Ba Ji Tian - Onglyza (Saxagliptin) Interaction
Herbal: Ba Ji Tian
Also Known As: Morinda officinalis, Ba Ji, Bajitian, Indian Mulberry, Morinda, Morinda Root, Morindae Radix, Noni, Racine du Morinda, Radix Morindae Officinalis
Drug: Saxagliptin
Brand names:
Onglyza
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Saxagliptin is classified as belonging to the following category: Antidiabetes Drugs
Animal research shows that taking ba ji tian extracts might increase or decrease blood glucose levels. Theoretically ba ji tian might have additive effects or attenuate the effects antidiabetes drugs. Monitor blood glucose levels closely; dose adjustments of antidiabetes drugs might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Soon, Y. Y. and Tan, B. K. Evaluation of the hypoglycemic and anti-oxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats. Singapore Med J 2002;43(2):077-085.
Ba Ji Tian Overview
Morinda officinalis, commonly known as Ba Ji Tian, is a perennial plant highly valued in traditional Chinese medicine for its root, which is rich in active compounds. These include morindolide, an iridoid lactone, iridoid glucosides such as monotropein and deacetyl asperulosidic acid, anthraquinones, monoterpene glycosides, and sterols like beta-sitosterol. Additionally, the root contains succinic acid, nystose, inulin-type hexasaccharide, and heptasaccharide, while its essential oil comprises compounds such as 1,2-benzedicarboxylic acid, hexadecanoic acid, hexanoic acid, nonanoic acid, aldehydes, alkenes, benzenes, and lactones.
Ba Ji Tian is traditionally used to tonify the kidneys, invigorate yang, support bone health, alleviate joint pain, and enhance vitality. Moreover, constituents isolated from Ba Ji Tian have demonstrated antidepressant properties, potentially through increasing serotonergic effects. Laboratory research indicates that its antidepressant effects are linked to oligosaccharides, which impact the brain-derived neurotrophic factor pathway in the medial prefrontal cortex. Commonly prepared as a decoction or in powdered form, Ba Ji Tian continues to be a key component of traditional Chinese medicine.
Saxagliptin Overview
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Saxagliptin is used along with diet and exercise to lower blood sugar levels in patients with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Saxagliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the amount of insulin produced by the body after meals when blood sugar is high. Saxagliptin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated).
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Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.
Ba Ji Tian - More Interactions
Ba Ji Tian interacts with 84 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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