Ashwagandha - Zoloft (Sertraline) Interaction
Also Known As: Withania somnifera, Ajagandha, Amangura, Asan, Asana, Asgand, Asgandh, Asgandha, Ashagandha, Ashvagandha, Ashwaganda, Ashwanga, Asoda, Asundha, Aswagandha, Avarada, Ayurvedic Ginseng, Cerise d'Hiver, Clustered Wintercherry, Ghoda Asoda
Brand names: Zoloft
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated Mar 25, 2023
There were no interactions found between Sertraline and Ashwagandha. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
The use of ashwagandha may result in potential interactions with certain classes of medication due to its known effects. However, these interactions are generally considered to be of minimal clinical significance.
Nevertheless, it is recommended to exercise caution when using ashwagandha in conjunction with the following classes of drugs:
- CNS Depressants
- Thyroid Hormones
Although ashwagandha can typically be used safely in combination with these drug classes, it is crucial to inform your healthcare provider of all medications and supplements you are taking to ensure proper monitoring. Based on available information, ashwagandha does not appear to cause any adverse interactions with the specific drug mentioned in this inquiry.
It is important to note that while some animal studies have reported that ashwagandha can enhance serotonergic transmission through alterations of certain serotonin (5-HT) receptors, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs, like Zoloft.
Some early studies have even suggested that ashwagandha may have some antidepressant effects, but more research is needed to understand the benefits and safety of taking it and Zoloft together.- Dr. Brian Staiger, PharmD
Sertraline is used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), panic attacks (sudden, unexpected attacks of extreme fear and worry about these attacks), posttraumatic stress disorder (disturbing psychological symptoms that develop after a frightening experience), and social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life). It is also used to relieve the symptoms of premenstrual dysphoric disorder, including mood swings, irritability, bloating, and breast tenderness. Sertraline is in a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amounts of serotonin, a natural substance in the brain that helps maintain mental balance.
Ashwagandha - More Interactions
Ashwagandha interacts with 622 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
|Major||The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.|
|Moderate||Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.|
|Minor||Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.|
|Unknown||No interactions have been reported or no interaction data is currently available.|
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.