Allspice - Agrylin (Anagrelide) Interaction
Herbal: Allspice
Also Known As: Pimenta dioica, All Spice, Allspice Essential Oil, Aqua Pimentae, Clove Pepper, Eugenia Piment, Jamaica Pepper, Jamaican Pepper, Kiln-Dried Allspice, Piment de la Jamaïque, Pimenta, Pimento, Pimienta de Jamaica, Poivre Anglais, Poivre Aromatique, Poivre de Jamaïque
Drug: Anagrelide
Brand names:
Agrylin
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Anagrelide is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Theoretically, combining allspice with an antiplatelet or anticoagulant drug might increase the risk of bleeding.
Eugenol, a constituent of allspice, is reported to have antiplatelet activity. However, this interaction has yet not been reported in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Chen SJ, Wang MH, Chen IJ. Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. Gen Pharmacol 1996;27:629-33.
Allspice Overview
Allspice (Pimenta dioica) is a tropical evergreen tree that is native to Central America and the Caribbean. It belongs to the myrtle family (Myrtaceae). The fruit of the allspice tree is a small, round berry that is green when unripe and turns a reddish-brown color when ripe. The dried berries of the tree are most often used as a spice in cooking, while both the berries and leaves have been used in traditional medicine for their purported inflammatory, analgesic, and digestive properties.
Anagrelide Overview
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Anagrelide is used to decrease the number of platelets (a type of blood cell that is needed to control bleeding) in the blood of patients who have a bone marrow disorder, in which the body makes too many of one or more types of blood cells, such as essential thrombocythemia (condition in which the body makes too many platelets) or polycythemia vera (condition in which the body makes too many red blood cells and sometimes too many platelets). Anagrelide is in a class of medications called platelet-reducing agents. It works by slowing the production of platelets in the body.
Allspice - More Interactions
Allspice interacts with 118 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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