7,8-benzoflavone - Topotecan Interaction

7,8-Benzoflavone acts as a steroidal aromatase inhibitor, which means it helps increase testosterone levels by blocking the conversion of testosterone to estrogen. This can be particularly beneficial when used alongside anabolic steroids to minimize side effects like gynecomastia caused by excess testosterone converting to estrogen. However, it's important to note that the World Anti-Doping Agency (WADA) has banned the use of aromatase inhibitors in sports to maintain fairness and integrity in athletic competition. Moreover, the consumption of dietary supplements containing aromatase inhibitors can pose significant risks. Adverse effects linked to these inhibitors encompass aggressive behavior, adrenal insufficiency, reduced bone maturation and growth rates, diminished sperm production, infertility, kidney failure, and liver dysfunction. The use of aromatase inhibitors (of which many are available by prescription) should be under the supervision of a medical professional.