Is Myfembree A Birth Control Pill?

In our latest question and answer, the pharmacist discusses what the drug Myfembree is used for.


I saw a commercial for Myfembree and wanted to know if that was a kind of birth control pill. I don't like the one I am on and was looking to make a switch.

Asked by Alison On Oct 12, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Oct 12, 2022
Last updated Jun 02, 2023

Key points

  • Myfembree is not a birth control pill. It is used for the management of heavy menstrual bleeding associated with uterine leiomyomas (fibroids) and for moderate to severe pain associated with endometriosis in premenopausal women.
  • Myfembree does not prevent against pregnancy and should not be used with birth control pills as they will make Myfembree less effective.
  • If birth control is needed while taking Myfembree, alternatives to oral birth control pills must be used.


Myfembree is not a birth control pill (i.e., oral contraceptive). While it does contain certain hormones that many birth control pills have (e.g., an estrogen and a progestin), it also contains relugolix, a gonadotropin-releasing hormone (GnRH) receptor antagonist. Myfembree is used for two indications:

  • The management of heavy menstrual bleeding associated with uterine leiomyomas (fibroids)
  • The management of moderate to severe pain associated with endometriosis in premenopausal women

How Does Myfembree Work?

Myfembree contains three drugs:

  • Relugolix
  • Estradiol
  • Norethindrone acetate

Relugolix, the gonadotropin-releasing hormone (GnRH) receptor antagonist contained in Myfembree, reduces bleeding by lowering estradiol and progesterone levels.

Specifically, relugolix binds to pituitary GnRH receptors, which reduces the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This leads to decreased concentrations estradiol and progesterone, and reduced bleeding associated with uterine fibroids and pain associated with endometriosis.

It may seem counterintuitive that Myfembree contains an estrogen and progesterone, but the estradiol and norethindrone in the drug are there in small amount to limit side effects, such as bone loss, hot flashes, and other risks of low estrogen.

Even though those hormones are there to limit side effects, Myfembree is only recommended to be used for up to 2 years maximum since the side effect of bone loss may not be reversible.

Can You Use Birth Control With Myfembree?

As mentioned, Myfembree is not a birth control pill and does not prevent pregnancy. If you are sexually active, you must use a different form of birth control. Per the Prescribing Information for Myfembree:

MYFEMBREE does not prevent pregnancy. You will need to use effective methods of birth control while taking MYFEMBREE and for 1 week after you stop taking MYFEMBREE. Examples of effective methods can include condoms or spermicide, which do not contain hormones.
Do not take hormonal birth control such as birth control pills because they may increase your side effects and MYFEMBREE may not work as well.

Myfembree Prescribing Information

It is important to emphasize that Myfembree should not be used with oral birth control pills as it may make Myfembree less effective.

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About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at! You can also connect with Dr. Brian Staiger on LinkedIn.

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