Andiroba - WelChol (Colesevelam) Interaction
Herbal: Andiroba
Also Known As: Carapa guianensis, Andiroba Oil, Andiroba-Saruba, Andiroba-Saruva, Bastard Mahogany, Brazilian Mahogany, Caoba Bastarda, Caobilla, Carapa, Carapa Rouge, Carapinha, Cedro Macho, Crabwood, Najesí, Nandiroba, Requia
Drug: Colesevelam
Brand names:
WelChol, Lodalis
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2024
Interaction Details
There were no interactions found between Colesevelam and Andiroba. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Andiroba Overview
Carapa guianensis, commonly known as Andiroba, is a tropical tree native to the Amazon rainforest, valued for various parts, including its bark, leaves, fruit oil, and seed oil. These parts contain bioactive compounds such as limonoids, triterpenes, coumarins, and flavonoids. The seed oil, rich in oleic and palmitic acids, also contains bitter substances like limonoids or meliacins, such as gedunin and andirobin. Andiroba is believed to possess medicinal properties, including potential anticonvulsant effects of fatty acid amides found in its oil, which may modulate GABA-A receptors. The oil's anti-inflammatory properties are attributed to its limonoid and triterpene content. It also demonstrates anti-plasmodial effects against parasites, primarily due to gedunin and its derivatives. Moreover, Andiroba leaves are used in the treatment of skin conditions such as ulcers and wounds, with research indicating that the leaf extract can accelerate wound healing and epithelialization, potentially through the augmentation of hydroxyproline concentrations.
Colesevelam Overview
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Colesevelam is used in adults along with diet, weight loss, and exercise to reduce the amount of cholesterol and certain fatty substances in the blood alone or in combination with other cholesterol-lowering medications known as HMG-CoA reductase inhibitors (statins). Colesevelam is also used alone or in combination with HMG-CoA reductase inhibitors in certain boys and in girls, ages 10 to 17, with familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally) to decrease the amount of cholesterol and other fatty substances in the blood. Colesevelam is also used along with diet and exercise to control blood sugar levels in adults with type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Colesevelam is in a class of medications called bile acid sequestrants. It works by binding bile acids in your intestines to form a product that is removed from the body.
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Bile acids are made when cholesterol is broken down in your body. Removing these bile acids helps to lower your blood cholesterol. Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats may help prevent heart disease, angina (chest pain), strokes, and heart attacks.
Andiroba - More Interactions
Andiroba interacts with 50 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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