Ashwagandha - Zoloft (Sertraline) Interaction

Interaction Details

Pharmacist Analysis

The use of ashwagandha may result in potential interactions with certain classes of medication due to its known effects. However, these interactions are generally considered to be of minimal clinical significance.

Nevertheless, it is recommended to exercise caution when using ashwagandha in conjunction with the following classes of drugs:

• Antidiabetes 
• Antihypertensives
• Benzodiazepines
• CNS Depressants
• Immunosuppressant
• Thyroid Hormones

Although ashwagandha can typically be used safely in combination with these drug classes, it is crucial to inform your healthcare provider of all medications and supplements you are taking to ensure proper monitoring. Based on available information, ashwagandha does not appear to cause any adverse interactions with the specific drug mentioned in this inquiry.

It is important to note that while some animal studies have reported that ashwagandha can enhance serotonergic transmission through alterations of certain serotonin (5-HT) receptors, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs, like Zoloft.

Some early studies have even suggested that ashwagandha may have some antidepressant effects, but more research is needed to understand the benefits and safety of taking it and Zoloft together.

Sertraline Overview

• Sertraline is used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), panic attacks (sudden, unexpected attacks of extreme fear and worry about these attacks), posttraumatic stress disorder (disturbing psychological symptoms that develop after a frightening experience), and social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life). It is also used to relieve the symptoms of premenstrual dysphoric disorder, including mood swings, irritability, bloating, and breast tenderness. Sertraline is in a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amounts of serotonin, a natural substance in the brain that helps maintain mental balance.

Ashwagandha - More Interactions

Ashwagandha interacts with 622 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.