American Spikenard - Diutensen (Cryptenamine, Methyclothiazide) Interaction
Herbal: American Spikenard
Also Known As: Aralia racemosa, Anis Sauvage, Grande Salsepareille, Indian Root, Life of Man, Life-of-Man, Old Man's Root, Pettymorell, Small Spikenard, Spignet, Spikenard
Drug: Cryptenamine, Methyclothiazide
Brand names:
Diutensen
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Feb 07, 2024
Interaction Details
Cryptenamine, Methyclothiazide is classified as belonging to the following category: Diuretic Drugs
American spikenard is purported to have diaphoretic properties. Diaphoretic substances can increase sweating and fluid loss from the body, which may enhance the effects of diuretics. This interaction could potentially lead to excessive fluid loss and electrolyte imbalance, especially in individuals taking diuretic medications. Healthcare providers need to monitor patients closely for signs of dehydration or electrolyte disturbances if they are using both Aralia racemosa and diuretic drugs concurrently.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
American Spikenard Overview
Aralia racemosa, also known as American spikenard, is a woody, flowering perennial native to eastern North America. It is characterized by its large, compound leaves and clusters of small white flowers that bloom in late summer to early fall. The rhizome and root of American spikenard have been traditionally used in herbal medicine for their purported expectorant and diaphoretic effects. However, there is insufficient reliable evidence to rate its effectiveness for asthma or the common cold. American spikenard is known to have several classes of bioactive components, such as petroselinic acid, triterpenoid saponins, sterols, diterpenoids, and acetylenic lipids.
American Spikenard - More Interactions
American Spikenard interacts with 75 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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