HCl is a nasal decongestant that works by constricting blood vessels in the nasal passages, reducing swelling and congestion.
While these drugs certainly do have interactions with some other medications, there are no known interactions between any of these and the ingredients contained in Zarbee's Cough.
What Is In Zarbee's Cough?
There are a few different Zarbee's Cough and Mucus products available, including an adult version, a children's version, and a 'baby' version.
There are also both day and nighttime versions available for the Children's product. Since you didn't specify, I assume you are asking about the daytime children's version, which contains the following ingredients:
- Dark honey
- English Ivy Leaf Extract
- Elderberry
- Zinc (zinc gluconate)
You'll notice that this Zarbee's product doesn't contain any 'conventional' drugs, but rather contains natural remedies.
Dark honey is a natural cough suppressant. Studies show that in many situations, it is as effective as other over-the-counter cough suppressants in relieving cough symptoms.
English Ivy Leaf Extract is an herbal remedy that has been used for centuries for the treatment of respiratory conditions such as cough, bronchitis, and asthma. It works by reducing inflammation and loosening mucus, making it easier to cough up.
Elderberry is a natural remedy that may have antiviral and anti-inflammatory properties. It is purported to help boost the immune system and reduce the severity and duration of cough and cold symptoms.
Like conventional drugs, there are studies that show some of these natural ingredients can interact with certain drugs, but overall, they tend to be very minor and essentially non-clinically significant.
There are no known clinically significant interactions between any of the ingredients in this Zarbee's Cough product and the ingredients in DayQuil.
Final Words
Thanks so much for reaching out to us!
It's always a good idea to look into potential interactions and we're always happy to provide guidance here.
Please feel free to reach back out again anytime.
References
- Vick's DayQuil, https://vicks.com/en-us/shop-products/dayquil/vicks-dayquil-kids-cold-and-cough-mucus-relief
- Zarbee's Cough + Mucus, https://www.zarbees.com/product/childrens-cough-mucus-day/
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Dr. Brian Staiger, PharmD
- 1221 views