Combining DayQuil With Zarbee's Cough Syrup

In our latest question and answer, our pharmacist discusses the safety of combining DayQuil with Zarbee's Cough syrup for kids.

3 min read Updated Jun 2026 Read by 1,901 people
Combining DayQuil With Zarbee's Cough Syrup
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Mom asked

Is it safe to take DayQuil Kids Daytime Plus Honey with Zarbee's cough syrup?

Mar 06, 2023
The quick answer
  • There is no known interaction between Kids DayQuil and Zarbee's Cough Syrup, so they are safe to use together.
  • Kids DayQuil contains medications like a cough suppressant and decongestant, while Zarbee's Cough contains natural ingredients like honey and herbal extracts.
  • Even though both products have different ingredients and work in different ways, there are no clinically significant interactions between them.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.

Quick Answer

There is no known interaction between Kids DayQuil and Zarbee's Cough Syrup. They are considered safe to use together.

Detailed Answer

Thanks so much for reaching out to us!

As mentioned in the 'quick answer' section above, there is no known interaction between DayQuil (you mentioned the kids' version) and Zarbee's Cough. I'll break down each product in the sections below and discuss their ingredients.

What Is In Kids DayQuil?

Kids DayQuilKids DayQuil contains the following medications:

  • Guaifenesin
  • Dextromethorphan HBr
  • Phenylephrine HCl

Guaifenesin is the active ingredient in the brand-name product Mucinex. It is an expectorant that works by thinning and loosening mucus in the respiratory tract, making it easier to cough up.

Dextromethorphan HBr is a commonly used cough suppressant that works by blocking the cough reflex in the brain. It is commonly used to relieve dry, hacking coughs associated with colds and other respiratory illnesses.

Phenylephrine HCl is a nasal decongestant that works by constricting blood vessels in the nasal passages, reducing swelling and congestion.

While these drugs certainly do have interactions with some other medications, there are no known interactions between any of these and the ingredients contained in Zarbee's Cough.

What Is In Zarbee's Cough?

Zarbee cough mucus

There are a few different Zarbee's Cough and Mucus products available, including an adult version, a children's version, and a 'baby' version.

There are also both day and nighttime versions available for the Children's product. Since you didn't specify, I assume you are asking about the daytime children's version, which contains the following ingredients:

  • Dark honey
  • English Ivy Leaf Extract
  • Elderberry
  • Zinc (zinc gluconate)

You'll notice that this Zarbee's product doesn't contain any 'conventional' drugs, but rather contains natural remedies.

Dark honey is a natural cough suppressant. Studies show that in many situations, it is as effective as other over-the-counter cough suppressants in relieving cough symptoms.

English Ivy Leaf Extract is an herbal remedy that has been used for centuries for the treatment of respiratory conditions such as cough, bronchitis, and asthma. It works by reducing inflammation and loosening mucus, making it easier to cough up.

Elderberry is a natural remedy that may have antiviral and anti-inflammatory properties. It is purported to help boost the immune system and reduce the severity and duration of cough and cold symptoms.

Like conventional drugs, there are studies that show some of these natural ingredients can interact with certain drugs, but overall, they tend to be very minor and essentially non-clinically significant.

There are no known clinically significant interactions between any of the ingredients in this Zarbee's Cough product and the ingredients in DayQuil.

Final Words

Thanks so much for reaching out to us!

It's always a good idea to look into potential interactions and we're always happy to provide guidance here.

Please feel free to reach back out again anytime.

References & sources
  1. Vick's DayQuil — https://vicks.com/en-us/shop-products/dayquil/vicks-dayquil-kids-cold-and-cough-mucus-relief
  2. Zarbee's Cough + Mucus — https://www.zarbees.com/product/childrens-cough-mucus-day/
Glossary — Terms in This Answer
Expectorant
A medication that thins and loosens mucus to make it easier to cough up.
Cough suppressant
A medication that reduces or stops the urge to cough by blocking the cough reflex.
Decongestant
A medication that reduces swelling and congestion in the nasal passages by constricting blood vessels.
Respiratory tract
The system of organs and passages involved in breathing, including the nose, throat, and lungs.
Cough reflex
An automatic bodily response in the brain that triggers coughing.
Anti-inflammatory
A substance that reduces inflammation or swelling in the body.
Antiviral
A substance that works against viruses or helps prevent viral infections.
Clinically significant
Important or meaningful enough to have a noticeable effect on a person's health or treatment.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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