Concerns Taking Xanax And Restoril Together

In our latest question and answer, the pharmacist discusses the combined use of Xanax (alprazolam) and Restoril (temazepam).

2 min read Updated Jun 2026 Read by 1,703 people
Concerns Taking Xanax And Restoril Together
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Robert asked

My doctor gives me Xanax 2mg, taken five times daily, and I also take Restoril 60mg at night. Is this a lot?

Aug 28, 2023
The quick answer
  • Both Xanax and Restoril are benzodiazepines, and taking them together increases the risk of serious side effects like excessive sedation, respiratory depression, and overdose.
  • The doses you mentioned exceed FDA-approved maximum daily amounts for each medication, which raises safety concerns that should be discussed with your prescribing doctor.
  • Regular monitoring by your healthcare provider is important when taking multiple benzodiazepines to watch for dangerous additive effects on your central nervous system.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
Medications in this answer — tap to explore

Quick Answer

Whether the prescribed doses of Xanax 2mg taken five times a day and Restoril 60mg at night are considered 'high' depends greatly on individual factors such as your specific condition, tolerance, and response to medication. However, without any additional context, it is important to note that on the surface, those doses would be regarded as very high. This is particularly concerning as both medications are benzodiazepines, and combining multiple benzodiazepines can pose serious risks.

Detailed Answer

Evaluating whether a specific dose of a benzodiazepine is considered high can vary based on individual factors, including:

  • The severity of the condition being treated
  • Your tolerance to benzodiazepines
  • Your medical and medication history

Nonetheless, based on the information provided, the doses you mentioned of both drugs would certainly be considered high by most.

Firstly, according to the FDA, the recommended maximum daily dose (MDD) of Restoril (temazepam) is 30mg per day. You are taking double that amount.

Additionally, for Xanax (alprazolam), the maximum daily dose approved by the FDA is 10mg. You are taking that amount.

So, you're not only taking high doses of each medication individually, but you are also combining two different benzodiazepines, which is risky in its own right.

It's important to remember that benzodiazepines are controlled substances and have a risk of abuse and misuse. They can also be very dangerous in regard to side effects if they are not prescribed or taken appropriately.

Benzodiazepine Risks

Taking high doses of multiple benzodiazepines can increase the risk of unwanted effects related to suppressing the central nervous system (CNS).

These effects can range from sedation and drowsiness to more severe outcomes like respiratory depression and even overdose.

The concomitant use of CNS depressant drugs should be carefully considered by your healthcare provider since combining multiple CNS depressants, such as benzodiazepines, may result in additive effects. Regular monitoring for additive CNS-depressant effects is crucial when using multiple CNS depressants, like benzodiazepines, simultaneously.

The benzodiazepine class is certainly a medication class where tolerance can develop. A high dose for one person may not necessarily be a high dose for someone else. Without knowing your medical background, it is impossible to say whether or not the medications you are taking are appropriate. It is still important to know of potential concerns though.

Final Words

Thanks for reaching out and I hope you found this helpful.

References & sources
  1. Xanax Prescribing Information — AccessFDA
  2. Restoril Prescribing Information — AccessFDA
Glossary — Terms in This Answer
Benzodiazepines
A class of prescription drugs that slow down brain activity and are used to treat anxiety, seizures, and sleep problems.
Maximum daily dose (MDD)
The highest amount of a medication that is safe to take in a 24-hour period.
Controlled substances
Medications or drugs that are strictly regulated by the government because they carry a risk of abuse or addiction.
Central nervous system (CNS)
The brain and spinal cord, which control all body functions and messages.
Respiratory depression
A dangerous slowing of breathing that can occur when too much medication suppresses the brain's respiratory control.
Concomitant use
Taking two or more medications at the same time.
Additive effects
The combined result when two drugs with similar actions are taken together, making their effects stronger.
Tolerance
A condition where the body becomes less responsive to a medication over time, requiring higher doses for the same effect.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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