What Cold Medications Can You Take With Claritin?

In our latest question and answer, the pharmacist discusses which cold medications you can take safely with Claritin (loratadine).


What cold medication can I take with Claritin? I have allergies and have gotten a bad cold during high allergy season.

Asked by Gen On May 02, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published May 02, 2022
Last updated Apr 12, 2024

Key points

  • For the most part, you can take any cold medication you want while on Claritin, with the exception of other antihistamines.
  • The only medications to avoid are other antihistamine products that are generally included in cold combination products.
  • The most common antihistamines that are included in these products are Benadryl (diphenhydramine) and dimenhydrinate, so be sure to read the label of what a product contains before taking it.

Hello! Thanks for writing in!

Safe To Take With Claritin

Claritin (loratadine), a non-sedating 24-hour antihistamine, can be taken with most over counter cold medications, including:

  • Analgesics such as Tylenol or Advil
  • Mucinex (guaifenesin)
  • Delsym (dextromethorphan)
  • Sudafed (pseudoephedrine)

There are no reported interactions between Claritin and any of these drugs.

Use Caution

It is important to keep an eye out for over-the-counter cold medications that are combination products, meaning they contain multiple ingredients.
Many of the over-the-counter combination products already contain an antihistamine, like Claritin.

If you take two antihistamines together, there is a potential for an increase in side effects (e.g. sedation, dry mouth etc...)

Most nighttime formulation combination products will contain a sedating antihistamine, such as Benadryl (diphenhydramine or doxylamine). These should be avoided while taking Claritin.

Use The Right Med For Your Symptoms

As mentioned in this answer, most over-the-counter cold medications are fine to take with Claritin.

Below are some safe options to use with Claritin, depending on your symptoms:

  • Congestion: Sudafed (pseudoephedrine) typically works well to treat these symptoms.
  • Cough: You can use a cough suppressant, like Delsym (dextromethorphan), to help reduce the frequency and severity of a cough.
  • Excess Mucus: Mucinex (guaifenesin) is usually a popular choice for helping with thinning mucus and secretions.
  • Pain/Fever: Pain relievers such as Tylenol (acetaminophen) or Advil/Motrin (ibuprofen) are safe to use with Claritin reduce fevers and treat mild to moderate pain symptoms.
  • Watering Eyes/Runny Nose: Antihistamines like Claritin are the most effective here

Final Words

Thanks again for your question and let us know if we can be of further help!


  • Loratadine Monograph, PubChem
  • Treatment of the common cold in children and adults, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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