What Is The Maximum Daily Dose Of Ibuprofen?

In our latest question and answer, the pharmacist discusses what the maximum daily dose of ibuprofen is for both prescription and OTC use.

2 min read Updated Jun 2026 Read by 22,564 people
What Is The Maximum Daily Dose Of Ibuprofen?
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Jacks asked

I just had drainage done on a tooth. I am aching still. I have taken two 800 mg ibuprofen since early this morning. I need another for the night. Can I take a 3rd one? Or is that too much for one day?

Aug 26, 2022
The quick answer
  • The maximum daily dose of prescription ibuprofen is 3,200 mg, while over-the-counter ibuprofen is limited to 1,200 mg per day because higher doses can cause serious side effects like gastrointestinal bleeding and increase cardiovascular risk.
  • Higher prescription doses should only be used under a doctor's direction, while over-the-counter use is self-limited to lower amounts for safety.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
Medications in this answer — tap to explore

Answer

Thanks for reaching out to us!

The maximum daily dose of ibuprofen varies depending on whether or not you are using ibuprofen via prescription or taking the over-the-counter (OTC) product.

The maximum daily dose of prescription ibuprofen is:

  • 3,200 mg

Prescription ibuprofen is available as a 400 mg tablet, 600 mg tablet and 800 mg tablet. Therefore, the maximum amount you can take in one day of the prescription tablets is as follows:

  • 8 tablets of 400 mg ibuprofen
  • 5 tablets of 600 mg ibuprofen
  • 4 tablets of 800 mg ibuprofen

The maximum daily dose of over-the-counter ibuprofen is:

  • 1,200 mg per day

Since over-the-counter ibuprofen only comes as a 200 mg tablet, the maximum daily dose is 6 tablets.

Rx Vs. OTC Ibuprofen Maximum Daily Dose

Even though prescription and OTC ibuprofen are the same active ingredient, the maximum daily dose varies, as you can see above.

This is because high doses of ibuprofen, for extended periods of time, can cause serious side effects such as gastrointestinal bleeding and increases your risk of cardiovascular events. Self-treatment (i.e. over-the-counter use) of ibuprofen is therefore limited and higher doses should only be used under the direction of your doctor or other prescribers.

In your situation, you have a prescription for ibuprofen 800 mg tablets. Therefore, you can take up to 4 per day (unless otherwise directed). The usual dosing interval is every four to six hours.

We wrote about this topic more comprehensively in another one of our Q+As, which can be found here: Are Prescription And Over-The-Counter Ibuprofen The Same?

Final Words

Thanks again for reaching out and please do so again if anything else comes up!

References & sources
  1. Ibuprofen Monograph — PubChem
  2. Ibuprofen: pharmacology, efficacy and safety — PubMed
Glossary — Terms in This Answer
Prescription
A medication that is ordered by a doctor and can only be obtained with a written authorization from a healthcare provider.
Over-the-counter (OTC)
A medication that can be purchased directly without a doctor's prescription.
Active ingredient
The substance in a medication that produces the therapeutic effect or works to treat a condition.
Side effects
Unwanted or harmful reactions that occur in addition to the intended therapeutic effect of a medication.
Gastrointestinal bleeding
Bleeding that occurs in the stomach or intestines, which can be a serious complication.
Cardiovascular events
Serious medical problems related to the heart and blood vessels, such as heart attacks or strokes.
Dosing interval
The amount of time that should pass between doses of a medication.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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