Does Mullein Interact With Eliquis?

Answer

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Mullein, a popular herbal supplement used mostly to support respiratory conditions, is known to be relatively safe based on the limited studies that have been done on it. It's one I often recommend for folks I think would benefit from it.

In regard to interactions, our drug-supplement interaction checker does list a minor interaction between mullein and Eliquis (or any blood-thinning drug for that matter) based on the fact that mullein contains compounds that lab studies show may have minor anticoagulant effects.

Specifically, mullein, which has a large number of constituents, contains triterpene saponins. Triterpene saponins have been reported in some studies to affect the coagulation of blood.

It is important to point out that this interaction is theoretical. There have been no human studies that I could find that report that mullein affects blood coagulation in humans at typical supplement dosages, and no studies have specifically reported mullein interacting with blood-thinning drugs like Eliquis and warfarin (the theoretical interaction being an increase in blood-thinning effects).

Based on the information we have available to us, I would rate this interaction as 'minor' and unlikely to occur to a clinically significant degree in humans, especially at dosages of mullein found in dietary supplements. I'm not even aware of anecdotal reports of mullein causing problems with blood coagulation.

Nevertheless, as always, I always recommend caution with herbal supplements based on the lack of data available. Please reach out to your doctor before making changes to your medication regimen so you can be appropriately monitored.

Final Words

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