How To Take Keflex (Cephalexin) Four Times A Day

In our latest question and answer, the pharmacist discusses how to take your Keflex (cephalexin) prescription when it says to take "four times a day".


My husband has a script for cephalexin which says to take it every 6 hrs. for 14 days. We’re out of the country and cannot ask this of our pharmacist. Would it be ok to take this med at 7 AM, Noon, 6 PM, and 11 PM so that he can get in 8 hrs. sleep?

Asked by dft4238 On Sep 11, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Sep 11, 2022
Last updated Sep 11, 2022

Key points

  • If you have been prescribed to take Keflex (cephalexin) four times daily, you can separate your doses by about 6 hours per dose.
  • As long as you evenly separate your Keflex doses during the time you are awake, you don't need to interrupt your usual sleep schedule.


Keflex (cephalexin) is a cephalosporin antibiotic that is typically dosed 2 to 4 times a day. When you receive your prescription and it says to "take one dose four times daily", I can certainly understand it being a little confusing in regard to how appropriately space the doses.

Spacing Keflex Doses

For Keflex, taking one dose four times daily equates to taking one dose about every 6 hours. In most cases, it is not necessary to interrupt your sleep schedule to take a dose at exactly a 6 hours interval. You can safely space your Keflex doses as evenly as possible four times throughout your waking hours.

The dosing schedule you write in your question will suffice for most individuals. Generally, four times daily dosing is recommended as follows:

  • One dose in the morning
  • One dose in the afternoon
  • One dose in the evening
  • One dose at bedtime

Having said all of the above, you should also reach out to your doctor to make sure they don't have a specific dosing schedule in mind.

In terms of taking Keflex (cephalexin), it may be administered without regard to meals although if it causes an upset stomach or other GI symptoms, food may decrease the incidence of these side effects.

Final Words

Thanks for your question! We love hearing from our readers.


About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at! You can also connect with Dr. Brian Staiger on LinkedIn.

Recent Questions