Does Trazodone Expire?

In our latest question and answer, the pharmacist discusses whether or not trazodone expires.

Question

My trazodone expired in 2017. Is it harmful to take now?

Asked by Keke On Jun 27, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Jun 27, 2022
Last updated Apr 19, 2024

Key points

  • Trazodone, like all prescription drugs, does expire.
  • In most cases, the expiration date of trazodone is 2 to 3 years after the date of manufacture. After dispensing by your pharmacy, the expiration date is generally one year from that date.
  • It is not recommended to take expired trazodone as it may not be as effective as it once was.

Trazodone, like all prescription drugs, does expire. It is not recommended that you take trazodone if it had an expiration date of 2017.

Concerns

The main concern with taking expired medication is that it may not have retained the desired potency level or effectiveness. This decreased potency can lead to incorrect dosing of the medication resulting in an increased risk for adverse effects.

The expiration date on trazodone is determined by multiple factors but, most importantly, it refers to how long the manufacturer is willing to guarantee that the product meets the labeled standards of potency and purity.

Most medication is listed with an expiration date of 2-3 years from the time of manufacturing and typically correlates with the time period for which the manufacturer performed stability testing.

After this expiration date, it doesn’t necessarily mean that the medication “goes bad”, it just means that there is no stability data regarding whether or not the medication will retain the listed potency and purity when stored under proper conditions.

When a pharmacy dispenses you a medication, it must be labeled with an expiration date or a beyond-use date.

The beyond-use date that is listed depends on the product being dispensed and takes into account how long a drug is stable after being dispensed. In most cases, the beyond-use date will be shorter than the manufacturer's expiration date as the beyond-use date specifically refers to an expiration time after dispensing or repackaging a medication.

The state in which you are located has laws to determine the beyond-use date for most dispensed products.

Most commonly, and as a general rule of thumb, the beyond-use date (commonly listed as the expiration date on the prescription bottle) will be one year, or the manufacturer listed expiration date, whichever is sooner.

Final Words

So, as mentioned above, expired trazodone shouldn't be harmful to take, but it may not be as potent as it once was.

This can potentially lead to treatment failure, which of course can be deleterious to your health. If you have been prescribed trazodone but your prescription is expired, it is recommended to reach out to your doctor for a refill.

References

  • Trazodone Monograph, PubChem
  • Should We Use Expired Drugs When Necessary?, PubMed
  • What can be done with expired pharmaceuticals? A review of literature as it pertains to special operations force?s medics, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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